Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2Z2_LEIMU

TriTrypDb:

LmxM.31.2120

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

E9B2Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Z2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.684
CLV_NRD_NRD_1	529	531	PF00675	0.444
CLV_NRD_NRD_1	57	59	PF00675	0.492
CLV_NRD_NRD_1	62	64	PF00675	0.464
CLV_PCSK_KEX2_1	384	386	PF00082	0.423
CLV_PCSK_KEX2_1	425	427	PF00082	0.397
CLV_PCSK_KEX2_1	529	531	PF00082	0.480
CLV_PCSK_KEX2_1	57	59	PF00082	0.477
CLV_PCSK_KEX2_1	62	64	PF00082	0.443
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.361
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.439
CLV_PCSK_PC7_1	525	531	PF00082	0.370
CLV_PCSK_PC7_1	58	64	PF00082	0.426
CLV_PCSK_SKI1_1	219	223	PF00082	0.394
CLV_PCSK_SKI1_1	425	429	PF00082	0.437
CLV_PCSK_SKI1_1	497	501	PF00082	0.473
DEG_Nend_UBRbox_1	1	4	PF02207	0.587
DOC_CDC14_PxL_1	294	302	PF14671	0.609
DOC_CYCLIN_yCln2_LP_2	145	148	PF00134	0.597
DOC_MAPK_MEF2A_6	174	181	PF00069	0.558
DOC_MAPK_MEF2A_6	306	315	PF00069	0.488
DOC_MAPK_MEF2A_6	399	406	PF00069	0.548
DOC_MAPK_MEF2A_6	599	608	PF00069	0.544
DOC_MAPK_NFAT4_5	174	182	PF00069	0.481
DOC_PP1_RVXF_1	272	278	PF00149	0.632
DOC_PP1_RVXF_1	495	501	PF00149	0.529
DOC_PP1_RVXF_1	629	635	PF00149	0.467
DOC_PP2B_LxvP_1	145	148	PF13499	0.597
DOC_PP2B_PxIxI_1	638	644	PF00149	0.214
DOC_PP4_FxxP_1	348	351	PF00568	0.430
DOC_PP4_FxxP_1	83	86	PF00568	0.725
DOC_SPAK_OSR1_1	426	430	PF12202	0.442
DOC_SPAK_OSR1_1	509	513	PF12202	0.424
DOC_USP7_MATH_1	148	152	PF00917	0.689
DOC_USP7_MATH_2	148	154	PF00917	0.602
DOC_WW_Pin1_4	87	92	PF00397	0.624
LIG_14-3-3_CanoR_1	124	134	PF00244	0.765
LIG_14-3-3_CanoR_1	140	144	PF00244	0.761
LIG_14-3-3_CanoR_1	233	238	PF00244	0.666
LIG_14-3-3_CanoR_1	274	278	PF00244	0.626
LIG_14-3-3_CanoR_1	667	673	PF00244	0.639
LIG_Actin_WH2_2	184	199	PF00022	0.629
LIG_APCC_ABBA_1	218	223	PF00400	0.523
LIG_BRCT_BRCA1_1	184	188	PF00533	0.623
LIG_BRCT_BRCA1_1	342	346	PF00533	0.435
LIG_BRCT_BRCA1_1	506	510	PF00533	0.451
LIG_BRCT_BRCA1_1	79	83	PF00533	0.639
LIG_FHA_1	174	180	PF00498	0.550
LIG_FHA_1	205	211	PF00498	0.585
LIG_FHA_1	270	276	PF00498	0.598
LIG_FHA_1	335	341	PF00498	0.420
LIG_FHA_1	487	493	PF00498	0.336
LIG_FHA_1	522	528	PF00498	0.656
LIG_FHA_1	551	557	PF00498	0.361
LIG_FHA_1	633	639	PF00498	0.393
LIG_FHA_1	654	660	PF00498	0.428
LIG_FHA_2	181	187	PF00498	0.573
LIG_FHA_2	622	628	PF00498	0.329
