Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B300_LEIMU

TriTrypDb:

LmxM.31.2190

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B300

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B300

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	550	554	PF00656	0.527
CLV_NRD_NRD_1	144	146	PF00675	0.725
CLV_NRD_NRD_1	30	32	PF00675	0.497
CLV_NRD_NRD_1	511	513	PF00675	0.694
CLV_PCSK_FUR_1	8	12	PF00082	0.605
CLV_PCSK_KEX2_1	10	12	PF00082	0.680
CLV_PCSK_KEX2_1	143	145	PF00082	0.732
CLV_PCSK_KEX2_1	30	32	PF00082	0.428
CLV_PCSK_KEX2_1	511	513	PF00082	0.736
CLV_PCSK_KEX2_1	7	9	PF00082	0.684
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.680
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.684
CLV_PCSK_SKI1_1	101	105	PF00082	0.548
CLV_PCSK_SKI1_1	544	548	PF00082	0.702
CLV_PCSK_SKI1_1	562	566	PF00082	0.510
CLV_PCSK_SKI1_1	7	11	PF00082	0.778
DEG_SPOP_SBC_1	249	253	PF00917	0.806
DEG_SPOP_SBC_1	445	449	PF00917	0.528
DEG_SPOP_SBC_1	572	576	PF00917	0.719
DOC_ANK_TNKS_1	142	149	PF00023	0.560
DOC_CYCLIN_RxL_1	541	550	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.654
DOC_MAPK_FxFP_2	463	466	PF00069	0.795
DOC_MAPK_gen_1	586	594	PF00069	0.721
DOC_MAPK_MEF2A_6	151	160	PF00069	0.545
DOC_MAPK_MEF2A_6	399	407	PF00069	0.729
DOC_PP2B_LxvP_1	156	159	PF13499	0.659
DOC_PP2B_LxvP_1	364	367	PF13499	0.814
DOC_PP4_FxxP_1	400	403	PF00568	0.772
DOC_PP4_FxxP_1	463	466	PF00568	0.795
DOC_USP7_MATH_1	117	121	PF00917	0.797
DOC_USP7_MATH_1	125	129	PF00917	0.760
DOC_USP7_MATH_1	146	150	PF00917	0.727
DOC_USP7_MATH_1	162	166	PF00917	0.633
DOC_USP7_MATH_1	231	235	PF00917	0.712
DOC_USP7_MATH_1	317	321	PF00917	0.791
DOC_USP7_MATH_1	328	332	PF00917	0.664
DOC_USP7_MATH_1	445	449	PF00917	0.678
DOC_USP7_MATH_1	456	460	PF00917	0.709
DOC_USP7_MATH_1	49	53	PF00917	0.810
DOC_USP7_MATH_1	492	496	PF00917	0.481
DOC_USP7_MATH_1	54	58	PF00917	0.759
DOC_USP7_MATH_1	9	13	PF00917	0.486
DOC_WW_Pin1_4	129	134	PF00397	0.772
DOC_WW_Pin1_4	365	370	PF00397	0.701
DOC_WW_Pin1_4	496	501	PF00397	0.684
DOC_WW_Pin1_4	506	511	PF00397	0.702
DOC_WW_Pin1_4	528	533	PF00397	0.796
LIG_14-3-3_CanoR_1	30	38	PF00244	0.474
LIG_Actin_WH2_2	608	624	PF00022	0.463
LIG_APCC_ABBA_1	339	344	PF00400	0.802
LIG_BIR_III_2	553	557	PF00653	0.531
LIG_BIR_III_2	60	64	PF00653	0.663
LIG_BRCT_BRCA1_1	607	611	PF00533	0.702
LIG_Clathr_ClatBox_1	546	550	PF01394	0.499
LIG_CtBP_PxDLS_1	375	379	PF00389	0.805
LIG_CtBP_PxDLS_1	515	519	PF00389	0.730
LIG_eIF4E_1	541	547	PF01652	0.641
LIG_FHA_1	111	117	PF00498	0.731
LIG_FHA_1	236	242	PF00498	0.800
LIG_FHA_1	349	355	PF00498	0.705
LIG_FHA_1	361	367	PF00498	0.470
LIG_FHA_2	15	21	PF00498	0.691
LIG_FHA_2	207	213	PF00498	0.698
LIG_FHA_2	24	30	PF00498	0.584
LIG_FHA_2	304	310	PF00498	0.748
LIG_FHA_2	317	323	PF00498	0.504
LIG_FHA_2	54	60	PF00498	0.754
