Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2V2_LEIMU

TriTrypDb:

LmxM.31.1760

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2V2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.654
CLV_C14_Caspase3-7	455	459	PF00656	0.491
CLV_NRD_NRD_1	205	207	PF00675	0.627
CLV_NRD_NRD_1	306	308	PF00675	0.439
CLV_NRD_NRD_1	351	353	PF00675	0.505
CLV_PCSK_FUR_1	304	308	PF00082	0.370
CLV_PCSK_FUR_1	352	356	PF00082	0.569
CLV_PCSK_KEX2_1	118	120	PF00082	0.487
CLV_PCSK_KEX2_1	205	207	PF00082	0.627
CLV_PCSK_KEX2_1	306	308	PF00082	0.439
CLV_PCSK_KEX2_1	354	356	PF00082	0.570
CLV_PCSK_KEX2_1	491	493	PF00082	0.517
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.462
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.570
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.517
CLV_PCSK_PC7_1	114	120	PF00082	0.460
CLV_PCSK_PC7_1	350	356	PF00082	0.565
CLV_PCSK_SKI1_1	217	221	PF00082	0.695
CLV_PCSK_SKI1_1	371	375	PF00082	0.637
CLV_PCSK_SKI1_1	471	475	PF00082	0.593
DEG_APCC_DBOX_1	233	241	PF00400	0.590
DEG_APCC_KENBOX_2	180	184	PF00400	0.424
DEG_Nend_UBRbox_1	1	4	PF02207	0.592
DEG_SPOP_SBC_1	431	435	PF00917	0.655
DOC_ANK_TNKS_1	335	342	PF00023	0.445
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.450
DOC_MAPK_gen_1	23	31	PF00069	0.456
DOC_MAPK_gen_1	304	312	PF00069	0.391
DOC_MAPK_gen_1	376	385	PF00069	0.524
DOC_MAPK_MEF2A_6	142	151	PF00069	0.430
DOC_PP2B_LxvP_1	383	386	PF13499	0.490
DOC_USP7_MATH_1	230	234	PF00917	0.597
DOC_USP7_MATH_1	24	28	PF00917	0.633
DOC_USP7_MATH_1	388	392	PF00917	0.669
DOC_USP7_MATH_1	431	435	PF00917	0.680
DOC_USP7_UBL2_3	370	374	PF12436	0.557
DOC_WW_Pin1_4	11	16	PF00397	0.635
DOC_WW_Pin1_4	427	432	PF00397	0.673
DOC_WW_Pin1_4	440	445	PF00397	0.588
LIG_14-3-3_CanoR_1	200	204	PF00244	0.438
LIG_14-3-3_CanoR_1	248	257	PF00244	0.559
LIG_14-3-3_CanoR_1	366	373	PF00244	0.422
LIG_14-3-3_CanoR_1	432	442	PF00244	0.608
LIG_Actin_WH2_2	457	473	PF00022	0.522
LIG_APCC_ABBA_1	136	141	PF00400	0.438
LIG_BIR_III_2	410	414	PF00653	0.506
LIG_BRCT_BRCA1_1	27	31	PF00533	0.629
LIG_Clathr_ClatBox_1	146	150	PF01394	0.481
LIG_EH1_1	30	38	PF00400	0.582
LIG_FHA_1	11	17	PF00498	0.477
LIG_FHA_1	249	255	PF00498	0.537
LIG_FHA_1	273	279	PF00498	0.675
LIG_FHA_1	472	478	PF00498	0.581
LIG_FHA_1	87	93	PF00498	0.378
LIG_FHA_2	333	339	PF00498	0.410
LIG_FHA_2	405	411	PF00498	0.530
LIG_FHA_2	435	441	PF00498	0.656
LIG_FHA_2	453	459	PF00498	0.616
LIG_FHA_2	476	482	PF00498	0.548
LIG_LIR_Gen_1	150	159	PF02991	0.489
LIG_LIR_Gen_1	297	308	PF02991	0.480
LIG_LIR_Gen_1	466	477	PF02991	0.643
LIG_LIR_Gen_1	54	64	PF02991	0.523
LIG_LIR_Gen_1	85	96	PF02991	0.485
LIG_LIR_Nem_3	150	154	PF02991	0.491
LIG_LIR_Nem_3	297	303	PF02991	0.480
LIG_LIR_Nem_3	440	445	PF02991	0.581
LIG_LIR_Nem_3	466	472	PF02991	0.647
LIG_LIR_Nem_3	54	60	PF02991	0.534
LIG_LIR_Nem_3	85	91	PF02991	0.487
LIG_NRBOX	236	242	PF00104	0.642
LIG_Pex14_2	57	61	PF04695	0.525
LIG_SH2_NCK_1	162	166	PF00017	0.322
LIG_SH2_STAP1	162	166	PF00017	0.322
LIG_SH2_STAT3	236	239	PF00017	0.583
LIG_SH2_STAT3	343	346	PF00017	0.541
LIG_SH2_STAT5	236	239	PF00017	0.507
LIG_SH2_STAT5	469	472	PF00017	0.598
LIG_SH3_3	382	388	PF00018	0.513
LIG_Sin3_3	109	116	PF02671	0.530
LIG_SUMO_SIM_par_1	145	150	PF11976	0.378
LIG_SUMO_SIM_par_1	255	260	PF11976	0.539
LIG_SUMO_SIM_par_1	308	314	PF11976	0.420
LIG_TRAF2_1	194	197	PF00917	0.400
LIG_TRAF2_1	344	347	PF00917	0.637
LIG_TRAF2_1	71	74	PF00917	0.517
LIG_TRAF2_1	82	85	PF00917	0.369
LIG_TYR_ITIM	467	472	PF00017	0.527
LIG_UBA3_1	126	132	PF00899	0.512
MOD_CDK_SPK_2	427	432	PF00069	0.584
MOD_CDK_SPxxK_3	440	447	PF00069	0.508
MOD_CK1_1	199	205	PF00069	0.526
MOD_CK1_1	244	250	PF00069	0.653
MOD_CK1_1	27	33	PF00069	0.485
MOD_CK1_1	400	406	PF00069	0.635
MOD_CK1_1	430	436	PF00069	0.645
MOD_CK1_1	443	449	PF00069	0.586
MOD_CK2_1	332	338	PF00069	0.413
MOD_CK2_1	475	481	PF00069	0.496
MOD_CK2_1	68	74	PF00069	0.523
MOD_Cter_Amidation	304	307	PF01082	0.349
MOD_GlcNHglycan	356	360	PF01048	0.521
MOD_GlcNHglycan	38	41	PF01048	0.500
MOD_GlcNHglycan	402	405	PF01048	0.533
MOD_GlcNHglycan	486	489	PF01048	0.534
MOD_GlcNHglycan	70	73	PF01048	0.634
MOD_GlcNHglycan	8	11	PF01048	0.599
MOD_GSK3_1	201	208	PF00069	0.432
MOD_GSK3_1	225	232	PF00069	0.585
MOD_GSK3_1	243	250	PF00069	0.686
MOD_GSK3_1	272	279	PF00069	0.667
MOD_GSK3_1	400	407	PF00069	0.730
MOD_GSK3_1	427	434	PF00069	0.640
MOD_GSK3_1	471	478	PF00069	0.584
MOD_GSK3_1	6	13	PF00069	0.475
MOD_N-GLC_1	440	445	PF02516	0.577
MOD_NEK2_1	201	206	PF00069	0.510
MOD_NEK2_1	213	218	PF00069	0.644
MOD_NEK2_1	241	246	PF00069	0.578
MOD_NEK2_1	257	262	PF00069	0.506
MOD_NEK2_1	272	277	PF00069	0.701
MOD_NEK2_1	332	337	PF00069	0.398
MOD_NEK2_1	36	41	PF00069	0.482
MOD_PIKK_1	365	371	PF00454	0.426
MOD_PKA_1	205	211	PF00069	0.607
MOD_PKA_2	199	205	PF00069	0.527
MOD_PKA_2	225	231	PF00069	0.578
MOD_PKA_2	247	253	PF00069	0.662
MOD_PKA_2	365	371	PF00069	0.426
MOD_PKA_2	431	437	PF00069	0.637
MOD_Plk_1	196	202	PF00069	0.573
MOD_ProDKin_1	11	17	PF00069	0.636
MOD_ProDKin_1	427	433	PF00069	0.674
MOD_ProDKin_1	440	446	PF00069	0.587
MOD_SUMO_for_1	490	493	PF00179	0.465
TRG_DiLeu_BaEn_1	107	112	PF01217	0.515
TRG_DiLeu_BaEn_1	150	155	PF01217	0.491
TRG_DiLeu_BaEn_3	121	127	PF01217	0.411
TRG_DiLeu_BaEn_4	168	174	PF01217	0.378
TRG_DiLeu_BaEn_4	196	202	PF01217	0.391
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.543
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.528
TRG_ENDOCYTIC_2	162	165	PF00928	0.321
TRG_ENDOCYTIC_2	300	303	PF00928	0.594
TRG_ENDOCYTIC_2	469	472	PF00928	0.598
TRG_ER_diArg_1	289	292	PF00400	0.460
TRG_ER_diArg_1	303	306	PF00400	0.450
TRG_ER_diArg_1	378	381	PF00400	0.636
TRG_NES_CRM1_1	124	140	PF08389	0.454
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW1	Leptomonas seymouri	44%	85%
A0A3Q8IG72	Leishmania donovani	83%	100%
A4HKG3	Leishmania braziliensis	62%	100%
A4I7Z1	Leishmania infantum	83%	100%
Q4Q5A4	Leishmania major	81%	99%