LeishMANIAdb
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Putative 1-acyl-sn-glycerol-3-phosphateacyltransferase-lik e protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 1-acyl-sn-glycerol-3-phosphateacyltransferase-lik e protein
Gene product:
1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative
Species:
Leishmania mexicana
UniProt:
E9B2X4_LEIMU
TriTrypDb:
LmxM.31.1960
Length:
293

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 36
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

E9B2X4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2X4

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 2
GO:0006644 phospholipid metabolic process 4 2
GO:0006650 glycerophospholipid metabolic process 5 1
GO:0006654 phosphatidic acid biosynthetic process 6 1
GO:0006793 phosphorus metabolic process 3 2
GO:0006796 phosphate-containing compound metabolic process 4 2
GO:0008152 metabolic process 1 2
GO:0008610 lipid biosynthetic process 4 2
GO:0008654 phospholipid biosynthetic process 5 2
GO:0009058 biosynthetic process 2 2
GO:0009987 cellular process 1 2
GO:0019637 organophosphate metabolic process 3 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 2
GO:0045017 glycerolipid biosynthetic process 4 1
GO:0046473 phosphatidic acid metabolic process 6 1
GO:0046474 glycerophospholipid biosynthetic process 5 1
GO:0046486 glycerolipid metabolic process 4 1
GO:0071704 organic substance metabolic process 2 2
GO:0090407 organophosphate biosynthetic process 4 2
GO:1901576 organic substance biosynthetic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 18
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 7 9
GO:0008374 O-acyltransferase activity 5 9
GO:0016411 acylglycerol O-acyltransferase activity 6 9
GO:0016740 transferase activity 2 18
GO:0016746 acyltransferase activity 3 18
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 9
GO:0042171 lysophosphatidic acid acyltransferase activity 6 9
GO:0071617 lysophospholipid acyltransferase activity 5 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.337
CLV_NRD_NRD_1 167 169 PF00675 0.418
CLV_NRD_NRD_1 4 6 PF00675 0.344
CLV_NRD_NRD_1 58 60 PF00675 0.513
CLV_PCSK_FUR_1 165 169 PF00082 0.442
CLV_PCSK_KEX2_1 167 169 PF00082 0.407
CLV_PCSK_KEX2_1 4 6 PF00082 0.344
CLV_PCSK_PC7_1 163 169 PF00082 0.438
CLV_PCSK_SKI1_1 106 110 PF00082 0.480
CLV_PCSK_SKI1_1 273 277 PF00082 0.480
DEG_SPOP_SBC_1 43 47 PF00917 0.373
DOC_CYCLIN_yClb1_LxF_4 190 195 PF00134 0.238
DOC_MAPK_gen_1 165 174 PF00069 0.204
DOC_MAPK_gen_1 261 270 PF00069 0.391
DOC_MAPK_gen_1 85 93 PF00069 0.256
DOC_MAPK_MEF2A_6 12 21 PF00069 0.443
DOC_MAPK_MEF2A_6 85 93 PF00069 0.222
DOC_PP1_RVXF_1 190 196 PF00149 0.225
DOC_PP1_RVXF_1 57 64 PF00149 0.325
DOC_PP4_FxxP_1 122 125 PF00568 0.214
DOC_PP4_FxxP_1 234 237 PF00568 0.279
DOC_USP7_MATH_1 101 105 PF00917 0.296
DOC_USP7_MATH_1 219 223 PF00917 0.340
LIG_14-3-3_CanoR_1 12 18 PF00244 0.429