LIG_LIR_Apic_2	635	639	PF02991	0.446
LIG_LIR_Apic_2	80	86	PF02991	0.714
LIG_LIR_Gen_1	133	138	PF02991	0.646
LIG_LIR_Gen_1	185	196	PF02991	0.599
LIG_LIR_Gen_1	206	216	PF02991	0.555
LIG_LIR_Gen_1	276	285	PF02991	0.567
LIG_LIR_Gen_1	286	295	PF02991	0.506
LIG_LIR_Gen_1	333	344	PF02991	0.419
LIG_LIR_Gen_1	412	420	PF02991	0.553
LIG_LIR_Gen_1	538	549	PF02991	0.503
LIG_LIR_LC3C_4	553	558	PF02991	0.289
LIG_LIR_Nem_3	133	137	PF02991	0.605
LIG_LIR_Nem_3	185	191	PF02991	0.572
LIG_LIR_Nem_3	206	211	PF02991	0.643
LIG_LIR_Nem_3	286	291	PF02991	0.545
LIG_LIR_Nem_3	296	300	PF02991	0.533
LIG_LIR_Nem_3	308	312	PF02991	0.664
LIG_LIR_Nem_3	326	330	PF02991	0.330
LIG_LIR_Nem_3	412	416	PF02991	0.444
LIG_LIR_Nem_3	507	513	PF02991	0.476
LIG_LIR_Nem_3	538	544	PF02991	0.488
LIG_LIR_Nem_3	545	550	PF02991	0.354
LIG_LIR_Nem_3	661	666	PF02991	0.591
LIG_LYPXL_yS_3	297	300	PF13949	0.600
LIG_MAD2	525	533	PF02301	0.561
LIG_NRBOX	654	660	PF00104	0.341
LIG_PCNA_PIPBox_1	453	462	PF02747	0.470
LIG_PCNA_yPIPBox_3	214	226	PF02747	0.625
LIG_PCNA_yPIPBox_3	233	246	PF02747	0.594
LIG_PCNA_yPIPBox_3	664	677	PF02747	0.668
LIG_Pex14_1	342	346	PF04695	0.451
LIG_Pex14_2	544	548	PF04695	0.438
LIG_Pex14_2	630	634	PF04695	0.510
LIG_PTB_Apo_2	392	399	PF02174	0.433
LIG_PTB_Apo_2	442	449	PF02174	0.414
LIG_PTB_Apo_2	465	472	PF02174	0.422
LIG_PTB_Phospho_1	465	471	PF10480	0.302
LIG_REV1ctd_RIR_1	425	435	PF16727	0.520
LIG_SH2_CRK	449	453	PF00017	0.407
LIG_SH2_CRK	495	499	PF00017	0.511
LIG_SH2_CRK	577	581	PF00017	0.329
LIG_SH2_GRB2like	386	389	PF00017	0.655
LIG_SH2_GRB2like	618	621	PF00017	0.533
LIG_SH2_NCK_1	449	453	PF00017	0.484
LIG_SH2_PTP2	290	293	PF00017	0.595
LIG_SH2_PTP2	320	323	PF00017	0.530
LIG_SH2_PTP2	413	416	PF00017	0.519
LIG_SH2_PTP2	618	621	PF00017	0.500
LIG_SH2_SRC	418	421	PF00017	0.521
LIG_SH2_SRC	618	621	PF00017	0.427
LIG_SH2_STAP1	386	390	PF00017	0.555
LIG_SH2_STAP1	407	411	PF00017	0.579
LIG_SH2_STAP1	418	422	PF00017	0.623
LIG_SH2_STAT3	386	389	PF00017	0.655
LIG_SH2_STAT5	263	266	PF00017	0.512
LIG_SH2_STAT5	290	293	PF00017	0.593
LIG_SH2_STAT5	299	302	PF00017	0.601
LIG_SH2_STAT5	312	315	PF00017	0.553
LIG_SH2_STAT5	320	323	PF00017	0.552
LIG_SH2_STAT5	364	367	PF00017	0.338
LIG_SH2_STAT5	368	371	PF00017	0.333
LIG_SH2_STAT5	413	416	PF00017	0.500
LIG_SH2_STAT5	44	47	PF00017	0.628
LIG_SH2_STAT5	471	474	PF00017	0.414
LIG_SH2_STAT5	547	550	PF00017	0.340
LIG_SH2_STAT5	618	621	PF00017	0.414
LIG_SH2_STAT5	676	679	PF00017	0.617
LIG_SH3_1	399	405	PF00018	0.524
LIG_SH3_3	399	405	PF00018	0.543
LIG_SH3_3	88	94	PF00018	0.624
LIG_SUMO_SIM_anti_2	289	296	PF11976	0.587
LIG_SUMO_SIM_anti_2	484	489	PF11976	0.289
LIG_SUMO_SIM_anti_2	553	558	PF11976	0.419
LIG_SUMO_SIM_anti_2	565	573	PF11976	0.473
LIG_SUMO_SIM_anti_2	584	590	PF11976	0.445
LIG_SUMO_SIM_par_1	330	335	PF11976	0.438
LIG_SUMO_SIM_par_1	557	562	PF11976	0.503
LIG_SUMO_SIM_par_1	586	592	PF11976	0.264
LIG_TRAF2_1	624	627	PF00917	0.300
LIG_TYR_ITIM	295	300	PF00017	0.606
LIG_TYR_ITIM	318	323	PF00017	0.613
LIG_TYR_ITIM	411	416	PF00017	0.502
LIG_TYR_ITIM	616	621	PF00017	0.289
LIG_TYR_ITSM	543	550	PF00017	0.438
LIG_UBA3_1	192	197	PF00899	0.631
LIG_UBA3_1	300	306	PF00899	0.606
LIG_WRC_WIRS_1	456	461	PF05994	0.372
MOD_CK1_1	126	132	PF00069	0.702
MOD_CK1_1	151	157	PF00069	0.619
MOD_CK1_1	266	272	PF00069	0.597
MOD_CK1_1	273	279	PF00069	0.597
MOD_CK1_1	31	37	PF00069	0.698
MOD_CK1_1	504	510	PF00069	0.518
MOD_CK1_1	514	520	PF00069	0.624
MOD_CK2_1	138	144	PF00069	0.735
MOD_CK2_1	150	156	PF00069	0.758
MOD_CK2_1	621	627	PF00069	0.324
MOD_CK2_1	87	93	PF00069	0.784
MOD_GlcNHglycan	112	115	PF01048	0.603
MOD_GlcNHglycan	128	131	PF01048	0.426
MOD_GlcNHglycan	150	153	PF01048	0.606
MOD_GlcNHglycan	211	214	PF01048	0.421
MOD_GlcNHglycan	22	25	PF01048	0.579
MOD_GlcNHglycan	223	226	PF01048	0.331
MOD_GlcNHglycan	256	259	PF01048	0.431
MOD_GlcNHglycan	285	288	PF01048	0.352
MOD_GlcNHglycan	419	423	PF01048	0.390
MOD_GlcNHglycan	79	82	PF01048	0.443
MOD_GSK3_1	146	153	PF00069	0.702
MOD_GSK3_1	192	199	PF00069	0.602
MOD_GSK3_1	233	240	PF00069	0.608
MOD_GSK3_1	266	273	PF00069	0.517
MOD_GSK3_1	28	35	PF00069	0.685
MOD_GSK3_1	319	326	PF00069	0.526
MOD_GSK3_1	330	337	PF00069	0.398
MOD_GSK3_1	368	375	PF00069	0.408
MOD_GSK3_1	455	462	PF00069	0.305
MOD_GSK3_1	511	518	PF00069	0.624
MOD_GSK3_1	531	538	PF00069	0.622
MOD_GSK3_1	559	566	PF00069	0.537
MOD_GSK3_1	589	596	PF00069	0.504
MOD_GSK3_1	621	628	PF00069	0.364
MOD_N-GLC_1	435	440	PF02516	0.273
MOD_N-GLC_1	593	598	PF02516	0.269
MOD_N-GLC_1	632	637	PF02516	0.554
MOD_N-GLC_1	87	92	PF02516	0.559
MOD_N-GLC_2	445	447	PF02516	0.320
MOD_NEK2_1	125	130	PF00069	0.702
MOD_NEK2_1	173	178	PF00069	0.530
MOD_NEK2_1	221	226	PF00069	0.540
MOD_NEK2_1	283	288	PF00069	0.572
MOD_NEK2_1	334	339	PF00069	0.363
MOD_NEK2_1	481	486	PF00069	0.280
MOD_NEK2_1	501	506	PF00069	0.502
MOD_NEK2_1	559	564	PF00069	0.491
MOD_NEK2_1	581	586	PF00069	0.359
MOD_NEK2_1	595	600	PF00069	0.522
