Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2Y4_LEIMU

TriTrypDb:

LmxM.31.2040

Length:

938

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Y4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.579
CLV_C14_Caspase3-7	293	297	PF00656	0.622
CLV_C14_Caspase3-7	567	571	PF00656	0.512
CLV_NRD_NRD_1	1	3	PF00675	0.556
CLV_NRD_NRD_1	115	117	PF00675	0.557
CLV_NRD_NRD_1	130	132	PF00675	0.592
CLV_NRD_NRD_1	327	329	PF00675	0.635
CLV_NRD_NRD_1	516	518	PF00675	0.593
CLV_NRD_NRD_1	528	530	PF00675	0.472
CLV_NRD_NRD_1	696	698	PF00675	0.583
CLV_NRD_NRD_1	875	877	PF00675	0.525
CLV_PCSK_FUR_1	128	132	PF00082	0.600
CLV_PCSK_KEX2_1	115	117	PF00082	0.556
CLV_PCSK_KEX2_1	130	132	PF00082	0.590
CLV_PCSK_KEX2_1	327	329	PF00082	0.635
CLV_PCSK_KEX2_1	516	518	PF00082	0.526
CLV_PCSK_KEX2_1	528	530	PF00082	0.509
CLV_PCSK_KEX2_1	813	815	PF00082	0.705
CLV_PCSK_KEX2_1	875	877	PF00082	0.739
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.596
CLV_PCSK_PC1ET2_1	813	815	PF00082	0.663
CLV_PCSK_PC7_1	512	518	PF00082	0.518
CLV_PCSK_SKI1_1	337	341	PF00082	0.580
CLV_PCSK_SKI1_1	360	364	PF00082	0.589
CLV_PCSK_SKI1_1	379	383	PF00082	0.362
CLV_PCSK_SKI1_1	50	54	PF00082	0.540
CLV_PCSK_SKI1_1	791	795	PF00082	0.733
CLV_PCSK_SKI1_1	861	865	PF00082	0.531
CLV_PCSK_SKI1_1	919	923	PF00082	0.367
DEG_APCC_DBOX_1	336	344	PF00400	0.518
DEG_APCC_DBOX_1	433	441	PF00400	0.316
DEG_APCC_DBOX_1	516	524	PF00400	0.344
DEG_Nend_UBRbox_1	1	4	PF02207	0.549
DEG_SCF_FBW7_1	622	627	PF00400	0.521
DEG_SPOP_SBC_1	320	324	PF00917	0.548
DEG_SPOP_SBC_1	592	596	PF00917	0.573
DEG_SPOP_SBC_1	674	678	PF00917	0.530
DOC_CKS1_1	26	31	PF01111	0.522
DOC_CKS1_1	657	662	PF01111	0.802
DOC_CKS1_1	90	95	PF01111	0.506
DOC_MAPK_DCC_7	658	667	PF00069	0.510
DOC_MAPK_gen_1	425	433	PF00069	0.554
DOC_MAPK_MEF2A_6	658	667	PF00069	0.655
DOC_MAPK_MEF2A_6	732	741	PF00069	0.492
DOC_PP1_RVXF_1	789	795	PF00149	0.517
DOC_PP2B_LxvP_1	88	91	PF13499	0.566
DOC_PP4_FxxP_1	78	81	PF00568	0.513
DOC_USP7_MATH_1	320	324	PF00917	0.564
DOC_USP7_MATH_1	503	507	PF00917	0.623
DOC_USP7_MATH_1	583	587	PF00917	0.675
DOC_USP7_MATH_1	613	617	PF00917	0.655
DOC_USP7_MATH_1	675	679	PF00917	0.709
DOC_USP7_MATH_1	735	739	PF00917	0.653
DOC_USP7_MATH_1	753	757	PF00917	0.636
DOC_USP7_MATH_1	809	813	PF00917	0.829
DOC_USP7_MATH_1	888	892	PF00917	0.718
DOC_USP7_MATH_1	91	95	PF00917	0.677
DOC_USP7_MATH_1	928	932	PF00917	0.734
DOC_USP7_UBL2_3	117	121	PF12436	0.658
DOC_USP7_UBL2_3	902	906	PF12436	0.387
DOC_WW_Pin1_4	208	213	PF00397	0.625
DOC_WW_Pin1_4	216	221	PF00397	0.682
DOC_WW_Pin1_4	25	30	PF00397	0.532
DOC_WW_Pin1_4	620	625	PF00397	0.596
DOC_WW_Pin1_4	653	658	PF00397	0.767
DOC_WW_Pin1_4	89	94	PF00397	0.732
DOC_WW_Pin1_4	890	895	PF00397	0.618
LIG_14-3-3_CanoR_1	15	19	PF00244	0.559
LIG_14-3-3_CanoR_1	300	307	PF00244	0.746
LIG_14-3-3_CanoR_1	642	651	PF00244	0.785
LIG_14-3-3_CanoR_1	686	692	PF00244	0.662
LIG_14-3-3_CanoR_1	732	738	PF00244	0.758
LIG_14-3-3_CanoR_1	754	760	PF00244	0.779
LIG_14-3-3_CanoR_1	771	777	PF00244	0.679
LIG_14-3-3_CanoR_1	919	925	PF00244	0.598
LIG_14-3-3_CanoR_1	927	936	PF00244	0.735
LIG_Actin_WH2_2	37	52	PF00022	0.524
LIG_Actin_WH2_2	472	489	PF00022	0.628
LIG_APCC_ABBA_1	433	438	PF00400	0.617
LIG_BIR_III_2	570	574	PF00653	0.502
LIG_BIR_III_4	194	198	PF00653	0.520
LIG_BIR_III_4	576	580	PF00653	0.722
LIG_BIR_III_4	787	791	PF00653	0.628
LIG_BRCT_BRCA1_1	587	591	PF00533	0.607
LIG_eIF4E_1	103	109	PF01652	0.639
LIG_EVH1_1	97	101	PF00568	0.479
LIG_FHA_1	102	108	PF00498	0.431
LIG_FHA_1	197	203	PF00498	0.623
LIG_FHA_1	274	280	PF00498	0.585
LIG_FHA_1	535	541	PF00498	0.458
LIG_FHA_1	576	582	PF00498	0.520
LIG_FHA_1	592	598	PF00498	0.508
LIG_FHA_1	606	612	PF00498	0.578
LIG_FHA_1	617	623	PF00498	0.709
LIG_FHA_1	787	793	PF00498	0.648
LIG_FHA_1	829	835	PF00498	0.683
LIG_FHA_1	844	850	PF00498	0.627
LIG_FHA_2	189	195	PF00498	0.728
LIG_FHA_2	288	294	PF00498	0.681
LIG_FHA_2	301	307	PF00498	0.584
LIG_FHA_2	365	371	PF00498	0.690
LIG_FHA_2	373	379	PF00498	0.560
LIG_FHA_2	489	495	PF00498	0.511
LIG_FHA_2	497	503	PF00498	0.531
LIG_FHA_2	565	571	PF00498	0.536
LIG_FHA_2	607	613	PF00498	0.779
LIG_FHA_2	781	787	PF00498	0.640
LIG_FHA_2	806	812	PF00498	0.750
LIG_IBAR_NPY_1	693	695	PF08397	0.603
LIG_IRF3_LxIS_1	583	590	PF10401	0.699
LIG_LIR_Apic_2	380	386	PF02991	0.675
LIG_LIR_Apic_2	690	694	PF02991	0.603
LIG_LIR_Apic_2	75	81	PF02991	0.516
LIG_LIR_Apic_2	94	100	PF02991	0.504
LIG_LIR_Gen_1	729	737	PF02991	0.688
LIG_LIR_Gen_1	762	769	PF02991	0.778
LIG_LIR_Gen_1	773	782	PF02991	0.565
LIG_LIR_Nem_3	305	310	PF02991	0.696
LIG_LIR_Nem_3	729	733	PF02991	0.677
LIG_LIR_Nem_3	762	766	PF02991	0.784
LIG_Pex14_1	691	695	PF04695	0.605
LIG_SH2_STAP1	593	597	PF00017	0.464
LIG_SH2_STAT3	700	703	PF00017	0.563
LIG_SH2_STAT5	103	106	PF00017	0.656
LIG_SH2_STAT5	112	115	PF00017	0.523
LIG_SH2_STAT5	403	406	PF00017	0.488
LIG_SH2_STAT5	519	522	PF00017	0.526
LIG_SH2_STAT5	555	558	PF00017	0.580
LIG_SH2_STAT5	593	596	PF00017	0.606
LIG_SH2_STAT5	700	703	PF00017	0.562
LIG_SH2_STAT5	776	779	PF00017	0.591
LIG_SH2_STAT5	920	923	PF00017	0.656
LIG_SH3_3	200	206	PF00018	0.779
LIG_SH3_3	382	388	PF00018	0.565
LIG_SH3_3	429	435	PF00018	0.565
