3'-5' exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3'-5' exonuclease, putative

Species:

Leishmania mexicana

UniProt:

E9B2W6_LEIMU

TriTrypDb:

LmxM.31.1880

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2W6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004518	nuclease activity	4	5
GO:0004527	exonuclease activity	5	5
GO:0005488	binding	1	5
GO:0008408	3'-5' exonuclease activity	6	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.622
CLV_C14_Caspase3-7	479	483	PF00656	0.732
CLV_NRD_NRD_1	138	140	PF00675	0.746
CLV_NRD_NRD_1	262	264	PF00675	0.530
CLV_NRD_NRD_1	468	470	PF00675	0.527
CLV_NRD_NRD_1	522	524	PF00675	0.530
CLV_NRD_NRD_1	526	528	PF00675	0.564
CLV_NRD_NRD_1	672	674	PF00675	0.229
CLV_PCSK_FUR_1	520	524	PF00082	0.449
CLV_PCSK_KEX2_1	137	139	PF00082	0.745
CLV_PCSK_KEX2_1	262	264	PF00082	0.530
CLV_PCSK_KEX2_1	281	283	PF00082	0.487
CLV_PCSK_KEX2_1	522	524	PF00082	0.530
CLV_PCSK_KEX2_1	526	528	PF00082	0.564
CLV_PCSK_KEX2_1	672	674	PF00082	0.266
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.724
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.526
CLV_PCSK_PC7_1	522	528	PF00082	0.590
CLV_PCSK_SKI1_1	10	14	PF00082	0.533
CLV_PCSK_SKI1_1	134	138	PF00082	0.594
CLV_PCSK_SKI1_1	282	286	PF00082	0.523
CLV_PCSK_SKI1_1	510	514	PF00082	0.546
CLV_PCSK_SKI1_1	596	600	PF00082	0.371
CLV_PCSK_SKI1_1	606	610	PF00082	0.381
CLV_PCSK_SKI1_1	651	655	PF00082	0.391
CLV_PCSK_SKI1_1	672	676	PF00082	0.391
CLV_PCSK_SKI1_1	689	693	PF00082	0.228
CLV_PCSK_SKI1_1	704	708	PF00082	0.247
CLV_Separin_Metazoa	511	515	PF03568	0.407
CLV_Separin_Metazoa	517	521	PF03568	0.450
DEG_APCC_DBOX_1	281	289	PF00400	0.523
DEG_ODPH_VHL_1	448	459	PF01847	0.770
DEG_SCF_FBW7_1	123	130	PF00400	0.501
DEG_SCF_FBW7_1	243	250	PF00400	0.616
DOC_CKS1_1	244	249	PF01111	0.739
DOC_CKS1_1	421	426	PF01111	0.745
DOC_CKS1_1	86	91	PF01111	0.722
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.617
DOC_MAPK_DCC_7	138	148	PF00069	0.728
DOC_MAPK_DCC_7	281	290	PF00069	0.524
DOC_MAPK_gen_1	115	125	PF00069	0.502
DOC_MAPK_MEF2A_6	173	180	PF00069	0.499
DOC_MAPK_MEF2A_6	281	290	PF00069	0.524
DOC_MAPK_MEF2A_6	602	609	PF00069	0.591
DOC_MAPK_MEF2A_6	651	659	PF00069	0.591
DOC_MAPK_NFAT4_5	602	610	PF00069	0.591
DOC_MAPK_RevD_3	123	139	PF00069	0.630
DOC_PP1_RVXF_1	604	610	PF00149	0.591
DOC_PP2B_LxvP_1	140	143	PF13499	0.716
DOC_PP2B_LxvP_1	84	87	PF13499	0.742
DOC_PP2B_PxIxI_1	3	9	PF00149	0.745
DOC_PP4_FxxP_1	244	247	PF00568	0.741
DOC_PP4_MxPP_1	1	4	PF00568	0.747
DOC_USP7_MATH_1	127	131	PF00917	0.501
DOC_USP7_MATH_1	167	171	PF00917	0.590
DOC_USP7_MATH_1	238	242	PF00917	0.628
DOC_USP7_MATH_1	388	392	PF00917	0.782
DOC_USP7_MATH_1	394	398	PF00917	0.696
