LeishMANIAdb
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Protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase
Gene product:
protein kinase, putative
Species:
Leishmania mexicana
UniProt:
E9B2V8_LEIMU
TriTrypDb:
LmxM.31.1810
Length:
655

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 15
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 66
NetGPI no yes: 0, no: 66
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B2V8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2V8

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 67
GO:0006793 phosphorus metabolic process 3 67
GO:0006796 phosphate-containing compound metabolic process 4 67
GO:0006807 nitrogen compound metabolic process 2 67
GO:0008152 metabolic process 1 67
GO:0009987 cellular process 1 67
GO:0016310 phosphorylation 5 67
GO:0019538 protein metabolic process 3 67
GO:0036211 protein modification process 4 67
GO:0043170 macromolecule metabolic process 3 67
GO:0043412 macromolecule modification 4 67
GO:0044237 cellular metabolic process 2 67
GO:0044238 primary metabolic process 2 67
GO:0071704 organic substance metabolic process 2 67
GO:1901564 organonitrogen compound metabolic process 3 67
GO:0006996 organelle organization 4 1
GO:0016043 cellular component organization 3 1
GO:0032392 DNA geometric change 7 1
GO:0032508 DNA duplex unwinding 8 1
GO:0051276 chromosome organization 5 1
GO:0071103 DNA conformation change 6 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 67
GO:0003824 catalytic activity 1 67
GO:0004672 protein kinase activity 3 67
GO:0005488 binding 1 67
GO:0005524 ATP binding 5 67
GO:0016301 kinase activity 4 67
GO:0016740 transferase activity 2 67
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 67
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 67
GO:0017076 purine nucleotide binding 4 67
GO:0030554 adenyl nucleotide binding 5 67
GO:0032553 ribonucleotide binding 3 67
GO:0032555 purine ribonucleotide binding 4 67
GO:0032559 adenyl ribonucleotide binding 5 67
GO:0035639 purine ribonucleoside triphosphate binding 4 67
GO:0036094 small molecule binding 2 67
GO:0043167 ion binding 2 67
GO:0043168 anion binding 3 67
GO:0097159 organic cyclic compound binding 2 67
GO:0097367 carbohydrate derivative binding 2 67
GO:0140096 catalytic activity, acting on a protein 2 67
GO:1901265 nucleoside phosphate binding 3 67
GO:1901363 heterocyclic compound binding 2 67
GO:0004674 protein serine/threonine kinase activity 4 41
