Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2W3_LEIMU

TriTrypDb:

LmxM.31.1860

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2W3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.636
CLV_C14_Caspase3-7	159	163	PF00656	0.589
CLV_NRD_NRD_1	115	117	PF00675	0.623
CLV_NRD_NRD_1	262	264	PF00675	0.612
CLV_NRD_NRD_1	408	410	PF00675	0.641
CLV_PCSK_KEX2_1	115	117	PF00082	0.623
CLV_PCSK_KEX2_1	261	263	PF00082	0.615
CLV_PCSK_KEX2_1	408	410	PF00082	0.641
CLV_PCSK_SKI1_1	312	316	PF00082	0.534
CLV_PCSK_SKI1_1	358	362	PF00082	0.692
CLV_PCSK_SKI1_1	408	412	PF00082	0.455
CLV_PCSK_SKI1_1	81	85	PF00082	0.586
DEG_APCC_DBOX_1	311	319	PF00400	0.527
DEG_APCC_DBOX_1	357	365	PF00400	0.719
DEG_APCC_DBOX_1	94	102	PF00400	0.561
DEG_SCF_TRCP1_1	320	326	PF00400	0.612
DOC_ANK_TNKS_1	37	44	PF00023	0.548
DOC_CYCLIN_RxL_1	355	365	PF00134	0.718
DOC_CYCLIN_RxL_1	405	414	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.669
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.697
DOC_MAPK_MEF2A_6	367	374	PF00069	0.702
DOC_PP2B_LxvP_1	154	157	PF13499	0.662
DOC_PP2B_LxvP_1	24	27	PF13499	0.499
DOC_PP2B_LxvP_1	386	389	PF13499	0.620
DOC_PP4_FxxP_1	201	204	PF00568	0.703
DOC_PP4_FxxP_1	213	216	PF00568	0.697
DOC_PP4_FxxP_1	29	32	PF00568	0.546
DOC_PP4_FxxP_1	51	54	PF00568	0.643
DOC_USP7_MATH_1	135	139	PF00917	0.505
DOC_USP7_MATH_1	220	224	PF00917	0.797
DOC_USP7_MATH_1	231	235	PF00917	0.789
DOC_USP7_MATH_1	25	29	PF00917	0.579
DOC_USP7_MATH_1	283	287	PF00917	0.728
DOC_USP7_MATH_1	289	293	PF00917	0.779
DOC_USP7_MATH_1	346	350	PF00917	0.738
DOC_USP7_MATH_1	389	393	PF00917	0.699
DOC_WW_Pin1_4	261	266	PF00397	0.611
DOC_WW_Pin1_4	279	284	PF00397	0.757
DOC_WW_Pin1_4	293	298	PF00397	0.677
LIG_14-3-3_CanoR_1	115	123	PF00244	0.344
LIG_14-3-3_CanoR_1	186	192	PF00244	0.752
LIG_14-3-3_CanoR_1	312	318	PF00244	0.530
LIG_14-3-3_CanoR_1	81	86	PF00244	0.590
LIG_14-3-3_CanoR_1	95	105	PF00244	0.588
LIG_Actin_WH2_2	121	139	PF00022	0.695
LIG_ActinCP_TwfCPI_2	29	38	PF01115	0.556
LIG_APCC_ABBA_1	37	42	PF00400	0.670
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BRCT_BRCA1_1	391	395	PF00533	0.693
LIG_FHA_1	361	367	PF00498	0.727
LIG_FHA_1	77	83	PF00498	0.636
LIG_FHA_2	188	194	PF00498	0.734
LIG_FHA_2	82	88	PF00498	0.510
LIG_FXI_DFP_1	172	176	PF00024	0.676
LIG_Integrin_isoDGR_2	310	312	PF01839	0.529
LIG_LIR_Apic_2	199	204	PF02991	0.707
LIG_LIR_Apic_2	28	32	PF02991	0.586
LIG_LIR_Apic_2	50	54	PF02991	0.549
LIG_LIR_Gen_1	117	128	PF02991	0.401
LIG_LIR_Gen_1	190	197	PF02991	0.585
LIG_LIR_Nem_3	117	123	PF02991	0.570
LIG_LIR_Nem_3	173	178	PF02991	0.588
LIG_LIR_Nem_3	190	195	PF02991	0.704
LIG_LIR_Nem_3	6	12	PF02991	0.640
LIG_Pex14_2	171	175	PF04695	0.637
LIG_SH2_CRK	10	14	PF00017	0.599
LIG_SH2_NCK_1	347	351	PF00017	0.773
LIG_SH2_SRC	192	195	PF00017	0.685
LIG_SH2_STAP1	120	124	PF00017	0.395
LIG_SH2_STAP1	192	196	PF00017	0.688
LIG_SH2_STAP1	92	96	PF00017	0.529
LIG_SH3_1	179	185	PF00018	0.681
LIG_SH3_2	396	401	PF14604	0.629
LIG_SH3_3	179	185	PF00018	0.681
LIG_SH3_3	201	207	PF00018	0.710
LIG_SH3_3	393	399	PF00018	0.625
LIG_SH3_3	68	74	PF00018	0.582
LIG_SUMO_SIM_par_1	156	162	PF11976	0.633
LIG_SUMO_SIM_par_1	81	87	PF11976	0.470
LIG_TYR_ITSM	188	195	PF00017	0.734
LIG_UBA3_1	22	31	PF00899	0.334
LIG_WRC_WIRS_1	26	31	PF05994	0.575
LIG_WRC_WIRS_1	48	53	PF05994	0.553
MOD_CDC14_SPxK_1	282	285	PF00782	0.525
MOD_CDK_SPxK_1	279	285	PF00069	0.668
MOD_CDK_SPxxK_3	261	268	PF00069	0.439
MOD_CK1_1	187	193	PF00069	0.705
MOD_CK1_1	345	351	PF00069	0.748
MOD_CK2_1	230	236	PF00069	0.606
MOD_CK2_1	261	267	PF00069	0.659
MOD_GlcNHglycan	130	134	PF01048	0.576
MOD_GlcNHglycan	137	140	PF01048	0.572
MOD_GlcNHglycan	217	220	PF01048	0.776
MOD_GlcNHglycan	272	275	PF01048	0.701
MOD_GlcNHglycan	320	323	PF01048	0.734
MOD_GlcNHglycan	325	328	PF01048	0.748
MOD_GlcNHglycan	344	347	PF01048	0.531
MOD_GlcNHglycan	348	351	PF01048	0.589
MOD_GlcNHglycan	5	8	PF01048	0.710
MOD_GSK3_1	215	222	PF00069	0.702
MOD_GSK3_1	266	273	PF00069	0.694
MOD_GSK3_1	279	286	PF00069	0.715
MOD_GSK3_1	289	296	PF00069	0.653
MOD_GSK3_1	342	349	PF00069	0.785
MOD_NEK2_1	1	6	PF00069	0.680
MOD_NEK2_1	164	169	PF00069	0.668
MOD_NEK2_1	238	243	PF00069	0.463
MOD_NEK2_1	266	271	PF00069	0.584
MOD_NEK2_1	33	38	PF00069	0.594
MOD_NEK2_1	360	365	PF00069	0.763
MOD_NEK2_1	47	52	PF00069	0.610
MOD_NEK2_2	389	394	PF00069	0.750
MOD_NEK2_2	76	81	PF00069	0.622
MOD_PIKK_1	11	17	PF00454	0.622
MOD_PIKK_1	114	120	PF00454	0.547
MOD_PIKK_1	272	278	PF00454	0.737
MOD_PKA_2	114	120	PF00069	0.562
MOD_PKA_2	225	231	PF00069	0.790
MOD_PKB_1	268	276	PF00069	0.486
MOD_Plk_1	238	244	PF00069	0.638
MOD_Plk_1	266	272	PF00069	0.719
MOD_Plk_4	187	193	PF00069	0.735
MOD_Plk_4	304	310	PF00069	0.770
MOD_Plk_4	313	319	PF00069	0.681
MOD_Plk_4	47	53	PF00069	0.522
MOD_Plk_4	81	87	PF00069	0.513
MOD_Plk_4	97	103	PF00069	0.542
MOD_ProDKin_1	261	267	PF00069	0.613
MOD_ProDKin_1	279	285	PF00069	0.759
MOD_ProDKin_1	293	299	PF00069	0.677
MOD_SUMO_rev_2	36	45	PF00179	0.669
MOD_SUMO_rev_2	369	375	PF00179	0.706
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.725
TRG_ENDOCYTIC_2	120	123	PF00928	0.566
TRG_ENDOCYTIC_2	192	195	PF00928	0.685
TRG_ENDOCYTIC_2	9	12	PF00928	0.542
TRG_ER_diArg_1	260	263	PF00400	0.596
TRG_ER_diArg_1	268	271	PF00400	0.661
TRG_ER_diArg_1	408	410	PF00400	0.687
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I475	Leptomonas seymouri	57%	100%
A0A1X0NUD6	Trypanosomatidae	32%	100%
A0A3Q8IGT2	Leishmania donovani	86%	100%
A4I801	Leishmania infantum	86%	100%
Q4Q593	Leishmania major	85%	100%
V5BF21	Trypanosoma cruzi	27%	100%