DOC_USP7_MATH_1	415	419	PF00917	0.772
DOC_USP7_MATH_1	439	443	PF00917	0.713
DOC_USP7_MATH_2	259	265	PF00917	0.527
DOC_WW_Pin1_4	123	128	PF00397	0.728
DOC_WW_Pin1_4	243	248	PF00397	0.741
DOC_WW_Pin1_4	250	255	PF00397	0.651
DOC_WW_Pin1_4	290	295	PF00397	0.761
DOC_WW_Pin1_4	305	310	PF00397	0.577
DOC_WW_Pin1_4	329	334	PF00397	0.726
DOC_WW_Pin1_4	343	348	PF00397	0.594
DOC_WW_Pin1_4	417	422	PF00397	0.758
DOC_WW_Pin1_4	59	64	PF00397	0.739
DOC_WW_Pin1_4	590	595	PF00397	0.591
DOC_WW_Pin1_4	641	646	PF00397	0.591
DOC_WW_Pin1_4	85	90	PF00397	0.727
LIG_14-3-3_CanoR_1	262	267	PF00244	0.527
LIG_14-3-3_CanoR_1	298	306	PF00244	0.551
LIG_14-3-3_CanoR_1	469	473	PF00244	0.522
LIG_14-3-3_CanoR_1	530	535	PF00244	0.708
LIG_14-3-3_CanoR_1	689	698	PF00244	0.591
LIG_Actin_WH2_2	498	516	PF00022	0.310
LIG_Actin_WH2_2	574	592	PF00022	0.517
LIG_APCC_ABBA_1	657	662	PF00400	0.591
LIG_BRCT_BRCA1_1	176	180	PF00533	0.501
LIG_BRCT_BRCA1_1	240	244	PF00533	0.751
LIG_BRCT_BRCA1_1	634	638	PF00533	0.591
LIG_BRCT_BRCA1_1	741	745	PF00533	0.564
LIG_EVH1_2	197	201	PF00568	0.487
LIG_FHA_1	102	108	PF00498	0.723
LIG_FHA_1	150	156	PF00498	0.734
LIG_FHA_1	266	272	PF00498	0.625
LIG_FHA_1	545	551	PF00498	0.576
LIG_FHA_1	573	579	PF00498	0.591
LIG_FHA_1	690	696	PF00498	0.591
LIG_FHA_2	231	237	PF00498	0.624
LIG_FHA_2	368	374	PF00498	0.759
LIG_FHA_2	659	665	PF00498	0.591
LIG_FHA_2	89	95	PF00498	0.729
LIG_FXI_DFP_1	745	749	PF00024	0.572
LIG_IRF3_LxIS_1	629	635	PF10401	0.591
LIG_LIR_Apic_2	241	247	PF02991	0.743
LIG_LIR_Apic_2	250	254	PF02991	0.624
LIG_LIR_Gen_1	230	240	PF02991	0.520
LIG_LIR_Gen_1	572	581	PF02991	0.591
LIG_LIR_Gen_1	635	645	PF02991	0.591
LIG_LIR_Gen_1	652	660	PF02991	0.591
LIG_LIR_Nem_3	230	235	PF02991	0.520
LIG_LIR_Nem_3	256	260	PF02991	0.655
LIG_LIR_Nem_3	572	576	PF02991	0.591
LIG_LIR_Nem_3	616	622	PF02991	0.633
LIG_LIR_Nem_3	635	641	PF02991	0.413
LIG_LIR_Nem_3	652	657	PF02991	0.591
LIG_LIR_Nem_3	742	748	PF02991	0.552
LIG_MYND_1	213	217	PF01753	0.718
LIG_PCNA_yPIPBox_3	231	244	PF02747	0.748
LIG_Pex14_1	528	532	PF04695	0.405
LIG_Pex14_2	323	327	PF04695	0.639
LIG_Pex14_2	95	99	PF04695	0.519
LIG_PTAP_UEV_1	429	434	PF05743	0.649
LIG_PTB_Apo_2	730	737	PF02174	0.544
LIG_Rb_pABgroove_1	603	611	PF01858	0.591
LIG_SH2_CRK	251	255	PF00017	0.746
LIG_SH2_CRK	573	577	PF00017	0.591
LIG_SH2_NCK_1	573	577	PF00017	0.591
LIG_SH2_PTP2	257	260	PF00017	0.530
LIG_SH2_SRC	257	260	PF00017	0.756
LIG_SH2_STAP1	573	577	PF00017	0.591
LIG_SH2_STAT3	491	494	PF00017	0.321
LIG_SH2_STAT5	257	260	PF00017	0.627
LIG_SH2_STAT5	474	477	PF00017	0.506
LIG_SH2_STAT5	491	494	PF00017	0.286
LIG_SH2_STAT5	577	580	PF00017	0.591
LIG_SH2_STAT5	622	625	PF00017	0.561
LIG_SH2_STAT5	698	701	PF00017	0.591
