Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2U1_LEIMU

TriTrypDb:

LmxM.31.1650

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	7
GO:0008287	protein serine/threonine phosphatase complex	4	7
GO:0032991	protein-containing complex	1	7
GO:1902494	catalytic complex	2	7
GO:1903293	phosphatase complex	3	7
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2U1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	7
GO:0019888	protein phosphatase regulator activity	4	7
GO:0030234	enzyme regulator activity	2	7
GO:0098772	molecular function regulator activity	1	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.666
CLV_C14_Caspase3-7	844	848	PF00656	0.481
CLV_NRD_NRD_1	3	5	PF00675	0.735
CLV_NRD_NRD_1	433	435	PF00675	0.611
CLV_NRD_NRD_1	504	506	PF00675	0.508
CLV_NRD_NRD_1	558	560	PF00675	0.501
CLV_NRD_NRD_1	695	697	PF00675	0.582
CLV_NRD_NRD_1	747	749	PF00675	0.508
CLV_NRD_NRD_1	86	88	PF00675	0.739
CLV_NRD_NRD_1	914	916	PF00675	0.545
CLV_PCSK_KEX2_1	141	143	PF00082	0.748
CLV_PCSK_KEX2_1	433	435	PF00082	0.613
CLV_PCSK_KEX2_1	504	506	PF00082	0.480
CLV_PCSK_KEX2_1	558	560	PF00082	0.501
CLV_PCSK_KEX2_1	86	88	PF00082	0.739
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.748
CLV_PCSK_PC7_1	500	506	PF00082	0.555
CLV_PCSK_SKI1_1	161	165	PF00082	0.803
CLV_PCSK_SKI1_1	500	504	PF00082	0.574
CLV_PCSK_SKI1_1	550	554	PF00082	0.459
CLV_PCSK_SKI1_1	887	891	PF00082	0.470
CLV_Separin_Metazoa	501	505	PF03568	0.558
DEG_APCC_DBOX_1	160	168	PF00400	0.810
DEG_Nend_UBRbox_2	1	3	PF02207	0.720
DEG_SCF_FBW7_1	140	147	PF00400	0.706
DEG_SPOP_SBC_1	274	278	PF00917	0.523
DEG_SPOP_SBC_1	309	313	PF00917	0.723
DEG_SPOP_SBC_1	79	83	PF00917	0.552
DOC_CDC14_PxL_1	400	408	PF14671	0.517
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.705
DOC_MAPK_MEF2A_6	737	744	PF00069	0.445
DOC_MAPK_NFAT4_5	737	745	PF00069	0.445
DOC_PP1_RVXF_1	526	533	PF00149	0.458
DOC_PP2B_LxvP_1	646	649	PF13499	0.531
DOC_PP2B_LxvP_1	853	856	PF13499	0.560
DOC_PP4_FxxP_1	372	375	PF00568	0.827
DOC_PP4_FxxP_1	728	731	PF00568	0.462
DOC_USP7_MATH_1	117	121	PF00917	0.739
DOC_USP7_MATH_1	176	180	PF00917	0.646
DOC_USP7_MATH_1	274	278	PF00917	0.737
DOC_USP7_MATH_1	282	286	PF00917	0.626
DOC_USP7_MATH_1	309	313	PF00917	0.657
DOC_USP7_MATH_1	318	322	PF00917	0.630
DOC_USP7_MATH_1	384	388	PF00917	0.570
DOC_USP7_MATH_1	46	50	PF00917	0.577
DOC_USP7_MATH_1	517	521	PF00917	0.540
DOC_USP7_MATH_1	61	65	PF00917	0.790
DOC_USP7_MATH_1	667	671	PF00917	0.492
DOC_USP7_MATH_1	699	703	PF00917	0.546
DOC_USP7_MATH_1	79	83	PF00917	0.661
