LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B2Z4_LEIMU
TriTrypDb:
LmxM.31.2140
Length:
133

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 8
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8
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Expansion

Sequence features

E9B2Z4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Z4

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
DOC_CKS1_1 15 20 PF01111 0.335
DOC_PP1_RVXF_1 84 90 PF00149 0.653
DOC_PP2B_LxvP_1 62 65 PF13499 0.481
DOC_PP4_FxxP_1 81 84 PF00568 0.209
DOC_WW_Pin1_4 14 19 PF00397 0.335
LIG_Actin_WH2_2 25 40 PF00022 0.490
LIG_BRCT_BRCA1_1 25 29 PF00533 0.355
LIG_BRCT_BRCA1_1 75 79 PF00533 0.408
LIG_BRCT_BRCA1_1 90 94 PF00533 0.630
LIG_CAP-Gly_1 126 133 PF01302 0.725
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PCE7 Leptomonas seymouri 56% 100%
A0A0S4IHK1 Bodo saltans 30% 100%
A0A1X0NU87 Trypanosomatidae 55% 100%
A0A3S7X5Q0 Leishmania donovani 93% 100%
A0A422MY14 Trypanosoma rangeli 39% 100%
A4HKK4 Leishmania braziliensis 84% 100%
A4I836 Leishmania infantum 93% 100%
D0AAA3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
Q4Q562 Leishmania major 93% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS