CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytidylyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B2Y7_LEIMU

TriTrypDb:

LmxM.31.2070

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Y7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0015936	coenzyme A metabolic process	6	1
GO:0015937	coenzyme A biosynthetic process	7	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033866	nucleoside bisphosphate biosynthetic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004140	dephospho-CoA kinase activity	5	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0016779	nucleotidyltransferase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.514
CLV_PCSK_KEX2_1	229	231	PF00082	0.340
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.201
CLV_PCSK_SKI1_1	202	206	PF00082	0.258
CLV_PCSK_SKI1_1	26	30	PF00082	0.490
CLV_PCSK_SKI1_1	35	39	PF00082	0.666
DEG_APCC_DBOX_1	25	33	PF00400	0.554
DEG_SCF_FBW7_1	28	34	PF00400	0.476
DEG_SPOP_SBC_1	127	131	PF00917	0.804
DOC_CKS1_1	28	33	PF01111	0.462
DOC_MAPK_gen_1	251	260	PF00069	0.444
DOC_MAPK_MEF2A_6	251	260	PF00069	0.446
DOC_MAPK_RevD_3	216	230	PF00069	0.498
DOC_USP7_MATH_1	126	130	PF00917	0.807
DOC_USP7_MATH_1	39	43	PF00917	0.710
DOC_USP7_MATH_1	46	50	PF00917	0.690
DOC_USP7_UBL2_3	168	172	PF12436	0.429
DOC_WW_Pin1_4	128	133	PF00397	0.775
DOC_WW_Pin1_4	27	32	PF00397	0.451
DOC_WW_Pin1_4	279	284	PF00397	0.442
DOC_WW_Pin1_4	312	317	PF00397	0.534
LIG_14-3-3_CanoR_1	217	226	PF00244	0.466
LIG_14-3-3_CanoR_1	53	63	PF00244	0.457
LIG_14-3-3_CanoR_1	78	82	PF00244	0.409
LIG_APCC_ABBA_1	154	159	PF00400	0.513
LIG_BIR_III_4	177	181	PF00653	0.457
LIG_deltaCOP1_diTrp_1	166	174	PF00928	0.430
LIG_FHA_1	205	211	PF00498	0.445
LIG_FHA_1	23	29	PF00498	0.533
LIG_FHA_1	268	274	PF00498	0.544
LIG_FHA_2	116	122	PF00498	0.476
LIG_FHA_2	36	42	PF00498	0.647
LIG_FHA_2	43	49	PF00498	0.640
LIG_FHA_2	78	84	PF00498	0.469
LIG_HP1_1	3	7	PF01393	0.385
LIG_IRF3_LxIS_1	95	102	PF10401	0.468
LIG_LIR_LC3C_4	277	281	PF02991	0.442
LIG_LIR_Nem_3	166	170	PF02991	0.456
LIG_LIR_Nem_3	193	197	PF02991	0.479
LIG_LIR_Nem_3	68	73	PF02991	0.410
LIG_PCNA_PIPBox_1	242	251	PF02747	0.461
LIG_Rb_pABgroove_1	151	159	PF01858	0.442
LIG_SH2_CRK	185	189	PF00017	0.368
LIG_SH2_NCK_1	124	128	PF00017	0.625
LIG_SH2_NCK_1	157	161	PF00017	0.455
LIG_SH2_PTP2	187	190	PF00017	0.440
LIG_SH2_SRC	124	127	PF00017	0.484
LIG_SH2_SRC	157	160	PF00017	0.454
LIG_SH2_SRC	87	90	PF00017	0.379
LIG_SH2_STAP1	157	161	PF00017	0.455
LIG_SH2_STAP1	89	93	PF00017	0.361
LIG_SH2_STAT5	187	190	PF00017	0.389
LIG_SH2_STAT5	23	26	PF00017	0.367
LIG_SH2_STAT5	70	73	PF00017	0.428
LIG_SH2_STAT5	87	90	PF00017	0.262
LIG_SH3_3	25	31	PF00018	0.446
LIG_SH3_3	277	283	PF00018	0.442
LIG_SH3_3	310	316	PF00018	0.506
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.356
LIG_SUMO_SIM_anti_2	2	10	PF11976	0.453
LIG_SUMO_SIM_par_1	150	159	PF11976	0.448
LIG_SUMO_SIM_par_1	2	10	PF11976	0.431
MOD_CDK_SPxxK_3	128	135	PF00069	0.571
MOD_CK1_1	130	136	PF00069	0.742
MOD_CK1_1	224	230	PF00069	0.543
MOD_CK1_1	234	240	PF00069	0.506
MOD_CK1_1	264	270	PF00069	0.455
MOD_CK1_1	27	33	PF00069	0.495
MOD_CK1_1	282	288	PF00069	0.390
MOD_CK1_1	320	326	PF00069	0.454
MOD_CK1_1	42	48	PF00069	0.689
MOD_CK2_1	115	121	PF00069	0.591
MOD_CK2_1	42	48	PF00069	0.565
MOD_CK2_1	52	58	PF00069	0.452
MOD_CK2_1	77	83	PF00069	0.476
MOD_GlcNHglycan	132	135	PF01048	0.761
MOD_GlcNHglycan	198	201	PF01048	0.337
MOD_GlcNHglycan	265	269	PF01048	0.277
MOD_GlcNHglycan	41	44	PF01048	0.620
MOD_GlcNHglycan	89	92	PF01048	0.452
MOD_GSK3_1	126	133	PF00069	0.704
MOD_GSK3_1	27	34	PF00069	0.569
MOD_GSK3_1	317	324	PF00069	0.393
MOD_GSK3_1	35	42	PF00069	0.533
MOD_NEK2_1	204	209	PF00069	0.473
MOD_NEK2_1	231	236	PF00069	0.508
MOD_NEK2_1	24	29	PF00069	0.457
MOD_NEK2_1	6	11	PF00069	0.388
MOD_NEK2_1	82	87	PF00069	0.431
MOD_NEK2_1	99	104	PF00069	0.302
MOD_PIKK_1	224	230	PF00454	0.367
MOD_PIKK_1	328	334	PF00454	0.543
MOD_PKA_2	52	58	PF00069	0.464
MOD_PKA_2	77	83	PF00069	0.345
MOD_Plk_1	120	126	PF00069	0.472
MOD_Plk_1	221	227	PF00069	0.560
MOD_Plk_1	82	88	PF00069	0.466
MOD_Plk_4	16	22	PF00069	0.381
MOD_Plk_4	221	227	PF00069	0.477
MOD_Plk_4	77	83	PF00069	0.363
MOD_ProDKin_1	128	134	PF00069	0.774
MOD_ProDKin_1	27	33	PF00069	0.463
MOD_ProDKin_1	279	285	PF00069	0.442
MOD_ProDKin_1	312	318	PF00069	0.534
TRG_ENDOCYTIC_2	185	188	PF00928	0.347
TRG_ENDOCYTIC_2	70	73	PF00928	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILA3	Leptomonas seymouri	58%	100%
A0A1X0NU95	Trypanosomatidae	37%	100%
A0A3Q8IFJ1	Leishmania donovani	89%	100%
A0A3R7M2F9	Trypanosoma rangeli	34%	100%
A4HKJ7	Leishmania braziliensis	76%	98%
A4I829	Leishmania infantum	89%	100%
D0AA94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q569	Leishmania major	88%	100%
V5DCC0	Trypanosoma cruzi	36%	100%