F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2V7_LEIMU

TriTrypDb:

LmxM.31.1802

Length:

153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2V7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.585
CLV_C14_Caspase3-7	67	71	PF00656	0.658
CLV_NRD_NRD_1	148	150	PF00675	0.625
CLV_NRD_NRD_1	5	7	PF00675	0.654
CLV_PCSK_KEX2_1	150	152	PF00082	0.553
CLV_PCSK_KEX2_1	5	7	PF00082	0.654
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.553
CLV_PCSK_SKI1_1	13	17	PF00082	0.696
DEG_SPOP_SBC_1	80	84	PF00917	0.638
DOC_USP7_MATH_1	4	8	PF00917	0.665
DOC_USP7_MATH_1	80	84	PF00917	0.658
DOC_USP7_UBL2_3	146	150	PF12436	0.603
LIG_14-3-3_CanoR_1	96	106	PF00244	0.679
LIG_APCC_ABBA_1	34	39	PF00400	0.545
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	106	110	PF00533	0.639
LIG_FHA_2	48	54	PF00498	0.754
LIG_FHA_2	62	68	PF00498	0.693
LIG_LIR_Nem_3	107	113	PF02991	0.619
LIG_NRP_CendR_1	150	153	PF00754	0.666
LIG_PCNA_PIPBox_1	121	130	PF02747	0.483
LIG_Pex14_1	28	32	PF04695	0.565
LIG_PTB_Apo_2	126	133	PF02174	0.487
LIG_SH2_NCK_1	20	24	PF00017	0.639
LIG_SH2_STAT5	32	35	PF00017	0.558
LIG_WRC_WIRS_1	124	129	PF05994	0.530
MOD_CK1_1	100	106	PF00069	0.727
MOD_CK1_1	109	115	PF00069	0.485
MOD_CK1_1	141	147	PF00069	0.595
MOD_CK1_1	60	66	PF00069	0.622
MOD_CK1_1	79	85	PF00069	0.595
MOD_CK2_1	47	53	PF00069	0.609
MOD_CK2_1	61	67	PF00069	0.675
MOD_GlcNHglycan	141	144	PF01048	0.634
MOD_GlcNHglycan	2	5	PF01048	0.596
MOD_GlcNHglycan	78	81	PF01048	0.622
MOD_GlcNHglycan	99	102	PF01048	0.575
MOD_GSK3_1	100	107	PF00069	0.637
MOD_GSK3_1	47	54	PF00069	0.518
MOD_GSK3_1	57	64	PF00069	0.637
MOD_GSK3_1	76	83	PF00069	0.566
MOD_NEK2_1	106	111	PF00069	0.459
MOD_NEK2_1	123	128	PF00069	0.520
MOD_PIKK_1	51	57	PF00454	0.656
MOD_PKA_2	139	145	PF00069	0.584
MOD_PKA_2	4	10	PF00069	0.708
MOD_PKA_2	95	101	PF00069	0.690
MOD_Plk_1	57	63	PF00069	0.659
MOD_Plk_4	123	129	PF00069	0.549
MOD_Plk_4	57	63	PF00069	0.625
MOD_SUMO_for_1	101	104	PF00179	0.601
TRG_DiLeu_BaEn_2	132	138	PF01217	0.510
TRG_ER_diArg_1	5	8	PF00400	0.702
TRG_NLS_MonoExtC_3	148	153	PF00514	0.670
TRG_NLS_MonoExtN_4	146	153	PF00514	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P974	Leptomonas seymouri	47%	100%
A0A1X0NT35	Trypanosomatidae	32%	90%
A0A3S7X5K4	Leishmania donovani	90%	100%
A0A422NH51	Trypanosoma rangeli	32%	95%
A4HKG8	Leishmania braziliensis	73%	100%
A4I7Z5	Leishmania infantum	89%	100%
D0AA62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	97%
Q4Q599	Leishmania major	88%	100%