LeishMANIAdb
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PPM-type phosphatase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PPM-type phosphatase domain-containing protein
Gene product:
protein phosphatase 2C, putative
Species:
Leishmania mexicana
UniProt:
E9B2U5_LEIMU
TriTrypDb:
LmxM.31.1690
Length:
563

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) no yes: 1
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 1
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 10
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0005737 cytoplasm 2 3
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0005654 nucleoplasm 2 1

Expansion

Sequence features

E9B2U5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2U5

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 16
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016311 dephosphorylation 5 16
GO:0019538 protein metabolic process 3 16
GO:0036211 protein modification process 4 16
GO:0043170 macromolecule metabolic process 3 16
GO:0043412 macromolecule modification 4 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
GO:0035970 peptidyl-threonine dephosphorylation 6 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 23
GO:0004721 phosphoprotein phosphatase activity 3 23
GO:0004722 protein serine/threonine phosphatase activity 4 23
GO:0016787 hydrolase activity 2 23
GO:0016788 hydrolase activity, acting on ester bonds 3 23
GO:0016791 phosphatase activity 5 23
GO:0042578 phosphoric ester hydrolase activity 4 23
GO:0140096 catalytic activity, acting on a protein 2 23
GO:0017018 myosin phosphatase activity 5 8
GO:0005488 binding 1 5
GO:0043167 ion binding 2 5
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 366 370 PF00656 0.331
CLV_NRD_NRD_1 10 12 PF00675 0.602
CLV_NRD_NRD_1 112 114 PF00675 0.377
CLV_NRD_NRD_1 145 147 PF00675 0.240
CLV_NRD_NRD_1 281 283 PF00675 0.240
CLV_NRD_NRD_1 45 47 PF00675 0.438
CLV_NRD_NRD_1 474 476 PF00675 0.494
CLV_PCSK_FUR_1 43 47 PF00082 0.466
CLV_PCSK_KEX2_1 10 12 PF00082 0.678
CLV_PCSK_KEX2_1 112 114 PF00082 0.377
CLV_PCSK_KEX2_1 145 147 PF00082 0.240
CLV_PCSK_KEX2_1 281 283 PF00082 0.243
CLV_PCSK_KEX2_1 392 394 PF00082 0.469
CLV_PCSK_KEX2_1 45 47 PF00082 0.471
CLV_PCSK_KEX2_1 474 476 PF00082 0.494
CLV_PCSK_KEX2_1 5 7 PF00082 0.645
CLV_PCSK_PC1ET2_1 392 394 PF00082 0.469
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.629
CLV_PCSK_PC7_1 6 12 PF00082 0.562
CLV_PCSK_SKI1_1 261 265 PF00082 0.429
CLV_PCSK_SKI1_1 51 55 PF00082 0.459
CLV_Separin_Metazoa 109 113 PF03568 0.440
DEG_APCC_DBOX_1 356 364 PF00400 0.268
DEG_APCC_DBOX_1 50 58 PF00400 0.344
DEG_COP1_1 548 556 PF00400 0.464
DEG_SPOP_SBC_1 404 408 PF00917 0.480
DOC_MAPK_gen_1 281 289 PF00069 0.238
DOC_MAPK_gen_1 351 360 PF00069 0.274
DOC_MAPK_gen_1 484 490 PF00069 0.470
DOC_MAPK_MEF2A_6 484 492 PF00069 0.467
DOC_MAPK_MEF2A_6 51 59 PF00069 0.425
DOC_PP4_FxxP_1 349 352 PF00568 0.326
DOC_USP7_MATH_1 17 21 PF00917 0.464
DOC_USP7_MATH_1 240 244 PF00917 0.240
DOC_USP7_MATH_1 310 314 PF00917 0.310
DOC_USP7_MATH_1 402 406 PF00917 0.595
DOC_USP7_MATH_1 420 424 PF00917 0.546
DOC_USP7_MATH_1 441 445 PF00917 0.796
DOC_USP7_MATH_1 491 495 PF00917 0.771
DOC_USP7_MATH_1 510 514 PF00917 0.673
DOC_USP7_MATH_1 549 553 PF00917 0.568
DOC_USP7_UBL2_3 190 194 PF12436 0.377
DOC_WW_Pin1_4 370 375 PF00397 0.285
DOC_WW_Pin1_4 406 411 PF00397 0.618
DOC_WW_Pin1_4 450 455 PF00397 0.530
DOC_WW_Pin1_4 483 488 PF00397 0.654
DOC_WW_Pin1_4 502 507 PF00397 0.468
DOC_WW_Pin1_4 513 518 PF00397 0.493
DOC_WW_Pin1_4 545 550 PF00397 0.618
LIG_14-3-3_CanoR_1 145 149 PF00244 0.278
LIG_14-3-3_CanoR_1 416 420 PF00244 0.446
LIG_14-3-3_CanoR_1 45 49 PF00244 0.456
LIG_14-3-3_CanoR_1 512 517 PF00244 0.564
LIG_APCC_ABBA_1 226 231 PF00400 0.326
LIG_Clathr_ClatBox_1 154 158 PF01394 0.326
LIG_DCNL_PONY_1 1 4 PF03556 0.512
LIG_FHA_1 151 157 PF00498 0.268
LIG_FHA_1 33 39 PF00498 0.468
