ABC transporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter-like protein

Species:

Leishmania mexicana

UniProt:

E9B2Y6_LEIMU

TriTrypDb:

LmxM.31.2060

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9B2Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Y6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0005215	transporter activity	1	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0015399	primary active transmembrane transporter activity	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0022804	active transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0042626	ATPase-coupled transmembrane transporter activity	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140359	ABC-type transporter activity	3	9
GO:0140657	ATP-dependent activity	1	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	556	558	PF00675	0.337
CLV_NRD_NRD_1	618	620	PF00675	0.280
CLV_PCSK_KEX2_1	556	558	PF00082	0.337
CLV_PCSK_KEX2_1	618	620	PF00082	0.268
CLV_PCSK_SKI1_1	134	138	PF00082	0.603
CLV_PCSK_SKI1_1	173	177	PF00082	0.368
CLV_PCSK_SKI1_1	367	371	PF00082	0.416
CLV_PCSK_SKI1_1	47	51	PF00082	0.467
CLV_PCSK_SKI1_1	557	561	PF00082	0.277
CLV_PCSK_SKI1_1	618	622	PF00082	0.375
CLV_PCSK_SKI1_1	656	660	PF00082	0.375
CLV_PCSK_SKI1_1	702	706	PF00082	0.384
CLV_PCSK_SKI1_1	79	83	PF00082	0.625
DEG_APCC_DBOX_1	172	180	PF00400	0.416
DEG_APCC_DBOX_1	415	423	PF00400	0.644
DEG_APCC_DBOX_1	655	663	PF00400	0.537
DEG_SCF_FBW7_2	214	221	PF00400	0.591
DEG_SPOP_SBC_1	92	96	PF00917	0.509
DOC_CKS1_1	215	220	PF01111	0.604
DOC_CYCLIN_RxL_1	170	178	PF00134	0.167
DOC_MAPK_FxFP_2	470	473	PF00069	0.586
DOC_MAPK_gen_1	134	144	PF00069	0.467
DOC_MAPK_gen_1	553	561	PF00069	0.520
DOC_MAPK_MEF2A_6	134	142	PF00069	0.468
DOC_MAPK_MEF2A_6	173	181	PF00069	0.346
DOC_MAPK_MEF2A_6	367	376	PF00069	0.410
DOC_MAPK_MEF2A_6	683	690	PF00069	0.609
DOC_PP2B_LxvP_1	109	112	PF13499	0.518
DOC_PP4_FxxP_1	470	473	PF00568	0.586
DOC_USP7_MATH_1	10	14	PF00917	0.703
DOC_USP7_MATH_1	104	108	PF00917	0.370
DOC_USP7_MATH_1	159	163	PF00917	0.453
DOC_USP7_MATH_1	360	364	PF00917	0.405
DOC_USP7_MATH_1	445	449	PF00917	0.628
DOC_USP7_MATH_1	491	495	PF00917	0.690
DOC_USP7_MATH_1	502	506	PF00917	0.698
DOC_USP7_MATH_1	624	628	PF00917	0.537
DOC_USP7_MATH_1	92	96	PF00917	0.425
DOC_WW_Pin1_4	16	21	PF00397	0.721
DOC_WW_Pin1_4	161	166	PF00397	0.418
DOC_WW_Pin1_4	214	219	PF00397	0.600
DOC_WW_Pin1_4	603	608	PF00397	0.422
DOC_WW_Pin1_4	8	13	PF00397	0.760
DOC_WW_Pin1_4	86	91	PF00397	0.359
LIG_14-3-3_CanoR_1	240	249	PF00244	0.627
LIG_14-3-3_CanoR_1	302	310	PF00244	0.609
LIG_14-3-3_CanoR_1	320	325	PF00244	0.469
LIG_14-3-3_CanoR_1	36	42	PF00244	0.564
LIG_14-3-3_CanoR_1	416	420	PF00244	0.568
LIG_14-3-3_CanoR_1	421	426	PF00244	0.543
LIG_14-3-3_CanoR_1	430	435	PF00244	0.512
LIG_14-3-3_CanoR_1	618	625	PF00244	0.499
LIG_Actin_WH2_2	401	418	PF00022	0.469
LIG_Actin_WH2_2	682	699	PF00022	0.606
LIG_APCC_ABBA_1	163	168	PF00400	0.408
LIG_BIR_II_1	1	5	PF00653	0.761
LIG_BRCT_BRCA1_1	51	55	PF00533	0.416
LIG_BRCT_BRCA1_1	633	637	PF00533	0.525
LIG_Clathr_ClatBox_1	671	675	PF01394	0.502
LIG_EH_1	634	638	PF12763	0.525
LIG_eIF4E_1	184	190	PF01652	0.416
LIG_FHA_1	104	110	PF00498	0.458
LIG_FHA_1	185	191	PF00498	0.394
LIG_FHA_1	244	250	PF00498	0.556
LIG_FHA_1	273	279	PF00498	0.372
LIG_FHA_1	321	327	PF00498	0.553
LIG_FHA_1	346	352	PF00498	0.587
LIG_FHA_1	364	370	PF00498	0.228
LIG_FHA_1	458	464	PF00498	0.577
LIG_FHA_1	515	521	PF00498	0.502
LIG_FHA_1	547	553	PF00498	0.539
LIG_FHA_1	586	592	PF00498	0.367
LIG_FHA_1	676	682	PF00498	0.560
LIG_FHA_1	701	707	PF00498	0.534
LIG_FHA_1	80	86	PF00498	0.460
LIG_FHA_2	243	249	PF00498	0.556
LIG_FHA_2	302	308	PF00498	0.618
LIG_FHA_2	437	443	PF00498	0.705
LIG_FHA_2	569	575	PF00498	0.460
LIG_FHA_2	610	616	PF00498	0.520
LIG_FHA_2	637	643	PF00498	0.502
LIG_FHA_2	677	683	PF00498	0.594
LIG_FHA_2	96	102	PF00498	0.577
LIG_LIR_Apic_2	469	473	PF02991	0.550
LIG_LIR_Gen_1	121	131	PF02991	0.344
LIG_LIR_Gen_1	612	620	PF02991	0.520
LIG_LIR_Gen_1	634	644	PF02991	0.572
LIG_LIR_Gen_1	666	677	PF02991	0.521
LIG_LIR_Nem_3	121	126	PF02991	0.428
LIG_LIR_Nem_3	133	139	PF02991	0.418
LIG_LIR_Nem_3	469	475	PF02991	0.565
LIG_LIR_Nem_3	612	616	PF02991	0.450
LIG_LIR_Nem_3	634	640	PF02991	0.503
LIG_LIR_Nem_3	666	672	PF02991	0.521
LIG_LYPXL_yS_3	472	475	PF13949	0.578
LIG_SH2_CRK	358	362	PF00017	0.416
LIG_SH2_CRK	669	673	PF00017	0.521
LIG_SH2_NCK_1	358	362	PF00017	0.416
LIG_SH2_SRC	166	169	PF00017	0.405
LIG_SH2_STAP1	669	673	PF00017	0.521
LIG_SH2_STAT3	379	382	PF00017	0.366
LIG_SH2_STAT5	259	262	PF00017	0.389
LIG_SH2_STAT5	313	316	PF00017	0.652
LIG_SH2_STAT5	358	361	PF00017	0.256
LIG_SH2_STAT5	394	397	PF00017	0.335
LIG_SH3_3	135	141	PF00018	0.423
LIG_SH3_3	14	20	PF00018	0.701
LIG_SH3_3	470	476	PF00018	0.570
LIG_SH3_3	593	599	PF00018	0.575
LIG_SH3_3	601	607	PF00018	0.481
LIG_SH3_3	641	647	PF00018	0.575
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.178
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.604
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.416
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.416
