Nsp1_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP53a

Species:

Leishmania mexicana

UniProt:

E9B314_LEIMU

TriTrypDb:

LmxM.31.2350

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	6
GO:0032991	protein-containing complex	1	6
GO:0140513	nuclear protein-containing complex	2	6
GO:0044613	nuclear pore central transport channel	3	1

Expansion

Sequence features

E9B314

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B314

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0033036	macromolecule localization	2	6
GO:0045184	establishment of protein localization	3	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6
GO:0006405	RNA export from nucleus	5	1
GO:0006606	protein import into nucleus	5	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051236	establishment of RNA localization	3	1
GO:0051649	establishment of localization in cell	3	1
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	6
GO:0017056	structural constituent of nuclear pore	2	6
GO:0005488	binding	1	1
GO:0005543	phospholipid binding	3	1
GO:0008289	lipid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	447	449	PF00675	0.385
CLV_PCSK_KEX2_1	416	418	PF00082	0.638
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.638
CLV_PCSK_SKI1_1	480	484	PF00082	0.368
CLV_PCSK_SKI1_1	490	494	PF00082	0.352
CLV_PCSK_SKI1_1	552	556	PF00082	0.492
DEG_APCC_DBOX_1	583	591	PF00400	0.552
DEG_SPOP_SBC_1	101	105	PF00917	0.515
DEG_SPOP_SBC_1	325	329	PF00917	0.560
DEG_SPOP_SBC_1	357	361	PF00917	0.572
DEG_SPOP_SBC_1	411	415	PF00917	0.542
DEG_SPOP_SBC_1	84	88	PF00917	0.608
DOC_CKS1_1	142	147	PF01111	0.489
DOC_CKS1_1	346	351	PF01111	0.488
DOC_MAPK_gen_1	448	456	PF00069	0.385
DOC_MAPK_MEF2A_6	448	456	PF00069	0.385
DOC_USP7_MATH_1	101	105	PF00917	0.531
DOC_USP7_MATH_1	122	126	PF00917	0.647
DOC_USP7_MATH_1	130	134	PF00917	0.553
DOC_USP7_MATH_1	188	192	PF00917	0.553
DOC_USP7_MATH_1	203	207	PF00917	0.602
DOC_USP7_MATH_1	266	270	PF00917	0.593
DOC_USP7_MATH_1	325	329	PF00917	0.554
DOC_USP7_MATH_1	356	360	PF00917	0.628
DOC_USP7_MATH_1	373	377	PF00917	0.520
DOC_USP7_MATH_1	411	415	PF00917	0.651
DOC_USP7_MATH_1	432	436	PF00917	0.385
DOC_USP7_MATH_1	495	499	PF00917	0.385
DOC_USP7_MATH_1	5	9	PF00917	0.636
DOC_USP7_MATH_1	612	616	PF00917	0.503
DOC_USP7_MATH_1	69	73	PF00917	0.639
DOC_USP7_MATH_1	85	89	PF00917	0.542
DOC_USP7_MATH_1	90	94	PF00917	0.620
DOC_WW_Pin1_4	102	107	PF00397	0.644
DOC_WW_Pin1_4	131	136	PF00397	0.652
DOC_WW_Pin1_4	141	146	PF00397	0.561
DOC_WW_Pin1_4	159	164	PF00397	0.594
DOC_WW_Pin1_4	16	21	PF00397	0.649
DOC_WW_Pin1_4	171	176	PF00397	0.566
DOC_WW_Pin1_4	224	229	PF00397	0.602
DOC_WW_Pin1_4	345	350	PF00397	0.556
DOC_WW_Pin1_4	391	396	PF00397	0.730
DOC_WW_Pin1_4	402	407	PF00397	0.737
DOC_WW_Pin1_4	430	435	PF00397	0.385
DOC_WW_Pin1_4	65	70	PF00397	0.627
LIG_14-3-3_CanoR_1	509	514	PF00244	0.342
LIG_14-3-3_CanoR_1	552	557	PF00244	0.492
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	132	136	PF00533	0.651
LIG_BRCT_BRCA1_1	361	365	PF00533	0.612
LIG_BRCT_BRCA1_1	434	438	PF00533	0.385
LIG_FHA_1	136	142	PF00498	0.505
LIG_FHA_1	594	600	PF00498	0.428
LIG_FHA_2	500	506	PF00498	0.385
LIG_FHA_2	510	516	PF00498	0.292
LIG_GBD_Chelix_1	613	621	PF00786	0.468
LIG_LIR_Gen_1	555	563	PF02991	0.439
LIG_LIR_Nem_3	162	167	PF02991	0.610
LIG_LIR_Nem_3	555	559	PF02991	0.439
LIG_LIR_Nem_3	73	79	PF02991	0.626
LIG_NRBOX	620	626	PF00104	0.485
LIG_PCNA_PIPBox_1	510	519	PF02747	0.385
LIG_PCNA_yPIPBox_3	507	517	PF02747	0.385
LIG_SH2_CRK	556	560	PF00017	0.441
LIG_SH2_GRB2like	556	559	PF00017	0.496
LIG_SH2_SRC	556	559	PF00017	0.496