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 18 22 PF00656 0.435
CLV_C14_Caspase3-7 27 31 PF00656 0.453
CLV_NRD_NRD_1 256 258 PF00675 0.369
CLV_NRD_NRD_1 312 314 PF00675 0.293
CLV_NRD_NRD_1 394 396 PF00675 0.287
CLV_NRD_NRD_1 75 77 PF00675 0.472
CLV_PCSK_FUR_1 581 585 PF00082 0.352
CLV_PCSK_KEX2_1 162 164 PF00082 0.415
CLV_PCSK_KEX2_1 256 258 PF00082 0.401
CLV_PCSK_KEX2_1 312 314 PF00082 0.299
CLV_PCSK_KEX2_1 371 373 PF00082 0.269
CLV_PCSK_KEX2_1 394 396 PF00082 0.271
CLV_PCSK_KEX2_1 456 458 PF00082 0.315
CLV_PCSK_KEX2_1 529 531 PF00082 0.567
CLV_PCSK_KEX2_1 583 585 PF00082 0.316
CLV_PCSK_PC1ET2_1 162 164 PF00082 0.383
CLV_PCSK_PC1ET2_1 371 373 PF00082 0.324
CLV_PCSK_PC1ET2_1 456 458 PF00082 0.303
CLV_PCSK_PC1ET2_1 529 531 PF00082 0.556
CLV_PCSK_PC1ET2_1 583 585 PF00082 0.345
CLV_PCSK_PC7_1 252 258 PF00082 0.400
CLV_PCSK_SKI1_1 143 147 PF00082 0.368
CLV_PCSK_SKI1_1 266 270 PF00082 0.349
CLV_PCSK_SKI1_1 317 321 PF00082 0.289
CLV_PCSK_SKI1_1 329 333 PF00082 0.286
CLV_PCSK_SKI1_1 443 447 PF00082 0.280
CLV_PCSK_SKI1_1 530 534 PF00082 0.584
CLV_PCSK_SKI1_1 556 560 PF00082 0.287
CLV_PCSK_SKI1_1 583 587 PF00082 0.278
DEG_APCC_DBOX_1 442 450 PF00400 0.265
DEG_APCC_DBOX_1 583 591 PF00400 0.272
DOC_CKS1_1 357 362 PF01111 0.335
DOC_CYCLIN_RxL_1 553 564 PF00134 0.260
DOC_CYCLIN_yCln2_LP_2 357 363 PF00134 0.364
DOC_MAPK_gen_1 317 326 PF00069 0.294
DOC_MAPK_RevD_3 300 313 PF00069 0.313
DOC_PP4_FxxP_1 414 417 PF00568 0.339
DOC_PP4_FxxP_1 504 507 PF00568 0.497
DOC_USP7_MATH_1 203 207 PF00917 0.407
DOC_USP7_MATH_1 624 628 PF00917 0.402
DOC_USP7_MATH_2 396 402 PF00917 0.280
DOC_USP7_UBL2_3 371 375 PF12436 0.250
DOC_USP7_UBL2_3 452 456 PF12436 0.172
DOC_WW_Pin1_4 112 117 PF00397 0.660
DOC_WW_Pin1_4 356 361 PF00397 0.309
DOC_WW_Pin1_4 591 596 PF00397 0.323
DOC_WW_Pin1_4 607 612 PF00397 0.268
DOC_WW_Pin1_4 64 69 PF00397 0.497
LIG_14-3-3_CanoR_1 202 211 PF00244 0.421
LIG_14-3-3_CanoR_1 478 484 PF00244 0.319
LIG_14-3-3_CanoR_1 530 538 PF00244 0.517
LIG_14-3-3_CanoR_1 54 59 PF00244 0.607
LIG_14-3-3_CanoR_1 584 593 PF00244 0.341
LIG_Actin_RPEL_3 306 325 PF02755 0.398
LIG_APCC_ABBA_1 265 270 PF00400 0.172
LIG_APCC_ABBAyCdc20_2 312 318 PF00400 0.285
LIG_BIR_III_4 79 83 PF00653 0.461
LIG_BRCT_BRCA1_1 327 331 PF00533 0.310
LIG_BRCT_BRCA1_1 629 633 PF00533 0.310
LIG_BRCT_BRCA1_2 327 333 PF00533 0.310
LIG_EH1_1 297 305 PF00400 0.267
LIG_eIF4E_1 298 304 PF01652 0.300
LIG_EVH1_2 617 621 PF00568 0.398
LIG_FHA_1 21 27 PF00498 0.477
LIG_FHA_1 240 246 PF00498 0.239
LIG_FHA_1 562 568 PF00498 0.278
LIG_FHA_1 626 632 PF00498 0.448
LIG_FHA_2 16 22 PF00498 0.750
LIG_FHA_2 25 31 PF00498 0.451
LIG_FHA_2 289 295 PF00498 0.405
LIG_FHA_2 529 535 PF00498 0.540
LIG_Integrin_RGD_1 252 254 PF01839 0.147
LIG_LIR_Apic_2 359 365 PF02991 0.296
LIG_LIR_Apic_2 411 417 PF02991 0.349
LIG_LIR_Apic_2 612 618 PF02991 0.315
LIG_LIR_Gen_1 142 150 PF02991 0.471
LIG_LIR_Gen_1 222 231 PF02991 0.297
LIG_LIR_Gen_1 328 339 PF02991 0.259
LIG_LIR_Gen_1 555 565 PF02991 0.286
LIG_LIR_Nem_3 222 228 PF02991 0.273
LIG_LIR_Nem_3 328 334 PF02991 0.258
LIG_LIR_Nem_3 537 543 PF02991 0.358
LIG_LIR_Nem_3 555 560 PF02991 0.238
LIG_Pex14_1 553 557 PF04695 0.294
LIG_PTB_Apo_2 161 168 PF02174 0.391
LIG_PTB_Phospho_1 161 167 PF10480 0.388
LIG_SH2_CRK 615 619 PF00017 0.417
LIG_SH2_NCK_1 486 490 PF00017 0.488
LIG_SH2_PTP2 128 131 PF00017 0.495
LIG_SH2_SRC 479 482 PF00017 0.209
LIG_SH2_STAP1 167 171 PF00017 0.318
LIG_SH2_STAP1 231 235 PF00017 0.303
LIG_SH2_STAP1 343 347 PF00017 0.286
LIG_SH2_STAP1 387 391 PF00017 0.310
LIG_SH2_STAP1 486 490 PF00017 0.445
LIG_SH2_STAP1 619 623 PF00017 0.345
LIG_SH2_STAT3 298 301 PF00017 0.275
LIG_SH2_STAT5 128 131 PF00017 0.458
LIG_SH2_STAT5 144 147 PF00017 0.387
LIG_SH2_STAT5 159 162 PF00017 0.378
LIG_SH2_STAT5 194 197 PF00017 0.448
LIG_SH2_STAT5 234 237 PF00017 0.331
LIG_SH2_STAT5 24 27 PF00017 0.732
LIG_SH2_STAT5 298 301 PF00017 0.261
LIG_SH2_STAT5 362 365 PF00017 0.296
LIG_SH2_STAT5 472 475 PF00017 0.355
LIG_SH2_STAT5 479 482 PF00017 0.378
LIG_SH2_STAT5 503 506 PF00017 0.431
LIG_SH2_STAT5 557 560 PF00017 0.295
LIG_SH3_3 184 190 PF00018 0.596
LIG_SH3_3 414 420 PF00018 0.211
LIG_SUMO_SIM_anti_2 237 248 PF11976 0.271
LIG_SUMO_SIM_par_1 237 248 PF11976 0.282
LIG_SUMO_SIM_par_1 563 570 PF11976 0.370
LIG_TRAF2_1 459 462 PF00917 0.411
LIG_TRAF2_1 637 640 PF00917 0.230
LIG_TRFH_1 361 365 PF08558 0.287
LIG_TYR_ITIM 126 131 PF00017 0.535
LIG_TYR_ITIM 385 390 PF00017 0.332
LIG_UBA3_1 445 452 PF00899 0.268
LIG_UBA3_1 586 591 PF00899 0.303
MOD_CK1_1 105 111 PF00069 0.737
MOD_CK1_1 273 279 PF00069 0.433
MOD_CK1_1 345 351 PF00069 0.309
MOD_CK1_1 37 43 PF00069 0.759
MOD_CK1_1 482 488 PF00069 0.458
MOD_CK1_1 589 595 PF00069 0.300
MOD_CK1_1 627 633 PF00069 0.381
MOD_CK2_1 235 241 PF00069 0.398
MOD_CK2_1 288 294 PF00069 0.343
MOD_CK2_1 398 404 PF00069 0.352
MOD_CK2_1 456 462 PF00069 0.340
MOD_CK2_1 52 58 PF00069 0.574
MOD_CK2_1 528 534 PF00069 0.514
MOD_CK2_1 591 597 PF00069 0.330
MOD_CK2_1 634 640 PF00069 0.274
MOD_Cter_Amidation 369 372 PF01082 0.264
MOD_Cter_Amidation 373 376 PF01082 0.240
MOD_Cter_Amidation 392 395 PF01082 0.294
MOD_GlcNHglycan 104 107 PF01048 0.589
MOD_GlcNHglycan 262 265 PF01048 0.362
MOD_GlcNHglycan 309 312 PF01048 0.355
MOD_GlcNHglycan 320 323 PF01048 0.318
MOD_GlcNHglycan 36 39 PF01048 0.684
MOD_GlcNHglycan 422 425 PF01048 0.290
MOD_GlcNHglycan 458 461 PF01048 0.247
MOD_GlcNHglycan 636 639 PF01048 0.307
MOD_GSK3_1 100 107 PF00069 0.728
MOD_GSK3_1 15 22 PF00069 0.750
MOD_GSK3_1 235 242 PF00069 0.462
MOD_GSK3_1 24 31 PF00069 0.705
MOD_GSK3_1 270 277 PF00069 0.373
MOD_GSK3_1 342 349 PF00069 0.303
MOD_GSK3_1 352 359 PF00069 0.297
MOD_GSK3_1 415 422 PF00069 0.434
MOD_GSK3_1 53 60 PF00069 0.652
MOD_GSK3_1 530 537 PF00069 0.556
MOD_GSK3_1 561 568 PF00069 0.301
MOD_GSK3_1 585 592 PF00069 0.308
MOD_GSK3_1 625 632 PF00069 0.296
MOD_N-GLC_1 112 117 PF02516 0.711
MOD_N-GLC_1 260 265 PF02516 0.426
MOD_N-GLC_1 534 539 PF02516 0.359
MOD_N-GLC_2 100 102 PF02516 0.465
MOD_NEK2_1 219 224 PF00069 0.312
MOD_NEK2_1 325 330 PF00069 0.294
MOD_NEK2_1 337 342 PF00069 0.281
MOD_NEK2_1 397 402 PF00069 0.325
MOD_NEK2_1 5 10 PF00069 0.739
MOD_NEK2_1 560 565 PF00069 0.268
MOD_NEK2_1 586 591 PF00069 0.349
MOD_NEK2_1 625 630 PF00069 0.283
MOD_NMyristoyl 1 7 PF02799 0.588
MOD_PIKK_1 185 191 PF00454 0.589
MOD_PIKK_1 203 209 PF00454 0.354
MOD_PIKK_1 270 276 PF00454 0.379
MOD_PIKK_1 283 289 PF00454 0.300
MOD_PIKK_1 337 343 PF00454 0.306
MOD_PIKK_1 5 11 PF00454 0.703
MOD_PK_1 146 152 PF00069 0.525
MOD_PKA_1 456 462 PF00069 0.298
MOD_PKA_2 100 106 PF00069 0.552
MOD_PKA_2 456 462 PF00069 0.295
MOD_PKA_2 53 59 PF00069 0.559
MOD_Plk_1 20 26 PF00069 0.689
MOD_Plk_1 239 245 PF00069 0.280
MOD_Plk_1 260 266 PF00069 0.409
MOD_Plk_1 343 349 PF00069 0.255
MOD_Plk_1 397 403 PF00069 0.198
MOD_Plk_1 534 540 PF00069 0.489
MOD_Plk_2-3 398 404 PF00069 0.316
MOD_Plk_4 20 26 PF00069 0.689
MOD_Plk_4 239 245 PF00069 0.308
MOD_Plk_4 352 358 PF00069 0.280
MOD_Plk_4 479 485 PF00069 0.363
MOD_ProDKin_1 112 118 PF00069 0.658
MOD_ProDKin_1 356 362 PF00069 0.309
MOD_ProDKin_1 591 597 PF00069 0.323
MOD_ProDKin_1 607 613 PF00069 0.268
MOD_ProDKin_1 64 70 PF00069 0.496
TRG_DiLeu_BaEn_1 555 560 PF01217 0.323
TRG_ENDOCYTIC_2 128 131 PF00928 0.502
TRG_ENDOCYTIC_2 144 147 PF00928 0.474
TRG_ENDOCYTIC_2 387 390 PF00928 0.310
TRG_ENDOCYTIC_2 472 475 PF00928 0.341
TRG_ENDOCYTIC_2 540 543 PF00928 0.328
TRG_ENDOCYTIC_2 557 560 PF00928 0.300
TRG_ER_diArg_1 255 257 PF00400 0.373
TRG_ER_diArg_1 312 314 PF00400 0.284
TRG_ER_diArg_1 394 396 PF00400 0.303
TRG_NES_CRM1_1 639 655 PF08389 0.220
TRG_Pf-PMV_PEXEL_1 556 561 PF00026 0.351
TRG_Pf-PMV_PEXEL_1 650 655 PF00026 0.549

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P953 Leptomonas seymouri 29% 100%
A0A0N1I9A0 Leptomonas seymouri 67% 100%
A0A0N1PD05 Leptomonas seymouri 32% 100%
A0A0S4IMB7 Bodo saltans 35% 100%
A0A0S4IRZ7 Bodo saltans 40% 100%
A0A0S4J804 Bodo saltans 32% 100%
A0A0S4JPZ1 Bodo saltans 28% 100%
A0A1X0NIX2 Trypanosomatidae 29% 100%
A0A1X0NUB2 Trypanosomatidae 47% 100%
A0A1X0P527 Trypanosomatidae 31% 100%
A0A1X0P549 Trypanosomatidae 30% 100%
A0A1X0P863 Trypanosomatidae 31% 100%
A0A1X0P8W3 Trypanosomatidae 25% 88%
A0A1X0P994 Trypanosomatidae 30% 100%
A0A3Q8IFK8 Leishmania donovani 31% 100%
A0A3Q8IHH8 Leishmania donovani 30% 100%
A0A3Q8IIH5 Leishmania donovani 26% 100%
A0A3Q8IJM9 Leishmania donovani 31% 100%
A0A3R7MKG5 Trypanosoma rangeli 28% 100%
A0A3S7X5M4 Leishmania donovani 91% 100%
A0A3S7X6T8 Leishmania donovani 34% 100%
A0A3S7XAL3 Leishmania donovani 30% 100%
A0A3S7XAT9 Leishmania donovani 31% 100%
A0A422NCP0 Trypanosoma rangeli 31% 100%
A0A422NH41 Trypanosoma rangeli 45% 100%
A4HHQ5 Leishmania braziliensis 31% 100%
A4HJT5 Leishmania braziliensis 31% 100%
A4HKG9 Leishmania braziliensis 73% 100%
A4HLR0 Leishmania braziliensis 34% 100%
A4HNI1 Leishmania braziliensis 28% 100%
A4HP12 Leishmania braziliensis 30% 100%
A4HP13 Leishmania braziliensis 30% 100%
A4HW88 Leishmania infantum 26% 100%
A4I4X0 Leishmania infantum 30% 100%
A4I7A1 Leishmania infantum 31% 100%
A4I7Z6 Leishmania infantum 91% 100%
A4I960 Leishmania infantum 34% 100%
A4IC37 Leishmania infantum 31% 100%
A4IDC1 Leishmania infantum 30% 100%
A4IDC2 Leishmania infantum 30% 100%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
D0A118 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 86%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AEB9 Leishmania major 31% 100%
E9AFZ2 Leishmania major 31% 100%
E9ALG7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AT06 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
O14427 Candida albicans 23% 67%
Q4Q1S3 Leishmania major 30% 100%
Q4Q1S4 Leishmania major 30% 100%
Q4Q3Y9 Leishmania major 32% 86%
Q4Q598 Leishmania major 88% 100%
Q4Q5W2 Leishmania major 32% 100%
Q5APR8 Candida albicans (strain SC5314 / ATCC MYA-2876) 23% 67%
V5BC28 Trypanosoma cruzi 28% 100%
V5BPJ0 Trypanosoma cruzi 32% 100%
V5D7G4 Trypanosoma cruzi 30% 79%
V5DFW9 Trypanosoma cruzi 45% 100%
V5DKY9 Trypanosoma cruzi 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS