Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2Z4_LEIMU

TriTrypDb:

LmxM.31.2140

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9B2Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Z4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_CKS1_1	15	20	PF01111	0.335
DOC_PP1_RVXF_1	84	90	PF00149	0.653
DOC_PP2B_LxvP_1	62	65	PF13499	0.481
DOC_PP4_FxxP_1	81	84	PF00568	0.209
DOC_WW_Pin1_4	14	19	PF00397	0.335
LIG_Actin_WH2_2	25	40	PF00022	0.490
LIG_BRCT_BRCA1_1	25	29	PF00533	0.355
LIG_BRCT_BRCA1_1	75	79	PF00533	0.408
LIG_BRCT_BRCA1_1	90	94	PF00533	0.630
LIG_CAP-Gly_1	126	133	PF01302	0.725
LIG_eIF4E_1	43	49	PF01652	0.447
LIG_FHA_1	45	51	PF00498	0.430
LIG_FHA_1	88	94	PF00498	0.555
LIG_IRF3_LxIS_1	33	40	PF10401	0.683
LIG_LIR_Apic_2	6	12	PF02991	0.469
LIG_LIR_Apic_2	80	84	PF02991	0.215
LIG_LIR_Gen_1	107	114	PF02991	0.605
LIG_LIR_Gen_1	26	37	PF02991	0.459
LIG_LIR_Gen_1	40	51	PF02991	0.458
LIG_LIR_Nem_3	26	32	PF02991	0.351
LIG_LIR_Nem_3	40	46	PF02991	0.463
LIG_LIR_Nem_3	8	13	PF02991	0.461
LIG_NRBOX	47	53	PF00104	0.447
LIG_PDZ_Class_3	128	133	PF00595	0.730
LIG_Pex14_1	9	13	PF04695	0.461
LIG_SH2_CRK	43	47	PF00017	0.447
LIG_SH2_GRB2like	43	46	PF00017	0.484
LIG_SH2_NCK_1	43	47	PF00017	0.447
LIG_SH2_STAT5	106	109	PF00017	0.586
LIG_SH2_STAT5	120	123	PF00017	0.571
LIG_SH2_STAT5	43	46	PF00017	0.451
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.480
LIG_WRC_WIRS_1	78	83	PF05994	0.308
MOD_GSK3_1	37	44	PF00069	0.487
MOD_GSK3_1	52	59	PF00069	0.355
MOD_GSK3_1	73	80	PF00069	0.406
MOD_N-GLC_1	2	7	PF02516	0.626
MOD_N-GLC_1	44	49	PF02516	0.480
MOD_NEK2_1	1	6	PF00069	0.648
MOD_NEK2_1	105	110	PF00069	0.509
MOD_NEK2_1	28	33	PF00069	0.445
MOD_NEK2_1	37	42	PF00069	0.456
MOD_NEK2_1	52	57	PF00069	0.294
MOD_NEK2_1	73	78	PF00069	0.283
MOD_NEK2_2	58	63	PF00069	0.288
MOD_NMyristoyl	1	7	PF02799	0.553
MOD_PKA_2	37	43	PF00069	0.463
MOD_Plk_1	44	50	PF00069	0.480
MOD_Plk_4	44	50	PF00069	0.453
MOD_Plk_4	73	79	PF00069	0.430
MOD_ProDKin_1	14	20	PF00069	0.355
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.589
TRG_ENDOCYTIC_2	109	112	PF00928	0.424
TRG_ENDOCYTIC_2	43	46	PF00928	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE7	Leptomonas seymouri	56%	100%
A0A0S4IHK1	Bodo saltans	30%	100%
A0A1X0NU87	Trypanosomatidae	55%	100%
A0A3S7X5Q0	Leishmania donovani	93%	100%
A0A422MY14	Trypanosoma rangeli	39%	100%
A4HKK4	Leishmania braziliensis	84%	100%
A4I836	Leishmania infantum	93%	100%
D0AAA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q4Q562	Leishmania major	93%	100%