DUF4201 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2X1_LEIMU

TriTrypDb:

LmxM.31.1930

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2X1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.686
CLV_C14_Caspase3-7	366	370	PF00656	0.648
CLV_C14_Caspase3-7	549	553	PF00656	0.775
CLV_C14_Caspase3-7	713	717	PF00656	0.767
CLV_NRD_NRD_1	299	301	PF00675	0.604
CLV_NRD_NRD_1	332	334	PF00675	0.478
CLV_NRD_NRD_1	395	397	PF00675	0.676
CLV_NRD_NRD_1	411	413	PF00675	0.415
CLV_NRD_NRD_1	443	445	PF00675	0.569
CLV_NRD_NRD_1	473	475	PF00675	0.700
CLV_NRD_NRD_1	494	496	PF00675	0.728
CLV_NRD_NRD_1	529	531	PF00675	0.595
CLV_NRD_NRD_1	546	548	PF00675	0.568
CLV_PCSK_KEX2_1	268	270	PF00082	0.513
CLV_PCSK_KEX2_1	299	301	PF00082	0.604
CLV_PCSK_KEX2_1	331	333	PF00082	0.488
CLV_PCSK_KEX2_1	395	397	PF00082	0.676
CLV_PCSK_KEX2_1	410	412	PF00082	0.443
CLV_PCSK_KEX2_1	431	433	PF00082	0.475
CLV_PCSK_KEX2_1	442	444	PF00082	0.533
CLV_PCSK_KEX2_1	473	475	PF00082	0.669
CLV_PCSK_KEX2_1	523	525	PF00082	0.664
CLV_PCSK_KEX2_1	529	531	PF00082	0.603
CLV_PCSK_KEX2_1	546	548	PF00082	0.568
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.513
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.547
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.604
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.533
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.581
CLV_PCSK_PC7_1	327	333	PF00082	0.646
CLV_PCSK_SKI1_1	327	331	PF00082	0.564
CLV_PCSK_SKI1_1	344	348	PF00082	0.534
CLV_PCSK_SKI1_1	379	383	PF00082	0.585
CLV_PCSK_SKI1_1	395	399	PF00082	0.644
CLV_PCSK_SKI1_1	431	435	PF00082	0.468
CLV_Separin_Metazoa	237	241	PF03568	0.439
DEG_APCC_DBOX_1	332	340	PF00400	0.644
DEG_APCC_DBOX_1	394	402	PF00400	0.664
DEG_APCC_DBOX_1	472	480	PF00400	0.713
DEG_APCC_DBOX_1	528	536	PF00400	0.631
DEG_SPOP_SBC_1	111	115	PF00917	0.647
DEG_SPOP_SBC_1	72	76	PF00917	0.768
DOC_MAPK_gen_1	344	355	PF00069	0.597
DOC_MAPK_RevD_3	319	333	PF00069	0.502
DOC_PP1_RVXF_1	432	439	PF00149	0.352
DOC_USP7_MATH_1	110	114	PF00917	0.699
DOC_USP7_MATH_1	124	128	PF00917	0.666
DOC_USP7_MATH_1	206	210	PF00917	0.750
DOC_USP7_MATH_1	282	286	PF00917	0.813
DOC_USP7_MATH_1	4	8	PF00917	0.584
DOC_USP7_MATH_1	540	544	PF00917	0.544
DOC_USP7_MATH_1	553	557	PF00917	0.582
DOC_USP7_MATH_1	569	573	PF00917	0.753
DOC_USP7_MATH_1	659	663	PF00917	0.560
DOC_USP7_MATH_1	706	710	PF00917	0.791
DOC_USP7_MATH_1	714	718	PF00917	0.757
DOC_USP7_MATH_1	72	76	PF00917	0.778
DOC_USP7_MATH_1	738	742	PF00917	0.782
DOC_USP7_MATH_1	765	769	PF00917	0.728
DOC_WW_Pin1_4	106	111	PF00397	0.700
DOC_WW_Pin1_4	118	123	PF00397	0.636
DOC_WW_Pin1_4	191	196	PF00397	0.567
DOC_WW_Pin1_4	556	561	PF00397	0.705
DOC_WW_Pin1_4	563	568	PF00397	0.629
DOC_WW_Pin1_4	68	73	PF00397	0.695
DOC_WW_Pin1_4	704	709	PF00397	0.549
DOC_WW_Pin1_4	763	768	PF00397	0.782
LIG_14-3-3_CanoR_1	15	21	PF00244	0.652
LIG_14-3-3_CanoR_1	187	191	PF00244	0.686
LIG_14-3-3_CanoR_1	48	56	PF00244	0.670
LIG_14-3-3_CanoR_1	524	532	PF00244	0.672
LIG_14-3-3_CanoR_1	596	601	PF00244	0.763
LIG_14-3-3_CanoR_1	86	91	PF00244	0.733
LIG_AP2alpha_1	21	25	PF02296	0.836
LIG_APCC_ABBAyCdc20_2	96	102	PF00400	0.646
LIG_deltaCOP1_diTrp_1	780	784	PF00928	0.829
LIG_FHA_1	289	295	PF00498	0.651
LIG_FHA_1	316	322	PF00498	0.531
LIG_FHA_2	1	7	PF00498	0.760
LIG_FHA_2	139	145	PF00498	0.783
LIG_FHA_2	232	238	PF00498	0.755
LIG_FHA_2	384	390	PF00498	0.365
LIG_FHA_2	509	515	PF00498	0.713
LIG_FHA_2	675	681	PF00498	0.692
LIG_FHA_2	698	704	PF00498	0.776
LIG_LIR_Gen_1	305	315	PF02991	0.485
LIG_LIR_Gen_1	629	637	PF02991	0.534
LIG_LIR_Gen_1	780	784	PF02991	0.829
LIG_LIR_Nem_3	305	311	PF02991	0.496
LIG_LIR_Nem_3	347	352	PF02991	0.636
LIG_LIR_Nem_3	629	635	PF02991	0.535
LIG_LIR_Nem_3	780	784	PF02991	0.829
LIG_PDZ_Class_2	779	784	PF00595	0.827
LIG_Pex14_2	21	25	PF04695	0.836
LIG_PTAP_UEV_1	766	771	PF05743	0.661
LIG_SH2_NCK_1	510	514	PF00017	0.713
LIG_SH2_NCK_1	632	636	PF00017	0.602
LIG_SH2_NCK_1	762	766	PF00017	0.781
LIG_SH2_PTP2	352	355	PF00017	0.554
LIG_SH2_SRC	352	355	PF00017	0.554
LIG_SH2_STAT3	167	170	PF00017	0.764
LIG_SH2_STAT5	352	355	PF00017	0.554
LIG_SH2_STAT5	510	513	PF00017	0.755
LIG_SH2_STAT5	520	523	PF00017	0.564
LIG_SH3_3	226	232	PF00018	0.802
LIG_SH3_3	588	594	PF00018	0.659
LIG_SH3_3	764	770	PF00018	0.779
LIG_SUMO_SIM_anti_2	359	366	PF11976	0.485
LIG_SUMO_SIM_anti_2	378	386	PF11976	0.648
LIG_TRAF2_1	141	144	PF00917	0.784
LIG_TRAF2_1	234	237	PF00917	0.757
LIG_TRAF2_1	580	583	PF00917	0.785
LIG_TRAF2_1	717	720	PF00917	0.767
LIG_TRAF2_1	723	726	PF00917	0.695
MOD_CDK_SPK_2	563	568	PF00069	0.785
MOD_CDK_SPxxK_3	118	125	PF00069	0.573
MOD_CDK_SPxxK_3	704	711	PF00069	0.551
MOD_CK1_1	113	119	PF00069	0.729
MOD_CK1_1	127	133	PF00069	0.631
MOD_CK1_1	17	23	PF00069	0.776
MOD_CK1_1	27	33	PF00069	0.751
MOD_CK1_1	285	291	PF00069	0.804
MOD_CK1_1	448	454	PF00069	0.425
MOD_CK1_1	494	500	PF00069	0.553
MOD_CK1_1	51	57	PF00069	0.715
MOD_CK1_1	545	551	PF00069	0.834
MOD_CK1_1	556	562	PF00069	0.688
MOD_CK1_1	638	644	PF00069	0.794
MOD_CK1_1	67	73	PF00069	0.756
MOD_CK1_1	674	680	PF00069	0.578
MOD_CK1_1	81	87	PF00069	0.624
MOD_CK2_1	138	144	PF00069	0.813
MOD_CK2_1	206	212	PF00069	0.620
MOD_CK2_1	231	237	PF00069	0.705
MOD_CK2_1	244	250	PF00069	0.492
MOD_CK2_1	383	389	PF00069	0.366
MOD_CK2_1	41	47	PF00069	0.663
MOD_CK2_1	508	514	PF00069	0.564
MOD_CK2_1	569	575	PF00069	0.807
MOD_CK2_1	623	629	PF00069	0.675
MOD_CK2_1	714	720	PF00069	0.769
MOD_CK2_1	726	732	PF00069	0.611
MOD_Cter_Amidation	482	485	PF01082	0.489
MOD_GlcNHglycan	128	132	PF01048	0.805
MOD_GlcNHglycan	184	187	PF01048	0.867
MOD_GlcNHglycan	35	38	PF01048	0.820
MOD_GlcNHglycan	420	423	PF01048	0.666
MOD_GlcNHglycan	447	450	PF01048	0.425
MOD_GlcNHglycan	489	492	PF01048	0.659
MOD_GlcNHglycan	50	53	PF01048	0.667
MOD_GlcNHglycan	542	545	PF01048	0.615
MOD_GlcNHglycan	555	558	PF01048	0.693
MOD_GlcNHglycan	56	59	PF01048	0.808
MOD_GlcNHglycan	561	564	PF01048	0.807
MOD_GlcNHglycan	585	588	PF01048	0.735
MOD_GlcNHglycan	617	621	PF01048	0.602
MOD_GlcNHglycan	625	628	PF01048	0.717
MOD_GlcNHglycan	654	658	PF01048	0.749
MOD_GlcNHglycan	740	743	PF01048	0.780
MOD_GlcNHglycan	75	78	PF01048	0.701
MOD_GlcNHglycan	767	770	PF01048	0.714
MOD_GSK3_1	102	109	PF00069	0.595
MOD_GSK3_1	110	117	PF00069	0.705
MOD_GSK3_1	123	130	PF00069	0.784
MOD_GSK3_1	176	183	PF00069	0.783
MOD_GSK3_1	212	219	PF00069	0.838
MOD_GSK3_1	24	31	PF00069	0.849
MOD_GSK3_1	260	267	PF00069	0.683
MOD_GSK3_1	282	289	PF00069	0.650
MOD_GSK3_1	290	297	PF00069	0.604
MOD_GSK3_1	483	490	PF00069	0.710
MOD_GSK3_1	494	501	PF00069	0.599
MOD_GSK3_1	542	549	PF00069	0.759
MOD_GSK3_1	552	559	PF00069	0.721
MOD_GSK3_1	602	609	PF00069	0.552
MOD_GSK3_1	635	642	PF00069	0.650
MOD_GSK3_1	64	71	PF00069	0.779
MOD_GSK3_1	78	85	PF00069	0.653
MOD_GSK3_1	86	93	PF00069	0.809
MOD_N-GLC_1	216	221	PF02516	0.837
MOD_N-GLC_1	244	249	PF02516	0.627
MOD_N-GLC_1	275	280	PF02516	0.690
MOD_N-GLC_1	383	388	PF02516	0.382
MOD_N-GLC_1	86	91	PF02516	0.650
MOD_NEK2_1	264	269	PF00069	0.708
MOD_NEK2_1	383	388	PF00069	0.490
MOD_NEK2_1	39	44	PF00069	0.764
MOD_NEK2_1	653	658	PF00069	0.558
MOD_PIKK_1	206	212	PF00454	0.756
