DUF647-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vitamin B6 photo-protection and homoeostasis, putative

Species:

Leishmania mexicana

UniProt:

E9B2X0_LEIMU

TriTrypDb:

LmxM.31.1920

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B2X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2X0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	253	255	PF00675	0.381
CLV_NRD_NRD_1	348	350	PF00675	0.478
CLV_NRD_NRD_1	355	357	PF00675	0.425
CLV_NRD_NRD_1	370	372	PF00675	0.332
CLV_NRD_NRD_1	439	441	PF00675	0.362
CLV_NRD_NRD_1	460	462	PF00675	0.458
CLV_PCSK_KEX2_1	252	254	PF00082	0.407
CLV_PCSK_KEX2_1	354	356	PF00082	0.505
CLV_PCSK_KEX2_1	370	372	PF00082	0.329
CLV_PCSK_KEX2_1	439	441	PF00082	0.341
CLV_PCSK_KEX2_1	460	462	PF00082	0.458
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.385
CLV_PCSK_SKI1_1	242	246	PF00082	0.345
CLV_PCSK_SKI1_1	254	258	PF00082	0.376
CLV_PCSK_SKI1_1	371	375	PF00082	0.319
CLV_PCSK_SKI1_1	429	433	PF00082	0.361
CLV_PCSK_SKI1_1	440	444	PF00082	0.364
CLV_PCSK_SKI1_1	461	465	PF00082	0.380
DEG_APCC_DBOX_1	28	36	PF00400	0.442
DOC_CKS1_1	255	260	PF01111	0.542
DOC_CYCLIN_RxL_1	231	240	PF00134	0.484
DOC_CYCLIN_RxL_1	423	435	PF00134	0.466
DOC_CYCLIN_RxL_1	437	444	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.316
DOC_MAPK_DCC_7	324	332	PF00069	0.630
DOC_MAPK_gen_1	109	118	PF00069	0.459
DOC_MAPK_gen_1	276	284	PF00069	0.658
DOC_MAPK_gen_1	370	376	PF00069	0.501
DOC_MAPK_MEF2A_6	111	120	PF00069	0.470
DOC_MAPK_MEF2A_6	324	332	PF00069	0.612
DOC_MAPK_RevD_3	241	254	PF00069	0.561
DOC_PP1_RVXF_1	232	239	PF00149	0.460
DOC_PP2B_LxvP_1	453	456	PF13499	0.578
DOC_PP4_FxxP_1	33	36	PF00568	0.470
DOC_USP7_UBL2_3	379	383	PF12436	0.612
DOC_WW_Pin1_4	254	259	PF00397	0.510
DOC_WW_Pin1_4	289	294	PF00397	0.507
DOC_WW_Pin1_4	323	328	PF00397	0.556
DOC_WW_Pin1_4	78	83	PF00397	0.249
LIG_14-3-3_CanoR_1	161	168	PF00244	0.534
LIG_14-3-3_CanoR_1	349	354	PF00244	0.725
LIG_14-3-3_CanoR_1	355	363	PF00244	0.662
LIG_14-3-3_CanoR_1	449	457	PF00244	0.560
LIG_14-3-3_CanoR_1	460	464	PF00244	0.614
LIG_Actin_WH2_2	260	278	PF00022	0.646
LIG_BRCT_BRCA1_1	73	77	PF00533	0.389
LIG_Clathr_ClatBox_1	235	239	PF01394	0.531
LIG_CtBP_PxDLS_1	456	460	PF00389	0.579
LIG_deltaCOP1_diTrp_1	334	341	PF00928	0.575
LIG_deltaCOP1_diTrp_1	418	427	PF00928	0.609
LIG_EH1_1	447	455	PF00400	0.624
LIG_FHA_1	10	16	PF00498	0.611
LIG_FHA_1	144	150	PF00498	0.329
LIG_FHA_1	205	211	PF00498	0.279
LIG_FHA_1	230	236	PF00498	0.477
LIG_FHA_1	238	244	PF00498	0.434
LIG_FHA_1	270	276	PF00498	0.614
LIG_FHA_1	284	290	PF00498	0.509
LIG_FHA_1	392	398	PF00498	0.582
LIG_FHA_2	255	261	PF00498	0.526
LIG_FHA_2	302	308	PF00498	0.624
LIG_FHA_2	329	335	PF00498	0.625
LIG_FHA_2	400	406	PF00498	0.560
LIG_LIR_Gen_1	178	189	PF02991	0.461
LIG_LIR_Gen_1	3	10	PF02991	0.658
LIG_LIR_Gen_1	425	434	PF02991	0.510
LIG_LIR_Gen_1	66	77	PF02991	0.324
LIG_LIR_Nem_3	178	184	PF02991	0.468
LIG_LIR_Nem_3	232	236	PF02991	0.540
LIG_LIR_Nem_3	3	9	PF02991	0.596
LIG_LIR_Nem_3	66	72	PF02991	0.326
LIG_MAD2	102	110	PF02301	0.484
LIG_MLH1_MIPbox_1	73	77	PF16413	0.396
LIG_PCNA_PIPBox_1	70	79	PF02747	0.292
LIG_PCNA_yPIPBox_3	440	454	PF02747	0.621
LIG_Pex14_1	344	348	PF04695	0.553
LIG_Pex14_2	47	51	PF04695	0.459
LIG_Pex14_2	59	63	PF04695	0.292
LIG_SH2_CRK	393	397	PF00017	0.478
LIG_SH2_CRK	69	73	PF00017	0.341
LIG_SH2_GRB2like	106	109	PF00017	0.412
LIG_SH2_GRB2like	311	314	PF00017	0.591
LIG_SH2_NCK_1	189	193	PF00017	0.436
LIG_SH2_PTP2	290	293	PF00017	0.436
LIG_SH2_STAP1	393	397	PF00017	0.478
LIG_SH2_STAT5	157	160	PF00017	0.445
LIG_SH2_STAT5	189	192	PF00017	0.306
LIG_SH2_STAT5	199	202	PF00017	0.271
LIG_SH2_STAT5	290	293	PF00017	0.436
LIG_SH2_STAT5	311	314	PF00017	0.498
LIG_SH2_STAT5	389	392	PF00017	0.482
LIG_SH2_STAT5	393	396	PF00017	0.517
LIG_SH2_STAT5	52	55	PF00017	0.454
LIG_SH3_3	12	18	PF00018	0.631
LIG_SH3_3	252	258	PF00018	0.519
LIG_SH3_3	288	294	PF00018	0.507
LIG_SH3_3	339	345	PF00018	0.630
LIG_SH3_3	435	441	PF00018	0.589
LIG_SUMO_SIM_anti_2	121	128	PF11976	0.174
LIG_SUMO_SIM_par_1	328	334	PF11976	0.576
LIG_TRAF2_1	257	260	PF00917	0.551
LIG_TRAF2_1	304	307	PF00917	0.599
LIG_TRAF2_1	402	405	PF00917	0.624
LIG_TYR_ITIM	391	396	PF00017	0.472
LIG_TYR_ITIM	67	72	PF00017	0.341
LIG_UBA3_1	317	324	PF00899	0.582
LIG_UBA3_1	32	37	PF00899	0.523
LIG_WRC_WIRS_1	181	186	PF05994	0.449
LIG_WRC_WIRS_1	203	208	PF05994	0.403
MOD_CK1_1	224	230	PF00069	0.297
MOD_CK1_1	54	60	PF00069	0.317
MOD_CK1_1	71	77	PF00069	0.141
MOD_CK2_1	254	260	PF00069	0.533
MOD_CK2_1	301	307	PF00069	0.603
MOD_CK2_1	328	334	PF00069	0.594
MOD_CK2_1	399	405	PF00069	0.556
MOD_DYRK1A_RPxSP_1	254	258	PF00069	0.520
MOD_GlcNHglycan	152	155	PF01048	0.296
MOD_GlcNHglycan	162	165	PF01048	0.255
MOD_GlcNHglycan	73	76	PF01048	0.464
MOD_GSK3_1	114	121	PF00069	0.300
MOD_GSK3_1	145	152	PF00069	0.423
MOD_GSK3_1	198	205	PF00069	0.295
MOD_GSK3_1	455	462	PF00069	0.553
MOD_GSK3_1	51	58	PF00069	0.457
MOD_NEK2_1	114	119	PF00069	0.309
MOD_NEK2_1	198	203	PF00069	0.387
MOD_NEK2_1	221	226	PF00069	0.317
MOD_NEK2_1	409	414	PF00069	0.524
MOD_NEK2_1	459	464	PF00069	0.552
MOD_NEK2_1	51	56	PF00069	0.449
MOD_NEK2_1	63	68	PF00069	0.292
MOD_NEK2_1	77	82	PF00069	0.232
MOD_PIKK_1	283	289	PF00454	0.442
MOD_PIKK_1	354	360	PF00454	0.726
MOD_PKA_1	349	355	PF00069	0.726
MOD_PKA_2	160	166	PF00069	0.534
MOD_PKA_2	22	28	PF00069	0.521
MOD_PKA_2	354	360	PF00069	0.657
MOD_PKA_2	448	454	PF00069	0.529
MOD_PKA_2	459	465	PF00069	0.598
MOD_Plk_4	11	17	PF00069	0.521
MOD_Plk_4	114	120	PF00069	0.322
MOD_Plk_4	130	136	PF00069	0.354
MOD_Plk_4	198	204	PF00069	0.326
MOD_Plk_4	224	230	PF00069	0.384
MOD_Plk_4	55	61	PF00069	0.356
MOD_Plk_4	68	74	PF00069	0.199
MOD_ProDKin_1	254	260	PF00069	0.512
MOD_ProDKin_1	289	295	PF00069	0.510
MOD_ProDKin_1	323	329	PF00069	0.561
MOD_ProDKin_1	78	84	PF00069	0.249
MOD_SUMO_rev_2	359	367	PF00179	0.643
TRG_DiLeu_BaEn_1	260	265	PF01217	0.594
TRG_DiLeu_BaEn_3	404	410	PF01217	0.552
TRG_DiLeu_BaEn_3	425	431	PF01217	0.576
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.552
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.553
TRG_ENDOCYTIC_2	389	392	PF00928	0.501
TRG_ENDOCYTIC_2	393	396	PF00928	0.471
TRG_ENDOCYTIC_2	52	55	PF00928	0.490
TRG_ENDOCYTIC_2	69	72	PF00928	0.141
TRG_ER_diArg_1	253	255	PF00400	0.599
TRG_ER_diArg_1	29	32	PF00400	0.480
TRG_ER_diArg_1	353	356	PF00400	0.696
TRG_ER_diArg_1	370	372	PF00400	0.528
TRG_ER_diArg_1	438	440	PF00400	0.547
TRG_ER_diArg_1	459	461	PF00400	0.594
TRG_NES_CRM1_1	239	251	PF08389	0.531
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I637	Leptomonas seymouri	72%	77%
A0A0N1I7Q2	Leptomonas seymouri	59%	89%
A0A0S4JVE4	Bodo saltans	41%	81%
A0A1X0NUW8	Trypanosomatidae	54%	74%
A0A3Q8IFI0	Leishmania donovani	93%	100%
A0A422NB59	Trypanosoma rangeli	53%	80%
A4HKI1	Leishmania braziliensis	84%	100%
A4I813	Leishmania infantum	93%	100%
D0AA76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	79%
Q4Q586	Leishmania major	93%	100%
V5ALC0	Trypanosoma cruzi	52%	74%