Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2W8_LEIMU

TriTrypDb:

LmxM.31.1900

Length:

606

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.718
CLV_C14_Caspase3-7	127	131	PF00656	0.568
CLV_C14_Caspase3-7	35	39	PF00656	0.667
CLV_C14_Caspase3-7	559	563	PF00656	0.647
CLV_NRD_NRD_1	26	28	PF00675	0.587
CLV_NRD_NRD_1	36	38	PF00675	0.508
CLV_NRD_NRD_1	540	542	PF00675	0.713
CLV_NRD_NRD_1	592	594	PF00675	0.656
CLV_NRD_NRD_1	602	604	PF00675	0.621
CLV_PCSK_KEX2_1	26	28	PF00082	0.587
CLV_PCSK_KEX2_1	36	38	PF00082	0.508
CLV_PCSK_KEX2_1	540	542	PF00082	0.713
CLV_PCSK_KEX2_1	546	548	PF00082	0.620
CLV_PCSK_KEX2_1	592	594	PF00082	0.687
CLV_PCSK_KEX2_1	601	603	PF00082	0.624
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.637
CLV_PCSK_SKI1_1	182	186	PF00082	0.559
CLV_PCSK_SKI1_1	197	201	PF00082	0.655
CLV_PCSK_SKI1_1	284	288	PF00082	0.714
CLV_PCSK_SKI1_1	29	33	PF00082	0.564
CLV_PCSK_SKI1_1	336	340	PF00082	0.531
CLV_PCSK_SKI1_1	593	597	PF00082	0.633
DEG_APCC_DBOX_1	592	600	PF00400	0.612
DEG_SCF_FBW7_1	147	154	PF00400	0.689
DEG_SCF_FBW7_2	406	413	PF00400	0.732
DEG_SPOP_SBC_1	449	453	PF00917	0.670
DOC_CKS1_1	148	153	PF01111	0.660
DOC_MAPK_gen_1	26	32	PF00069	0.544
DOC_MAPK_MEF2A_6	53	60	PF00069	0.412
DOC_MAPK_MEF2A_6	92	101	PF00069	0.568
DOC_PP1_RVXF_1	519	526	PF00149	0.738
DOC_PP2B_LxvP_1	338	341	PF13499	0.651
DOC_PP2B_LxvP_1	493	496	PF13499	0.762
DOC_USP7_MATH_1	100	104	PF00917	0.649
DOC_USP7_MATH_1	106	110	PF00917	0.643
DOC_USP7_MATH_1	258	262	PF00917	0.731
DOC_USP7_MATH_1	303	307	PF00917	0.686
DOC_USP7_MATH_1	361	365	PF00917	0.716
DOC_USP7_MATH_1	386	390	PF00917	0.743
DOC_USP7_MATH_1	411	415	PF00917	0.861
DOC_USP7_MATH_1	45	49	PF00917	0.614
DOC_USP7_MATH_1	545	549	PF00917	0.632
DOC_USP7_MATH_1	71	75	PF00917	0.566
DOC_USP7_MATH_1	79	83	PF00917	0.574
DOC_WW_Pin1_4	139	144	PF00397	0.736
DOC_WW_Pin1_4	147	152	PF00397	0.644
DOC_WW_Pin1_4	153	158	PF00397	0.544
DOC_WW_Pin1_4	168	173	PF00397	0.538
DOC_WW_Pin1_4	229	234	PF00397	0.494
DOC_WW_Pin1_4	399	404	PF00397	0.786
DOC_WW_Pin1_4	406	411	PF00397	0.672
DOC_WW_Pin1_4	479	484	PF00397	0.709
DOC_WW_Pin1_4	499	504	PF00397	0.516
DOC_WW_Pin1_4	567	572	PF00397	0.683
LIG_14-3-3_CanoR_1	262	270	PF00244	0.785
LIG_14-3-3_CanoR_1	336	341	PF00244	0.581
LIG_14-3-3_CanoR_1	42	50	PF00244	0.444
LIG_14-3-3_CanoR_1	450	455	PF00244	0.666
LIG_14-3-3_CanoR_1	576	585	PF00244	0.490
LIG_14-3-3_CterR_2	602	606	PF00244	0.492
LIG_Actin_WH2_2	181	199	PF00022	0.685
