DUF4200 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagella-associated protein 100, putative

Species:

Leishmania mexicana

UniProt:

E9B2X8_LEIMU

TriTrypDb:

LmxM.31.1980

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9B2X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.556
CLV_C14_Caspase3-7	727	731	PF00656	0.716
CLV_NRD_NRD_1	120	122	PF00675	0.388
CLV_NRD_NRD_1	164	166	PF00675	0.295
CLV_NRD_NRD_1	194	196	PF00675	0.295
CLV_NRD_NRD_1	278	280	PF00675	0.731
CLV_NRD_NRD_1	289	291	PF00675	0.748
CLV_NRD_NRD_1	34	36	PF00675	0.607
CLV_NRD_NRD_1	527	529	PF00675	0.737
CLV_NRD_NRD_1	586	588	PF00675	0.772
CLV_NRD_NRD_1	659	661	PF00675	0.507
CLV_NRD_NRD_1	679	681	PF00675	0.498
CLV_NRD_NRD_1	712	714	PF00675	0.625
CLV_PCSK_FUR_1	677	681	PF00082	0.550
CLV_PCSK_KEX2_1	103	105	PF00082	0.295
CLV_PCSK_KEX2_1	132	134	PF00082	0.309
CLV_PCSK_KEX2_1	164	166	PF00082	0.308
CLV_PCSK_KEX2_1	278	280	PF00082	0.758
CLV_PCSK_KEX2_1	34	36	PF00082	0.565
CLV_PCSK_KEX2_1	467	469	PF00082	0.787
CLV_PCSK_KEX2_1	586	588	PF00082	0.778
CLV_PCSK_KEX2_1	658	660	PF00082	0.507
CLV_PCSK_KEX2_1	679	681	PF00082	0.549
CLV_PCSK_KEX2_1	712	714	PF00082	0.666
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.295
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.318
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.731
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.714
CLV_PCSK_SKI1_1	173	177	PF00082	0.388
CLV_PCSK_SKI1_1	208	212	PF00082	0.388
CLV_PCSK_SKI1_1	235	239	PF00082	0.521
CLV_PCSK_SKI1_1	27	31	PF00082	0.651
CLV_PCSK_SKI1_1	568	572	PF00082	0.779
CLV_PCSK_SKI1_1	679	683	PF00082	0.546
DEG_Nend_UBRbox_2	1	3	PF02207	0.654
DEG_SPOP_SBC_1	59	63	PF00917	0.508
DOC_ANK_TNKS_1	527	534	PF00023	0.668
DOC_CYCLIN_RxL_1	232	242	PF00134	0.517
DOC_CYCLIN_RxL_1	24	32	PF00134	0.658
DOC_MAPK_gen_1	145	154	PF00069	0.553
DOC_MAPK_gen_1	171	180	PF00069	0.495
DOC_MAPK_gen_1	195	201	PF00069	0.495
DOC_MAPK_gen_1	658	667	PF00069	0.503
DOC_PIKK_1	36	44	PF02985	0.589
DOC_PP4_FxxP_1	10	13	PF00568	0.673
DOC_USP7_MATH_1	20	24	PF00917	0.640
DOC_USP7_MATH_1	334	338	PF00917	0.470
DOC_USP7_MATH_1	425	429	PF00917	0.494
DOC_USP7_MATH_1	458	462	PF00917	0.742
DOC_USP7_MATH_1	463	467	PF00917	0.754
DOC_USP7_MATH_1	471	475	PF00917	0.815
DOC_USP7_MATH_1	486	490	PF00917	0.527
DOC_USP7_MATH_1	556	560	PF00917	0.830
DOC_USP7_MATH_1	57	61	PF00917	0.723
DOC_USP7_MATH_1	581	585	PF00917	0.741
DOC_USP7_MATH_1	588	592	PF00917	0.748
DOC_USP7_UBL2_3	122	126	PF12436	0.543
DOC_USP7_UBL2_3	648	652	PF12436	0.537
DOC_USP7_UBL2_3	710	714	PF12436	0.657
DOC_WW_Pin1_4	296	301	PF00397	0.648
DOC_WW_Pin1_4	489	494	PF00397	0.603
LIG_14-3-3_CanoR_1	110	114	PF00244	0.588
LIG_14-3-3_CanoR_1	247	252	PF00244	0.464