DOC_USP7_MATH_1	805	809	PF00917	0.620
DOC_USP7_MATH_1	821	825	PF00917	0.405
DOC_USP7_MATH_1	856	860	PF00917	0.675
DOC_USP7_MATH_1	89	93	PF00917	0.682
DOC_USP7_MATH_2	111	117	PF00917	0.831
DOC_USP7_UBL2_3	5	9	PF12436	0.750
DOC_USP7_UBL2_3	509	513	PF12436	0.503
DOC_WW_Pin1_4	12	17	PF00397	0.753
DOC_WW_Pin1_4	136	141	PF00397	0.726
DOC_WW_Pin1_4	261	266	PF00397	0.736
DOC_WW_Pin1_4	338	343	PF00397	0.681
DOC_WW_Pin1_4	475	480	PF00397	0.719
DOC_WW_Pin1_4	535	540	PF00397	0.556
DOC_WW_Pin1_4	560	565	PF00397	0.543
LIG_14-3-3_CanoR_1	190	196	PF00244	0.801
LIG_14-3-3_CanoR_1	212	218	PF00244	0.643
LIG_14-3-3_CanoR_1	310	319	PF00244	0.740
LIG_14-3-3_CanoR_1	433	439	PF00244	0.670
LIG_14-3-3_CanoR_1	504	512	PF00244	0.439
LIG_14-3-3_CanoR_1	80	89	PF00244	0.540
LIG_14-3-3_CanoR_1	899	905	PF00244	0.453
LIG_14-3-3_CanoR_1	915	919	PF00244	0.462
LIG_BRCT_BRCA1_1	342	346	PF00533	0.677
LIG_BRCT_BRCA1_1	368	372	PF00533	0.676
LIG_BRCT_BRCA1_1	581	585	PF00533	0.574
LIG_BRCT_BRCA1_1	669	673	PF00533	0.479
LIG_EH_1	708	712	PF12763	0.642
LIG_eIF4E_1	904	910	PF01652	0.513
LIG_FHA_1	488	494	PF00498	0.623
LIG_FHA_1	602	608	PF00498	0.474
LIG_FHA_1	850	856	PF00498	0.413
LIG_FHA_1	883	889	PF00498	0.508
LIG_FHA_2	241	247	PF00498	0.815
LIG_FHA_2	274	280	PF00498	0.597
LIG_FHA_2	393	399	PF00498	0.431
LIG_FHA_2	544	550	PF00498	0.452
LIG_FHA_2	83	89	PF00498	0.824
LIG_FHA_2	863	869	PF00498	0.699
LIG_Integrin_isoDGR_2	906	908	PF01839	0.527
LIG_LIR_Apic_2	369	375	PF02991	0.814
LIG_LIR_Apic_2	727	731	PF02991	0.472
LIG_LIR_Gen_1	563	571	PF02991	0.561
LIG_LIR_Gen_1	582	593	PF02991	0.571
LIG_LIR_Gen_1	616	627	PF02991	0.454
LIG_LIR_Gen_1	736	747	PF02991	0.448
LIG_LIR_Gen_1	774	784	PF02991	0.480
LIG_LIR_Nem_3	214	220	PF02991	0.642
LIG_LIR_Nem_3	418	422	PF02991	0.469
LIG_LIR_Nem_3	560	565	PF02991	0.543
LIG_LIR_Nem_3	582	588	PF02991	0.578
LIG_LIR_Nem_3	599	603	PF02991	0.496
LIG_LIR_Nem_3	616	622	PF02991	0.460
LIG_LIR_Nem_3	736	742	PF02991	0.441
LIG_LIR_Nem_3	774	780	PF02991	0.485
LIG_LIR_Nem_3	88	93	PF02991	0.696
LIG_MAD2	887	895	PF02301	0.485
LIG_MLH1_MIPbox_1	581	585	PF16413	0.574
LIG_MYND_1	12	16	PF01753	0.754
LIG_PCNA_yPIPBox_3	548	559	PF02747	0.465
LIG_PDZ_Class_3	915	920	PF00595	0.429
LIG_Pex14_2	351	355	PF04695	0.632
LIG_Pex14_2	628	632	PF04695	0.462
LIG_PTB_Apo_2	354	361	PF02174	0.684
LIG_Rb_pABgroove_1	790	798	PF01858	0.445
LIG_SH2_CRK	207	211	PF00017	0.657
LIG_SH2_CRK	220	224	PF00017	0.657
LIG_SH2_GRB2like	771	774	PF00017	0.510
LIG_SH2_NCK_1	132	136	PF00017	0.666
LIG_SH2_SRC	698	701	PF00017	0.660
LIG_SH2_SRC	716	719	PF00017	0.317
LIG_SH2_SRC	766	769	PF00017	0.457
LIG_SH2_STAP1	250	254	PF00017	0.650
LIG_SH2_STAP1	716	720	PF00017	0.481
LIG_SH2_STAP1	796	800	PF00017	0.472
LIG_SH2_STAT5	419	422	PF00017	0.471
LIG_SH2_STAT5	526	529	PF00017	0.456
LIG_SH2_STAT5	544	547	PF00017	0.212
LIG_SH2_STAT5	584	587	PF00017	0.586
LIG_SH2_STAT5	739	742	PF00017	0.446
LIG_SH2_STAT5	762	765	PF00017	0.479
LIG_SH2_STAT5	766	769	PF00017	0.479
LIG_SH2_STAT5	902	905	PF00017	0.414
LIG_SH2_STAT5	911	914	PF00017	0.444
LIG_SH3_1	132	138	PF00018	0.761
LIG_SH3_3	105	111	PF00018	0.552
LIG_SH3_3	132	138	PF00018	0.761
LIG_SH3_3	15	21	PF00018	0.747
LIG_SH3_3	254	260	PF00018	0.751
LIG_SH3_3	372	378	PF00018	0.530
LIG_SH3_3	586	592	PF00018	0.573
LIG_SH3_3	747	753	PF00018	0.492
LIG_SH3_3	799	805	PF00018	0.449
LIG_SH3_CIN85_PxpxPR_1	263	268	PF14604	0.735
LIG_SUMO_SIM_anti_2	387	392	PF11976	0.490
LIG_SUMO_SIM_par_1	780	786	PF11976	0.471
LIG_SUMO_SIM_par_1	834	840	PF11976	0.446
LIG_TRAF2_1	614	617	PF00917	0.316
LIG_TYR_ITIM	417	422	PF00017	0.465
LIG_UBA3_1	594	598	PF00899	0.513
LIG_UBA3_1	756	765	PF00899	0.482
MOD_CDC14_SPxK_1	139	142	PF00782	0.713
MOD_CDK_SPK_2	136	141	PF00069	0.707
MOD_CDK_SPxK_1	136	142	PF00069	0.730
MOD_CDK_SPxxK_3	261	268	PF00069	0.737
MOD_CK1_1	116	122	PF00069	0.735
MOD_CK1_1	157	163	PF00069	0.799
MOD_CK1_1	30	36	PF00069	0.723
MOD_CK1_1	311	317	PF00069	0.709
MOD_CK1_1	338	344	PF00069	0.793
MOD_CK1_1	484	490	PF00069	0.678
MOD_CK1_1	540	546	PF00069	0.488
MOD_CK1_1	702	708	PF00069	0.508
MOD_CK1_1	724	730	PF00069	0.452
MOD_CK1_1	808	814	PF00069	0.656
MOD_CK1_1	82	88	PF00069	0.775
MOD_CK1_1	859	865	PF00069	0.823
MOD_CK1_1	92	98	PF00069	0.652
MOD_CK2_1	104	110	PF00069	0.603
MOD_CK2_1	117	123	PF00069	0.690
MOD_CK2_1	191	197	PF00069	0.690
MOD_CK2_1	240	246	PF00069	0.705
MOD_CK2_1	273	279	PF00069	0.602
MOD_CK2_1	543	549	PF00069	0.450
MOD_CK2_1	566	572	PF00069	0.378
MOD_CK2_1	610	616	PF00069	0.297
MOD_CK2_1	766	772	PF00069	0.485
MOD_Cter_Amidation	694	697	PF01082	0.407
MOD_GlcNHglycan	113	118	PF01048	0.740
MOD_GlcNHglycan	161	164	PF01048	0.744
MOD_GlcNHglycan	178	181	PF01048	0.752
MOD_GlcNHglycan	304	307	PF01048	0.720
MOD_GlcNHglycan	316	319	PF01048	0.670
MOD_GlcNHglycan	320	323	PF01048	0.661
MOD_GlcNHglycan	332	335	PF01048	0.713
MOD_GlcNHglycan	381	385	PF01048	0.651
MOD_GlcNHglycan	400	403	PF01048	0.556
MOD_GlcNHglycan	412	416	PF01048	0.471
MOD_GlcNHglycan	475	478	PF01048	0.782
MOD_GlcNHglycan	486	489	PF01048	0.556
MOD_GlcNHglycan	50	53	PF01048	0.763
MOD_GlcNHglycan	568	571	PF01048	0.460
