Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B310_LEIMU

TriTrypDb:

LmxM.31.2300

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B310

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B310

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.439
CLV_NRD_NRD_1	152	154	PF00675	0.614
CLV_NRD_NRD_1	288	290	PF00675	0.609
CLV_NRD_NRD_1	332	334	PF00675	0.492
CLV_NRD_NRD_1	34	36	PF00675	0.436
CLV_NRD_NRD_1	377	379	PF00675	0.573
CLV_NRD_NRD_1	439	441	PF00675	0.609
CLV_NRD_NRD_1	71	73	PF00675	0.452
CLV_NRD_NRD_1	96	98	PF00675	0.488
CLV_PCSK_KEX2_1	152	154	PF00082	0.614
CLV_PCSK_KEX2_1	263	265	PF00082	0.691
CLV_PCSK_KEX2_1	34	36	PF00082	0.436
CLV_PCSK_KEX2_1	362	364	PF00082	0.564
CLV_PCSK_KEX2_1	439	441	PF00082	0.609
CLV_PCSK_KEX2_1	71	73	PF00082	0.574
CLV_PCSK_KEX2_1	96	98	PF00082	0.478
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.646
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.564
CLV_PCSK_PC7_1	30	36	PF00082	0.437
CLV_PCSK_SKI1_1	153	157	PF00082	0.710
CLV_PCSK_SKI1_1	221	225	PF00082	0.606
CLV_PCSK_SKI1_1	242	246	PF00082	0.634
CLV_PCSK_SKI1_1	348	352	PF00082	0.668
CLV_PCSK_SKI1_1	96	100	PF00082	0.473
DOC_ANK_TNKS_1	249	256	PF00023	0.517
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	415	421	PF00134	0.633
DOC_MAPK_DCC_7	412	421	PF00069	0.629
DOC_MAPK_gen_1	171	180	PF00069	0.490
DOC_MAPK_gen_1	260	267	PF00069	0.613
DOC_MAPK_gen_1	412	421	PF00069	0.610
DOC_PP1_RVXF_1	171	177	PF00149	0.327
DOC_PP1_RVXF_1	261	268	PF00149	0.581
DOC_PP2B_LxvP_1	415	418	PF13499	0.626
DOC_USP7_MATH_1	131	135	PF00917	0.574
DOC_USP7_MATH_1	136	140	PF00917	0.527
DOC_USP7_MATH_1	346	350	PF00917	0.539
DOC_USP7_MATH_1	361	365	PF00917	0.562
DOC_USP7_MATH_1	431	435	PF00917	0.525
DOC_USP7_MATH_1	82	86	PF00917	0.435
DOC_WW_Pin1_4	127	132	PF00397	0.623
DOC_WW_Pin1_4	255	260	PF00397	0.798
DOC_WW_Pin1_4	373	378	PF00397	0.799
DOC_WW_Pin1_4	420	425	PF00397	0.734
LIG_14-3-3_CanoR_1	126	131	PF00244	0.500
LIG_14-3-3_CanoR_1	171	177	PF00244	0.326
LIG_14-3-3_CanoR_1	348	353	PF00244	0.535
LIG_14-3-3_CanoR_1	439	443	PF00244	0.622
LIG_BIR_II_1	1	5	PF00653	0.451
LIG_BRCT_BRCA1_1	337	341	PF00533	0.588
LIG_FHA_1	173	179	PF00498	0.436
LIG_FHA_1	34	40	PF00498	0.498
LIG_FHA_1	340	346	PF00498	0.577
LIG_FHA_2	23	29	PF00498	0.434
LIG_FHA_2	381	387	PF00498	0.525
LIG_LIR_Gen_1	9	18	PF02991	0.353
LIG_LIR_Nem_3	9	15	PF02991	0.431
LIG_NRBOX	165	171	PF00104	0.390
LIG_SH2_GRB2like	408	411	PF00017	0.598
LIG_SH2_STAT5	325	328	PF00017	0.541
LIG_SH2_STAT5	408	411	PF00017	0.675
LIG_SH2_STAT5	68	71	PF00017	0.392
LIG_SH3_3	182	188	PF00018	0.662
LIG_SH3_3	223	229	PF00018	0.622
LIG_SH3_3	233	239	PF00018	0.566
LIG_SH3_3	303	309	PF00018	0.663
LIG_SH3_3	400	406	PF00018	0.529
LIG_SUMO_SIM_par_1	105	111	PF11976	0.383
LIG_SUMO_SIM_par_1	166	172	PF11976	0.391
LIG_SUMO_SIM_par_1	417	423	PF11976	0.635
LIG_TRAF2_1	7	10	PF00917	0.425
LIG_TRAF2_1	88	91	PF00917	0.486
LIG_UBA3_1	166	173	PF00899	0.424
LIG_WW_1	405	408	PF00397	0.561
MOD_CDC14_SPxK_1	376	379	PF00782	0.696
MOD_CDK_SPK_2	255	260	PF00069	0.570
MOD_CDK_SPK_2	373	378	PF00069	0.643
MOD_CDK_SPK_2	420	425	PF00069	0.644
MOD_CDK_SPxK_1	373	379	PF00069	0.690
MOD_CDK_SPxxK_3	255	262	PF00069	0.602
MOD_CK1_1	127	133	PF00069	0.744
MOD_CK1_1	364	370	PF00069	0.560
MOD_CK1_1	390	396	PF00069	0.638
MOD_CK1_1	423	429	PF00069	0.672
MOD_CK1_1	434	440	PF00069	0.618
MOD_CK2_1	199	205	PF00069	0.647
MOD_CK2_1	255	261	PF00069	0.603
MOD_CK2_1	4	10	PF00069	0.448
MOD_Cter_Amidation	437	440	PF01082	0.565
MOD_GlcNHglycan	119	122	PF01048	0.614
MOD_GlcNHglycan	133	136	PF01048	0.640
MOD_GlcNHglycan	140	143	PF01048	0.690
MOD_GlcNHglycan	144	147	PF01048	0.471
MOD_GlcNHglycan	192	195	PF01048	0.530
MOD_GlcNHglycan	302	305	PF01048	0.659
MOD_GlcNHglycan	337	340	PF01048	0.585
MOD_GlcNHglycan	348	351	PF01048	0.651
MOD_GlcNHglycan	389	392	PF01048	0.664
MOD_GlcNHglycan	425	428	PF01048	0.677
MOD_GlcNHglycan	433	436	PF01048	0.644
MOD_GlcNHglycan	6	9	PF01048	0.438
MOD_GlcNHglycan	84	87	PF01048	0.429
MOD_GSK3_1	126	133	PF00069	0.768
MOD_GSK3_1	136	143	PF00069	0.580
MOD_GSK3_1	195	202	PF00069	0.705
MOD_GSK3_1	335	342	PF00069	0.598
MOD_GSK3_1	344	351	PF00069	0.460
MOD_GSK3_1	369	376	PF00069	0.554
MOD_GSK3_1	434	441	PF00069	0.649
MOD_GSK3_1	443	450	PF00069	0.696
MOD_N-GLC_1	127	132	PF02516	0.556
MOD_N-GLC_1	327	332	PF02516	0.528
MOD_N-GLC_1	370	375	PF02516	0.594
MOD_N-GLC_1	431	436	PF02516	0.648
MOD_NEK2_1	169	174	PF00069	0.354
MOD_NEK2_2	339	344	PF00069	0.644
MOD_PIKK_1	22	28	PF00454	0.448
MOD_PIKK_1	370	376	PF00454	0.615
MOD_PIKK_1	62	68	PF00454	0.466
MOD_PKA_2	117	123	PF00069	0.553
MOD_PKA_2	210	216	PF00069	0.656
MOD_PKA_2	274	280	PF00069	0.724
MOD_PKA_2	285	291	PF00069	0.603
MOD_PKA_2	300	306	PF00069	0.509
MOD_PKA_2	33	39	PF00069	0.452
MOD_PKA_2	364	370	PF00069	0.726
MOD_PKA_2	438	444	PF00069	0.666
MOD_PKA_2	446	452	PF00069	0.743
MOD_PKA_2	82	88	PF00069	0.494
MOD_Plk_1	153	159	PF00069	0.612
MOD_Plk_4	153	159	PF00069	0.612
MOD_Plk_4	222	228	PF00069	0.627
MOD_Plk_4	348	354	PF00069	0.535
MOD_ProDKin_1	127	133	PF00069	0.623
MOD_ProDKin_1	255	261	PF00069	0.798
MOD_ProDKin_1	373	379	PF00069	0.802
MOD_ProDKin_1	420	426	PF00069	0.734
MOD_SUMO_rev_2	257	265	PF00179	0.645
TRG_DiLeu_BaEn_1	10	15	PF01217	0.429
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.484
TRG_ENDOCYTIC_2	12	15	PF00928	0.433
TRG_ER_diArg_1	151	153	PF00400	0.600
TRG_ER_diArg_1	71	73	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSL3	Leptomonas seymouri	30%	95%
A0A3Q8ITE5	Leishmania donovani	77%	100%
A4HKM1	Leishmania braziliensis	63%	100%
A4I853	Leishmania infantum	77%	100%
Q4Q545	Leishmania major	79%	100%