LIG_SH3_3	560	566	PF00018	0.656
LIG_SH3_3	61	67	PF00018	0.541
LIG_SH3_3	654	660	PF00018	0.684
LIG_SH3_3	789	795	PF00018	0.752
LIG_SH3_3	831	837	PF00018	0.485
LIG_SH3_3	87	93	PF00018	0.671
LIG_SH3_3	95	101	PF00018	0.739
LIG_SUMO_SIM_par_1	267	276	PF11976	0.636
LIG_TRAF2_1	291	294	PF00917	0.736
LIG_TRAF2_1	323	326	PF00917	0.410
LIG_TRAF2_1	499	502	PF00917	0.603
LIG_UBA3_1	332	341	PF00899	0.551
LIG_WRC_WIRS_1	763	768	PF05994	0.782
LIG_WRC_WIRS_1	921	926	PF05994	0.378
LIG_WW_1	100	103	PF00397	0.682
MOD_CDC14_SPxK_1	219	222	PF00782	0.824
MOD_CDK_SPK_2	653	658	PF00069	0.543
MOD_CDK_SPxK_1	216	222	PF00069	0.831
MOD_CK1_1	272	278	PF00069	0.402
MOD_CK1_1	287	293	PF00069	0.601
MOD_CK1_1	38	44	PF00069	0.536
MOD_CK1_1	538	544	PF00069	0.588
MOD_CK1_1	57	63	PF00069	0.564
MOD_CK1_1	616	622	PF00069	0.632
MOD_CK1_1	645	651	PF00069	0.667
MOD_CK1_1	656	662	PF00069	0.761
MOD_CK1_1	762	768	PF00069	0.784
MOD_CK1_1	812	818	PF00069	0.747
MOD_CK1_1	822	828	PF00069	0.584
MOD_CK1_1	856	862	PF00069	0.693
MOD_CK1_1	890	896	PF00069	0.499
MOD_CK2_1	287	293	PF00069	0.669
MOD_CK2_1	319	325	PF00069	0.650
MOD_CK2_1	364	370	PF00069	0.693
MOD_CK2_1	372	378	PF00069	0.568
MOD_CK2_1	475	481	PF00069	0.466
MOD_CK2_1	488	494	PF00069	0.479
MOD_CK2_1	496	502	PF00069	0.406
MOD_CK2_1	539	545	PF00069	0.713
MOD_CK2_1	606	612	PF00069	0.777
MOD_CK2_1	805	811	PF00069	0.750
MOD_Cter_Amidation	873	876	PF01082	0.745
MOD_GlcNHglycan	125	128	PF01048	0.643
MOD_GlcNHglycan	172	175	PF01048	0.661
MOD_GlcNHglycan	337	340	PF01048	0.425
MOD_GlcNHglycan	548	551	PF01048	0.717
MOD_GlcNHglycan	721	725	PF01048	0.734
MOD_GlcNHglycan	742	745	PF01048	0.585
MOD_GlcNHglycan	814	817	PF01048	0.788
MOD_GlcNHglycan	861	864	PF01048	0.480
MOD_GlcNHglycan	882	885	PF01048	0.767
MOD_GSK3_1	204	211	PF00069	0.607
MOD_GSK3_1	269	276	PF00069	0.483
MOD_GSK3_1	284	291	PF00069	0.456
MOD_GSK3_1	296	303	PF00069	0.705
MOD_GSK3_1	35	42	PF00069	0.515
MOD_GSK3_1	354	361	PF00069	0.737
MOD_GSK3_1	51	58	PF00069	0.572
MOD_GSK3_1	534	541	PF00069	0.545
MOD_GSK3_1	583	590	PF00069	0.680
MOD_GSK3_1	612	619	PF00069	0.700
MOD_GSK3_1	620	627	PF00069	0.750
MOD_GSK3_1	642	649	PF00069	0.724
MOD_GSK3_1	755	762	PF00069	0.702
MOD_GSK3_1	805	812	PF00069	0.776
MOD_GSK3_1	819	826	PF00069	0.694
MOD_GSK3_1	849	856	PF00069	0.544
MOD_GSK3_1	880	887	PF00069	0.687
MOD_GSK3_1	888	895	PF00069	0.648
MOD_GSK3_1	919	926	PF00069	0.548
MOD_N-GLC_1	888	893	PF02516	0.619
MOD_NEK2_1	391	396	PF00069	0.499
MOD_NEK2_1	404	409	PF00069	0.389
MOD_NEK2_1	486	491	PF00069	0.632
MOD_NEK2_1	51	56	PF00069	0.561
MOD_NEK2_1	556	561	PF00069	0.528
MOD_NEK2_1	575	580	PF00069	0.582
MOD_NEK2_1	587	592	PF00069	0.739
MOD_NEK2_1	626	631	PF00069	0.670
MOD_NEK2_1	819	824	PF00069	0.693
MOD_NEK2_1	849	854	PF00069	0.573
MOD_NEK2_2	637	642	PF00069	0.573
MOD_NEK2_2	663	668	PF00069	0.589
MOD_PIKK_1	14	20	PF00454	0.563
MOD_PIKK_1	144	150	PF00454	0.578
MOD_PIKK_1	535	541	PF00454	0.705
MOD_PIKK_1	635	641	PF00454	0.530
MOD_PKA_1	528	534	PF00069	0.614
MOD_PKA_1	875	881	PF00069	0.747
MOD_PKA_2	14	20	PF00069	0.563
MOD_PKA_2	486	492	PF00069	0.537
MOD_PKA_2	528	534	PF00069	0.614
MOD_PKA_2	630	636	PF00069	0.765
MOD_PKA_2	753	759	PF00069	0.574
MOD_PKA_2	770	776	PF00069	0.519
MOD_PKA_2	875	881	PF00069	0.747
MOD_PKA_2	910	916	PF00069	0.531
MOD_PKB_1	510	518	PF00069	0.404
MOD_Plk_1	287	293	PF00069	0.455
MOD_Plk_1	379	385	PF00069	0.468
MOD_Plk_1	583	589	PF00069	0.603
MOD_Plk_1	888	894	PF00069	0.666
MOD_Plk_2-3	288	294	PF00069	0.467
MOD_Plk_2-3	475	481	PF00069	0.522
MOD_Plk_4	103	109	PF00069	0.443
MOD_Plk_4	254	260	PF00069	0.527
MOD_Plk_4	347	353	PF00069	0.427
MOD_Plk_4	35	41	PF00069	0.511
MOD_Plk_4	372	378	PF00069	0.592
MOD_Plk_4	503	509	PF00069	0.549
MOD_Plk_4	528	534	PF00069	0.609
MOD_Plk_4	564	570	PF00069	0.650
MOD_Plk_4	577	583	PF00069	0.711
MOD_Plk_4	663	669	PF00069	0.592
MOD_Plk_4	759	765	PF00069	0.737
MOD_Plk_4	772	778	PF00069	0.578
MOD_Plk_4	849	855	PF00069	0.541
MOD_ProDKin_1	208	214	PF00069	0.629
MOD_ProDKin_1	216	222	PF00069	0.717
MOD_ProDKin_1	25	31	PF00069	0.531
MOD_ProDKin_1	620	626	PF00069	0.597
MOD_ProDKin_1	653	659	PF00069	0.763
MOD_ProDKin_1	89	95	PF00069	0.730
MOD_ProDKin_1	890	896	PF00069	0.616
MOD_SUMO_rev_2	173	183	PF00179	0.601
MOD_SUMO_rev_2	488	497	PF00179	0.491
MOD_SUMO_rev_2	501	506	PF00179	0.430
MOD_SUMO_rev_2	807	815	PF00179	0.667
TRG_DiLeu_BaEn_1	481	486	PF01217	0.525
TRG_DiLeu_BaEn_4	141	147	PF01217	0.576
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.403
TRG_DiLeu_BaLyEn_6	660	665	PF01217	0.503
TRG_DiLeu_BaLyEn_6	678	683	PF01217	0.624
TRG_ENDOCYTIC_2	776	779	PF00928	0.672
TRG_ER_diArg_1	128	131	PF00400	0.679
TRG_ER_diArg_1	150	153	PF00400	0.583
TRG_ER_diArg_1	424	427	PF00400	0.566
TRG_ER_diArg_1	641	644	PF00400	0.757
TRG_NES_CRM1_1	232	246	PF08389	0.669
TRG_NES_CRM1_1	840	851	PF08389	0.452
TRG_NLS_MonoExtN_4	694	701	PF00514	0.609
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	681	685	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A7	Leptomonas seymouri	38%	100%
A0A3Q8IH17	Leishmania donovani	81%	100%
A4HKJ4	Leishmania braziliensis	58%	100%
A4I826	Leishmania infantum	81%	100%
Q4Q572	Leishmania major	78%	100%