RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9B2Z3_LEIMU

TriTrypDb:

LmxM.31.2130

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B2Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Z3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006379	mRNA cleavage	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.770
CLV_NRD_NRD_1	167	169	PF00675	0.513
CLV_NRD_NRD_1	316	318	PF00675	0.808
CLV_NRD_NRD_1	385	387	PF00675	0.618
CLV_NRD_NRD_1	67	69	PF00675	0.346
CLV_PCSK_KEX2_1	112	114	PF00082	0.650
CLV_PCSK_KEX2_1	167	169	PF00082	0.513
CLV_PCSK_KEX2_1	318	320	PF00082	0.801
CLV_PCSK_KEX2_1	394	396	PF00082	0.591
CLV_PCSK_KEX2_1	67	69	PF00082	0.334
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.650
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.801
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.623
CLV_PCSK_SKI1_1	220	224	PF00082	0.508
CLV_PCSK_SKI1_1	298	302	PF00082	0.711
CLV_PCSK_SKI1_1	368	372	PF00082	0.541
CLV_PCSK_SKI1_1	394	398	PF00082	0.614
DEG_APCC_DBOX_1	241	249	PF00400	0.672
DEG_APCC_DBOX_1	385	393	PF00400	0.617
DEG_COP1_1	373	383	PF00400	0.647
DEG_Nend_UBRbox_2	1	3	PF02207	0.695
DEG_SCF_FBW7_1	281	288	PF00400	0.727
DEG_SCF_FBW7_2	342	348	PF00400	0.729
DEG_SPOP_SBC_1	84	88	PF00917	0.684
DOC_CKS1_1	282	287	PF01111	0.697
DOC_CKS1_1	342	347	PF01111	0.738
DOC_CYCLIN_RxL_1	206	214	PF00134	0.473
DOC_CYCLIN_RxL_1	391	400	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.752
DOC_MAPK_gen_1	165	173	PF00069	0.625
DOC_PP2B_LxvP_1	339	342	PF13499	0.623
DOC_USP7_MATH_1	105	109	PF00917	0.741
DOC_USP7_MATH_1	121	125	PF00917	0.587
DOC_USP7_MATH_1	228	232	PF00917	0.549
DOC_USP7_MATH_1	244	248	PF00917	0.542
DOC_USP7_MATH_1	252	256	PF00917	0.643
DOC_USP7_MATH_1	274	278	PF00917	0.771
DOC_USP7_MATH_1	307	311	PF00917	0.699
DOC_USP7_MATH_1	322	326	PF00917	0.530
DOC_USP7_MATH_1	330	334	PF00917	0.787
DOC_USP7_MATH_1	83	87	PF00917	0.573
DOC_USP7_UBL2_3	298	302	PF12436	0.795
DOC_USP7_UBL2_3	305	309	PF12436	0.711
DOC_WW_Pin1_4	117	122	PF00397	0.637
DOC_WW_Pin1_4	267	272	PF00397	0.768
DOC_WW_Pin1_4	281	286	PF00397	0.642
DOC_WW_Pin1_4	293	298	PF00397	0.627
DOC_WW_Pin1_4	341	346	PF00397	0.755
LIG_14-3-3_CanoR_1	175	180	PF00244	0.587
LIG_14-3-3_CanoR_1	194	202	PF00244	0.342
LIG_14-3-3_CanoR_1	368	373	PF00244	0.524
LIG_14-3-3_CanoR_1	4	8	PF00244	0.656
LIG_14-3-3_CanoR_1	85	90	PF00244	0.720
LIG_BRCT_BRCA1_1	8	12	PF00533	0.443
LIG_FHA_1	176	182	PF00498	0.504
LIG_FHA_1	335	341	PF00498	0.799
LIG_FHA_2	345	351	PF00498	0.629
LIG_FHA_2	59	65	PF00498	0.535
LIG_FHA_2	71	77	PF00498	0.537
LIG_LIR_Apic_2	116	121	PF02991	0.683
LIG_LIR_Gen_1	199	210	PF02991	0.479
LIG_LIR_Gen_1	376	384	PF02991	0.593
LIG_LIR_Nem_3	10	16	PF02991	0.424
LIG_LIR_Nem_3	170	176	PF02991	0.647
LIG_LIR_Nem_3	199	205	PF02991	0.472
LIG_LIR_Nem_3	376	380	PF02991	0.589
LIG_LIR_Nem_3	48	54	PF02991	0.482
LIG_MLH1_MIPbox_1	9	13	PF16413	0.422
LIG_SH2_CRK	51	55	PF00017	0.447
LIG_SH2_NCK_1	202	206	PF00017	0.460
LIG_SH2_STAT5	177	180	PF00017	0.456
LIG_SH3_1	111	117	PF00018	0.714
LIG_SH3_3	111	117	PF00018	0.772
LIG_SH3_3	265	271	PF00018	0.777
LIG_SH3_3	286	292	PF00018	0.703
LIG_SH3_3	339	345	PF00018	0.722
LIG_SH3_3	377	383	PF00018	0.672
LIG_SH3_4	298	305	PF00018	0.615
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.447
LIG_SUMO_SIM_anti_2	352	360	PF11976	0.545
LIG_SUMO_SIM_par_1	209	214	PF11976	0.474
LIG_TRAF2_1	197	200	PF00917	0.561
LIG_TRAF2_1	61	64	PF00917	0.482
MOD_CDK_SPK_2	293	298	PF00069	0.538
MOD_CK1_1	120	126	PF00069	0.789
MOD_CK1_1	325	331	PF00069	0.757
MOD_CK1_1	335	341	PF00069	0.718
MOD_CK1_1	6	12	PF00069	0.487
MOD_CK2_1	200	206	PF00069	0.612
MOD_CK2_1	344	350	PF00069	0.633
MOD_CK2_1	357	363	PF00069	0.518
MOD_CK2_1	58	64	PF00069	0.483
MOD_CK2_1	70	76	PF00069	0.484
MOD_GlcNHglycan	101	104	PF01048	0.758
MOD_GlcNHglycan	147	150	PF01048	0.568
MOD_GlcNHglycan	202	205	PF01048	0.588
MOD_GlcNHglycan	230	233	PF01048	0.555
MOD_GlcNHglycan	305	308	PF01048	0.776
MOD_GlcNHglycan	309	312	PF01048	0.778
MOD_GlcNHglycan	324	327	PF01048	0.804
MOD_GlcNHglycan	332	335	PF01048	0.750
MOD_GlcNHglycan	372	375	PF01048	0.703
MOD_GSK3_1	117	124	PF00069	0.782
MOD_GSK3_1	155	162	PF00069	0.716
MOD_GSK3_1	281	288	PF00069	0.789
MOD_GSK3_1	3	10	PF00069	0.522
MOD_GSK3_1	303	310	PF00069	0.807
MOD_GSK3_1	320	327	PF00069	0.643
MOD_GSK3_1	330	337	PF00069	0.681
MOD_GSK3_1	340	347	PF00069	0.628
MOD_GSK3_1	79	86	PF00069	0.525
MOD_N-GLC_1	36	41	PF02516	0.233
MOD_NEK2_1	357	362	PF00069	0.637
MOD_NEK2_1	370	375	PF00069	0.571
MOD_NEK2_1	69	74	PF00069	0.499
MOD_NEK2_1	79	84	PF00069	0.473
MOD_PIKK_1	155	161	PF00454	0.646
MOD_PIKK_1	274	280	PF00454	0.654
MOD_PIKK_1	332	338	PF00454	0.742
MOD_PIKK_1	397	403	PF00454	0.571
MOD_PKA_1	167	173	PF00069	0.349
MOD_PKA_2	167	173	PF00069	0.641
MOD_PKA_2	3	9	PF00069	0.619
MOD_PKA_2	79	85	PF00069	0.599
MOD_Plk_1	105	111	PF00069	0.727
MOD_Plk_1	36	42	PF00069	0.550
MOD_Plk_2-3	70	76	PF00069	0.586
MOD_Plk_4	14	20	PF00069	0.355
MOD_Plk_4	184	190	PF00069	0.504
MOD_Plk_4	335	341	PF00069	0.799
MOD_Plk_4	7	13	PF00069	0.444
MOD_ProDKin_1	117	123	PF00069	0.640
MOD_ProDKin_1	267	273	PF00069	0.770
MOD_ProDKin_1	281	287	PF00069	0.641
MOD_ProDKin_1	293	299	PF00069	0.623
MOD_ProDKin_1	341	347	PF00069	0.745
MOD_SUMO_for_1	300	303	PF00179	0.738
MOD_SUMO_rev_2	214	222	PF00179	0.622
TRG_DiLeu_BaEn_1	218	223	PF01217	0.472
TRG_DiLeu_BaEn_1	353	358	PF01217	0.650
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.480
TRG_ENDOCYTIC_2	202	205	PF00928	0.455
TRG_ENDOCYTIC_2	51	54	PF00928	0.477
TRG_ER_diArg_1	110	113	PF00400	0.770
TRG_ER_diArg_1	253	256	PF00400	0.590
TRG_ER_diArg_1	66	68	PF00400	0.562
TRG_NLS_MonoExtC_3	110	115	PF00514	0.801
TRG_Pf-PMV_PEXEL_1	209	214	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4N7	Leptomonas seymouri	56%	100%
A0A1X0NU71	Trypanosomatidae	36%	100%
A0A3Q8ITD1	Leishmania donovani	92%	100%
A0A3R7KNF2	Trypanosoma rangeli	36%	100%
A4HKK3	Leishmania braziliensis	81%	100%
A4I835	Leishmania infantum	91%	100%
D0AAA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q563	Leishmania major	91%	100%
V5BKQ1	Trypanosoma cruzi	35%	100%