FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2Z1_LEIMU

TriTrypDb:

LmxM.31.2110

Length:

871

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.524
CLV_C14_Caspase3-7	546	550	PF00656	0.659
CLV_NRD_NRD_1	148	150	PF00675	0.608
CLV_NRD_NRD_1	389	391	PF00675	0.511
CLV_NRD_NRD_1	433	435	PF00675	0.591
CLV_NRD_NRD_1	599	601	PF00675	0.675
CLV_NRD_NRD_1	72	74	PF00675	0.707
CLV_NRD_NRD_1	851	853	PF00675	0.330
CLV_PCSK_KEX2_1	148	150	PF00082	0.608
CLV_PCSK_KEX2_1	433	435	PF00082	0.717
CLV_PCSK_KEX2_1	599	601	PF00082	0.728
CLV_PCSK_KEX2_1	71	73	PF00082	0.652
CLV_PCSK_KEX2_1	868	870	PF00082	0.630
CLV_PCSK_KEX2_1	97	99	PF00082	0.615
CLV_PCSK_PC1ET2_1	868	870	PF00082	0.630
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.615
CLV_PCSK_SKI1_1	193	197	PF00082	0.490
CLV_PCSK_SKI1_1	217	221	PF00082	0.550
CLV_PCSK_SKI1_1	249	253	PF00082	0.627
CLV_PCSK_SKI1_1	312	316	PF00082	0.590
CLV_PCSK_SKI1_1	464	468	PF00082	0.584
CLV_PCSK_SKI1_1	575	579	PF00082	0.724
CLV_PCSK_SKI1_1	672	676	PF00082	0.563
CLV_PCSK_SKI1_1	716	720	PF00082	0.607
CLV_PCSK_SKI1_1	777	781	PF00082	0.457
CLV_PCSK_SKI1_1	831	835	PF00082	0.411
DEG_APCC_DBOX_1	97	105	PF00400	0.570
DEG_SCF_FBW7_1	127	132	PF00400	0.654
DEG_SCF_TRCP1_1	31	37	PF00400	0.614
DEG_SPOP_SBC_1	244	248	PF00917	0.562
DEG_SPOP_SBC_1	47	51	PF00917	0.611
DEG_SPOP_SBC_1	499	503	PF00917	0.542
DEG_SPOP_SBC_1	528	532	PF00917	0.669
DOC_CYCLIN_RxL_1	190	201	PF00134	0.467
DOC_CYCLIN_RxL_1	349	362	PF00134	0.550
DOC_CYCLIN_RxL_1	813	822	PF00134	0.446
DOC_CYCLIN_RxL_1	828	838	PF00134	0.406
DOC_MAPK_gen_1	148	155	PF00069	0.475
DOC_MAPK_gen_1	97	103	PF00069	0.614
DOC_MAPK_HePTP_8	652	664	PF00069	0.611
DOC_MAPK_JIP1_4	149	155	PF00069	0.559
DOC_MAPK_MEF2A_6	655	664	PF00069	0.585
DOC_PP1_RVXF_1	829	835	PF00149	0.425
DOC_PP2B_LxvP_1	617	620	PF13499	0.569
DOC_PP2B_LxvP_1	664	667	PF13499	0.647
DOC_PP4_FxxP_1	374	377	PF00568	0.616
DOC_PP4_FxxP_1	775	778	PF00568	0.444
DOC_PP4_FxxP_1	820	823	PF00568	0.461
DOC_USP7_MATH_1	127	131	PF00917	0.695
DOC_USP7_MATH_1	17	21	PF00917	0.553
DOC_USP7_MATH_1	244	248	PF00917	0.780
DOC_USP7_MATH_1	274	278	PF00917	0.678
DOC_USP7_MATH_1	29	33	PF00917	0.523
DOC_USP7_MATH_1	332	336	PF00917	0.600
DOC_USP7_MATH_1	399	403	PF00917	0.529
DOC_USP7_MATH_1	47	51	PF00917	0.611
