18S rRNA aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome biogenesis protein TSR3, putative

Species:

Leishmania mexicana

UniProt:

E9B2X6_LEIMU

TriTrypDb:

LmxM.31.1970

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B2X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2X6

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	12
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	12
GO:0001522	pseudouridine synthesis	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0031118	rRNA pseudouridine synthesis	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0030490	maturation of SSU-rRNA	9	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0106388	18S rRNA aminocarboxypropyltransferase activity	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140102	catalytic activity, acting on a rRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901681	sulfur compound binding	2	12
GO:1904047	S-adenosyl-L-methionine binding	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.457
CLV_C14_Caspase3-7	265	269	PF00656	0.752
CLV_NRD_NRD_1	119	121	PF00675	0.385
CLV_NRD_NRD_1	217	219	PF00675	0.447
CLV_NRD_NRD_1	236	238	PF00675	0.589
CLV_NRD_NRD_1	243	245	PF00675	0.589
CLV_NRD_NRD_1	282	284	PF00675	0.590
CLV_PCSK_KEX2_1	217	219	PF00082	0.448
CLV_PCSK_KEX2_1	236	238	PF00082	0.489
CLV_PCSK_KEX2_1	243	245	PF00082	0.507
CLV_PCSK_KEX2_1	282	284	PF00082	0.590
CLV_PCSK_PC7_1	239	245	PF00082	0.544
CLV_PCSK_SKI1_1	184	188	PF00082	0.429
CLV_PCSK_SKI1_1	61	65	PF00082	0.176
DEG_SCF_FBW7_1	81	88	PF00400	0.280
DEG_SPOP_SBC_1	25	29	PF00917	0.606
DOC_CKS1_1	82	87	PF01111	0.245
DOC_CYCLIN_RxL_1	215	226	PF00134	0.522
DOC_CYCLIN_RxL_1	65	76	PF00134	0.263
DOC_MAPK_gen_1	61	71	PF00069	0.245
DOC_USP7_MATH_1	249	253	PF00917	0.604
DOC_USP7_MATH_1	273	277	PF00917	0.568
DOC_WW_Pin1_4	81	86	PF00397	0.245
DOC_WW_Pin1_4	89	94	PF00397	0.245
LIG_14-3-3_CanoR_1	123	127	PF00244	0.385
LIG_14-3-3_CanoR_1	73	77	PF00244	0.400
LIG_Actin_WH2_2	59	75	PF00022	0.357
LIG_BIR_III_2	115	119	PF00653	0.305
LIG_BIR_III_2	229	233	PF00653	0.466
LIG_BRCT_BRCA1_1	74	78	PF00533	0.434
LIG_FHA_1	26	32	PF00498	0.410
LIG_FHA_1	86	92	PF00498	0.338
LIG_Integrin_RGD_1	3	5	PF01839	0.536
LIG_LIR_Apic_2	245	249	PF02991	0.579
LIG_LIR_Nem_3	108	114	PF02991	0.245
LIG_LIR_Nem_3	178	182	PF02991	0.247
LIG_LIR_Nem_3	75	81	PF02991	0.314
LIG_MYND_1	127	131	PF01753	0.245
LIG_PDZ_Class_3	292	297	PF00595	0.576
LIG_Pex14_1	175	179	PF04695	0.210
LIG_Rb_LxCxE_1	145	165	PF01857	0.246
LIG_SH2_CRK	141	145	PF00017	0.275
LIG_SH2_SRC	206	209	PF00017	0.313
LIG_SH2_STAT5	172	175	PF00017	0.278
LIG_SH2_STAT5	206	209	PF00017	0.416
LIG_SH3_3	34	40	PF00018	0.596
LIG_SH3_3	79	85	PF00018	0.245
MOD_CDK_SPxxK_3	89	96	PF00069	0.385
MOD_CK2_1	107	113	PF00069	0.338
MOD_CK2_1	247	253	PF00069	0.611
MOD_CK2_1	83	89	PF00069	0.250
MOD_Cter_Amidation	59	62	PF01082	0.245
MOD_GlcNHglycan	101	104	PF01048	0.385
MOD_GlcNHglycan	124	127	PF01048	0.342
MOD_GlcNHglycan	195	198	PF01048	0.352
MOD_GlcNHglycan	199	202	PF01048	0.349
MOD_GlcNHglycan	21	24	PF01048	0.562
MOD_GlcNHglycan	28	31	PF01048	0.565
MOD_GlcNHglycan	58	61	PF01048	0.261
MOD_GlcNHglycan	85	88	PF01048	0.385
MOD_GlcNHglycan	9	12	PF01048	0.697
MOD_GSK3_1	171	178	PF00069	0.306
MOD_GSK3_1	193	200	PF00069	0.323
MOD_GSK3_1	26	33	PF00069	0.592
MOD_GSK3_1	264	271	PF00069	0.728
MOD_GSK3_1	81	88	PF00069	0.263
MOD_N-GLC_2	56	58	PF02516	0.305
MOD_NEK2_1	122	127	PF00069	0.385
MOD_NEK2_2	175	180	PF00069	0.245
MOD_PKA_1	282	288	PF00069	0.510
MOD_PKA_2	122	128	PF00069	0.385
MOD_PKA_2	142	148	PF00069	0.104
MOD_PKA_2	282	288	PF00069	0.463
MOD_PKA_2	72	78	PF00069	0.419
MOD_Plk_1	107	113	PF00069	0.245
MOD_Plk_1	197	203	PF00069	0.363
MOD_Plk_4	175	181	PF00069	0.273
MOD_ProDKin_1	81	87	PF00069	0.245
MOD_ProDKin_1	89	95	PF00069	0.245
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.245
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.245
TRG_ER_diArg_1	236	239	PF00400	0.540
TRG_ER_diArg_1	6	9	PF00400	0.627
TRG_NES_CRM1_1	151	165	PF08389	0.385
TRG_NLS_MonoExtN_4	118	124	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKZ2	Leptomonas seymouri	83%	100%
A0A0S4JEU2	Bodo saltans	63%	100%
A0A1X0NUA5	Trypanosomatidae	70%	100%
A0A3S7X5P4	Leishmania donovani	92%	100%
A0A422NB90	Trypanosoma rangeli	65%	87%
A4I818	Leishmania infantum	92%	100%
D0AA84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AIV1	Leishmania braziliensis	82%	100%
Q10409	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
Q4Q580	Leishmania major	93%	100%
Q9UJK0	Homo sapiens	41%	95%
V5BG92	Trypanosoma cruzi	66%	100%