Pumilio/PUF RNA binding protein 7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio/PUF RNA binding protein 7, putative

Species:

Leishmania mexicana

UniProt:

E9B2V1_LEIMU

TriTrypDb:

LmxM.31.1750

Length:

779

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2V1

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.400
CLV_C14_Caspase3-7	416	420	PF00656	0.672
CLV_C14_Caspase3-7	591	595	PF00656	0.739
CLV_NRD_NRD_1	128	130	PF00675	0.454
CLV_NRD_NRD_1	357	359	PF00675	0.507
CLV_NRD_NRD_1	614	616	PF00675	0.580
CLV_NRD_NRD_1	662	664	PF00675	0.415
CLV_NRD_NRD_1	724	726	PF00675	0.635
CLV_NRD_NRD_1	83	85	PF00675	0.427
CLV_PCSK_KEX2_1	128	130	PF00082	0.467
CLV_PCSK_KEX2_1	273	275	PF00082	0.705
CLV_PCSK_KEX2_1	359	361	PF00082	0.357
CLV_PCSK_KEX2_1	723	725	PF00082	0.649
CLV_PCSK_KEX2_1	738	740	PF00082	0.434
CLV_PCSK_KEX2_1	83	85	PF00082	0.427
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.705
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.357
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.685
CLV_PCSK_PC1ET2_1	738	740	PF00082	0.650
CLV_PCSK_PC7_1	734	740	PF00082	0.556
CLV_PCSK_SKI1_1	216	220	PF00082	0.465
CLV_PCSK_SKI1_1	359	363	PF00082	0.520
CLV_PCSK_SKI1_1	405	409	PF00082	0.637
CLV_PCSK_SKI1_1	434	438	PF00082	0.370
CLV_PCSK_SKI1_1	663	667	PF00082	0.474
CLV_PCSK_SKI1_1	685	689	PF00082	0.405
CLV_PCSK_SKI1_1	734	738	PF00082	0.617
CLV_PCSK_SKI1_1	771	775	PF00082	0.633
CLV_PCSK_SKI1_1	84	88	PF00082	0.517
DEG_APCC_DBOX_1	524	532	PF00400	0.184
DEG_APCC_DBOX_1	684	692	PF00400	0.387
DEG_APCC_DBOX_1	82	90	PF00400	0.445
DOC_CKS1_1	238	243	PF01111	0.556
DOC_CKS1_1	367	372	PF01111	0.563
DOC_CYCLIN_RxL_1	15	28	PF00134	0.539
DOC_CYCLIN_RxL_1	356	363	PF00134	0.541
DOC_CYCLIN_RxL_1	657	669	PF00134	0.538
DOC_CYCLIN_RxL_1	768	776	PF00134	0.709
DOC_CYCLIN_RxL_1	81	88	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	367	373	PF00134	0.575
DOC_MAPK_gen_1	236	244	PF00069	0.548
DOC_MAPK_gen_1	358	367	PF00069	0.468
DOC_MAPK_gen_1	83	89	PF00069	0.433
DOC_MAPK_MEF2A_6	142	150	PF00069	0.222
DOC_MAPK_MEF2A_6	341	348	PF00069	0.382
DOC_MAPK_MEF2A_6	57	66	PF00069	0.419
DOC_PP1_RVXF_1	3	9	PF00149	0.473
DOC_PP1_RVXF_1	702	709	PF00149	0.470
DOC_PP1_RVXF_1	744	751	PF00149	0.545
DOC_USP7_MATH_1	225	229	PF00917	0.498
DOC_USP7_MATH_1	250	254	PF00917	0.493
DOC_USP7_MATH_1	412	416	PF00917	0.801
DOC_USP7_MATH_1	420	424	PF00917	0.552
DOC_USP7_MATH_1	432	436	PF00917	0.192
DOC_USP7_MATH_1	465	469	PF00917	0.549
DOC_USP7_MATH_1	507	511	PF00917	0.413
DOC_USP7_MATH_1	547	551	PF00917	0.298
DOC_USP7_MATH_1	633	637	PF00917	0.325
DOC_USP7_UBL2_3	398	402	PF12436	0.773
DOC_USP7_UBL2_3	41	45	PF12436	0.412
DOC_USP7_UBL2_3	607	611	PF12436	0.731
DOC_USP7_UBL2_3	612	616	PF12436	0.652
DOC_WW_Pin1_4	237	242	PF00397	0.524
DOC_WW_Pin1_4	298	303	PF00397	0.537
DOC_WW_Pin1_4	366	371	PF00397	0.584
