Putative calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C2, putative

Species:

Leishmania mexicana

UniProt:

E9B2Y1_LEIMU

TriTrypDb:

LmxM.31.2010

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B2Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Y1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.620
CLV_NRD_NRD_1	253	255	PF00675	0.662
CLV_NRD_NRD_1	3	5	PF00675	0.455
CLV_NRD_NRD_1	86	88	PF00675	0.525
CLV_PCSK_FUR_1	18	22	PF00082	0.509
CLV_PCSK_KEX2_1	20	22	PF00082	0.433
CLV_PCSK_KEX2_1	252	254	PF00082	0.674
CLV_PCSK_KEX2_1	3	5	PF00082	0.517
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.656
CLV_PCSK_SKI1_1	3	7	PF00082	0.463
CLV_PCSK_SKI1_1	87	91	PF00082	0.493
DEG_ODPH_VHL_1	54	67	PF01847	0.416
DOC_CKS1_1	113	118	PF01111	0.395
DOC_CKS1_1	160	165	PF01111	0.528
DOC_PP4_FxxP_1	125	128	PF00568	0.584
DOC_PP4_FxxP_1	160	163	PF00568	0.570
DOC_PP4_FxxP_1	65	68	PF00568	0.340
DOC_USP7_MATH_1	223	227	PF00917	0.321
DOC_WW_Pin1_4	112	117	PF00397	0.535
DOC_WW_Pin1_4	159	164	PF00397	0.493
DOC_WW_Pin1_4	176	181	PF00397	0.249
DOC_WW_Pin1_4	47	52	PF00397	0.334
DOC_WW_Pin1_4	87	92	PF00397	0.571
LIG_14-3-3_CanoR_1	109	113	PF00244	0.466
LIG_14-3-3_CanoR_1	216	224	PF00244	0.414
LIG_14-3-3_CanoR_1	245	249	PF00244	0.481
LIG_BIR_III_2	193	197	PF00653	0.532
LIG_deltaCOP1_diTrp_1	261	266	PF00928	0.342
LIG_FHA_1	109	115	PF00498	0.426
LIG_FHA_1	168	174	PF00498	0.564
LIG_FHA_2	143	149	PF00498	0.347
LIG_LIR_Apic_2	122	128	PF02991	0.595
LIG_LIR_Apic_2	158	163	PF02991	0.528
LIG_LIR_Apic_2	176	180	PF02991	0.232
LIG_LIR_Gen_1	229	239	PF02991	0.434
LIG_LIR_Gen_1	261	269	PF02991	0.298
LIG_LIR_Gen_1	60	70	PF02991	0.347
LIG_LIR_Gen_1	76	84	PF02991	0.282
LIG_LIR_Nem_3	229	235	PF02991	0.444
LIG_LIR_Nem_3	261	267	PF02991	0.329
LIG_LIR_Nem_3	60	65	PF02991	0.347
LIG_LIR_Nem_3	76	82	PF02991	0.282
LIG_Pex14_2	231	235	PF04695	0.342
LIG_PTB_Apo_2	192	199	PF02174	0.411
LIG_PTB_Phospho_1	192	198	PF10480	0.411
LIG_SH2_CRK	137	141	PF00017	0.327
LIG_SH2_PTP2	66	69	PF00017	0.438
LIG_SH2_STAT5	142	145	PF00017	0.442
LIG_SH2_STAT5	177	180	PF00017	0.398
LIG_SH2_STAT5	62	65	PF00017	0.330
LIG_SH2_STAT5	66	69	PF00017	0.327
LIG_SH3_1	254	260	PF00018	0.452
LIG_SH3_3	110	116	PF00018	0.348
LIG_SH3_3	254	260	PF00018	0.452
LIG_SUMO_SIM_par_1	110	115	PF11976	0.368
LIG_TRAF2_1	102	105	PF00917	0.532
LIG_TRAF2_1	197	200	PF00917	0.555
LIG_TRAF2_1	226	229	PF00917	0.233
MOD_CK1_1	108	114	PF00069	0.448
MOD_CK1_1	167	173	PF00069	0.410
MOD_CK2_1	142	148	PF00069	0.331
MOD_CK2_1	223	229	PF00069	0.442
MOD_GlcNHglycan	183	186	PF01048	0.550
MOD_GlcNHglycan	27	30	PF01048	0.560
MOD_GlcNHglycan	290	294	PF01048	0.700
MOD_GlcNHglycan	33	37	PF01048	0.621
MOD_GSK3_1	104	111	PF00069	0.466
MOD_GSK3_1	155	162	PF00069	0.480
MOD_GSK3_1	244	251	PF00069	0.489
MOD_GSK3_1	285	292	PF00069	0.676
MOD_N-GLC_1	217	222	PF02516	0.364
MOD_NEK2_1	173	178	PF00069	0.519
MOD_NEK2_2	142	147	PF00069	0.385
MOD_PIKK_1	167	173	PF00454	0.442
MOD_PIKK_1	285	291	PF00454	0.690
MOD_PKA_2	108	114	PF00069	0.431
MOD_PKA_2	167	173	PF00069	0.442
MOD_PKA_2	244	250	PF00069	0.492
MOD_Plk_4	108	114	PF00069	0.449
MOD_Plk_4	173	179	PF00069	0.453
MOD_Plk_4	244	250	PF00069	0.359
MOD_ProDKin_1	112	118	PF00069	0.549
MOD_ProDKin_1	159	165	PF00069	0.485
MOD_ProDKin_1	176	182	PF00069	0.249
MOD_ProDKin_1	47	53	PF00069	0.339
MOD_ProDKin_1	87	93	PF00069	0.570
MOD_SUMO_rev_2	81	90	PF00179	0.503
TRG_DiLeu_BaEn_2	150	156	PF01217	0.271
TRG_ENDOCYTIC_2	232	235	PF00928	0.379
TRG_ENDOCYTIC_2	62	65	PF00928	0.330
TRG_ENDOCYTIC_2	66	69	PF00928	0.327
TRG_ER_diArg_1	2	4	PF00400	0.540
TRG_ER_diArg_1	20	22	PF00400	0.428
TRG_ER_diArg_1	213	216	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B1	Leptomonas seymouri	75%	98%
A0A0S4JVF9	Bodo saltans	34%	100%
A0A1X0NUI0	Trypanosomatidae	59%	100%
A0A3R7MHS5	Trypanosoma rangeli	59%	100%
A0A3S7X5P5	Leishmania donovani	95%	100%
A4HKJ1	Leishmania braziliensis	88%	100%
A4I823	Leishmania infantum	95%	100%
D0AA89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	98%
Q4Q575	Leishmania major	93%	100%
V5BBL7	Trypanosoma cruzi	57%	100%