LIG_14-3-3_CanoR_1 59 64 PF00244 0.319
LIG_AP2alpha_2 100 102 PF02296 0.227
LIG_APCC_ABBA_1 172 177 PF00400 0.237
LIG_BIR_II_1 1 5 PF00653 0.639
LIG_BRCT_BRCA1_1 40 44 PF00533 0.362
LIG_deltaCOP1_diTrp_1 112 122 PF00928 0.214
LIG_EH_1 188 192 PF12763 0.318
LIG_EH_1 69 73 PF12763 0.264
LIG_eIF4E_1 18 24 PF01652 0.394
LIG_FHA_1 14 20 PF00498 0.241
LIG_FHA_1 212 218 PF00498 0.331
LIG_FHA_2 43 49 PF00498 0.336
LIG_LIR_Apic_2 233 237 PF02991 0.274
LIG_LIR_Gen_1 100 110 PF02991 0.253
LIG_LIR_Gen_1 146 155 PF02991 0.317
LIG_LIR_Gen_1 16 25 PF02991 0.280
LIG_LIR_Nem_3 100 105 PF02991 0.261
LIG_LIR_Nem_3 146 151 PF02991 0.322
LIG_LIR_Nem_3 16 21 PF02991 0.282
LIG_LIR_Nem_3 229 234 PF02991 0.321
LIG_NRBOX 16 22 PF00104 0.356
LIG_Pex14_2 122 126 PF04695 0.245
LIG_Pex14_2 191 195 PF04695 0.214
LIG_PTAP_UEV_1 281 286 PF05743 0.307
LIG_SH2_STAT5 140 143 PF00017 0.314
LIG_SH2_STAT5 18 21 PF00017 0.312
LIG_SH2_STAT5 231 234 PF00017 0.272
LIG_SH3_2 187 192 PF14604 0.318
LIG_SH3_3 181 187 PF00018 0.275
LIG_SH3_3 279 285 PF00018 0.328
LIG_SH3_3 37 43 PF00018 0.377
LIG_SUMO_SIM_par_1 207 212 PF11976 0.248
LIG_TRAF2_1 245 248 PF00917 0.278
LIG_WRC_WIRS_1 231 236 PF05994 0.358
MOD_CK1_1 104 110 PF00069 0.260
MOD_CK1_1 147 153 PF00069 0.332
MOD_CK2_1 209 215 PF00069 0.299
MOD_CK2_1 242 248 PF00069 0.296
MOD_CK2_1 42 48 PF00069 0.380
MOD_GlcNHglycan 211 214 PF01048 0.444
MOD_GlcNHglycan 221 224 PF01048 0.494
MOD_GlcNHglycan 244 247 PF01048 0.601
MOD_GlcNHglycan 282 285 PF01048 0.533
MOD_GlcNHglycan 97 100 PF01048 0.425
MOD_GSK3_1 143 150 PF00069 0.214
MOD_GSK3_1 38 45 PF00069 0.464
MOD_NEK2_1 13 18 PF00069 0.309
MOD_NEK2_1 19 24 PF00069 0.307
MOD_NEK2_1 209 214 PF00069 0.326
MOD_NEK2_2 101 106 PF00069 0.293
MOD_PKA_1 59 65 PF00069 0.296
MOD_PKA_2 219 225 PF00069 0.381
MOD_Plk_4 111 117 PF00069 0.243
MOD_Plk_4 13 19 PF00069 0.303
MOD_Plk_4 202 208 PF00069 0.247
MOD_Plk_4 59 65 PF00069 0.362
MOD_SUMO_rev_2 283 293 PF00179 0.520
TRG_ENDOCYTIC_2 18 21 PF00928 0.310
TRG_ENDOCYTIC_2 231 234 PF00928 0.336
TRG_ER_diArg_1 163 166 PF00400 0.222
TRG_ER_diArg_1 167 170 PF00400 0.209

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6B0 Leptomonas seymouri 78% 100%
A0A0S4IQ05 Bodo saltans 30% 86%
A0A0S4IXV9 Bodo saltans 28% 97%
A0A0S4JRP7 Bodo saltans 49% 100%
A0A1X0NUQ7 Trypanosomatidae 57% 100%
A0A3Q8IFY7 Leishmania donovani 90% 100%
A0A3S5IQW0 Trypanosoma rangeli 58% 100%
A0A3S7WNW6 Leishmania donovani 28% 82%
A4H419 Leishmania braziliensis 28% 87%
A4H420 Leishmania braziliensis 29% 83%
A4HKI5 Leishmania braziliensis 82% 100%
A4HSA2 Leishmania infantum 28% 82%
A4I4U1 Leishmania infantum 24% 90%
A4I816 Leishmania infantum 90% 100%
D0AA81 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AE89 Leishmania major 24% 100%
Q42670 Cocos nucifera 24% 95%
Q42868 Limnanthes alba 27% 100%
Q42870 Limnanthes douglasii 26% 100%
Q4Q582 Leishmania major 87% 100%
V5ALB6 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS