WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2V5_LEIMU

TriTrypDb:

LmxM.31.1790

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2V5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.536
CLV_C14_Caspase3-7	577	581	PF00656	0.419
CLV_NRD_NRD_1	118	120	PF00675	0.534
CLV_NRD_NRD_1	393	395	PF00675	0.260
CLV_NRD_NRD_1	460	462	PF00675	0.304
CLV_NRD_NRD_1	608	610	PF00675	0.529
CLV_PCSK_KEX2_1	118	120	PF00082	0.534
CLV_PCSK_KEX2_1	393	395	PF00082	0.260
CLV_PCSK_KEX2_1	459	461	PF00082	0.314
CLV_PCSK_SKI1_1	100	104	PF00082	0.302
CLV_PCSK_SKI1_1	23	27	PF00082	0.381
CLV_PCSK_SKI1_1	252	256	PF00082	0.439
CLV_PCSK_SKI1_1	284	288	PF00082	0.470
CLV_PCSK_SKI1_1	45	49	PF00082	0.398
CLV_PCSK_SKI1_1	461	465	PF00082	0.324
CLV_PCSK_SKI1_1	610	614	PF00082	0.633
DEG_APCC_DBOX_1	22	30	PF00400	0.360
DEG_APCC_DBOX_1	482	490	PF00400	0.355
DEG_ODPH_VHL_1	7	20	PF01847	0.343
DOC_CKS1_1	342	347	PF01111	0.384
DOC_CYCLIN_RxL_1	281	291	PF00134	0.514
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.431
DOC_MAPK_gen_1	249	258	PF00069	0.434
DOC_MAPK_gen_1	393	400	PF00069	0.272
DOC_MAPK_gen_1	459	466	PF00069	0.341
DOC_MAPK_HePTP_8	115	130	PF00069	0.287
DOC_MAPK_HePTP_8	184	196	PF00069	0.442
DOC_MAPK_MEF2A_6	119	128	PF00069	0.503
DOC_MAPK_MEF2A_6	187	196	PF00069	0.450
DOC_PP2B_LxvP_1	242	245	PF13499	0.496
DOC_PP2B_LxvP_1	29	32	PF13499	0.474
DOC_PP2B_LxvP_1	371	374	PF13499	0.412
DOC_PP2B_LxvP_1	539	542	PF13499	0.479
DOC_PP2B_LxvP_1	7	10	PF13499	0.453
DOC_PP4_FxxP_1	110	113	PF00568	0.378
DOC_PP4_FxxP_1	342	345	PF00568	0.358
DOC_USP7_MATH_1	245	249	PF00917	0.416
DOC_USP7_MATH_1	254	258	PF00917	0.512
DOC_USP7_MATH_1	269	273	PF00917	0.570
DOC_USP7_MATH_1	289	293	PF00917	0.440
DOC_USP7_MATH_1	297	301	PF00917	0.647
DOC_USP7_MATH_1	38	42	PF00917	0.283
DOC_WW_Pin1_4	262	267	PF00397	0.708
DOC_WW_Pin1_4	341	346	PF00397	0.372
DOC_WW_Pin1_4	413	418	PF00397	0.411
DOC_WW_Pin1_4	449	454	PF00397	0.279
DOC_WW_Pin1_4	550	555	PF00397	0.568
DOC_WW_Pin1_4	56	61	PF00397	0.442
DOC_WW_Pin1_4	569	574	PF00397	0.417
LIG_14-3-3_CanoR_1	100	105	PF00244	0.455
LIG_14-3-3_CanoR_1	106	113	PF00244	0.465
LIG_14-3-3_CanoR_1	282	287	PF00244	0.532
LIG_14-3-3_CanoR_1	461	467	PF00244	0.369
LIG_14-3-3_CanoR_1	483	487	PF00244	0.346
LIG_14-3-3_CanoR_1	540	546	PF00244	0.379
LIG_14-3-3_CanoR_1	609	619	PF00244	0.403
LIG_ActinCP_TwfCPI_2	110	119	PF01115	0.367
LIG_APCC_ABBA_1	442	447	PF00400	0.360
LIG_APCC_ABBA_1	70	75	PF00400	0.414
LIG_APCC_ABBAyCdc20_2	284	290	PF00400	0.393
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_CtBP_PxDLS_1	374	378	PF00389	0.419
LIG_deltaCOP1_diTrp_1	104	110	PF00928	0.379
LIG_deltaCOP1_diTrp_1	519	526	PF00928	0.424
LIG_FHA_1	145	151	PF00498	0.605
LIG_FHA_1	164	170	PF00498	0.476
LIG_FHA_1	35	41	PF00498	0.258
LIG_FHA_1	358	364	PF00498	0.423
LIG_FHA_1	49	55	PF00498	0.260
LIG_FHA_1	611	617	PF00498	0.593
LIG_FHA_2	153	159	PF00498	0.394
LIG_FHA_2	342	348	PF00498	0.383
LIG_FHA_2	515	521	PF00498	0.482
LIG_FHA_2	575	581	PF00498	0.369
LIG_GBD_Chelix_1	18	26	PF00786	0.409
LIG_LIR_Apic_2	108	113	PF02991	0.371
LIG_LIR_Apic_2	340	345	PF02991	0.352
LIG_LIR_Apic_2	529	535	PF02991	0.487
LIG_LIR_Gen_1	104	115	PF02991	0.410
LIG_LIR_Gen_1	131	140	PF02991	0.364
LIG_LIR_Gen_1	519	528	PF02991	0.457
LIG_LIR_Nem_3	104	110	PF02991	0.399
LIG_LIR_Nem_3	138	143	PF02991	0.367
LIG_LIR_Nem_3	41	47	PF02991	0.330
LIG_LIR_Nem_3	519	524	PF02991	0.383
LIG_LYPXL_S_1	565	569	PF13949	0.431
LIG_LYPXL_yS_3	566	569	PF13949	0.438
LIG_MYND_3	71	75	PF01753	0.368
LIG_NRBOX	485	491	PF00104	0.380
LIG_PCNA_PIPBox_1	221	230	PF02747	0.474
LIG_PCNA_PIPBox_1	392	401	PF02747	0.365
LIG_PCNA_yPIPBox_3	385	399	PF02747	0.364
LIG_PCNA_yPIPBox_3	488	501	PF02747	0.516
LIG_PDZ_Class_2	616	621	PF00595	0.316
LIG_Pex14_1	521	525	PF04695	0.470
LIG_Pex14_2	140	144	PF04695	0.352
LIG_SH2_CRK	420	424	PF00017	0.459
LIG_SH2_PTP2	561	564	PF00017	0.323
LIG_SH2_SRC	561	564	PF00017	0.432
LIG_SH2_SRC	73	76	PF00017	0.482
LIG_SH2_STAP1	321	325	PF00017	0.369
LIG_SH2_STAT3	422	425	PF00017	0.444
LIG_SH2_STAT5	405	408	PF00017	0.380
LIG_SH2_STAT5	422	425	PF00017	0.405
LIG_SH2_STAT5	440	443	PF00017	0.246
LIG_SH2_STAT5	506	509	PF00017	0.627
LIG_SH2_STAT5	561	564	PF00017	0.383
LIG_SH2_STAT5	589	592	PF00017	0.346
LIG_SH2_STAT5	605	608	PF00017	0.395
LIG_SH2_STAT5	73	76	PF00017	0.489
LIG_SH3_3	147	153	PF00018	0.556
LIG_SH3_3	189	195	PF00018	0.395
LIG_SH3_3	44	50	PF00018	0.407
LIG_SH3_3	561	567	PF00018	0.477
LIG_SUMO_SIM_anti_2	360	366	PF11976	0.422
LIG_SUMO_SIM_par_1	335	340	PF11976	0.460
LIG_SUMO_SIM_par_1	359	366	PF11976	0.422
LIG_TRAF2_1	139	142	PF00917	0.529
LIG_TRAF2_1	155	158	PF00917	0.525
LIG_TRAF2_1	517	520	PF00917	0.462
LIG_TRAF2_1	66	69	PF00917	0.431
LIG_TYR_ITIM	418	423	PF00017	0.334
LIG_UBA3_1	311	318	PF00899	0.378
LIG_UBA3_1	602	610	PF00899	0.416
LIG_WRC_WIRS_1	130	135	PF05994	0.392
LIG_WRC_WIRS_1	137	142	PF05994	0.307
MOD_CK1_1	171	177	PF00069	0.470
MOD_CK1_1	265	271	PF00069	0.701
MOD_CK1_1	272	278	PF00069	0.656
MOD_CK1_1	479	485	PF00069	0.380
MOD_CK2_1	135	141	PF00069	0.395
MOD_CK2_1	152	158	PF00069	0.424
MOD_CK2_1	171	177	PF00069	0.537
MOD_CK2_1	341	347	PF00069	0.378
MOD_CK2_1	507	513	PF00069	0.556
MOD_CK2_1	514	520	PF00069	0.412
MOD_CK2_1	63	69	PF00069	0.486
MOD_GlcNHglycan	267	270	PF01048	0.715
MOD_GlcNHglycan	272	275	PF01048	0.699
MOD_GlcNHglycan	278	281	PF01048	0.486
MOD_GlcNHglycan	290	294	PF01048	0.326
MOD_GlcNHglycan	300	303	PF01048	0.632
MOD_GlcNHglycan	365	368	PF01048	0.301
MOD_GlcNHglycan	502	505	PF01048	0.440
MOD_GlcNHglycan	509	512	PF01048	0.580
MOD_GlcNHglycan	548	551	PF01048	0.510
MOD_GSK3_1	265	272	PF00069	0.749
MOD_GSK3_1	34	41	PF00069	0.327
MOD_GSK3_1	478	485	PF00069	0.413
MOD_GSK3_1	546	553	PF00069	0.631
MOD_GSK3_1	574	581	PF00069	0.422
MOD_GSK3_1	85	92	PF00069	0.390
MOD_N-GLC_1	375	380	PF02516	0.209
MOD_N-GLC_2	231	233	PF02516	0.372
MOD_N-GLC_2	331	333	PF02516	0.416
MOD_NEK2_1	144	149	PF00069	0.376
MOD_NEK2_1	377	382	PF00069	0.404
MOD_NEK2_1	478	483	PF00069	0.456
MOD_NEK2_1	85	90	PF00069	0.365
MOD_NEK2_2	310	315	PF00069	0.249
MOD_NEK2_2	462	467	PF00069	0.328
MOD_PIKK_1	152	158	PF00454	0.410
MOD_PIKK_1	217	223	PF00454	0.343
MOD_PIKK_1	24	30	PF00454	0.457
MOD_PIKK_1	375	381	PF00454	0.208
MOD_PKA_1	393	399	PF00069	0.390
MOD_PKA_2	105	111	PF00069	0.334
MOD_PKA_2	393	399	PF00069	0.420
MOD_PKA_2	482	488	PF00069	0.335
MOD_PKA_2	80	86	PF00069	0.478
MOD_Plk_1	2	8	PF00069	0.525
MOD_Plk_1	401	407	PF00069	0.311
MOD_Plk_1	428	434	PF00069	0.405
MOD_Plk_1	582	588	PF00069	0.536
MOD_Plk_2-3	578	584	PF00069	0.487
MOD_Plk_4	202	208	PF00069	0.332
MOD_Plk_4	214	220	PF00069	0.347
MOD_Plk_4	310	316	PF00069	0.493
MOD_Plk_4	401	407	PF00069	0.433
MOD_Plk_4	428	434	PF00069	0.396
MOD_ProDKin_1	262	268	PF00069	0.708
MOD_ProDKin_1	341	347	PF00069	0.378
MOD_ProDKin_1	413	419	PF00069	0.405
MOD_ProDKin_1	449	455	PF00069	0.272
MOD_ProDKin_1	550	556	PF00069	0.557
MOD_ProDKin_1	56	62	PF00069	0.428
MOD_ProDKin_1	569	575	PF00069	0.412
MOD_SUMO_rev_2	247	257	PF00179	0.742
MOD_SUMO_rev_2	259	263	PF00179	0.643
MOD_SUMO_rev_2	591	599	PF00179	0.498
TRG_DiLeu_BaEn_4	177	183	PF01217	0.425
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.256
TRG_DiLeu_BaLyEn_6	485	490	PF01217	0.428
TRG_ENDOCYTIC_2	321	324	PF00928	0.350
TRG_ENDOCYTIC_2	420	423	PF00928	0.341
TRG_ENDOCYTIC_2	525	528	PF00928	0.355
TRG_ENDOCYTIC_2	561	564	PF00928	0.432
TRG_ENDOCYTIC_2	566	569	PF00928	0.447
TRG_ENDOCYTIC_2	589	592	PF00928	0.356
TRG_ER_diArg_1	117	119	PF00400	0.509
TRG_ER_diArg_1	281	284	PF00400	0.412
TRG_ER_diArg_1	393	395	PF00400	0.260
TRG_ER_diArg_1	458	461	PF00400	0.317
TRG_ER_diArg_1	606	609	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G9	Leptomonas seymouri	62%	98%
A0A0S4IM38	Bodo saltans	37%	100%
A0A1X0NUS4	Trypanosomatidae	42%	100%
A0A3Q8ID57	Leishmania donovani	89%	100%
A0A422NH67	Trypanosoma rangeli	43%	100%
A4HKG6	Leishmania braziliensis	80%	100%
D0AA61	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q5A1	Leishmania major	88%	100%