Putative 1-acyl-sn-glycerol-3-phosphateacyltransferase-lik e protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9B2X4_LEIMU

TriTrypDb:

LmxM.31.1960

Length:

293

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

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Expansion

Sequence features

E9B2X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2X4

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006654	phosphatidic acid biosynthetic process	6	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	9
GO:0008374	O-acyltransferase activity	5	9
GO:0016411	acylglycerol O-acyltransferase activity	6	9
GO:0016740	transferase activity	2	18
GO:0016746	acyltransferase activity	3	18
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9
GO:0042171	lysophosphatidic acid acyltransferase activity	6	9
GO:0071617	lysophospholipid acyltransferase activity	5	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.337
CLV_NRD_NRD_1	167	169	PF00675	0.418
CLV_NRD_NRD_1	4	6	PF00675	0.344
CLV_NRD_NRD_1	58	60	PF00675	0.513
CLV_PCSK_FUR_1	165	169	PF00082	0.442
CLV_PCSK_KEX2_1	167	169	PF00082	0.407
CLV_PCSK_KEX2_1	4	6	PF00082	0.344
CLV_PCSK_PC7_1	163	169	PF00082	0.438
CLV_PCSK_SKI1_1	106	110	PF00082	0.480
CLV_PCSK_SKI1_1	273	277	PF00082	0.480

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B0	Leptomonas seymouri	78%	100%
A0A0S4IQ05	Bodo saltans	30%	86%
A0A0S4IXV9	Bodo saltans	28%	97%
A0A0S4JRP7	Bodo saltans	49%	100%
A0A1X0NUQ7	Trypanosomatidae	57%	100%
A0A3Q8IFY7	Leishmania donovani	90%	100%
A0A3S5IQW0	Trypanosoma rangeli	58%	100%
A0A3S7WNW6	Leishmania donovani	28%	82%
A4H419	Leishmania braziliensis	28%	87%
A4H420	Leishmania braziliensis	29%	83%

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