DOC_WW_Pin1_4	468	473	PF00397	0.407
DOC_WW_Pin1_4	517	522	PF00397	0.262
DOC_WW_Pin1_4	677	682	PF00397	0.416
DOC_WW_Pin1_4	89	94	PF00397	0.344
LIG_Actin_WH2_2	40	58	PF00022	0.489
LIG_BIR_III_4	753	757	PF00653	0.582
LIG_BRCT_BRCA1_1	496	500	PF00533	0.563
LIG_CaM_IQ_9	644	660	PF13499	0.321
LIG_EH1_1	644	652	PF00400	0.344
LIG_eIF4E_1	645	651	PF01652	0.385
LIG_FHA_1	230	236	PF00498	0.484
LIG_FHA_1	262	268	PF00498	0.502
LIG_FHA_1	286	292	PF00498	0.661
LIG_FHA_1	428	434	PF00498	0.415
LIG_FHA_1	452	458	PF00498	0.559
LIG_FHA_1	499	505	PF00498	0.427
LIG_FHA_1	57	63	PF00498	0.440
LIG_FHA_1	654	660	PF00498	0.449
LIG_FHA_2	238	244	PF00498	0.485
LIG_FHA_2	575	581	PF00498	0.534
LIG_FHA_2	63	69	PF00498	0.444
LIG_LIR_Apic_2	258	262	PF02991	0.465
LIG_LIR_Apic_2	278	284	PF02991	0.620
LIG_LIR_Gen_1	322	331	PF02991	0.424
LIG_LIR_Gen_1	497	508	PF02991	0.468
LIG_LIR_Nem_3	124	130	PF02991	0.432
LIG_LIR_Nem_3	190	196	PF02991	0.416
LIG_LIR_Nem_3	322	327	PF02991	0.427
LIG_LIR_Nem_3	497	503	PF02991	0.546
LIG_NRBOX	490	496	PF00104	0.490
LIG_NRBOX	62	68	PF00104	0.434
LIG_PCNA_yPIPBox_3	96	109	PF02747	0.336
LIG_PTB_Apo_2	702	709	PF02174	0.429
LIG_SH2_CRK	308	312	PF00017	0.533
LIG_SH2_CRK	33	37	PF00017	0.494
LIG_SH2_NCK_1	196	200	PF00017	0.496
LIG_SH2_SRC	196	199	PF00017	0.300
LIG_SH2_STAP1	536	540	PF00017	0.460
LIG_SH2_STAT3	645	648	PF00017	0.340
LIG_SH2_STAT5	160	163	PF00017	0.314
LIG_SH2_STAT5	177	180	PF00017	0.474
LIG_SH2_STAT5	259	262	PF00017	0.414
LIG_SH2_STAT5	308	311	PF00017	0.354
LIG_SH2_STAT5	645	648	PF00017	0.385
LIG_SH3_3	149	155	PF00018	0.464
LIG_SH3_3	466	472	PF00018	0.414
LIG_SH3_3	501	507	PF00018	0.475
LIG_SH3_3	521	527	PF00018	0.145
LIG_SUMO_SIM_par_1	240	246	PF11976	0.475
LIG_SUMO_SIM_par_1	423	431	PF11976	0.518
LIG_SUMO_SIM_par_1	527	534	PF11976	0.362
LIG_SUMO_SIM_par_1	62	68	PF11976	0.462
LIG_TRAF2_1	224	227	PF00917	0.518
LIG_TRAF2_1	520	523	PF00917	0.410
LIG_TRAF2_1	577	580	PF00917	0.497
LIG_UBA3_1	333	341	PF00899	0.416
LIG_UBA3_1	666	671	PF00899	0.426
LIG_UBA3_1	773	779	PF00899	0.692
MOD_CK1_1	292	298	PF00069	0.739
MOD_CK1_1	325	331	PF00069	0.471
MOD_CK1_1	375	381	PF00069	0.643
MOD_CK1_1	406	412	PF00069	0.703
MOD_CK1_1	468	474	PF00069	0.492
MOD_CK1_1	502	508	PF00069	0.413
MOD_CK1_1	574	580	PF00069	0.549
MOD_CK1_1	693	699	PF00069	0.549
MOD_CK1_1	716	722	PF00069	0.630
MOD_CK2_1	192	198	PF00069	0.505
MOD_CK2_1	221	227	PF00069	0.468
MOD_CK2_1	237	243	PF00069	0.524
MOD_CK2_1	517	523	PF00069	0.184
MOD_CK2_1	574	580	PF00069	0.525
MOD_CK2_1	755	761	PF00069	0.759
MOD_GlcNHglycan	223	226	PF01048	0.445
MOD_GlcNHglycan	324	327	PF01048	0.542
MOD_GlcNHglycan	405	408	PF01048	0.634
MOD_GlcNHglycan	487	490	PF01048	0.494
MOD_GlcNHglycan	695	698	PF01048	0.474
MOD_GlcNHglycan	758	761	PF01048	0.790
MOD_GSK3_1	221	228	PF00069	0.489
MOD_GSK3_1	285	292	PF00069	0.709
MOD_GSK3_1	375	382	PF00069	0.723
MOD_GSK3_1	387	394	PF00069	0.653