MOD_PIKK_1	262	268	PF00454	0.771
MOD_PIKK_1	400	406	PF00454	0.656
MOD_PIKK_1	498	504	PF00454	0.705
MOD_PIKK_1	569	575	PF00454	0.784
MOD_PIKK_1	659	665	PF00454	0.564
MOD_PIKK_1	669	675	PF00454	0.553
MOD_PIKK_1	697	703	PF00454	0.773
MOD_PK_1	546	552	PF00069	0.776
MOD_PK_1	596	602	PF00069	0.765
MOD_PK_1	86	92	PF00069	0.756
MOD_PKA_1	344	350	PF00069	0.637
MOD_PKA_1	523	529	PF00069	0.506
MOD_PKA_1	546	552	PF00069	0.776
MOD_PKA_2	124	130	PF00069	0.731
MOD_PKA_2	14	20	PF00069	0.691
MOD_PKA_2	186	192	PF00069	0.807
MOD_PKA_2	494	500	PF00069	0.632
MOD_PKA_2	523	529	PF00069	0.665
MOD_PKA_2	545	551	PF00069	0.680
MOD_PKA_2	85	91	PF00069	0.726
MOD_PKB_1	300	308	PF00069	0.499
MOD_Plk_1	155	161	PF00069	0.723
MOD_Plk_1	17	23	PF00069	0.718
MOD_Plk_1	216	222	PF00069	0.837
MOD_Plk_1	244	250	PF00069	0.630
MOD_Plk_1	275	281	PF00069	0.691
MOD_Plk_1	294	300	PF00069	0.449
MOD_Plk_1	383	389	PF00069	0.403
MOD_Plk_1	616	622	PF00069	0.780
MOD_Plk_1	86	92	PF00069	0.853
MOD_Plk_2-3	14	20	PF00069	0.634
MOD_Plk_2-3	244	250	PF00069	0.555
MOD_Plk_2-3	726	732	PF00069	0.736
MOD_Plk_4	156	162	PF00069	0.804
MOD_Plk_4	309	315	PF00069	0.615
MOD_Plk_4	383	389	PF00069	0.397
MOD_Plk_4	86	92	PF00069	0.853
MOD_ProDKin_1	106	112	PF00069	0.700
MOD_ProDKin_1	118	124	PF00069	0.633
MOD_ProDKin_1	191	197	PF00069	0.567
MOD_ProDKin_1	556	562	PF00069	0.707
MOD_ProDKin_1	563	569	PF00069	0.630
MOD_ProDKin_1	68	74	PF00069	0.696
MOD_ProDKin_1	704	710	PF00069	0.551
MOD_ProDKin_1	763	769	PF00069	0.781
MOD_SUMO_for_1	436	439	PF00179	0.564
MOD_SUMO_for_1	464	467	PF00179	0.387
MOD_SUMO_for_1	567	570	PF00179	0.782
MOD_SUMO_rev_2	185	195	PF00179	0.560
MOD_SUMO_rev_2	334	339	PF00179	0.432
TRG_DiLeu_BaEn_1	325	330	PF01217	0.649
TRG_DiLeu_BaEn_1	335	340	PF01217	0.549
TRG_DiLeu_BaEn_1	378	383	PF01217	0.569
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.670
TRG_ENDOCYTIC_2	352	355	PF00928	0.621
TRG_ENDOCYTIC_2	632	635	PF00928	0.553
TRG_ER_diArg_1	298	300	PF00400	0.612
TRG_ER_diArg_1	395	397	PF00400	0.676
TRG_ER_diArg_1	410	412	PF00400	0.443
TRG_ER_diArg_1	472	474	PF00400	0.595
TRG_ER_diArg_1	528	530	PF00400	0.594
TRG_NLS_Bipartite_1	473	488	PF00514	0.461
TRG_NLS_MonoExtN_4	493	499	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5K7	Leishmania donovani	81%	100%
A4HKI2	Leishmania braziliensis	57%	100%
A4I814	Leishmania infantum	81%	100%
Q4Q585	Leishmania major	79%	99%