LIG_14-3-3_CanoR_1	470	480	PF00244	0.758
LIG_14-3-3_CanoR_1	50	56	PF00244	0.666
LIG_14-3-3_CanoR_1	528	532	PF00244	0.810
LIG_14-3-3_CanoR_1	580	588	PF00244	0.769
LIG_14-3-3_CanoR_1	698	703	PF00244	0.677
LIG_Actin_WH2_2	497	514	PF00022	0.684
LIG_APCC_ABBA_1	7	12	PF00400	0.506
LIG_EH_1	7	11	PF12763	0.611
LIG_FHA_1	175	181	PF00498	0.588
LIG_FHA_1	231	237	PF00498	0.510
LIG_FHA_1	297	303	PF00498	0.646
LIG_FHA_1	333	339	PF00498	0.519
LIG_FHA_1	418	424	PF00498	0.564
LIG_FHA_1	425	431	PF00498	0.568
LIG_FHA_1	480	486	PF00498	0.644
LIG_FHA_1	559	565	PF00498	0.738
LIG_FHA_1	59	65	PF00498	0.522
LIG_FHA_1	637	643	PF00498	0.406
LIG_FHA_2	250	256	PF00498	0.475
LIG_FHA_2	344	350	PF00498	0.571
LIG_FHA_2	366	372	PF00498	0.500
LIG_FHA_2	620	626	PF00498	0.498
LIG_FHA_2	704	710	PF00498	0.618
LIG_FHA_2	93	99	PF00498	0.628
LIG_HCF-1_HBM_1	317	320	PF13415	0.542
LIG_LIR_Gen_1	146	154	PF02991	0.497
LIG_LIR_Gen_1	209	217	PF02991	0.515
LIG_LIR_Gen_1	317	327	PF02991	0.525
LIG_LIR_Gen_1	375	385	PF02991	0.449
LIG_LIR_Gen_1	505	515	PF02991	0.629
LIG_LIR_Nem_3	146	151	PF02991	0.497
LIG_LIR_Nem_3	209	213	PF02991	0.501
LIG_LIR_Nem_3	317	323	PF02991	0.474
LIG_LIR_Nem_3	375	380	PF02991	0.433
LIG_LIR_Nem_3	505	511	PF02991	0.511
LIG_LIR_Nem_3	629	634	PF02991	0.498
LIG_SH2_CRK	221	225	PF00017	0.413
LIG_SH2_NCK_1	320	324	PF00017	0.465
LIG_SH2_STAP1	86	90	PF00017	0.707
LIG_SH2_STAT3	576	579	PF00017	0.596
LIG_SH2_STAT5	634	637	PF00017	0.509
LIG_SH3_3	301	307	PF00018	0.502
LIG_SH3_3	693	699	PF00018	0.670
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.515
LIG_SUMO_SIM_anti_2	619	625	PF11976	0.488
LIG_SUMO_SIM_anti_2	643	648	PF11976	0.595
LIG_SUMO_SIM_par_1	299	306	PF11976	0.507
LIG_SUMO_SIM_par_1	619	625	PF11976	0.485
LIG_TRAF2_1	252	255	PF00917	0.567
LIG_TRAF2_1	311	314	PF00917	0.619
LIG_TRAF2_1	322	325	PF00917	0.444
LIG_TRAF2_1	492	495	PF00917	0.670
LIG_UBA3_1	620	627	PF00899	0.480
LIG_UBA3_1	689	695	PF00899	0.574
MOD_CK1_1	112	118	PF00069	0.581
MOD_CK1_1	23	29	PF00069	0.566
MOD_CK1_1	461	467	PF00069	0.797
MOD_CK1_1	489	495	PF00069	0.450
MOD_CK1_1	60	66	PF00069	0.743
MOD_CK1_1	701	707	PF00069	0.777
MOD_CK2_1	152	158	PF00069	0.535
MOD_CK2_1	185	191	PF00069	0.551
MOD_CK2_1	249	255	PF00069	0.566
MOD_CK2_1	319	325	PF00069	0.508
MOD_CK2_1	489	495	PF00069	0.655
MOD_CK2_1	619	625	PF00069	0.521
MOD_CK2_1	703	709	PF00069	0.556
MOD_CK2_1	92	98	PF00069	0.502
MOD_GlcNHglycan	183	186	PF01048	0.295
MOD_GlcNHglycan	247	250	PF01048	0.518
MOD_GlcNHglycan	284	287	PF01048	0.752
MOD_GlcNHglycan	368	371	PF01048	0.356
MOD_GlcNHglycan	486	489	PF01048	0.723
MOD_GlcNHglycan	583	586	PF01048	0.772
MOD_GlcNHglycan	591	594	PF01048	0.693
MOD_GlcNHglycan	70	73	PF01048	0.631
MOD_GlcNHglycan	82	85	PF01048	0.554
MOD_GSK3_1	181	188	PF00069	0.551
MOD_GSK3_1	19	26	PF00069	0.663
MOD_GSK3_1	245	252	PF00069	0.468
MOD_GSK3_1	458	465	PF00069	0.735
MOD_GSK3_1	527	534	PF00069	0.843
MOD_GSK3_1	568	575	PF00069	0.779
MOD_GSK3_1	58	65	PF00069	0.657
MOD_GSK3_1	589	596	PF00069	0.826
MOD_GSK3_1	90	97	PF00069	0.645
MOD_N-GLC_1	296	301	PF02516	0.734
MOD_N-GLC_1	538	543	PF02516	0.760
MOD_N-GLC_1	589	594	PF02516	0.628
MOD_N-GLC_1	722	727	PF02516	0.683
MOD_NEK2_1	152	157	PF00069	0.495
MOD_NEK2_1	194	199	PF00069	0.601
MOD_NEK2_1	220	225	PF00069	0.481
MOD_NEK2_1	365	370	PF00069	0.615
MOD_NEK2_1	518	523	PF00069	0.722
MOD_NEK2_1	68	73	PF00069	0.779
MOD_NEK2_1	682	687	PF00069	0.503
MOD_NEK2_1	80	85	PF00069	0.556
MOD_NEK2_2	334	339	PF00069	0.455
MOD_NEK2_2	51	56	PF00069	0.508
MOD_PIKK_1	666	672	PF00454	0.484
MOD_PIKK_1	682	688	PF00454	0.535
MOD_PK_1	280	286	PF00069	0.707
MOD_PKA_1	181	187	PF00069	0.495
MOD_PKA_1	280	286	PF00069	0.741
MOD_PKA_2	109	115	PF00069	0.575
MOD_PKA_2	194	200	PF00069	0.478
MOD_PKA_2	280	286	PF00069	0.741
MOD_PKA_2	527	533	PF00069	0.790
MOD_PKA_2	579	585	PF00069	0.830
MOD_PKA_2	588	594	PF00069	0.872
MOD_PKB_1	587	595	PF00069	0.558
MOD_Plk_1	20	26	PF00069	0.628
MOD_Plk_1	500	506	PF00069	0.565
MOD_Plk_1	611	617	PF00069	0.789
MOD_Plk_2-3	619	625	PF00069	0.502
MOD_Plk_4	109	115	PF00069	0.503
MOD_Plk_4	619	625	PF00069	0.488
MOD_ProDKin_1	296	302	PF00069	0.647
MOD_ProDKin_1	489	495	PF00069	0.599
MOD_SUMO_for_1	350	353	PF00179	0.485
MOD_SUMO_rev_2	119	127	PF00179	0.560
MOD_SUMO_rev_2	303	310	PF00179	0.609
MOD_SUMO_rev_2	619	628	PF00179	0.484
MOD_SUMO_rev_2	704	711	PF00179	0.694
TRG_DiLeu_BaEn_3	381	387	PF01217	0.435
TRG_DiLeu_BaEn_3	410	416	PF01217	0.474
TRG_ENDOCYTIC_2	207	210	PF00928	0.495
TRG_ENDOCYTIC_2	221	224	PF00928	0.398
TRG_ENDOCYTIC_2	320	323	PF00928	0.518
TRG_ER_diArg_1	163	165	PF00400	0.508
TRG_ER_diArg_1	198	201	PF00400	0.419
TRG_ER_diArg_1	279	282	PF00400	0.723
TRG_ER_diArg_1	33	35	PF00400	0.618
TRG_ER_diArg_1	586	589	PF00400	0.556
TRG_ER_diArg_1	658	660	PF00400	0.526
TRG_ER_diArg_1	677	680	PF00400	0.526
TRG_ER_diArg_1	697	700	PF00400	0.417
TRG_NES_CRM1_1	393	407	PF08389	0.474
TRG_NLS_Bipartite_1	181	199	PF00514	0.588
TRG_NLS_Bipartite_1	278	294	PF00514	0.655
TRG_NLS_MonoExtN_4	278	283	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	633	637	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP4	Leptomonas seymouri	53%	96%
A0A1X0NUV9	Trypanosomatidae	38%	100%
A0A3Q8IG83	Leishmania donovani	87%	100%
A0A422NB67	Trypanosoma rangeli	41%	100%
A4HKI8	Leishmania braziliensis	73%	100%
A4I820	Leishmania infantum	87%	100%
D0AA86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q578	Leishmania major	87%	100%
V5DCC5	Trypanosoma cruzi	38%	100%