LIG_SH2_STAT5	705	708	PF00017	0.524
LIG_SH3_1	139	145	PF00018	0.722
LIG_SH3_1	419	425	PF00018	0.645
LIG_SH3_2	421	426	PF14604	0.745
LIG_SH3_3	139	145	PF00018	0.552
LIG_SH3_3	158	164	PF00018	0.481
LIG_SH3_3	191	197	PF00018	0.523
LIG_SH3_3	210	216	PF00018	0.694
LIG_SH3_3	418	424	PF00018	0.750
LIG_SH3_3	427	433	PF00018	0.638
LIG_SH3_3	438	444	PF00018	0.483
LIG_SH3_3	448	454	PF00018	0.585
LIG_SH3_3	639	645	PF00018	0.591
LIG_SH3_3	84	90	PF00018	0.730
LIG_SUMO_SIM_par_1	545	553	PF11976	0.523
LIG_SUMO_SIM_par_1	566	572	PF11976	0.577
LIG_TRAF2_1	14	17	PF00917	0.660
LIG_TRFH_1	638	642	PF08558	0.591
LIG_TYR_ITIM	696	701	PF00017	0.591
LIG_WRC_WIRS_1	203	208	PF05994	0.650
LIG_WW_2	213	216	PF00397	0.677
LIG_WW_3	332	336	PF00397	0.714
LIG_WW_3	423	427	PF00397	0.754
MOD_CDC14_SPxK_1	332	335	PF00782	0.708
MOD_CDC14_SPxK_1	593	596	PF00782	0.502
MOD_CDK_SPK_2	641	646	PF00069	0.429
MOD_CDK_SPxK_1	329	335	PF00069	0.715
MOD_CDK_SPxK_1	420	426	PF00069	0.748
MOD_CDK_SPxK_1	590	596	PF00069	0.502
MOD_CDK_SPxxK_3	59	66	PF00069	0.742
MOD_CK1_1	100	106	PF00069	0.724
MOD_CK1_1	11	17	PF00069	0.762
MOD_CK1_1	129	135	PF00069	0.629
MOD_CK1_1	189	195	PF00069	0.750
MOD_CK1_1	202	208	PF00069	0.577
MOD_CK1_1	239	245	PF00069	0.715
MOD_CK1_1	265	271	PF00069	0.625
MOD_CK1_1	293	299	PF00069	0.766
MOD_CK1_1	316	322	PF00069	0.549
MOD_CK1_1	33	39	PF00069	0.746
MOD_CK1_1	341	347	PF00069	0.755
MOD_CK1_1	367	373	PF00069	0.758
MOD_CK1_1	397	403	PF00069	0.775
MOD_CK1_1	420	426	PF00069	0.748
MOD_CK1_1	431	437	PF00069	0.600
MOD_CK1_1	71	77	PF00069	0.734
MOD_CK1_1	739	745	PF00069	0.566
MOD_CK2_1	11	17	PF00069	0.757
MOD_CK2_1	180	186	PF00069	0.511
MOD_CK2_1	261	267	PF00069	0.526
MOD_CK2_1	36	42	PF00069	0.523
MOD_CK2_1	367	373	PF00069	0.758
MOD_CK2_1	389	395	PF00069	0.780
MOD_CK2_1	88	94	PF00069	0.725
MOD_Cter_Amidation	670	673	PF01082	0.229
MOD_DYRK1A_RPxSP_1	59	63	PF00069	0.738
MOD_DYRK1A_RPxSP_1	590	594	PF00069	0.517
MOD_GlcNHglycan	10	13	PF01048	0.762
MOD_GlcNHglycan	119	122	PF01048	0.726
MOD_GlcNHglycan	152	155	PF01048	0.643
MOD_GlcNHglycan	169	172	PF01048	0.496
MOD_GlcNHglycan	186	191	PF01048	0.635
MOD_GlcNHglycan	318	321	PF01048	0.550
MOD_GlcNHglycan	358	361	PF01048	0.722
MOD_GlcNHglycan	386	389	PF01048	0.781
MOD_GlcNHglycan	391	394	PF01048	0.712
MOD_GlcNHglycan	395	399	PF01048	0.657
MOD_GlcNHglycan	430	433	PF01048	0.716
MOD_GlcNHglycan	436	439	PF01048	0.693
MOD_GlcNHglycan	441	444	PF01048	0.647
MOD_GlcNHglycan	73	76	PF01048	0.704
MOD_GSK3_1	123	130	PF00069	0.693
MOD_GSK3_1	174	181	PF00069	0.698
MOD_GSK3_1	204	211	PF00069	0.729
MOD_GSK3_1	238	245	PF00069	0.749
MOD_GSK3_1	261	268	PF00069	0.741
MOD_GSK3_1	293	300	PF00069	0.562
MOD_GSK3_1	30	37	PF00069	0.732
MOD_GSK3_1	305	312	PF00069	0.527
MOD_GSK3_1	337	344	PF00069	0.743
MOD_GSK3_1	384	391	PF00069	0.780
MOD_GSK3_1	44	51	PF00069	0.567
MOD_GSK3_1	464	471	PF00069	0.757
MOD_GSK3_1	658	665	PF00069	0.517
MOD_GSK3_1	66	73	PF00069	0.749
MOD_GSK3_1	737	744	PF00069	0.567
MOD_GSK3_1	97	104	PF00069	0.732
MOD_N-GLC_1	208	213	PF02516	0.747
MOD_N-GLC_1	236	241	PF02516	0.521
MOD_N-GLC_1	304	309	PF02516	0.552
MOD_N-GLC_1	383	388	PF02516	0.717
MOD_N-GLC_2	628	630	PF02516	0.391
MOD_N-GLC_2	77	79	PF02516	0.741
MOD_NEK2_1	148	153	PF00069	0.545
MOD_NEK2_1	178	183	PF00069	0.716
MOD_NEK2_1	266	271	PF00069	0.748
MOD_NEK2_1	297	302	PF00069	0.560
MOD_NEK2_1	304	309	PF00069	0.587
MOD_NEK2_1	34	39	PF00069	0.747
MOD_NEK2_1	472	477	PF00069	0.508
MOD_NEK2_1	632	637	PF00069	0.591
MOD_NEK2_1	736	741	PF00069	0.569
MOD_NEK2_2	276	281	PF00069	0.639
MOD_NEK2_2	349	354	PF00069	0.530
MOD_NEK2_2	649	654	PF00069	0.591
MOD_OFUCOSY	630	637	PF10250	0.391
MOD_PIKK_1	219	225	PF00454	0.665
MOD_PIKK_1	297	303	PF00454	0.567
MOD_PIKK_1	313	319	PF00454	0.627
MOD_PK_1	530	536	PF00069	0.660
MOD_PK_1	561	567	PF00069	0.591
MOD_PKA_1	262	268	PF00069	0.526
MOD_PKA_2	117	123	PF00069	0.530
MOD_PKA_2	261	267	PF00069	0.742
MOD_PKA_2	297	303	PF00069	0.546
MOD_PKA_2	468	474	PF00069	0.516
MOD_PKA_2	726	732	PF00069	0.405
MOD_PKA_2	736	742	PF00069	0.550
MOD_Plk_1	186	192	PF00069	0.644
MOD_Plk_1	236	242	PF00069	0.588
MOD_Plk_1	266	272	PF00069	0.522
MOD_Plk_1	373	379	PF00069	0.756
MOD_Plk_1	544	550	PF00069	0.383
MOD_Plk_1	97	103	PF00069	0.733
MOD_Plk_2-3	373	379	PF00069	0.756
MOD_Plk_4	239	245	PF00069	0.703
MOD_Plk_4	431	437	PF00069	0.624
MOD_Plk_4	572	578	PF00069	0.591
MOD_Plk_4	649	655	PF00069	0.591
MOD_ProDKin_1	123	129	PF00069	0.728
MOD_ProDKin_1	243	249	PF00069	0.740
MOD_ProDKin_1	250	256	PF00069	0.654
MOD_ProDKin_1	290	296	PF00069	0.760
MOD_ProDKin_1	305	311	PF00069	0.578
MOD_ProDKin_1	329	335	PF00069	0.728
MOD_ProDKin_1	343	349	PF00069	0.593
MOD_ProDKin_1	417	423	PF00069	0.759
MOD_ProDKin_1	59	65	PF00069	0.740
MOD_ProDKin_1	590	596	PF00069	0.591
MOD_ProDKin_1	641	647	PF00069	0.591
MOD_ProDKin_1	85	91	PF00069	0.727
TRG_ENDOCYTIC_2	257	260	PF00928	0.653
TRG_ENDOCYTIC_2	573	576	PF00928	0.591
TRG_ENDOCYTIC_2	698	701	PF00928	0.591
TRG_ER_diArg_1	138	140	PF00400	0.745
TRG_ER_diArg_1	519	522	PF00400	0.438
TRG_ER_diArg_1	526	528	PF00400	0.435
TRG_ER_diArg_1	56	59	PF00400	0.642
TRG_ER_diArg_1	672	674	PF00400	0.429
TRG_NES_CRM1_1	616	627	PF08389	0.591
TRG_NLS_MonoExtN_4	134	141	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	689	693	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5Q4	Leishmania donovani	84%	99%
A4I804	Leishmania infantum	84%	99%
Q4Q590	Leishmania major	83%	100%