LIG_FHA_1 506 512 PF00498 0.706
LIG_FHA_1 548 554 PF00498 0.526
LIG_FHA_1 56 62 PF00498 0.548
LIG_FHA_1 75 81 PF00498 0.338
LIG_LIR_Apic_2 348 352 PF02991 0.326
LIG_LIR_Gen_1 180 191 PF02991 0.280
LIG_LIR_Gen_1 203 212 PF02991 0.281
LIG_LIR_Gen_1 327 337 PF02991 0.367
LIG_LIR_Nem_3 130 136 PF02991 0.321
LIG_LIR_Nem_3 180 186 PF02991 0.280
LIG_LIR_Nem_3 203 208 PF02991 0.281
LIG_LIR_Nem_3 327 332 PF02991 0.367
LIG_LIR_Nem_3 63 68 PF02991 0.358
LIG_LIR_Nem_3 69 73 PF02991 0.361
LIG_PCNA_yPIPBox_3 273 287 PF02747 0.326
LIG_SH2_CRK 70 74 PF00017 0.419
LIG_SH2_SRC 211 214 PF00017 0.317
LIG_SH2_SRC 229 232 PF00017 0.239
LIG_SH2_STAT3 181 184 PF00017 0.326
LIG_SH2_STAT3 26 29 PF00017 0.480
LIG_SH2_STAT5 177 180 PF00017 0.394
LIG_SH2_STAT5 211 214 PF00017 0.334
LIG_SH2_STAT5 229 232 PF00017 0.325
LIG_SH2_STAT5 236 239 PF00017 0.240
LIG_SH2_STAT5 26 29 PF00017 0.455
LIG_SH2_STAT5 277 280 PF00017 0.228
LIG_SH2_STAT5 48 51 PF00017 0.439
LIG_SH3_1 6 12 PF00018 0.502
LIG_SH3_3 259 265 PF00018 0.298
LIG_SH3_3 514 520 PF00018 0.491
LIG_SH3_3 543 549 PF00018 0.531
LIG_SH3_3 6 12 PF00018 0.521
LIG_SUMO_SIM_anti_2 153 158 PF11976 0.268
LIG_SUMO_SIM_anti_2 385 390 PF11976 0.340
LIG_SUMO_SIM_anti_2 58 63 PF11976 0.293
LIG_SUMO_SIM_par_1 152 158 PF11976 0.326
LIG_SUMO_SIM_par_1 285 290 PF11976 0.326
LIG_SUMO_SIM_par_1 57 63 PF11976 0.505
LIG_SUMO_SIM_par_1 72 77 PF11976 0.297
LIG_UBA3_1 1 5 PF00899 0.513
LIG_UBA3_1 154 159 PF00899 0.326
LIG_WRC_WIRS_1 215 220 PF05994 0.308
LIG_WW_3 7 11 PF00397 0.530
MOD_CDK_SPxxK_3 502 509 PF00069 0.473
MOD_CK1_1 214 220 PF00069 0.321
MOD_CK1_1 405 411 PF00069 0.567
MOD_CK1_1 418 424 PF00069 0.467
MOD_CK1_1 444 450 PF00069 0.554
MOD_CK1_1 500 506 PF00069 0.554
MOD_CK1_1 513 519 PF00069 0.542
MOD_CK1_1 533 539 PF00069 0.545
MOD_CK2_1 310 316 PF00069 0.317
MOD_GlcNHglycan 127 130 PF01048 0.442
MOD_GlcNHglycan 169 172 PF01048 0.283
MOD_GlcNHglycan 312 315 PF01048 0.313
MOD_GlcNHglycan 461 464 PF01048 0.614
MOD_GlcNHglycan 470 473 PF01048 0.521
MOD_GlcNHglycan 494 497 PF01048 0.656
MOD_GlcNHglycan 499 502 PF01048 0.592
MOD_GlcNHglycan 525 528 PF01048 0.627
MOD_GlcNHglycan 536 539 PF01048 0.594
MOD_GSK3_1 167 174 PF00069 0.328
MOD_GSK3_1 398 405 PF00069 0.587
MOD_GSK3_1 426 433 PF00069 0.584
MOD_GSK3_1 444 451 PF00069 0.530
MOD_GSK3_1 492 499 PF00069 0.586
MOD_GSK3_1 512 519 PF00069 0.718
MOD_GSK3_1 529 536 PF00069 0.656
MOD_GSK3_1 545 552 PF00069 0.784
MOD_N-GLC_1 249 254 PF02516 0.331
MOD_N-GLC_1 382 387 PF02516 0.379
MOD_N-GLC_1 436 441 PF02516 0.631
MOD_N-GLC_1 533 538 PF02516 0.711
MOD_NEK2_1 287 292 PF00069 0.352
MOD_NEK2_1 415 420 PF00069 0.451
MOD_NEK2_1 492 497 PF00069 0.495
MOD_NEK2_1 511 516 PF00069 0.615
MOD_NEK2_1 55 60 PF00069 0.353
MOD_NEK2_2 554 559 PF00069 0.482
MOD_PIKK_1 25 31 PF00454 0.418
MOD_PIKK_1 396 402 PF00454 0.471
MOD_PK_1 249 255 PF00069 0.239
MOD_PKA_2 144 150 PF00069 0.361
MOD_PKA_2 317 323 PF00069 0.272
MOD_PKA_2 415 421 PF00069 0.637
MOD_PKA_2 44 50 PF00069 0.396
MOD_PKA_2 511 517 PF00069 0.640
MOD_Plk_1 382 388 PF00069 0.390
MOD_Plk_1 554 560 PF00069 0.472
MOD_Plk_4 150 156 PF00069 0.299
MOD_Plk_4 382 388 PF00069 0.325
MOD_Plk_4 74 80 PF00069 0.490
MOD_ProDKin_1 370 376 PF00069 0.285
MOD_ProDKin_1 406 412 PF00069 0.613
MOD_ProDKin_1 450 456 PF00069 0.531
MOD_ProDKin_1 483 489 PF00069 0.653
MOD_ProDKin_1 502 508 PF00069 0.470
MOD_ProDKin_1 513 519 PF00069 0.493
MOD_ProDKin_1 545 551 PF00069 0.617
MOD_SUMO_for_1 193 196 PF00179 0.239
MOD_SUMO_rev_2 254 263 PF00179 0.326
MOD_SUMO_rev_2 476 486 PF00179 0.557
TRG_DiLeu_BaLyEn_6 33 38 PF01217 0.330
TRG_ENDOCYTIC_2 202 205 PF00928 0.240
TRG_ENDOCYTIC_2 70 73 PF00928 0.421
TRG_ER_diArg_1 111 113 PF00400 0.367
TRG_ER_diArg_1 144 146 PF00400 0.240
TRG_ER_diArg_1 281 283 PF00400 0.240
TRG_ER_diArg_1 350 353 PF00400 0.228
TRG_ER_diArg_1 9 11 PF00400 0.616
TRG_Pf-PMV_PEXEL_1 291 295 PF00026 0.240
TRG_Pf-PMV_PEXEL_1 36 40 PF00026 0.505

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PET0 Leptomonas seymouri 79% 97%
A0A1X0NUB7 Trypanosomatidae 52% 100%
A0A3Q8IFG7 Leishmania donovani 31% 100%
A0A3Q8IGS1 Leishmania donovani 88% 100%
A0A3Q8IL63 Leishmania donovani 29% 100%
A0A3S7WTA2 Leishmania donovani 36% 100%
A0A3S7WZ14 Leishmania donovani 31% 100%
A4H7Y6 Leishmania braziliensis 36% 100%
A4HAW5 Leishmania braziliensis 29% 100%
A4HE10 Leishmania braziliensis 30% 100%
A4HHY5 Leishmania braziliensis 29% 100%
A4HKF6 Leishmania braziliensis 78% 100%
A4HWB4 Leishmania infantum 36% 100%
A4I1B7 Leishmania infantum 31% 100%
A4I565 Leishmania infantum 31% 100%
A4I7Y4 Leishmania infantum 88% 100%
A4IA25 Leishmania infantum 29% 100%
D0AA51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AQ14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AXF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B0G2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B540 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q2U6 Leishmania major 29% 100%
Q4Q5B1 Leishmania major 88% 100%
Q4Q7S1 Leishmania major 31% 100%
Q4QA19 Leishmania major 31% 100%
Q4QFG7 Leishmania major 35% 100%
Q6K1U0 Oryza sativa subsp. japonica 28% 77%
Q6K5I0 Oryza sativa subsp. japonica 30% 100%
Q9CAJ0 Arabidopsis thaliana 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS