RNA methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2U7_LEIMU

TriTrypDb:

LmxM.31.1710

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2U7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.586
CLV_C14_Caspase3-7	346	350	PF00656	0.575
CLV_C14_Caspase3-7	358	362	PF00656	0.565
CLV_C14_Caspase3-7	588	592	PF00656	0.432
CLV_C14_Caspase3-7	632	636	PF00656	0.745
CLV_NRD_NRD_1	2	4	PF00675	0.716
CLV_NRD_NRD_1	214	216	PF00675	0.553
CLV_NRD_NRD_1	320	322	PF00675	0.577
CLV_NRD_NRD_1	394	396	PF00675	0.312
CLV_NRD_NRD_1	464	466	PF00675	0.381
CLV_NRD_NRD_1	568	570	PF00675	0.552
CLV_PCSK_KEX2_1	2	4	PF00082	0.721
CLV_PCSK_KEX2_1	214	216	PF00082	0.533
CLV_PCSK_KEX2_1	319	321	PF00082	0.594
CLV_PCSK_KEX2_1	464	466	PF00082	0.469
CLV_PCSK_KEX2_1	568	570	PF00082	0.552
CLV_PCSK_SKI1_1	215	219	PF00082	0.507
CLV_PCSK_SKI1_1	395	399	PF00082	0.416
CLV_PCSK_SKI1_1	568	572	PF00082	0.599
CLV_PCSK_SKI1_1	92	96	PF00082	0.404
DEG_Nend_UBRbox_1	1	4	PF02207	0.682
DOC_CKS1_1	243	248	PF01111	0.388
DOC_CYCLIN_RxL_1	212	222	PF00134	0.557
DOC_CYCLIN_RxL_1	392	402	PF00134	0.326
DOC_CYCLIN_yClb3_PxF_3	374	382	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.387
DOC_MAPK_DCC_7	331	339	PF00069	0.377
DOC_MAPK_MEF2A_6	168	176	PF00069	0.334
DOC_MAPK_MEF2A_6	198	206	PF00069	0.421
DOC_PP2B_LxvP_1	12	15	PF13499	0.658
DOC_PP2B_LxvP_1	333	336	PF13499	0.624
DOC_PP2B_LxvP_1	522	525	PF13499	0.421
DOC_PP2B_LxvP_1	596	599	PF13499	0.366
DOC_PP4_FxxP_1	154	157	PF00568	0.450
DOC_USP7_MATH_1	122	126	PF00917	0.759
DOC_USP7_MATH_1	237	241	PF00917	0.419
DOC_USP7_MATH_1	350	354	PF00917	0.711
DOC_USP7_MATH_1	355	359	PF00917	0.704
DOC_USP7_MATH_1	407	411	PF00917	0.613
DOC_USP7_MATH_1	418	422	PF00917	0.746
DOC_USP7_MATH_1	472	476	PF00917	0.519
DOC_USP7_MATH_1	494	498	PF00917	0.727
DOC_USP7_MATH_1	556	560	PF00917	0.562
DOC_USP7_MATH_1	59	63	PF00917	0.375
DOC_WW_Pin1_4	133	138	PF00397	0.500
DOC_WW_Pin1_4	242	247	PF00397	0.591
DOC_WW_Pin1_4	301	306	PF00397	0.620
DOC_WW_Pin1_4	364	369	PF00397	0.587
DOC_WW_Pin1_4	419	424	PF00397	0.639
DOC_WW_Pin1_4	476	481	PF00397	0.385
DOC_WW_Pin1_4	487	492	PF00397	0.437
DOC_WW_Pin1_4	557	562	PF00397	0.406
DOC_WW_Pin1_4	70	75	PF00397	0.536
DOC_WW_Pin1_4	92	97	PF00397	0.457
LIG_14-3-3_CanoR_1	2	6	PF00244	0.694
LIG_14-3-3_CanoR_1	214	218	PF00244	0.500
LIG_14-3-3_CanoR_1	294	301	PF00244	0.629
LIG_14-3-3_CanoR_1	659	666	PF00244	0.377
LIG_14-3-3_CanoR_1	79	84	PF00244	0.379
LIG_Actin_WH2_2	384	402	PF00022	0.421
LIG_APCC_ABBA_1	141	146	PF00400	0.441
LIG_BRCT_BRCA1_1	150	154	PF00533	0.339
LIG_Clathr_ClatBox_1	173	177	PF01394	0.353
LIG_EH_1	23	27	PF12763	0.284
LIG_FHA_1	223	229	PF00498	0.680
LIG_FHA_1	260	266	PF00498	0.527
LIG_FHA_1	354	360	PF00498	0.772
LIG_FHA_1	365	371	PF00498	0.570
LIG_FHA_1	477	483	PF00498	0.414
LIG_FHA_1	574	580	PF00498	0.306
LIG_FHA_1	58	64	PF00498	0.415
LIG_FHA_1	612	618	PF00498	0.429
LIG_FHA_2	344	350	PF00498	0.665
LIG_FHA_2	93	99	PF00498	0.549
LIG_GBD_Chelix_1	267	275	PF00786	0.397
LIG_HP1_1	172	176	PF01393	0.377
LIG_Integrin_RGD_1	630	632	PF01839	0.504
LIG_LIR_Apic_2	151	157	PF02991	0.529
LIG_LIR_Apic_2	409	414	PF02991	0.473
LIG_LIR_Apic_2	475	481	PF02991	0.409
LIG_LIR_Gen_1	148	157	PF02991	0.496
LIG_LIR_Gen_1	310	318	PF02991	0.571
LIG_LIR_Gen_1	324	333	PF02991	0.500
LIG_LIR_Nem_3	136	141	PF02991	0.502
LIG_LIR_Nem_3	148	153	PF02991	0.438
LIG_LIR_Nem_3	310	315	PF02991	0.574
LIG_LIR_Nem_3	324	328	PF02991	0.456
LIG_LIR_Nem_3	457	461	PF02991	0.514
LIG_LIR_Nem_3	81	86	PF02991	0.456
LIG_Pex14_2	150	154	PF04695	0.390
LIG_REV1ctd_RIR_1	326	333	PF16727	0.459
LIG_RPA_C_Fungi	227	239	PF08784	0.413
LIG_SH2_CRK	478	482	PF00017	0.399
LIG_SH2_GRB2like	435	438	PF00017	0.351
LIG_SH2_STAP1	435	439	PF00017	0.402
LIG_SH2_STAP1	539	543	PF00017	0.524
LIG_SH2_STAT3	255	258	PF00017	0.351
LIG_SH2_STAT5	149	152	PF00017	0.557
LIG_SH2_STAT5	255	258	PF00017	0.351
LIG_SH2_STAT5	277	280	PF00017	0.369
LIG_SH2_STAT5	380	383	PF00017	0.563
LIG_SH2_STAT5	458	461	PF00017	0.334
LIG_SH2_STAT5	478	481	PF00017	0.517
LIG_SH2_STAT5	68	71	PF00017	0.419
LIG_SH3_3	12	18	PF00018	0.615
LIG_SH3_3	240	246	PF00018	0.553
LIG_SH3_3	251	257	PF00018	0.354
LIG_SH3_3	303	309	PF00018	0.444
LIG_SH3_3	371	377	PF00018	0.474
LIG_SH3_3	485	491	PF00018	0.464
LIG_SH3_3	660	666	PF00018	0.401
LIG_SUMO_SIM_par_1	172	177	PF11976	0.354
LIG_WW_3	13	17	PF00397	0.556
MOD_CDK_SPK_2	364	369	PF00069	0.631
MOD_CDK_SPK_2	92	97	PF00069	0.411
MOD_CK1_1	130	136	PF00069	0.512
MOD_CK1_1	292	298	PF00069	0.492
MOD_CK1_1	343	349	PF00069	0.587
MOD_CK1_1	353	359	PF00069	0.775
MOD_CK1_1	421	427	PF00069	0.676
MOD_CK1_1	560	566	PF00069	0.548
MOD_CK1_1	582	588	PF00069	0.536
MOD_CK1_1	62	68	PF00069	0.375
MOD_CK1_1	73	79	PF00069	0.371
MOD_CK2_1	308	314	PF00069	0.551
MOD_CK2_1	582	588	PF00069	0.504
MOD_Cter_Amidation	462	465	PF01082	0.341
MOD_GlcNHglycan	112	115	PF01048	0.575
MOD_GlcNHglycan	124	127	PF01048	0.747
MOD_GlcNHglycan	129	132	PF01048	0.634
MOD_GlcNHglycan	133	136	PF01048	0.568
MOD_GlcNHglycan	291	294	PF01048	0.462
MOD_GlcNHglycan	342	345	PF01048	0.678
MOD_GlcNHglycan	352	355	PF01048	0.682
MOD_GlcNHglycan	401	404	PF01048	0.446
MOD_GlcNHglycan	449	452	PF01048	0.403
MOD_GlcNHglycan	502	505	PF01048	0.622
MOD_GlcNHglycan	522	525	PF01048	0.346
MOD_GlcNHglycan	54	57	PF01048	0.409
MOD_GlcNHglycan	652	655	PF01048	0.450
MOD_GlcNHglycan	660	663	PF01048	0.324
MOD_GSK3_1	127	134	PF00069	0.669
MOD_GSK3_1	182	189	PF00069	0.380
MOD_GSK3_1	20	27	PF00069	0.616
MOD_GSK3_1	237	244	PF00069	0.475
MOD_GSK3_1	292	299	PF00069	0.599
MOD_GSK3_1	345	352	PF00069	0.695
MOD_GSK3_1	472	479	PF00069	0.403
MOD_GSK3_1	489	496	PF00069	0.561
MOD_GSK3_1	556	563	PF00069	0.559
MOD_GSK3_1	575	582	PF00069	0.424
MOD_GSK3_1	611	618	PF00069	0.408
MOD_GSK3_1	646	653	PF00069	0.545
MOD_N-GLC_1	110	115	PF02516	0.539
MOD_N-GLC_1	364	369	PF02516	0.600
MOD_N-GLC_1	57	62	PF02516	0.412
MOD_N-GLC_2	169	171	PF02516	0.418
MOD_NEK2_1	1	6	PF00069	0.700
MOD_NEK2_1	109	114	PF00069	0.591
MOD_NEK2_1	296	301	PF00069	0.605
MOD_NEK2_1	399	404	PF00069	0.524
MOD_NEK2_1	429	434	PF00069	0.357
MOD_NEK2_1	447	452	PF00069	0.484
MOD_NEK2_1	500	505	PF00069	0.649
MOD_NEK2_1	57	62	PF00069	0.372
MOD_NEK2_1	78	83	PF00069	0.305
MOD_NEK2_2	59	64	PF00069	0.335
MOD_PIKK_1	193	199	PF00454	0.677
MOD_PIKK_1	222	228	PF00454	0.485
MOD_PIKK_1	421	427	PF00454	0.504
MOD_PIKK_1	646	652	PF00454	0.454
MOD_PK_1	182	188	PF00069	0.342
MOD_PKA_2	1	7	PF00069	0.766
MOD_PKA_2	189	195	PF00069	0.354
MOD_PKA_2	213	219	PF00069	0.549
MOD_PKA_2	27	33	PF00069	0.437
MOD_PKA_2	381	387	PF00069	0.455
MOD_PKA_2	399	405	PF00069	0.548
MOD_PKA_2	658	664	PF00069	0.374
MOD_PKA_2	78	84	PF00069	0.396
MOD_PKB_1	188	196	PF00069	0.393
MOD_Plk_1	110	116	PF00069	0.539
MOD_Plk_1	539	545	PF00069	0.592
MOD_Plk_1	582	588	PF00069	0.435
MOD_Plk_4	182	188	PF00069	0.378
MOD_Plk_4	429	435	PF00069	0.332
MOD_Plk_4	615	621	PF00069	0.361
MOD_Plk_4	73	79	PF00069	0.347
MOD_ProDKin_1	133	139	PF00069	0.494
MOD_ProDKin_1	242	248	PF00069	0.582
MOD_ProDKin_1	301	307	PF00069	0.621
MOD_ProDKin_1	364	370	PF00069	0.579
MOD_ProDKin_1	419	425	PF00069	0.630
MOD_ProDKin_1	476	482	PF00069	0.385
MOD_ProDKin_1	487	493	PF00069	0.443
MOD_ProDKin_1	557	563	PF00069	0.398
MOD_ProDKin_1	70	76	PF00069	0.534
MOD_ProDKin_1	92	98	PF00069	0.462
TRG_DiLeu_BaEn_4	517	523	PF01217	0.393
TRG_ENDOCYTIC_2	277	280	PF00928	0.385
TRG_ENDOCYTIC_2	312	315	PF00928	0.600
TRG_ENDOCYTIC_2	325	328	PF00928	0.418
TRG_ER_diArg_1	1	3	PF00400	0.727
TRG_ER_diArg_1	187	190	PF00400	0.571
TRG_ER_diArg_1	213	215	PF00400	0.510
TRG_ER_diArg_1	318	321	PF00400	0.573
TRG_ER_diArg_1	567	569	PF00400	0.557
TRG_NES_CRM1_1	38	51	PF08389	0.381
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P977	Leptomonas seymouri	47%	98%
A0A0S4IV62	Bodo saltans	35%	100%
A0A1X0NUB8	Trypanosomatidae	33%	100%
A0A3Q8IFH0	Leishmania donovani	87%	100%
A0A3R7KBD3	Trypanosoma rangeli	37%	100%
A4HKF8	Leishmania braziliensis	71%	100%
A4I7Y6	Leishmania infantum	87%	100%
D0AA55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q5A9	Leishmania major	86%	100%
V5BF12	Trypanosoma cruzi	41%	100%