Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B309_LEIMU

TriTrypDb:

LmxM.31.2280

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B309

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B309

PDB structure(s): 7aih_Ao , 7ane_Ao

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.496
CLV_NRD_NRD_1	173	175	PF00675	0.388
CLV_NRD_NRD_1	209	211	PF00675	0.449
CLV_NRD_NRD_1	27	29	PF00675	0.599
CLV_NRD_NRD_1	96	98	PF00675	0.506
CLV_PCSK_KEX2_1	173	175	PF00082	0.388
CLV_PCSK_KEX2_1	26	28	PF00082	0.585
CLV_PCSK_KEX2_1	96	98	PF00082	0.505
CLV_PCSK_SKI1_1	174	178	PF00082	0.524
CLV_PCSK_SKI1_1	220	224	PF00082	0.477
DEG_Nend_Nbox_1	1	3	PF02207	0.708
DEG_SCF_FBW7_2	222	229	PF00400	0.486
DOC_CDC14_PxL_1	231	239	PF14671	0.442
DOC_CKS1_1	123	128	PF01111	0.446
DOC_CKS1_1	223	228	PF01111	0.487
DOC_MAPK_MEF2A_6	238	246	PF00069	0.520
DOC_PP1_SILK_1	220	225	PF00149	0.480
DOC_USP7_MATH_1	209	213	PF00917	0.503
DOC_USP7_MATH_1	247	251	PF00917	0.537
DOC_WW_Pin1_4	107	112	PF00397	0.504
DOC_WW_Pin1_4	122	127	PF00397	0.443
DOC_WW_Pin1_4	222	227	PF00397	0.484
DOC_WW_Pin1_4	39	44	PF00397	0.498
LIG_14-3-3_CanoR_1	210	214	PF00244	0.565
LIG_14-3-3_CanoR_1	3	9	PF00244	0.740
LIG_14-3-3_CanoR_1	81	89	PF00244	0.440
LIG_14-3-3_CanoR_1	96	100	PF00244	0.433
LIG_Actin_WH2_2	151	167	PF00022	0.432
LIG_BRCT_BRCA1_1	254	258	PF00533	0.469
LIG_FHA_1	2	8	PF00498	0.692
LIG_FHA_1	257	263	PF00498	0.368
LIG_FHA_2	164	170	PF00498	0.574
LIG_LIR_Apic_2	132	136	PF02991	0.415
LIG_LIR_Apic_2	229	235	PF02991	0.450
LIG_LIR_Gen_1	114	123	PF02991	0.542
LIG_LIR_Gen_1	255	266	PF02991	0.530
LIG_LIR_Nem_3	110	116	PF02991	0.501
LIG_LIR_Nem_3	229	234	PF02991	0.458
LIG_PDZ_Class_2	279	284	PF00595	0.492
LIG_SH2_CRK	133	137	PF00017	0.398
LIG_SH2_CRK	232	236	PF00017	0.456
LIG_SH2_GRB2like	16	19	PF00017	0.574
LIG_SH2_NCK_1	116	120	PF00017	0.411
LIG_SH2_NCK_1	123	127	PF00017	0.379
LIG_SH2_NCK_1	133	137	PF00017	0.351
LIG_SH2_SRC	116	119	PF00017	0.409
LIG_SH2_STAT3	213	216	PF00017	0.306
LIG_SH2_STAT5	133	136	PF00017	0.390
LIG_SH2_STAT5	141	144	PF00017	0.346
LIG_SH2_STAT5	154	157	PF00017	0.393
LIG_SH2_STAT5	178	181	PF00017	0.535
LIG_SH2_STAT5	32	35	PF00017	0.638
LIG_SH3_2	240	245	PF14604	0.327
LIG_SH3_3	237	243	PF00018	0.451
LIG_SH3_3	37	43	PF00018	0.582
LIG_SH3_5	111	115	PF00018	0.472
LIG_TRAF2_2	269	274	PF00917	0.553
MOD_CK1_1	100	106	PF00069	0.555
MOD_CK1_1	163	169	PF00069	0.277
MOD_CK1_1	8	14	PF00069	0.616
MOD_CK2_1	150	156	PF00069	0.480
MOD_CK2_1	169	175	PF00069	0.507
MOD_CK2_1	57	63	PF00069	0.547
MOD_CMANNOS	79	82	PF00535	0.449
MOD_GlcNHglycan	182	185	PF01048	0.494
MOD_GlcNHglycan	249	252	PF01048	0.504
MOD_GlcNHglycan	254	257	PF01048	0.462
MOD_GlcNHglycan	59	62	PF01048	0.520
MOD_GlcNHglycan	99	102	PF01048	0.547
MOD_GSK3_1	1	8	PF00069	0.662
MOD_GSK3_1	159	166	PF00069	0.475
MOD_GSK3_1	176	183	PF00069	0.414
MOD_GSK3_1	252	259	PF00069	0.526
MOD_GSK3_1	95	102	PF00069	0.538
MOD_LATS_1	236	242	PF00433	0.513
MOD_N-GLC_1	107	112	PF02516	0.383
MOD_NEK2_1	1	6	PF00069	0.670
MOD_NEK2_1	131	136	PF00069	0.484
MOD_PIKK_1	256	262	PF00454	0.563
MOD_PKA_2	2	8	PF00069	0.659
MOD_PKA_2	209	215	PF00069	0.570
MOD_PKA_2	80	86	PF00069	0.437
MOD_PKA_2	95	101	PF00069	0.430
MOD_Plk_2-3	150	156	PF00069	0.453
MOD_Plk_4	150	156	PF00069	0.500
MOD_Plk_4	176	182	PF00069	0.507
MOD_ProDKin_1	107	113	PF00069	0.504
MOD_ProDKin_1	122	128	PF00069	0.448
MOD_ProDKin_1	222	228	PF00069	0.485
MOD_ProDKin_1	39	45	PF00069	0.487
TRG_ENDOCYTIC_2	116	119	PF00928	0.409
TRG_ENDOCYTIC_2	231	234	PF00928	0.444
TRG_ER_diArg_1	26	28	PF00400	0.585
TRG_ER_diArg_1	68	71	PF00400	0.449
TRG_NLS_MonoExtN_4	26	32	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P338	Leptomonas seymouri	77%	100%
A0A1X0NU54	Trypanosomatidae	61%	100%
A0A3S7X5S2	Leishmania donovani	96%	100%
A0A422MUA3	Trypanosoma rangeli	56%	100%
A4HKL9	Leishmania braziliensis	85%	100%
A4I851	Leishmania infantum	96%	100%
D0AAB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
D0AAB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	73%
Q4Q547	Leishmania major	96%	100%
V5BKN6	Trypanosoma cruzi	57%	100%