DOC_USP7_MATH_1	499	503	PF00917	0.787
DOC_USP7_MATH_1	518	522	PF00917	0.533
DOC_USP7_MATH_1	528	532	PF00917	0.677
DOC_USP7_MATH_1	678	682	PF00917	0.587
DOC_USP7_MATH_1	684	688	PF00917	0.575
DOC_USP7_UBL2_3	249	253	PF12436	0.501
DOC_USP7_UBL2_3	387	391	PF12436	0.515
DOC_USP7_UBL2_3	651	655	PF12436	0.529
DOC_USP7_UBL2_3	716	720	PF12436	0.552
DOC_WW_Pin1_4	123	128	PF00397	0.601
DOC_WW_Pin1_4	238	243	PF00397	0.652
DOC_WW_Pin1_4	590	595	PF00397	0.705
DOC_WW_Pin1_4	646	651	PF00397	0.604
DOC_WW_Pin1_4	66	71	PF00397	0.779
DOC_WW_Pin1_4	96	101	PF00397	0.549
LIG_14-3-3_CanoR_1	133	142	PF00244	0.813
LIG_14-3-3_CanoR_1	171	176	PF00244	0.578
LIG_14-3-3_CanoR_1	276	280	PF00244	0.623
LIG_14-3-3_CanoR_1	312	317	PF00244	0.567
LIG_14-3-3_CanoR_1	485	489	PF00244	0.487
LIG_14-3-3_CanoR_1	599	609	PF00244	0.721
LIG_14-3-3_CanoR_1	679	688	PF00244	0.663
LIG_14-3-3_CanoR_1	690	699	PF00244	0.741
LIG_14-3-3_CanoR_1	708	715	PF00244	0.542
LIG_14-3-3_CanoR_1	852	856	PF00244	0.318
LIG_14-3-3_CanoR_1	98	104	PF00244	0.617
LIG_APCC_ABBA_1	216	221	PF00400	0.552
LIG_APCC_ABBA_1	817	822	PF00400	0.458
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BIR_III_4	56	60	PF00653	0.503
LIG_BRCT_BRCA1_1	31	35	PF00533	0.734
LIG_BRCT_BRCA1_1	405	409	PF00533	0.445
LIG_BRCT_BRCA1_1	726	730	PF00533	0.506
LIG_deltaCOP1_diTrp_1	403	409	PF00928	0.443
LIG_eIF4E_1	654	660	PF01652	0.617
LIG_FHA_1	1	7	PF00498	0.620
LIG_FHA_1	306	312	PF00498	0.508
LIG_FHA_1	379	385	PF00498	0.483
LIG_FHA_1	47	53	PF00498	0.626
LIG_FHA_1	470	476	PF00498	0.618
LIG_FHA_1	540	546	PF00498	0.643
LIG_FHA_1	590	596	PF00498	0.728
LIG_FHA_1	72	78	PF00498	0.676
LIG_FHA_1	753	759	PF00498	0.577
LIG_FHA_1	824	830	PF00498	0.445
LIG_FHA_2	313	319	PF00498	0.653
LIG_FHA_2	35	41	PF00498	0.609
LIG_FHA_2	544	550	PF00498	0.561
LIG_LIR_Apic_2	373	377	PF02991	0.611
LIG_LIR_Apic_2	774	778	PF02991	0.331
LIG_LIR_Gen_1	256	261	PF02991	0.591
LIG_LIR_Gen_1	401	410	PF02991	0.484
LIG_LIR_Gen_1	445	453	PF02991	0.513
LIG_LIR_Gen_1	727	737	PF02991	0.457
LIG_LIR_Nem_3	256	260	PF02991	0.658
LIG_LIR_Nem_3	401	407	PF02991	0.486
LIG_LIR_Nem_3	445	449	PF02991	0.570
LIG_LIR_Nem_3	604	610	PF02991	0.569
LIG_LIR_Nem_3	653	657	PF02991	0.699
LIG_LIR_Nem_3	668	674	PF02991	0.488
LIG_LIR_Nem_3	712	718	PF02991	0.504
LIG_LIR_Nem_3	727	733	PF02991	0.524
LIG_LIR_Nem_3	774	779	PF02991	0.428
LIG_LYPXL_yS_3	607	610	PF13949	0.500
LIG_MLH1_MIPbox_1	405	409	PF16413	0.445
LIG_NRP_CendR_1	868	871	PF00754	0.572
LIG_PCNA_PIPBox_1	435	444	PF02747	0.584
LIG_PCNA_yPIPBox_3	193	206	PF02747	0.491
LIG_PCNA_yPIPBox_3	433	442	PF02747	0.587
LIG_Pex14_1	404	408	PF04695	0.446
LIG_Pex14_2	775	779	PF04695	0.419
LIG_SH2_CRK	671	675	PF00017	0.560
LIG_SH2_NCK_1	16	20	PF00017	0.606
LIG_SH2_SRC	16	19	PF00017	0.542
LIG_SH2_SRC	43	46	PF00017	0.678
LIG_SH2_STAP1	48	52	PF00017	0.577
LIG_SH2_STAT3	422	425	PF00017	0.535
LIG_SH2_STAT3	698	701	PF00017	0.562
LIG_SH2_STAT3	812	815	PF00017	0.493
LIG_SH2_STAT5	43	46	PF00017	0.751
LIG_SH2_STAT5	446	449	PF00017	0.591
LIG_SH2_STAT5	48	51	PF00017	0.665
LIG_SH2_STAT5	698	701	PF00017	0.562
LIG_SH2_STAT5	721	724	PF00017	0.492
LIG_SH2_STAT5	812	815	PF00017	0.421
LIG_SH2_STAT5	824	827	PF00017	0.444
LIG_SH2_STAT5	837	840	PF00017	0.446
LIG_SH3_2	67	72	PF14604	0.697
LIG_SH3_3	39	45	PF00018	0.613
LIG_SH3_3	583	589	PF00018	0.560
LIG_SH3_3	61	67	PF00018	0.755
LIG_SH3_3	617	623	PF00018	0.592
LIG_SH3_3	696	702	PF00018	0.587
LIG_SH3_3	755	761	PF00018	0.548
LIG_SUMO_SIM_anti_2	99	105	PF11976	0.571
LIG_SUMO_SIM_par_1	99	105	PF11976	0.679
LIG_TYR_ITIM	652	657	PF00017	0.612
LIG_WRC_WIRS_1	371	376	PF05994	0.609
LIG_WRC_WIRS_1	772	777	PF05994	0.432
LIG_WRPW_2	776	779	PF00400	0.368
MOD_CDC14_SPxK_1	69	72	PF00782	0.702
MOD_CDK_SPK_2	646	651	PF00069	0.547
MOD_CDK_SPK_2	66	71	PF00069	0.656
MOD_CDK_SPxK_1	66	72	PF00069	0.698
MOD_CDK_SPxxK_3	66	73	PF00069	0.629
MOD_CK1_1	123	129	PF00069	0.615
MOD_CK1_1	198	204	PF00069	0.523
MOD_CK1_1	275	281	PF00069	0.739
MOD_CK1_1	370	376	PF00069	0.531
MOD_CK1_1	378	384	PF00069	0.484
MOD_CK1_1	46	52	PF00069	0.633
MOD_CK1_1	502	508	PF00069	0.721
MOD_CK1_1	510	516	PF00069	0.741
MOD_CK1_1	531	537	PF00069	0.629
MOD_CK1_1	540	546	PF00069	0.683
MOD_CK1_1	603	609	PF00069	0.609
MOD_CK1_1	62	68	PF00069	0.579
MOD_CK1_1	639	645	PF00069	0.647
MOD_CK1_1	693	699	PF00069	0.616
MOD_CK1_1	75	81	PF00069	0.639
MOD_CK1_1	797	803	PF00069	0.368
MOD_CK1_1	87	93	PF00069	0.619
MOD_CK1_1	96	102	PF00069	0.622
MOD_CK2_1	312	318	PF00069	0.599
MOD_CK2_1	510	516	PF00069	0.766
MOD_CK2_1	843	849	PF00069	0.508
MOD_CK2_1	99	105	PF00069	0.679
MOD_GlcNHglycan	164	167	PF01048	0.695
MOD_GlcNHglycan	186	189	PF01048	0.525
MOD_GlcNHglycan	290	293	PF01048	0.639
MOD_GlcNHglycan	305	308	PF01048	0.646
MOD_GlcNHglycan	31	34	PF01048	0.671
MOD_GlcNHglycan	324	328	PF01048	0.595
MOD_GlcNHglycan	330	335	PF01048	0.592
MOD_GlcNHglycan	45	48	PF01048	0.528
MOD_GlcNHglycan	451	454	PF01048	0.512
MOD_GlcNHglycan	531	534	PF01048	0.555
MOD_GlcNHglycan	542	545	PF01048	0.670
MOD_GlcNHglycan	583	586	PF01048	0.575
MOD_GlcNHglycan	682	685	PF01048	0.686
MOD_GlcNHglycan	797	800	PF01048	0.489
MOD_GSK3_1	123	130	PF00069	0.697
MOD_GSK3_1	134	141	PF00069	0.715
MOD_GSK3_1	158	165	PF00069	0.544
MOD_GSK3_1	184	191	PF00069	0.529
MOD_GSK3_1	220	227	PF00069	0.557
MOD_GSK3_1	234	241	PF00069	0.811
MOD_GSK3_1	274	281	PF00069	0.659
MOD_GSK3_1	330	337	PF00069	0.582
MOD_GSK3_1	394	401	PF00069	0.472
MOD_GSK3_1	43	50	PF00069	0.598
MOD_GSK3_1	498	505	PF00069	0.528
MOD_GSK3_1	527	534	PF00069	0.619
MOD_GSK3_1	535	542	PF00069	0.612
MOD_GSK3_1	62	69	PF00069	0.644
MOD_GSK3_1	646	653	PF00069	0.573
MOD_GSK3_1	674	681	PF00069	0.560
MOD_GSK3_1	71	78	PF00069	0.563
MOD_GSK3_1	787	794	PF00069	0.510
MOD_GSK3_1	80	87	PF00069	0.651
MOD_GSK3_1	835	842	PF00069	0.543
MOD_GSK3_1	851	858	PF00069	0.390
MOD_N-GLC_1	412	417	PF02516	0.495
MOD_N-GLC_1	483	488	PF02516	0.618
MOD_N-GLC_1	75	80	PF02516	0.682
MOD_NEK2_1	134	139	PF00069	0.717
MOD_NEK2_1	162	167	PF00069	0.574
MOD_NEK2_1	184	189	PF00069	0.511
MOD_NEK2_1	195	200	PF00069	0.521
MOD_NEK2_1	448	453	PF00069	0.518
MOD_NEK2_1	552	557	PF00069	0.504
MOD_NEK2_1	636	641	PF00069	0.696
MOD_NEK2_1	787	792	PF00069	0.470
MOD_NEK2_1	851	856	PF00069	0.365
MOD_NEK2_2	334	339	PF00069	0.450
MOD_NEK2_2	48	53	PF00069	0.597
MOD_NEK2_2	558	563	PF00069	0.575
MOD_NEK2_2	725	730	PF00069	0.579
MOD_NEK2_2	80	85	PF00069	0.503
MOD_PIKK_1	120	126	PF00454	0.586
MOD_PIKK_1	195	201	PF00454	0.486
MOD_PIKK_1	537	543	PF00454	0.520
MOD_PKA_1	71	77	PF00069	0.672
MOD_PKA_2	134	140	PF00069	0.743
MOD_PKA_2	176	182	PF00069	0.598
MOD_PKA_2	221	227	PF00069	0.691
MOD_PKA_2	275	281	PF00069	0.636
MOD_PKA_2	378	384	PF00069	0.506
MOD_PKA_2	484	490	PF00069	0.669
MOD_PKA_2	601	607	PF00069	0.673
MOD_PKA_2	678	684	PF00069	0.592
MOD_PKA_2	71	77	PF00069	0.601
MOD_PKA_2	764	770	PF00069	0.508
MOD_PKA_2	851	857	PF00069	0.317
MOD_Plk_1	158	164	PF00069	0.524
MOD_Plk_1	17	23	PF00069	0.678
MOD_Plk_1	323	329	PF00069	0.632
MOD_Plk_1	483	489	PF00069	0.539
MOD_Plk_1	59	65	PF00069	0.618
MOD_Plk_1	725	731	PF00069	0.581
MOD_Plk_1	90	96	PF00069	0.522
MOD_Plk_4	158	164	PF00069	0.558
MOD_Plk_4	171	177	PF00069	0.724
MOD_Plk_4	18	24	PF00069	0.675
MOD_Plk_4	305	311	PF00069	0.502
MOD_Plk_4	370	376	PF00069	0.531
MOD_Plk_4	403	409	PF00069	0.443
MOD_Plk_4	504	510	PF00069	0.506
MOD_Plk_4	725	731	PF00069	0.635
MOD_Plk_4	764	770	PF00069	0.488
MOD_Plk_4	771	777	PF00069	0.434
MOD_Plk_4	99	105	PF00069	0.631
MOD_ProDKin_1	123	129	PF00069	0.603
MOD_ProDKin_1	238	244	PF00069	0.647
MOD_ProDKin_1	590	596	PF00069	0.707
MOD_ProDKin_1	646	652	PF00069	0.600
MOD_ProDKin_1	66	72	PF00069	0.783
MOD_ProDKin_1	96	102	PF00069	0.550
MOD_SUMO_rev_2	110	116	PF00179	0.634
MOD_SUMO_rev_2	28	37	PF00179	0.662
MOD_SUMO_rev_2	516	523	PF00179	0.531
MOD_SUMO_rev_2	572	577	PF00179	0.643
TRG_DiLeu_BaEn_2	323	329	PF01217	0.499
TRG_ENDOCYTIC_2	16	19	PF00928	0.559
TRG_ENDOCYTIC_2	389	392	PF00928	0.487
TRG_ENDOCYTIC_2	439	442	PF00928	0.581
TRG_ENDOCYTIC_2	446	449	PF00928	0.478
TRG_ENDOCYTIC_2	607	610	PF00928	0.561
TRG_ENDOCYTIC_2	654	657	PF00928	0.723
TRG_ENDOCYTIC_2	671	674	PF00928	0.493
TRG_ENDOCYTIC_2	715	718	PF00928	0.533
TRG_ENDOCYTIC_2	776	779	PF00928	0.598
TRG_ENDOCYTIC_2	811	814	PF00928	0.409
TRG_ER_diArg_1	133	136	PF00400	0.707
TRG_ER_diArg_1	148	151	PF00400	0.495
TRG_ER_diArg_1	432	434	PF00400	0.545
TRG_ER_diArg_1	599	602	PF00400	0.632
TRG_ER_diArg_1	70	73	PF00400	0.645
TRG_ER_diArg_1	762	765	PF00400	0.619
TRG_ER_diArg_1	869	871	PF00400	0.574
TRG_ER_diLys_1	867	871	PF00400	0.678
TRG_NLS_Bipartite_1	852	871	PF00514	0.529
TRG_NLS_MonoCore_2	866	871	PF00514	0.626
TRG_NLS_MonoExtC_3	866	871	PF00514	0.565
TRG_NLS_MonoExtN_4	249	256	PF00514	0.549
TRG_NLS_MonoExtN_4	864	871	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	831	835	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	845	849	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P5	Leptomonas seymouri	49%	100%
A0A3Q8IG94	Leishmania donovani	84%	100%
A4HKK1	Leishmania braziliensis	64%	100%
A4I833	Leishmania infantum	84%	100%
Q4Q565	Leishmania major	82%	100%