LIG_SH2_STAP1	556	560	PF00017	0.496
LIG_SH2_STAT3	527	530	PF00017	0.385
LIG_SH2_STAT5	516	519	PF00017	0.399
LIG_SH3_3	139	145	PF00018	0.614
LIG_SH3_3	172	178	PF00018	0.499
LIG_SH3_3	343	349	PF00018	0.598
LIG_SUMO_SIM_par_1	229	234	PF11976	0.621
LIG_TRAF2_1	434	437	PF00917	0.385
LIG_TRAF2_2	434	439	PF00917	0.342
MOD_CK1_1	104	110	PF00069	0.566
MOD_CK1_1	125	131	PF00069	0.490
MOD_CK1_1	191	197	PF00069	0.584
MOD_CK1_1	252	258	PF00069	0.622
MOD_CK1_1	296	302	PF00069	0.607
MOD_CK1_1	359	365	PF00069	0.502
MOD_CK1_1	377	383	PF00069	0.582
MOD_CK1_1	389	395	PF00069	0.615
MOD_CK1_1	53	59	PF00069	0.634
MOD_CK1_1	93	99	PF00069	0.676
MOD_CK2_1	499	505	PF00069	0.385
MOD_CK2_1	509	515	PF00069	0.292
MOD_CK2_1	580	586	PF00069	0.566
MOD_CK2_1	588	594	PF00069	0.483
MOD_CK2_1	612	618	PF00069	0.506
MOD_GlcNHglycan	111	114	PF01048	0.503
MOD_GlcNHglycan	119	122	PF01048	0.588
MOD_GlcNHglycan	124	127	PF01048	0.537
MOD_GlcNHglycan	146	149	PF01048	0.671
MOD_GlcNHglycan	157	160	PF01048	0.563
MOD_GlcNHglycan	164	167	PF01048	0.495
MOD_GlcNHglycan	188	191	PF01048	0.609
MOD_GlcNHglycan	193	196	PF01048	0.582
MOD_GlcNHglycan	205	208	PF01048	0.532
MOD_GlcNHglycan	251	254	PF01048	0.568
MOD_GlcNHglycan	268	271	PF01048	0.564
MOD_GlcNHglycan	295	298	PF01048	0.601
MOD_GlcNHglycan	328	331	PF01048	0.666
MOD_GlcNHglycan	361	364	PF01048	0.546
MOD_GlcNHglycan	388	391	PF01048	0.721
MOD_GlcNHglycan	48	51	PF01048	0.644
MOD_GlcNHglycan	497	500	PF01048	0.392
MOD_GlcNHglycan	52	55	PF01048	0.614
MOD_GlcNHglycan	541	544	PF01048	0.493
MOD_GlcNHglycan	58	61	PF01048	0.567
MOD_GlcNHglycan	610	613	PF01048	0.484
MOD_GlcNHglycan	614	617	PF01048	0.425
MOD_GlcNHglycan	79	82	PF01048	0.584
MOD_GlcNHglycan	92	95	PF01048	0.625
MOD_GSK3_1	100	107	PF00069	0.565
MOD_GSK3_1	131	138	PF00069	0.547
MOD_GSK3_1	155	162	PF00069	0.649
MOD_GSK3_1	182	189	PF00069	0.612
MOD_GSK3_1	281	288	PF00069	0.541
MOD_GSK3_1	359	366	PF00069	0.639
MOD_GSK3_1	373	380	PF00069	0.547
MOD_GSK3_1	405	412	PF00069	0.723
MOD_GSK3_1	423	430	PF00069	0.571
MOD_GSK3_1	46	53	PF00069	0.614
MOD_GSK3_1	480	487	PF00069	0.393
MOD_GSK3_1	491	498	PF00069	0.369
MOD_GSK3_1	608	615	PF00069	0.511
MOD_GSK3_1	65	72	PF00069	0.512
MOD_GSK3_1	90	97	PF00069	0.653
MOD_N-GLC_1	402	407	PF02516	0.533
MOD_N-GLC_1	580	585	PF02516	0.535
MOD_NEK2_1	109	114	PF00069	0.685
MOD_NEK2_1	152	157	PF00069	0.619
MOD_NEK2_1	301	306	PF00069	0.490
MOD_NEK2_1	367	372	PF00069	0.658
MOD_NEK2_1	6	11	PF00069	0.637
MOD_PIKK_1	432	438	PF00454	0.385
MOD_PKA_2	508	514	PF00069	0.342
MOD_PKB_1	478	486	PF00069	0.265
MOD_Plk_1	452	458	PF00069	0.342
MOD_Plk_1	499	505	PF00069	0.390
MOD_Plk_4	484	490	PF00069	0.385
MOD_ProDKin_1	102	108	PF00069	0.637
MOD_ProDKin_1	131	137	PF00069	0.653
MOD_ProDKin_1	141	147	PF00069	0.563
MOD_ProDKin_1	159	165	PF00069	0.595
MOD_ProDKin_1	16	22	PF00069	0.649
MOD_ProDKin_1	171	177	PF00069	0.565
MOD_ProDKin_1	224	230	PF00069	0.599
MOD_ProDKin_1	345	351	PF00069	0.555
MOD_ProDKin_1	391	397	PF00069	0.735
MOD_ProDKin_1	402	408	PF00069	0.737
MOD_ProDKin_1	430	436	PF00069	0.385
MOD_ProDKin_1	65	71	PF00069	0.625
MOD_SUMO_rev_2	433	443	PF00179	0.342
MOD_SUMO_rev_2	515	524	PF00179	0.385
MOD_SUMO_rev_2	564	573	PF00179	0.500
TRG_DiLeu_BaEn_1	620	625	PF01217	0.485
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.493
TRG_DiLeu_LyEn_5	620	625	PF01217	0.485
TRG_ENDOCYTIC_2	556	559	PF00928	0.441
TRG_Pf-PMV_PEXEL_1	448	453	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5T9	Leishmania donovani	82%	97%
A4HKM6	Leishmania braziliensis	65%	100%
A4I861	Leishmania infantum	82%	97%
Q4Q540	Leishmania major	81%	99%