CMP/dCMP-type deaminase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cytidine and deoxycytidylate deaminase zinc-binding region, putative

Species:

Leishmania mexicana

UniProt:

E9B2Y8_LEIMU

TriTrypDb:

LmxM.31.2080

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Y8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.499
CLV_C14_Caspase3-7	192	196	PF00656	0.545
CLV_NRD_NRD_1	309	311	PF00675	0.531
CLV_NRD_NRD_1	391	393	PF00675	0.545
CLV_PCSK_KEX2_1	309	311	PF00082	0.443
CLV_PCSK_KEX2_1	393	395	PF00082	0.678
CLV_PCSK_KEX2_1	49	51	PF00082	0.466
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.647
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.466
CLV_PCSK_SKI1_1	280	284	PF00082	0.406
CLV_PCSK_SKI1_1	309	313	PF00082	0.432
CLV_PCSK_SKI1_1	498	502	PF00082	0.275
DEG_Nend_UBRbox_1	1	4	PF02207	0.425
DEG_SCF_FBW7_1	69	76	PF00400	0.674
DEG_SPOP_SBC_1	102	106	PF00917	0.542
DEG_SPOP_SBC_1	356	360	PF00917	0.445
DOC_CKS1_1	70	75	PF01111	0.685
DOC_CYCLIN_yClb5_NLxxxL_5	31	40	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	407	413	PF00134	0.378
DOC_MAPK_gen_1	299	307	PF00069	0.419
DOC_MAPK_gen_1	49	59	PF00069	0.522
DOC_MAPK_MEF2A_6	316	325	PF00069	0.651
DOC_MAPK_MEF2A_6	32	40	PF00069	0.477
DOC_MAPK_MEF2A_6	50	59	PF00069	0.395
DOC_PP1_RVXF_1	496	502	PF00149	0.475
DOC_PP2B_LxvP_1	255	258	PF13499	0.445
DOC_PP2B_LxvP_1	36	39	PF13499	0.485
DOC_PP2B_LxvP_1	542	545	PF13499	0.337
DOC_USP7_MATH_1	102	106	PF00917	0.627
DOC_USP7_MATH_1	118	122	PF00917	0.515
DOC_USP7_MATH_1	137	141	PF00917	0.686
DOC_USP7_MATH_1	155	159	PF00917	0.385
DOC_USP7_MATH_1	175	179	PF00917	0.520
DOC_USP7_MATH_1	223	227	PF00917	0.507
DOC_USP7_MATH_1	264	268	PF00917	0.359
DOC_USP7_MATH_1	357	361	PF00917	0.445
DOC_USP7_MATH_1	439	443	PF00917	0.547
DOC_USP7_MATH_1	444	448	PF00917	0.546
DOC_USP7_MATH_1	449	453	PF00917	0.587
DOC_USP7_MATH_1	464	468	PF00917	0.533
DOC_USP7_MATH_2	243	249	PF00917	0.506
DOC_WW_Pin1_4	11	16	PF00397	0.490
DOC_WW_Pin1_4	211	216	PF00397	0.570
DOC_WW_Pin1_4	317	322	PF00397	0.658
DOC_WW_Pin1_4	380	385	PF00397	0.692
DOC_WW_Pin1_4	65	70	PF00397	0.584
LIG_14-3-3_CanoR_1	176	183	PF00244	0.544
LIG_14-3-3_CanoR_1	304	308	PF00244	0.630
LIG_14-3-3_CanoR_1	429	433	PF00244	0.563
LIG_14-3-3_CanoR_1	462	471	PF00244	0.569
LIG_14-3-3_CanoR_1	54	60	PF00244	0.603
LIG_BIR_III_4	107	111	PF00653	0.651
LIG_BRCT_BRCA1_1	225	229	PF00533	0.469
LIG_deltaCOP1_diTrp_1	245	253	PF00928	0.468
LIG_FHA_1	12	18	PF00498	0.483
LIG_FHA_1	155	161	PF00498	0.496
LIG_FHA_1	185	191	PF00498	0.483
LIG_FHA_1	217	223	PF00498	0.495
LIG_FHA_1	269	275	PF00498	0.377
LIG_FHA_1	350	356	PF00498	0.535
LIG_FHA_1	538	544	PF00498	0.307
LIG_FHA_1	92	98	PF00498	0.597
LIG_FHA_2	133	139	PF00498	0.558
LIG_IRF3_LxIS_1	15	22	PF10401	0.429
LIG_LIR_Gen_1	226	236	PF02991	0.448
LIG_LIR_Gen_1	537	547	PF02991	0.476
LIG_LIR_LC3C_4	540	544	PF02991	0.321
LIG_LIR_Nem_3	537	542	PF02991	0.439
LIG_NRBOX	76	82	PF00104	0.527
LIG_PCNA_PIPBox_1	520	529	PF02747	0.429
LIG_REV1ctd_RIR_1	498	508	PF16727	0.567
LIG_SH2_CRK	376	380	PF00017	0.572
LIG_SH2_CRK	539	543	PF00017	0.301
LIG_SH2_STAP1	539	543	PF00017	0.301
LIG_SH2_STAT5	200	203	PF00017	0.776
LIG_SH2_STAT5	376	379	PF00017	0.485
LIG_SH2_STAT5	470	473	PF00017	0.408
LIG_SH2_STAT5	478	481	PF00017	0.467
LIG_SH2_STAT5	539	542	PF00017	0.486
LIG_SH3_3	254	260	PF00018	0.443
LIG_SH3_3	344	350	PF00018	0.409