LIG_LIR_Apic_2	351	356	PF02991	0.782
LIG_LIR_Apic_2	397	403	PF02991	0.735
LIG_LIR_Gen_1	340	350	PF02991	0.692
LIG_LIR_Gen_1	414	420	PF02991	0.532
LIG_LIR_Gen_1	616	626	PF02991	0.459
LIG_LIR_Nem_3	340	345	PF02991	0.694
LIG_LIR_Nem_3	385	391	PF02991	0.721
LIG_LIR_Nem_3	414	418	PF02991	0.534
LIG_LIR_Nem_3	434	439	PF02991	0.664
LIG_LIR_Nem_3	464	468	PF02991	0.716
LIG_LIR_Nem_3	536	541	PF02991	0.706
LIG_LIR_Nem_3	616	621	PF02991	0.469
LIG_LYPXL_S_1	435	439	PF13949	0.685
LIG_LYPXL_yS_3	436	439	PF13949	0.683
LIG_LYPXL_yS_3	465	468	PF13949	0.793
LIG_MYND_1	437	441	PF01753	0.725
LIG_Rb_pABgroove_1	605	613	PF01858	0.672
LIG_SH2_CRK	415	419	PF00017	0.506
LIG_SH2_CRK	44	48	PF00017	0.722
LIG_SH2_CRK	529	533	PF00017	0.788
LIG_SH2_NCK_1	415	419	PF00017	0.506
LIG_SH2_NCK_1	44	48	PF00017	0.508
LIG_SH2_NCK_1	498	502	PF00017	0.796
LIG_SH2_NCK_1	529	533	PF00017	0.664
LIG_SH2_PTP2	353	356	PF00017	0.492
LIG_SH2_SRC	353	356	PF00017	0.783
LIG_SH2_SRC	581	584	PF00017	0.755
LIG_SH2_STAP1	415	419	PF00017	0.506
LIG_SH2_STAP1	490	494	PF00017	0.491
LIG_SH2_STAP1	566	570	PF00017	0.611
LIG_SH2_STAT5	353	356	PF00017	0.754
LIG_SH2_STAT5	609	612	PF00017	0.669
LIG_SH3_3	335	341	PF00018	0.687
LIG_SH3_3	363	369	PF00018	0.802
LIG_SH3_3	434	440	PF00018	0.718
LIG_SH3_3	463	469	PF00018	0.759
LIG_SH3_3	600	606	PF00018	0.704
LIG_WRC_WIRS_1	432	437	PF05994	0.787
LIG_WRC_WIRS_1	470	475	PF05994	0.505
MOD_CDC14_SPxK_1	368	371	PF00782	0.805
MOD_CDK_SPK_2	129	134	PF00069	0.772
MOD_CDK_SPK_2	506	511	PF00069	0.726
MOD_CDK_SPxK_1	365	371	PF00069	0.805
MOD_CDK_SPxK_1	506	512	PF00069	0.727
MOD_CK1_1	120	126	PF00069	0.676
MOD_CK1_1	129	135	PF00069	0.745
MOD_CK1_1	149	155	PF00069	0.832
MOD_CK1_1	173	179	PF00069	0.670
MOD_CK1_1	182	188	PF00069	0.731
MOD_CK1_1	204	210	PF00069	0.796
MOD_CK1_1	219	225	PF00069	0.634
MOD_CK1_1	254	260	PF00069	0.774
MOD_CK1_1	268	274	PF00069	0.697
MOD_CK1_1	302	308	PF00069	0.600
MOD_CK1_1	320	326	PF00069	0.805
MOD_CK1_1	446	452	PF00069	0.769
MOD_CK1_1	52	58	PF00069	0.538
MOD_CK2_1	14	20	PF00069	0.694
MOD_CK2_1	206	212	PF00069	0.780
MOD_CK2_1	23	29	PF00069	0.582
MOD_CK2_1	316	322	PF00069	0.754
MOD_CK2_1	444	450	PF00069	0.721
MOD_CK2_1	451	457	PF00069	0.635
MOD_CK2_1	496	502	PF00069	0.784
MOD_CK2_1	53	59	PF00069	0.753
MOD_CK2_1	92	98	PF00069	0.674
MOD_Cter_Amidation	198	201	PF01082	0.550
MOD_GlcNHglycan	164	167	PF01048	0.755
MOD_GlcNHglycan	185	188	PF01048	0.772
MOD_GlcNHglycan	204	207	PF01048	0.517
MOD_GlcNHglycan	217	221	PF01048	0.634
MOD_GlcNHglycan	229	232	PF01048	0.771
MOD_GlcNHglycan	291	294	PF01048	0.725
MOD_GlcNHglycan	301	304	PF01048	0.628
MOD_GlcNHglycan	322	325	PF01048	0.804
MOD_GlcNHglycan	450	454	PF01048	0.723
MOD_GlcNHglycan	457	461	PF01048	0.695
MOD_GlcNHglycan	559	562	PF01048	0.752
MOD_GlcNHglycan	575	578	PF01048	0.642