LIG_BRCT_BRCA1_1	117	121	PF00533	0.568
LIG_Clathr_ClatBox_1	65	69	PF01394	0.578
LIG_CSL_BTD_1	97	100	PF09270	0.567
LIG_CtBP_PxDLS_1	495	499	PF00389	0.785
LIG_deltaCOP1_diTrp_1	244	250	PF00928	0.571
LIG_FHA_1	183	189	PF00498	0.553
LIG_FHA_1	210	216	PF00498	0.702
LIG_FHA_1	300	306	PF00498	0.699
LIG_FHA_1	450	456	PF00498	0.777
LIG_FHA_1	47	53	PF00498	0.694
LIG_FHA_2	125	131	PF00498	0.552
LIG_FHA_2	20	26	PF00498	0.625
LIG_FHA_2	249	255	PF00498	0.602
LIG_FHA_2	290	296	PF00498	0.702
LIG_FHA_2	33	39	PF00498	0.453
LIG_FHA_2	451	457	PF00498	0.728
LIG_IRF3_LxIS_1	278	283	PF10401	0.597
LIG_LIR_Nem_3	451	457	PF02991	0.680
LIG_LIR_Nem_3	511	515	PF02991	0.654
LIG_MYND_1	147	151	PF01753	0.697
LIG_PCNA_PIPBox_1	471	480	PF02747	0.710
LIG_PCNA_PIPBox_1	572	581	PF02747	0.682
LIG_Pex14_1	454	458	PF04695	0.660
LIG_SH2_CRK	478	482	PF00017	0.710
LIG_SH2_NCK_1	478	482	PF00017	0.710
LIG_SH2_STAT5	478	481	PF00017	0.722
LIG_SH2_STAT5	579	582	PF00017	0.703
LIG_SH3_3	166	172	PF00018	0.510
LIG_SH3_3	227	233	PF00018	0.549
LIG_SH3_3	243	249	PF00018	0.662
LIG_SH3_3	288	294	PF00018	0.743
LIG_SH3_3	400	406	PF00018	0.786
LIG_SH3_3	477	483	PF00018	0.711
LIG_SH3_3	94	100	PF00018	0.551
LIG_SUMO_SIM_anti_2	57	62	PF11976	0.554
LIG_SUMO_SIM_anti_2	586	592	PF11976	0.613
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.648
LIG_SUMO_SIM_par_1	59	64	PF11976	0.583
LIG_TRAF2_1	534	537	PF00917	0.787
LIG_TYR_ITIM	510	515	PF00017	0.597
LIG_UBA3_1	485	490	PF00899	0.659
MOD_CDC14_SPxK_1	142	145	PF00782	0.697
MOD_CDK_SPxK_1	139	145	PF00069	0.694
MOD_CDK_SPxxK_3	567	574	PF00069	0.682
MOD_CK1_1	223	229	PF00069	0.676
MOD_CK1_1	261	267	PF00069	0.792
MOD_CK1_1	276	282	PF00069	0.524
MOD_CK1_1	289	295	PF00069	0.571
MOD_CK1_1	391	397	PF00069	0.747
MOD_CK1_1	399	405	PF00069	0.667
MOD_CK1_1	415	421	PF00069	0.622
MOD_CK1_1	499	505	PF00069	0.838
MOD_CK1_1	531	537	PF00069	0.710
MOD_CK1_1	563	569	PF00069	0.759
MOD_CK2_1	19	25	PF00069	0.622
MOD_CK2_1	248	254	PF00069	0.613
MOD_CK2_1	289	295	PF00069	0.683
MOD_CK2_1	45	51	PF00069	0.687
MOD_CK2_1	531	537	PF00069	0.729
MOD_GlcNHglycan	102	105	PF01048	0.597
MOD_GlcNHglycan	108	111	PF01048	0.620
MOD_GlcNHglycan	165	168	PF01048	0.683
MOD_GlcNHglycan	256	259	PF01048	0.648
MOD_GlcNHglycan	275	278	PF01048	0.593
MOD_GlcNHglycan	295	299	PF01048	0.761
MOD_GlcNHglycan	349	352	PF01048	0.711
MOD_GlcNHglycan	361	364	PF01048	0.673
MOD_GlcNHglycan	368	371	PF01048	0.593
MOD_GlcNHglycan	374	377	PF01048	0.557
MOD_GlcNHglycan	498	501	PF01048	0.733
MOD_GlcNHglycan	531	534	PF01048	0.727
MOD_GlcNHglycan	547	550	PF01048	0.485
MOD_GlcNHglycan	562	566	PF01048	0.591
MOD_GlcNHglycan	585	588	PF01048	0.560
MOD_GSK3_1	102	109	PF00069	0.701
MOD_GSK3_1	147	154	PF00069	0.637
MOD_GSK3_1	202	209	PF00069	0.730
MOD_GSK3_1	254	261	PF00069	0.671
MOD_GSK3_1	269	276	PF00069	0.699
MOD_GSK3_1	299	306	PF00069	0.706
MOD_GSK3_1	325	332	PF00069	0.691
MOD_GSK3_1	386	393	PF00069	0.747
MOD_GSK3_1	394	401	PF00069	0.666
MOD_GSK3_1	402	409	PF00069	0.520
MOD_GSK3_1	41	48	PF00069	0.667
MOD_GSK3_1	411	418	PF00069	0.678
MOD_GSK3_1	440	447	PF00069	0.518
MOD_GSK3_1	560	567	PF00069	0.734
MOD_GSK3_1	577	584	PF00069	0.520
MOD_N-GLC_1	523	528	PF02516	0.684
MOD_NEK2_1	163	168	PF00069	0.733
MOD_NEK2_1	177	182	PF00069	0.580
MOD_NEK2_1	263	268	PF00069	0.790
MOD_NEK2_1	280	285	PF00069	0.526
MOD_NEK2_1	287	292	PF00069	0.685
MOD_NEK2_1	32	37	PF00069	0.630
MOD_NEK2_1	529	534	PF00069	0.629
MOD_PIKK_1	459	465	PF00454	0.739
MOD_PKA_2	261	267	PF00069	0.810
MOD_PKA_2	303	309	PF00069	0.781
MOD_PKA_2	347	353	PF00069	0.689
MOD_PKA_2	41	47	PF00069	0.435
MOD_PKA_2	449	455	PF00069	0.730
MOD_Plk_1	412	418	PF00069	0.552
MOD_Plk_4	220	226	PF00069	0.503
MOD_Plk_4	276	282	PF00069	0.721
MOD_Plk_4	303	309	PF00069	0.718
MOD_Plk_4	450	456	PF00069	0.665
MOD_Plk_4	9	15	PF00069	0.648
MOD_ProDKin_1	139	145	PF00069	0.738
MOD_ProDKin_1	147	153	PF00069	0.640
MOD_ProDKin_1	158	164	PF00069	0.530
MOD_ProDKin_1	168	174	PF00069	0.565
MOD_ProDKin_1	229	235	PF00069	0.492
MOD_ProDKin_1	399	405	PF00069	0.787
MOD_ProDKin_1	406	412	PF00069	0.672
MOD_ProDKin_1	479	485	PF00069	0.708
MOD_ProDKin_1	499	505	PF00069	0.513
MOD_ProDKin_1	567	573	PF00069	0.683
MOD_SUMO_for_1	489	492	PF00179	0.498
MOD_SUMO_rev_2	538	548	PF00179	0.644
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.664
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.509
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.503
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.665
TRG_ENDOCYTIC_2	512	515	PF00928	0.599
TRG_ENDOCYTIC_2	579	582	PF00928	0.678
TRG_ER_diArg_1	539	541	PF00400	0.711
TRG_ER_diArg_1	573	576	PF00400	0.533
TRG_ER_diArg_1	591	593	PF00400	0.636
TRG_ER_diArg_1	601	603	PF00400	0.611
TRG_NES_CRM1_1	59	69	PF08389	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5N2	Leishmania donovani	81%	100%
A4HKH9	Leishmania braziliensis	62%	100%
A4I811	Leishmania infantum	81%	100%
Q4Q588	Leishmania major	82%	100%