LIG_SH3_3	364	370	PF00018	0.324
LIG_SH3_3	397	403	PF00018	0.562
LIG_SH3_3	67	73	PF00018	0.653
LIG_SH3_CIN85_PxpxPR_1	254	259	PF14604	0.523
LIG_SUMO_SIM_anti_2	342	349	PF11976	0.407
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.625
LIG_SUMO_SIM_par_1	16	23	PF11976	0.406
MOD_CK1_1	103	109	PF00069	0.756
MOD_CK1_1	202	208	PF00069	0.622
MOD_CK1_1	216	222	PF00069	0.557
MOD_CK1_1	303	309	PF00069	0.683
MOD_CK1_1	360	366	PF00069	0.530
MOD_CK1_1	435	441	PF00069	0.567
MOD_CK1_1	442	448	PF00069	0.568
MOD_CK1_1	454	460	PF00069	0.595
MOD_CK1_1	96	102	PF00069	0.638
MOD_CK2_1	132	138	PF00069	0.550
MOD_CK2_1	321	327	PF00069	0.646
MOD_CK2_1	525	531	PF00069	0.395
MOD_CK2_1	72	78	PF00069	0.637
MOD_GlcNHglycan	100	103	PF01048	0.608
MOD_GlcNHglycan	115	118	PF01048	0.601
MOD_GlcNHglycan	120	123	PF01048	0.603
MOD_GlcNHglycan	141	144	PF01048	0.420
MOD_GlcNHglycan	170	173	PF01048	0.548
MOD_GlcNHglycan	177	180	PF01048	0.619
MOD_GlcNHglycan	247	250	PF01048	0.506
MOD_GlcNHglycan	266	269	PF01048	0.341
MOD_GlcNHglycan	336	340	PF01048	0.513
MOD_GlcNHglycan	359	362	PF01048	0.465
MOD_GlcNHglycan	434	437	PF01048	0.550
MOD_GlcNHglycan	444	447	PF01048	0.605
MOD_GlcNHglycan	453	456	PF01048	0.572
MOD_GlcNHglycan	527	530	PF01048	0.384
MOD_GSK3_1	109	116	PF00069	0.585
MOD_GSK3_1	149	156	PF00069	0.542
MOD_GSK3_1	194	201	PF00069	0.740
MOD_GSK3_1	210	217	PF00069	0.530
MOD_GSK3_1	230	237	PF00069	0.463
MOD_GSK3_1	264	271	PF00069	0.435
MOD_GSK3_1	312	319	PF00069	0.633
MOD_GSK3_1	356	363	PF00069	0.433
MOD_GSK3_1	428	435	PF00069	0.679
MOD_GSK3_1	440	447	PF00069	0.546
MOD_GSK3_1	450	457	PF00069	0.569
MOD_GSK3_1	55	62	PF00069	0.547
MOD_GSK3_1	65	72	PF00069	0.658
MOD_GSK3_1	93	100	PF00069	0.608
MOD_N-GLC_1	464	469	PF02516	0.586
MOD_NEK2_1	154	159	PF00069	0.534
MOD_NEK2_1	166	171	PF00069	0.336
MOD_NEK2_1	300	305	PF00069	0.436
MOD_NEK2_1	311	316	PF00069	0.494
MOD_NEK2_1	450	455	PF00069	0.507
MOD_NEK2_1	491	496	PF00069	0.312
MOD_NEK2_1	538	543	PF00069	0.304
MOD_NEK2_1	98	103	PF00069	0.501
MOD_NEK2_2	361	366	PF00069	0.444
MOD_PIKK_1	132	138	PF00454	0.427
MOD_PKA_1	309	315	PF00069	0.436
MOD_PKA_2	175	181	PF00069	0.525
MOD_PKA_2	300	306	PF00069	0.548
MOD_PKA_2	309	315	PF00069	0.430
MOD_PKA_2	428	434	PF00069	0.615
MOD_Plk_1	137	143	PF00069	0.559
MOD_Plk_1	386	392	PF00069	0.628
MOD_Plk_4	26	32	PF00069	0.423
MOD_Plk_4	538	544	PF00069	0.307
MOD_Plk_4	55	61	PF00069	0.537
MOD_Plk_4	93	99	PF00069	0.614
MOD_ProDKin_1	11	17	PF00069	0.487
MOD_ProDKin_1	211	217	PF00069	0.566
MOD_ProDKin_1	317	323	PF00069	0.661
MOD_ProDKin_1	380	386	PF00069	0.690
MOD_ProDKin_1	65	71	PF00069	0.582
MOD_SUMO_rev_2	22	27	PF00179	0.458
TRG_DiLeu_BaEn_1	336	341	PF01217	0.559
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.346
TRG_ENDOCYTIC_2	376	379	PF00928	0.560
TRG_ENDOCYTIC_2	539	542	PF00928	0.486
TRG_ER_diArg_1	309	311	PF00400	0.486
TRG_ER_diArg_1	50	53	PF00400	0.467
TRG_NLS_MonoExtC_3	391	396	PF00514	0.515
TRG_NLS_MonoExtC_3	48	53	PF00514	0.458
TRG_NLS_MonoExtN_4	392	397	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	148	153	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.432
TRG_PTS1	544	547	PF00515	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXU5	Leptomonas seymouri	44%	100%
A0A3Q8IL67	Leishmania donovani	89%	100%
A4HKJ8	Leishmania braziliensis	69%	99%
A4I830	Leishmania infantum	89%	100%
Q4Q568	Leishmania major	86%	100%