MOD_NEK2_1	632	637	PF00069	0.418
MOD_NEK2_1	647	652	PF00069	0.383
MOD_NEK2_2	625	630	PF00069	0.417
MOD_PIKK_1	512	518	PF00454	0.642
MOD_PIKK_1	666	672	PF00454	0.583
MOD_PK_1	233	239	PF00069	0.518
MOD_PKA_2	110	116	PF00069	0.771
MOD_PKA_2	123	129	PF00069	0.625
MOD_PKA_2	139	145	PF00069	0.640
MOD_PKA_2	161	167	PF00069	0.588
MOD_PKA_2	273	279	PF00069	0.613
MOD_PKA_2	283	289	PF00069	0.534
MOD_PKA_2	666	672	PF00069	0.646
MOD_Plk_1	32	38	PF00069	0.682
MOD_Plk_1	521	527	PF00069	0.581
MOD_Plk_1	593	599	PF00069	0.625
MOD_Plk_1	632	638	PF00069	0.272
MOD_Plk_2-3	161	167	PF00069	0.695
MOD_Plk_2-3	204	210	PF00069	0.621
MOD_Plk_4	173	179	PF00069	0.532
MOD_Plk_4	233	239	PF00069	0.551
MOD_Plk_4	368	374	PF00069	0.324
MOD_Plk_4	409	415	PF00069	0.562
MOD_Plk_4	435	441	PF00069	0.472
MOD_Plk_4	455	461	PF00069	0.250
MOD_Plk_4	483	489	PF00069	0.291
MOD_Plk_4	552	558	PF00069	0.359
MOD_Plk_4	581	587	PF00069	0.366
MOD_Plk_4	625	631	PF00069	0.400
MOD_Plk_4	637	643	PF00069	0.301
MOD_Plk_4	647	653	PF00069	0.332
MOD_Plk_4	67	73	PF00069	0.637
MOD_ProDKin_1	87	93	PF00069	0.625
MOD_SUMO_rev_2	379	383	PF00179	0.655
MOD_SUMO_rev_2	48	55	PF00179	0.608
TRG_ENDOCYTIC_2	285	288	PF00928	0.559
TRG_ENDOCYTIC_2	290	293	PF00928	0.545
TRG_ENDOCYTIC_2	297	300	PF00928	0.550
TRG_ENDOCYTIC_2	312	315	PF00928	0.656
TRG_ENDOCYTIC_2	320	323	PF00928	0.607
TRG_ENDOCYTIC_2	358	361	PF00928	0.363
TRG_ENDOCYTIC_2	407	410	PF00928	0.510
TRG_ENDOCYTIC_2	413	416	PF00928	0.489
TRG_ENDOCYTIC_2	476	479	PF00928	0.376
TRG_ENDOCYTIC_2	495	498	PF00928	0.384
TRG_ENDOCYTIC_2	547	550	PF00928	0.372
TRG_ENDOCYTIC_2	577	580	PF00928	0.467
TRG_ENDOCYTIC_2	618	621	PF00928	0.449
TRG_ER_diArg_1	1	4	PF00400	0.587
TRG_ER_diArg_1	529	531	PF00400	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A4	Leptomonas seymouri	48%	96%
A0A0S4IIV3	Bodo saltans	25%	89%
A0A0S4IZJ9	Bodo saltans	22%	71%
A0A1X0NUP0	Trypanosomatidae	28%	100%
A0A3Q8IDV0	Leishmania donovani	22%	100%
A0A3R7R847	Trypanosoma rangeli	24%	100%
A0A3S7X5M8	Leishmania donovani	87%	100%
A0A422MY34	Trypanosoma rangeli	31%	100%
A4HKK2	Leishmania braziliensis	72%	100%
A4HLQ6	Leishmania braziliensis	24%	100%
A4I834	Leishmania infantum	87%	100%
A4I956	Leishmania infantum	21%	100%
D0AAA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B431	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	67%
Q4Q3Z3	Leishmania major	24%	100%
Q4Q564	Leishmania major	87%	100%
V5BBK9	Trypanosoma cruzi	27%	100%