LIG_SUMO_SIM_anti_2	670	676	PF11976	0.502
LIG_SUMO_SIM_anti_2	684	691	PF11976	0.573
LIG_SUMO_SIM_par_1	433	439	PF11976	0.638
LIG_SUMO_SIM_par_1	451	458	PF11976	0.625
LIG_SUMO_SIM_par_1	60	65	PF11976	0.314
LIG_SUMO_SIM_par_1	670	676	PF11976	0.537
LIG_SUMO_SIM_par_1	702	708	PF11976	0.548
LIG_TRAF2_1	304	307	PF00917	0.622
LIG_UBA3_1	689	694	PF00899	0.547
LIG_WRC_WIRS_1	143	148	PF05994	0.270
LIG_WRC_WIRS_1	398	403	PF05994	0.372
LIG_WRC_WIRS_1	581	586	PF05994	0.520
LIG_WRC_WIRS_1	637	642	PF05994	0.575
MOD_CDK_SPxxK_3	8	15	PF00069	0.658
MOD_CK1_1	19	25	PF00069	0.762
MOD_CK1_1	243	249	PF00069	0.593
MOD_CK1_1	301	307	PF00069	0.617
MOD_CK1_1	363	369	PF00069	0.334
MOD_CK1_1	40	46	PF00069	0.569
MOD_CK1_1	400	406	PF00069	0.373
MOD_CK1_1	407	413	PF00069	0.364
MOD_CK1_1	512	518	PF00069	0.537
MOD_CK1_1	583	589	PF00069	0.507
MOD_CK1_1	95	101	PF00069	0.566
MOD_CK2_1	242	248	PF00069	0.577
MOD_CK2_1	301	307	PF00069	0.622
MOD_CK2_1	436	442	PF00069	0.709
MOD_CK2_1	568	574	PF00069	0.474
MOD_CK2_1	584	590	PF00069	0.419
MOD_CK2_1	609	615	PF00069	0.520
MOD_CK2_1	636	642	PF00069	0.537
MOD_CK2_1	681	687	PF00069	0.631
MOD_CK2_1	723	729	PF00069	0.714
MOD_CK2_1	95	101	PF00069	0.510
MOD_GlcNHglycan	106	109	PF01048	0.646
MOD_GlcNHglycan	12	15	PF01048	0.524
MOD_GlcNHglycan	199	202	PF01048	0.389
MOD_GlcNHglycan	2	5	PF01048	0.591
MOD_GlcNHglycan	237	240	PF01048	0.365
MOD_GlcNHglycan	362	365	PF01048	0.404
MOD_GlcNHglycan	409	412	PF01048	0.392
MOD_GlcNHglycan	457	460	PF01048	0.379
MOD_GlcNHglycan	51	54	PF01048	0.323
MOD_GlcNHglycan	529	532	PF01048	0.278
MOD_GlcNHglycan	590	594	PF01048	0.299
MOD_GlcNHglycan	600	603	PF01048	0.208
MOD_GlcNHglycan	626	629	PF01048	0.337
MOD_GlcNHglycan	649	652	PF01048	0.260
MOD_GlcNHglycan	682	686	PF01048	0.389
MOD_GlcNHglycan	723	726	PF01048	0.481
MOD_GlcNHglycan	8	11	PF01048	0.547
MOD_GlcNHglycan	86	89	PF01048	0.657
MOD_GlcNHglycan	95	98	PF01048	0.742
MOD_GSK3_1	248	255	PF00069	0.525
MOD_GSK3_1	268	275	PF00069	0.139
MOD_GSK3_1	356	363	PF00069	0.501
MOD_GSK3_1	397	404	PF00069	0.425
MOD_GSK3_1	406	413	PF00069	0.401
MOD_GSK3_1	498	505	PF00069	0.733
MOD_GSK3_1	576	583	PF00069	0.513
MOD_GSK3_1	585	592	PF00069	0.529
MOD_GSK3_1	594	601	PF00069	0.548
MOD_GSK3_1	6	13	PF00069	0.746
MOD_GSK3_1	605	612	PF00069	0.416
MOD_GSK3_1	631	638	PF00069	0.521
MOD_GSK3_1	663	670	PF00069	0.533
MOD_GSK3_1	696	703	PF00069	0.571
MOD_GSK3_1	77	84	PF00069	0.399
MOD_GSK3_1	88	95	PF00069	0.499
MOD_N-GLC_1	351	356	PF02516	0.378
MOD_N-GLC_1	579	584	PF02516	0.292
MOD_N-GLC_1	721	726	PF02516	0.267
MOD_NEK2_1	142	147	PF00069	0.335
MOD_NEK2_1	175	180	PF00069	0.259
MOD_NEK2_1	242	247	PF00069	0.554
MOD_NEK2_1	268	273	PF00069	0.358
MOD_NEK2_1	274	279	PF00069	0.368
MOD_NEK2_1	318	323	PF00069	0.615
MOD_NEK2_1	327	332	PF00069	0.541
MOD_NEK2_1	351	356	PF00069	0.597
MOD_NEK2_1	37	42	PF00069	0.597
MOD_NEK2_1	374	379	PF00069	0.435
MOD_NEK2_1	388	393	PF00069	0.308
MOD_NEK2_1	401	406	PF00069	0.400
MOD_NEK2_1	415	420	PF00069	0.570
MOD_NEK2_1	436	441	PF00069	0.721
MOD_NEK2_1	54	59	PF00069	0.290
MOD_NEK2_1	568	573	PF00069	0.502
MOD_NEK2_1	584	589	PF00069	0.502
MOD_NEK2_1	62	67	PF00069	0.424
MOD_NEK2_1	681	686	PF00069	0.568
MOD_NEK2_1	696	701	PF00069	0.528
MOD_NEK2_1	723	728	PF00069	0.668
MOD_OFUCOSY	532	537	PF10250	0.375
MOD_PIKK_1	252	258	PF00454	0.469
MOD_PIKK_1	318	324	PF00454	0.651
MOD_PIKK_1	502	508	PF00454	0.733
MOD_PIKK_1	509	515	PF00454	0.474
MOD_PIKK_1	551	557	PF00454	0.537
MOD_PKA_1	618	624	PF00069	0.537
MOD_PKA_2	301	307	PF00069	0.598
MOD_PKA_2	345	351	PF00069	0.593
MOD_PKA_2	388	394	PF00069	0.340
MOD_PKA_2	415	421	PF00069	0.609
MOD_PKA_2	618	624	PF00069	0.537
MOD_PKA_2	696	702	PF00069	0.647
MOD_Plk_1	351	357	PF00069	0.567
MOD_Plk_1	579	585	PF00069	0.436
MOD_Plk_1	589	595	PF00069	0.388
MOD_Plk_1	667	673	PF00069	0.527
MOD_Plk_1	681	687	PF00069	0.612
MOD_Plk_4	185	191	PF00069	0.389
MOD_Plk_4	274	280	PF00069	0.369
MOD_Plk_4	320	326	PF00069	0.578
MOD_Plk_4	37	43	PF00069	0.588
MOD_Plk_4	388	394	PF00069	0.364
MOD_Plk_4	397	403	PF00069	0.371
MOD_Plk_4	57	63	PF00069	0.357
MOD_Plk_4	636	642	PF00069	0.505
MOD_Plk_4	667	673	PF00069	0.501
MOD_Plk_4	700	706	PF00069	0.556
MOD_ProDKin_1	16	22	PF00069	0.719
MOD_ProDKin_1	161	167	PF00069	0.413
MOD_ProDKin_1	214	220	PF00069	0.600
MOD_ProDKin_1	603	609	PF00069	0.422
MOD_ProDKin_1	8	14	PF00069	0.760
MOD_ProDKin_1	86	92	PF00069	0.362
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.458
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.416
TRG_DiLeu_BaLyEn_6	536	541	PF01217	0.537
TRG_ENDOCYTIC_2	358	361	PF00928	0.416
TRG_ENDOCYTIC_2	39	42	PF00928	0.620
TRG_ENDOCYTIC_2	472	475	PF00928	0.578
TRG_ENDOCYTIC_2	669	672	PF00928	0.521
TRG_ER_diArg_1	618	620	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P4	Leptomonas seymouri	62%	100%
A0A0S4J6G3	Bodo saltans	29%	100%
A0A1X0NU80	Trypanosomatidae	35%	100%
A0A3S5H7S2	Leishmania donovani	89%	99%
A4HKJ6	Leishmania braziliensis	78%	99%
A4I828	Leishmania infantum	88%	99%
E9AD24	Leishmania major	23%	100%
Q2NUA5	Sodalis glossinidius (strain morsitans)	23%	100%
Q4Q570	Leishmania major	89%	100%
Q9NRK6	Homo sapiens	25%	99%