Putative methionyl-tRNA formyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methionyl-tRNA formyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B305_LEIMU

TriTrypDb:

LmxM.31.2240

Length:

984

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B305

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B305

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019988	charged-tRNA amino acid modification	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0071951	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA	8	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:0009058	biosynthetic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004479	methionyl-tRNA formyltransferase activity	5	6
GO:0016740	transferase activity	2	7
GO:0016741	transferase activity, transferring one-carbon groups	3	6
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	6
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0140101	catalytic activity, acting on a tRNA	4	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.619
CLV_C14_Caspase3-7	342	346	PF00656	0.748
CLV_C14_Caspase3-7	571	575	PF00656	0.610
CLV_C14_Caspase3-7	614	618	PF00656	0.667
CLV_NRD_NRD_1	116	118	PF00675	0.663
CLV_NRD_NRD_1	240	242	PF00675	0.300
CLV_NRD_NRD_1	306	308	PF00675	0.614
CLV_NRD_NRD_1	659	661	PF00675	0.510
CLV_NRD_NRD_1	767	769	PF00675	0.694
CLV_NRD_NRD_1	784	786	PF00675	0.672
CLV_NRD_NRD_1	814	816	PF00675	0.710
CLV_NRD_NRD_1	964	966	PF00675	0.547
CLV_PCSK_KEX2_1	209	211	PF00082	0.363
CLV_PCSK_KEX2_1	240	242	PF00082	0.300
CLV_PCSK_KEX2_1	306	308	PF00082	0.614
CLV_PCSK_KEX2_1	538	540	PF00082	0.594
CLV_PCSK_KEX2_1	659	661	PF00082	0.524
CLV_PCSK_KEX2_1	664	666	PF00082	0.565
CLV_PCSK_KEX2_1	767	769	PF00082	0.694
CLV_PCSK_KEX2_1	784	786	PF00082	0.672
CLV_PCSK_KEX2_1	814	816	PF00082	0.710
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.363
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.594
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.663
CLV_PCSK_PC7_1	660	666	PF00082	0.649
CLV_PCSK_SKI1_1	106	110	PF00082	0.572
CLV_PCSK_SKI1_1	111	115	PF00082	0.557
CLV_PCSK_SKI1_1	204	208	PF00082	0.346
CLV_PCSK_SKI1_1	209	213	PF00082	0.346
CLV_PCSK_SKI1_1	488	492	PF00082	0.604
CLV_PCSK_SKI1_1	659	663	PF00082	0.546
CLV_PCSK_SKI1_1	664	668	PF00082	0.615
CLV_PCSK_SKI1_1	67	71	PF00082	0.600
CLV_PCSK_SKI1_1	76	80	PF00082	0.534
CLV_PCSK_SKI1_1	797	801	PF00082	0.687
CLV_PCSK_SKI1_1	827	831	PF00082	0.583
DEG_COP1_1	897	908	PF00400	0.734
DEG_Nend_UBRbox_1	1	4	PF02207	0.587
DEG_SCF_FBW7_1	507	513	PF00400	0.594
DEG_SPOP_SBC_1	177	181	PF00917	0.241
DOC_CKS1_1	507	512	PF01111	0.632
DOC_CYCLIN_RxL_1	485	496	PF00134	0.471
DOC_CYCLIN_RxL_1	794	804	PF00134	0.688
DOC_MAPK_gen_1	814	824	PF00069	0.740
DOC_MAPK_HePTP_8	962	979	PF00069	0.574
DOC_MAPK_MEF2A_6	712	720	PF00069	0.394
DOC_MAPK_MEF2A_6	957	964	PF00069	0.558
DOC_MAPK_MEF2A_6	971	979	PF00069	0.579
DOC_PP1_RVXF_1	278	284	PF00149	0.509
DOC_PP1_RVXF_1	486	493	PF00149	0.605
DOC_PP1_RVXF_1	782	789	PF00149	0.713
DOC_PP2B_LxvP_1	318	321	PF13499	0.669
DOC_PP2B_LxvP_1	734	737	PF13499	0.675
DOC_USP7_MATH_1	14	18	PF00917	0.634
DOC_USP7_MATH_1	146	150	PF00917	0.710
DOC_USP7_MATH_1	177	181	PF00917	0.261
DOC_USP7_MATH_1	259	263	PF00917	0.546
DOC_USP7_MATH_1	31	35	PF00917	0.777
DOC_USP7_MATH_1	321	325	PF00917	0.638
DOC_USP7_MATH_1	415	419	PF00917	0.672
DOC_USP7_MATH_1	510	514	PF00917	0.761
DOC_USP7_MATH_1	730	734	PF00917	0.409
DOC_USP7_MATH_1	862	866	PF00917	0.553
DOC_USP7_MATH_2	528	534	PF00917	0.532
DOC_USP7_UBL2_3	166	170	PF12436	0.812
DOC_USP7_UBL2_3	667	671	PF12436	0.696
DOC_USP7_UBL2_3	953	957	PF12436	0.607
DOC_WW_Pin1_4	132	137	PF00397	0.629
DOC_WW_Pin1_4	157	162	PF00397	0.721
DOC_WW_Pin1_4	178	183	PF00397	0.558
DOC_WW_Pin1_4	230	235	PF00397	0.546
DOC_WW_Pin1_4	24	29	PF00397	0.647
DOC_WW_Pin1_4	371	376	PF00397	0.676
DOC_WW_Pin1_4	445	450	PF00397	0.743
DOC_WW_Pin1_4	473	478	PF00397	0.604
DOC_WW_Pin1_4	494	499	PF00397	0.770
DOC_WW_Pin1_4	506	511	PF00397	0.557
DOC_WW_Pin1_4	564	569	PF00397	0.643
DOC_WW_Pin1_4	644	649	PF00397	0.667
DOC_WW_Pin1_4	67	72	PF00397	0.600
DOC_WW_Pin1_4	690	695	PF00397	0.521
LIG_14-3-3_CanoR_1	142	148	PF00244	0.759
LIG_14-3-3_CanoR_1	369	374	PF00244	0.681
LIG_14-3-3_CanoR_1	539	544	PF00244	0.503
LIG_14-3-3_CanoR_1	581	589	PF00244	0.492
LIG_14-3-3_CanoR_1	612	617	PF00244	0.643
LIG_14-3-3_CanoR_1	735	741	PF00244	0.638
LIG_Actin_WH2_2	646	661	PF00022	0.624
LIG_APCC_ABBA_1	566	571	PF00400	0.635
LIG_APCC_ABBA_1	977	982	PF00400	0.566
LIG_BRCT_BRCA1_1	232	236	PF00533	0.546
LIG_BRCT_BRCA1_1	326	330	PF00533	0.510
LIG_BRCT_BRCA1_1	399	403	PF00533	0.498
LIG_BRCT_BRCA1_1	578	582	PF00533	0.624
LIG_deltaCOP1_diTrp_1	571	576	PF00928	0.609
LIG_deltaCOP1_diTrp_1	942	947	PF00928	0.551
LIG_FHA_1	167	173	PF00498	0.534
LIG_FHA_1	196	202	PF00498	0.619
LIG_FHA_1	397	403	PF00498	0.696
LIG_FHA_1	538	544	PF00498	0.739
LIG_FHA_1	739	745	PF00498	0.639
LIG_FHA_1	970	976	PF00498	0.633
LIG_FHA_2	182	188	PF00498	0.411
LIG_FHA_2	256	262	PF00498	0.619
LIG_FHA_2	340	346	PF00498	0.745
LIG_FHA_2	389	395	PF00498	0.667
LIG_FHA_2	673	679	PF00498	0.529
LIG_FHA_2	68	74	PF00498	0.587
LIG_FHA_2	696	702	PF00498	0.591
LIG_FHA_2	726	732	PF00498	0.671
LIG_LIR_Apic_2	202	208	PF02991	0.546
LIG_LIR_Apic_2	596	602	PF02991	0.552
LIG_LIR_Apic_2	632	636	PF02991	0.636
LIG_LIR_Gen_1	233	243	PF02991	0.541
LIG_LIR_Gen_1	590	599	PF02991	0.641
LIG_LIR_Gen_1	739	748	PF02991	0.628
LIG_LIR_Gen_1	915	923	PF02991	0.469
LIG_LIR_Nem_3	202	206	PF02991	0.546
LIG_LIR_Nem_3	23	29	PF02991	0.744
LIG_LIR_Nem_3	233	239	PF02991	0.541
LIG_LIR_Nem_3	364	368	PF02991	0.788
LIG_LIR_Nem_3	590	594	PF02991	0.623
LIG_LIR_Nem_3	739	743	PF02991	0.641
LIG_LIR_Nem_3	915	921	PF02991	0.704
LIG_LIR_Nem_3	932	938	PF02991	0.516
LIG_MAD2	660	668	PF02301	0.514
LIG_MYND_1	223	227	PF01753	0.546
LIG_MYND_1	746	750	PF01753	0.590
LIG_Pex14_1	572	576	PF04695	0.545
LIG_Pex14_2	576	580	PF04695	0.630
LIG_Rb_LxCxE_1	933	949	PF01857	0.537
LIG_SH2_CRK	133	137	PF00017	0.626
LIG_SH2_CRK	599	603	PF00017	0.686
LIG_SH2_CRK	789	793	PF00017	0.691
LIG_SH2_CRK	935	939	PF00017	0.512
LIG_SH2_PTP2	918	921	PF00017	0.460
LIG_SH2_PTP2	976	979	PF00017	0.574
LIG_SH2_SRC	918	921	PF00017	0.460
LIG_SH2_STAP1	195	199	PF00017	0.546
LIG_SH2_STAP1	578	582	PF00017	0.646
LIG_SH2_STAT5	205	208	PF00017	0.546
LIG_SH2_STAT5	282	285	PF00017	0.457
LIG_SH2_STAT5	633	636	PF00017	0.635
LIG_SH2_STAT5	87	90	PF00017	0.480
LIG_SH2_STAT5	904	907	PF00017	0.728
LIG_SH2_STAT5	918	921	PF00017	0.649
LIG_SH2_STAT5	927	930	PF00017	0.542
LIG_SH2_STAT5	976	979	PF00017	0.574
LIG_SH3_1	599	605	PF00018	0.686
LIG_SH3_3	211	217	PF00018	0.530
LIG_SH3_3	268	274	PF00018	0.549
LIG_SH3_3	314	320	PF00018	0.774
LIG_SH3_3	374	380	PF00018	0.733
LIG_SH3_3	381	387	PF00018	0.789
LIG_SH3_3	453	459	PF00018	0.726
LIG_SH3_3	504	510	PF00018	0.620
LIG_SH3_3	562	568	PF00018	0.711
LIG_SH3_3	57	63	PF00018	0.489
LIG_SH3_3	599	605	PF00018	0.585
LIG_SH3_3	740	746	PF00018	0.616
LIG_SH3_3	91	97	PF00018	0.529
LIG_SH3_4	166	173	PF00018	0.631
LIG_SH3_4	667	674	PF00018	0.619
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.546
LIG_SUMO_SIM_anti_2	314	319	PF11976	0.610
LIG_SUMO_SIM_anti_2	56	62	PF11976	0.548
LIG_SUMO_SIM_par_1	196	202	PF11976	0.619
LIG_SUMO_SIM_par_1	539	544	PF11976	0.717
LIG_SUMO_SIM_par_1	693	703	PF11976	0.651
LIG_SUMO_SIM_par_1	820	826	PF11976	0.733
LIG_TRAF2_1	444	447	PF00917	0.615
LIG_TRAF2_1	675	678	PF00917	0.588
LIG_TRAF2_1	70	73	PF00917	0.585
LIG_TRAF2_1	808	811	PF00917	0.735
LIG_TYR_ITIM	974	979	PF00017	0.570
LIG_UBA3_1	109	118	PF00899	0.682
LIG_WRC_WIRS_1	200	205	PF05994	0.546
MOD_CDK_SPxK_1	644	650	PF00069	0.662
MOD_CK1_1	12	18	PF00069	0.472
MOD_CK1_1	121	127	PF00069	0.565
MOD_CK1_1	173	179	PF00069	0.807
MOD_CK1_1	324	330	PF00069	0.568
MOD_CK1_1	356	362	PF00069	0.647
MOD_CK1_1	389	395	PF00069	0.762
MOD_CK1_1	445	451	PF00069	0.782
MOD_CK1_1	537	543	PF00069	0.692
MOD_CK1_1	564	570	PF00069	0.655
MOD_CK1_1	693	699	PF00069	0.623
MOD_CK1_1	802	808	PF00069	0.635
MOD_CK2_1	441	447	PF00069	0.797
MOD_CK2_1	67	73	PF00069	0.601
MOD_CK2_1	672	678	PF00069	0.524
MOD_CK2_1	725	731	PF00069	0.667
MOD_CMANNOS	944	947	PF00535	0.523
MOD_DYRK1A_RPxSP_1	371	375	PF00069	0.724
MOD_GlcNHglycan	106	109	PF01048	0.662
MOD_GlcNHglycan	119	123	PF01048	0.569
MOD_GlcNHglycan	138	141	PF01048	0.648
MOD_GlcNHglycan	161	164	PF01048	0.594
MOD_GlcNHglycan	175	178	PF01048	0.759
MOD_GlcNHglycan	261	264	PF01048	0.304
MOD_GlcNHglycan	323	326	PF01048	0.717
MOD_GlcNHglycan	327	330	PF01048	0.669
MOD_GlcNHglycan	335	338	PF01048	0.639
MOD_GlcNHglycan	358	361	PF01048	0.618
MOD_GlcNHglycan	512	515	PF01048	0.808
MOD_GlcNHglycan	521	524	PF01048	0.670
MOD_GlcNHglycan	532	535	PF01048	0.485
MOD_GlcNHglycan	543	546	PF01048	0.766
MOD_GlcNHglycan	690	693	PF01048	0.583
MOD_GlcNHglycan	761	765	PF01048	0.720
MOD_GlcNHglycan	833	836	PF01048	0.539
MOD_GlcNHglycan	864	867	PF01048	0.786
MOD_GSK3_1	118	125	PF00069	0.676
MOD_GSK3_1	132	139	PF00069	0.776
MOD_GSK3_1	166	173	PF00069	0.834
MOD_GSK3_1	177	184	PF00069	0.335
MOD_GSK3_1	195	202	PF00069	0.581
MOD_GSK3_1	230	237	PF00069	0.546
MOD_GSK3_1	255	262	PF00069	0.619
MOD_GSK3_1	321	328	PF00069	0.761
MOD_GSK3_1	329	336	PF00069	0.698
MOD_GSK3_1	349	356	PF00069	0.751
MOD_GSK3_1	388	395	PF00069	0.723
MOD_GSK3_1	410	417	PF00069	0.680
MOD_GSK3_1	441	448	PF00069	0.812
MOD_GSK3_1	506	513	PF00069	0.728
MOD_GSK3_1	530	537	PF00069	0.646
MOD_GSK3_1	572	579	PF00069	0.662
MOD_GSK3_1	634	641	PF00069	0.644
MOD_GSK3_1	695	702	PF00069	0.522
MOD_GSK3_1	795	802	PF00069	0.651
MOD_GSK3_1	806	813	PF00069	0.623
MOD_GSK3_1	827	834	PF00069	0.618
MOD_GSK3_1	98	105	PF00069	0.575
MOD_LATS_1	519	525	PF00433	0.529
MOD_LATS_1	765	771	PF00433	0.476
MOD_N-GLC_1	15	20	PF02516	0.644
MOD_N-GLC_1	241	246	PF02516	0.363
MOD_N-GLC_1	403	408	PF02516	0.553
MOD_N-GLC_1	638	643	PF02516	0.661
MOD_N-GLC_2	439	441	PF02516	0.513
MOD_NEK2_1	104	109	PF00069	0.562
MOD_NEK2_1	113	118	PF00069	0.596
MOD_NEK2_1	410	415	PF00069	0.735
MOD_NEK2_1	549	554	PF00069	0.698
MOD_NEK2_1	576	581	PF00069	0.634
MOD_NEK2_1	799	804	PF00069	0.677
MOD_NEK2_1	855	860	PF00069	0.535
MOD_NEK2_1	9	14	PF00069	0.606
MOD_NEK2_2	398	403	PF00069	0.615
MOD_NEK2_2	483	488	PF00069	0.611
MOD_NEK2_2	730	735	PF00069	0.710
MOD_PIKK_1	248	254	PF00454	0.563
MOD_PIKK_1	284	290	PF00454	0.506
MOD_PIKK_1	32	38	PF00454	0.819
MOD_PIKK_1	335	341	PF00454	0.733
MOD_PIKK_1	580	586	PF00454	0.456
MOD_PIKK_1	673	679	PF00454	0.625
MOD_PIKK_1	738	744	PF00454	0.622
MOD_PIKK_1	806	812	PF00454	0.601
MOD_PIKK_1	912	918	PF00454	0.795
MOD_PK_1	306	312	PF00069	0.509
MOD_PK_1	817	823	PF00069	0.738
MOD_PKA_1	306	312	PF00069	0.509
MOD_PKA_1	76	82	PF00069	0.577
MOD_PKA_1	767	773	PF00069	0.507
MOD_PKA_2	141	147	PF00069	0.778
MOD_PKA_2	306	312	PF00069	0.801
MOD_PKA_2	325	331	PF00069	0.795
MOD_PKA_2	349	355	PF00069	0.787
MOD_PKA_2	580	586	PF00069	0.456
MOD_PKA_2	611	617	PF00069	0.645
MOD_PKA_2	767	773	PF00069	0.708
MOD_PKA_2	802	808	PF00069	0.726
MOD_PKA_2	9	15	PF00069	0.607
MOD_PKB_1	815	823	PF00069	0.699
MOD_Plk_1	195	201	PF00069	0.619
MOD_Plk_1	241	247	PF00069	0.563
MOD_Plk_1	255	261	PF00069	0.392
MOD_Plk_1	313	319	PF00069	0.704
MOD_Plk_1	638	644	PF00069	0.661
MOD_Plk_1	730	736	PF00069	0.714
MOD_Plk_1	931	937	PF00069	0.535
MOD_Plk_4	195	201	PF00069	0.473
MOD_Plk_4	221	227	PF00069	0.536
MOD_Plk_4	313	319	PF00069	0.740
MOD_Plk_4	361	367	PF00069	0.706
MOD_Plk_4	398	404	PF00069	0.744
MOD_Plk_4	561	567	PF00069	0.660
MOD_Plk_4	817	823	PF00069	0.524
MOD_ProDKin_1	132	138	PF00069	0.627
MOD_ProDKin_1	157	163	PF00069	0.720
MOD_ProDKin_1	178	184	PF00069	0.558
MOD_ProDKin_1	230	236	PF00069	0.546
MOD_ProDKin_1	24	30	PF00069	0.648
MOD_ProDKin_1	371	377	PF00069	0.674
MOD_ProDKin_1	445	451	PF00069	0.743
MOD_ProDKin_1	473	479	PF00069	0.598
MOD_ProDKin_1	494	500	PF00069	0.775
MOD_ProDKin_1	506	512	PF00069	0.559
MOD_ProDKin_1	564	570	PF00069	0.640
MOD_ProDKin_1	644	650	PF00069	0.662
MOD_ProDKin_1	67	73	PF00069	0.601
MOD_ProDKin_1	690	696	PF00069	0.516
MOD_SUMO_for_1	253	256	PF00179	0.530
MOD_SUMO_rev_2	526	533	PF00179	0.570
MOD_SUMO_rev_2	99	104	PF00179	0.681
TRG_DiLeu_BaEn_2	48	54	PF01217	0.567
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.555
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.581
TRG_ENDOCYTIC_2	282	285	PF00928	0.457
TRG_ENDOCYTIC_2	591	594	PF00928	0.691
TRG_ENDOCYTIC_2	918	921	PF00928	0.686
TRG_ENDOCYTIC_2	935	938	PF00928	0.496
TRG_ENDOCYTIC_2	976	979	PF00928	0.574
TRG_ER_diArg_1	239	241	PF00400	0.500
TRG_ER_diArg_1	306	308	PF00400	0.614
TRG_ER_diArg_1	368	371	PF00400	0.705
TRG_ER_diArg_1	658	660	PF00400	0.512
TRG_ER_diArg_1	766	768	PF00400	0.688
TRG_ER_diArg_1	784	787	PF00400	0.675
TRG_ER_diArg_1	814	817	PF00400	0.777
TRG_NLS_MonoExtC_3	663	668	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	2	6	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE1	Leptomonas seymouri	49%	84%
A0A3Q8IG07	Leishmania donovani	86%	100%
A4HKL4	Leishmania braziliensis	67%	98%
A4I847	Leishmania infantum	85%	100%
Q4Q551	Leishmania major	82%	98%