MOD_GSK3_1	494	501	PF00069	0.561
MOD_GSK3_1	51	58	PF00069	0.427
MOD_GSK3_1	561	568	PF00069	0.432
MOD_GSK3_1	601	608	PF00069	0.748
MOD_N-GLC_1	375	380	PF02516	0.747
MOD_N-GLC_1	495	500	PF02516	0.483
MOD_N-GLC_1	55	60	PF02516	0.487
MOD_NEK2_1	18	23	PF00069	0.549
MOD_NEK2_1	214	219	PF00069	0.424
MOD_NEK2_1	229	234	PF00069	0.315
MOD_NEK2_1	365	370	PF00069	0.498
MOD_NEK2_1	512	517	PF00069	0.425
MOD_NEK2_1	540	545	PF00069	0.500
MOD_NEK2_1	55	60	PF00069	0.406
MOD_NEK2_1	773	778	PF00069	0.626
MOD_NEK2_1	9	14	PF00069	0.550
MOD_NEK2_2	289	294	PF00069	0.455
MOD_OFUCOSY	587	592	PF10250	0.588
MOD_PIKK_1	451	457	PF00454	0.498
MOD_PKA_1	403	409	PF00069	0.799
MOD_PKA_2	421	427	PF00069	0.530
MOD_Plk_1	214	220	PF00069	0.449
MOD_Plk_1	225	231	PF00069	0.393
MOD_Plk_1	498	504	PF00069	0.538
MOD_Plk_1	561	567	PF00069	0.413
MOD_Plk_2-3	413	419	PF00069	0.482
MOD_Plk_4	214	220	PF00069	0.465
MOD_Plk_4	225	231	PF00069	0.422
MOD_Plk_4	421	427	PF00069	0.547
MOD_Plk_4	499	505	PF00069	0.381
MOD_Plk_4	507	513	PF00069	0.297
MOD_Plk_4	531	537	PF00069	0.491
MOD_Plk_4	561	567	PF00069	0.359
MOD_Plk_4	62	68	PF00069	0.377
MOD_Plk_4	646	652	PF00069	0.184
MOD_Plk_4	687	693	PF00069	0.464
MOD_Plk_4	94	100	PF00069	0.449
MOD_ProDKin_1	237	243	PF00069	0.525
MOD_ProDKin_1	298	304	PF00069	0.523
MOD_ProDKin_1	366	372	PF00069	0.597
MOD_ProDKin_1	468	474	PF00069	0.404
MOD_ProDKin_1	517	523	PF00069	0.262
MOD_ProDKin_1	677	683	PF00069	0.412
MOD_ProDKin_1	89	95	PF00069	0.344
MOD_SUMO_rev_2	394	401	PF00179	0.705
MOD_SUMO_rev_2	579	588	PF00179	0.593
MOD_SUMO_rev_2	603	613	PF00179	0.703
MOD_SUMO_rev_2	660	666	PF00179	0.528
MOD_SUMO_rev_2	668	672	PF00179	0.494
MOD_SUMO_rev_2	755	765	PF00179	0.750
TRG_DiLeu_BaEn_1	499	504	PF01217	0.449
TRG_DiLeu_BaEn_1	662	667	PF01217	0.534
TRG_DiLeu_BaEn_4	226	232	PF01217	0.505
TRG_ENDOCYTIC_2	308	311	PF00928	0.410
TRG_ENDOCYTIC_2	627	630	PF00928	0.590
TRG_ER_diArg_1	127	129	PF00400	0.429
TRG_ER_diArg_1	358	361	PF00400	0.350
TRG_ER_diArg_1	654	657	PF00400	0.385
TRG_ER_diArg_1	82	84	PF00400	0.407
TRG_NLS_Bipartite_1	751	773	PF00514	0.676
TRG_NLS_MonoCore_2	401	406	PF00514	0.728
TRG_NLS_MonoCore_2	768	773	PF00514	0.740
TRG_NLS_MonoExtC_3	271	277	PF00514	0.700
TRG_NLS_MonoExtC_3	357	363	PF00514	0.341
TRG_NLS_MonoExtN_4	399	406	PF00514	0.794
TRG_NLS_MonoExtN_4	722	727	PF00514	0.676
TRG_NLS_MonoExtN_4	766	773	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	446	451	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICI6	Leptomonas seymouri	68%	100%
A0A0S4JFA8	Bodo saltans	41%	100%
A0A1X0NUE8	Trypanosomatidae	41%	100%
A0A3Q8IJA2	Leishmania donovani	92%	100%
A0A422NH58	Trypanosoma rangeli	45%	100%
A4HKG2	Leishmania braziliensis	79%	99%
A4I7Z0	Leishmania infantum	92%	100%
D0AA57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q5A5	Leishmania major	92%	100%
V5DFW5	Trypanosoma cruzi	44%	100%