MOD_GlcNHglycan	588	591	PF01048	0.725
MOD_GlcNHglycan	598	601	PF01048	0.601
MOD_GlcNHglycan	64	67	PF01048	0.559
MOD_GlcNHglycan	77	80	PF01048	0.839
MOD_GSK3_1	125	132	PF00069	0.761
MOD_GSK3_1	170	177	PF00069	0.698
MOD_GSK3_1	179	186	PF00069	0.669
MOD_GSK3_1	202	209	PF00069	0.770
MOD_GSK3_1	212	219	PF00069	0.667
MOD_GSK3_1	227	234	PF00069	0.812
MOD_GSK3_1	244	251	PF00069	0.748
MOD_GSK3_1	266	273	PF00069	0.767
MOD_GSK3_1	299	306	PF00069	0.736
MOD_GSK3_1	316	323	PF00069	0.779
MOD_GSK3_1	324	331	PF00069	0.723
MOD_GSK3_1	439	446	PF00069	0.711
MOD_GSK3_1	49	56	PF00069	0.767
MOD_GSK3_1	492	499	PF00069	0.744
MOD_GSK3_1	536	543	PF00069	0.690
MOD_GSK3_1	586	593	PF00069	0.798
MOD_N-GLC_1	108	113	PF02516	0.747
MOD_N-GLC_1	317	322	PF02516	0.748
MOD_N-GLC_1	405	410	PF02516	0.606
MOD_N-GLC_1	584	589	PF02516	0.707
MOD_N-GLC_1	590	595	PF02516	0.661
MOD_NEK2_1	265	270	PF00069	0.726
MOD_NEK2_1	43	48	PF00069	0.651
MOD_NEK2_1	564	569	PF00069	0.657
MOD_NEK2_1	573	578	PF00069	0.608
MOD_NEK2_1	610	615	PF00069	0.679
MOD_NEK2_1	91	96	PF00069	0.543
MOD_NEK2_2	431	436	PF00069	0.591
MOD_NEK2_2	492	497	PF00069	0.696
MOD_NMyristoyl	1	7	PF02799	0.670
MOD_PIKK_1	212	218	PF00454	0.638
MOD_PIKK_1	231	237	PF00454	0.785
MOD_PIKK_1	439	445	PF00454	0.499
MOD_PKA_2	117	123	PF00069	0.788
MOD_PKA_2	14	20	PF00069	0.649
MOD_PKA_2	170	176	PF00069	0.697
MOD_PKA_2	180	186	PF00069	0.675
MOD_PKA_2	23	29	PF00069	0.610
MOD_PKA_2	91	97	PF00069	0.651
MOD_PKB_1	169	177	PF00069	0.529
MOD_Plk_1	152	158	PF00069	0.548
MOD_Plk_1	317	323	PF00069	0.784
MOD_Plk_1	328	334	PF00069	0.691
MOD_Plk_1	405	411	PF00069	0.553
MOD_Plk_1	492	498	PF00069	0.700
MOD_Plk_1	590	596	PF00069	0.727
MOD_Plk_1	611	617	PF00069	0.749
MOD_Plk_2-3	411	417	PF00069	0.582
MOD_Plk_4	14	20	PF00069	0.596
MOD_Plk_4	431	437	PF00069	0.758
MOD_Plk_4	469	475	PF00069	0.502
MOD_Plk_4	514	520	PF00069	0.683
MOD_Plk_4	536	542	PF00069	0.687
MOD_Plk_4	605	611	PF00069	0.671
MOD_ProDKin_1	129	135	PF00069	0.774
MOD_ProDKin_1	365	371	PF00069	0.703
MOD_ProDKin_1	496	502	PF00069	0.687
MOD_ProDKin_1	506	512	PF00069	0.703
MOD_ProDKin_1	528	534	PF00069	0.794
TRG_ENDOCYTIC_2	342	345	PF00928	0.755
TRG_ENDOCYTIC_2	415	418	PF00928	0.531
TRG_ENDOCYTIC_2	436	439	PF00928	0.677
TRG_ENDOCYTIC_2	44	47	PF00928	0.718
TRG_ENDOCYTIC_2	465	468	PF00928	0.793
TRG_ENDOCYTIC_2	486	489	PF00928	0.804
TRG_ER_diArg_1	142	145	PF00400	0.731
TRG_ER_diArg_1	510	512	PF00400	0.728
TRG_NLS_MonoExtC_3	6	11	PF00514	0.663
TRG_NLS_MonoExtN_4	7	14	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	629	634	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4H4	Leptomonas seymouri	26%	91%
A0A3S5H7S3	Leishmania donovani	79%	100%
A4HKK9	Leishmania braziliensis	46%	95%
A4I842	Leishmania infantum	79%	100%
Q4Q556	Leishmania major	77%	99%