MOD_GlcNHglycan	612	615	PF01048	0.485
MOD_GlcNHglycan	649	652	PF01048	0.553
MOD_GlcNHglycan	678	681	PF01048	0.469
MOD_GlcNHglycan	723	726	PF01048	0.549
MOD_GlcNHglycan	785	790	PF01048	0.455
MOD_GlcNHglycan	797	800	PF01048	0.304
MOD_GlcNHglycan	82	85	PF01048	0.829
MOD_GSK3_1	113	120	PF00069	0.776
MOD_GSK3_1	136	143	PF00069	0.727
MOD_GSK3_1	155	162	PF00069	0.750
MOD_GSK3_1	240	247	PF00069	0.585
MOD_GSK3_1	27	34	PF00069	0.724
MOD_GSK3_1	304	311	PF00069	0.699
MOD_GSK3_1	314	321	PF00069	0.708
MOD_GSK3_1	336	343	PF00069	0.801
MOD_GSK3_1	35	42	PF00069	0.737
MOD_GSK3_1	362	369	PF00069	0.624
MOD_GSK3_1	380	387	PF00069	0.679
MOD_GSK3_1	420	427	PF00069	0.630
MOD_GSK3_1	428	435	PF00069	0.737
MOD_GSK3_1	46	53	PF00069	0.746
MOD_GSK3_1	461	468	PF00069	0.733
MOD_GSK3_1	487	494	PF00069	0.681
MOD_GSK3_1	575	582	PF00069	0.564
MOD_GSK3_1	62	69	PF00069	0.814
MOD_GSK3_1	628	635	PF00069	0.513
MOD_GSK3_1	661	668	PF00069	0.468
MOD_GSK3_1	698	705	PF00069	0.643
MOD_GSK3_1	75	82	PF00069	0.791
MOD_GSK3_1	808	815	PF00069	0.550
MOD_GSK3_1	847	854	PF00069	0.563
MOD_GSK3_1	856	863	PF00069	0.756
MOD_GSK3_1	89	96	PF00069	0.643
MOD_N-GLC_1	294	299	PF02516	0.708
MOD_N-GLC_1	329	334	PF02516	0.681
MOD_N-GLC_1	351	356	PF02516	0.664
MOD_N-GLC_1	428	433	PF02516	0.751
MOD_N-GLC_1	491	496	PF02516	0.756
MOD_N-GLC_1	772	777	PF02516	0.492
MOD_N-GLC_2	480	482	PF02516	0.823
MOD_NEK2_1	154	159	PF00069	0.802
MOD_NEK2_1	206	211	PF00069	0.651
MOD_NEK2_1	281	286	PF00069	0.689
MOD_NEK2_1	31	36	PF00069	0.723
MOD_NEK2_1	351	356	PF00069	0.707
MOD_NEK2_1	368	373	PF00069	0.640
MOD_NEK2_1	420	425	PF00069	0.506
MOD_NEK2_1	511	516	PF00069	0.465
MOD_NEK2_1	579	584	PF00069	0.576
MOD_NEK2_1	673	678	PF00069	0.448
MOD_NEK2_1	795	800	PF00069	0.493
MOD_NEK2_1	806	811	PF00069	0.507
MOD_NEK2_1	812	817	PF00069	0.457
MOD_NEK2_1	841	846	PF00069	0.501
MOD_NEK2_1	900	905	PF00069	0.464
MOD_NEK2_2	428	433	PF00069	0.751
MOD_NEK2_2	766	771	PF00069	0.477
MOD_PIKK_1	244	250	PF00454	0.521
MOD_PIKK_1	699	705	PF00454	0.642
MOD_PIKK_1	847	853	PF00454	0.587
MOD_PIKK_1	860	866	PF00454	0.653
MOD_PKA_1	504	510	PF00069	0.499
MOD_PKA_2	104	110	PF00069	0.749
MOD_PKA_2	117	123	PF00069	0.727
MOD_PKA_2	211	217	PF00069	0.628
MOD_PKA_2	309	315	PF00069	0.734
MOD_PKA_2	31	37	PF00069	0.720
MOD_PKA_2	432	438	PF00069	0.668
MOD_PKA_2	461	467	PF00069	0.783
MOD_PKA_2	504	510	PF00069	0.499
MOD_PKA_2	62	68	PF00069	0.744
MOD_PKA_2	676	682	PF00069	0.462
MOD_PKA_2	73	79	PF00069	0.743
MOD_PKA_2	859	865	PF00069	0.706
MOD_PKA_2	914	920	PF00069	0.608
MOD_PKA_2	93	99	PF00069	0.604
MOD_PKB_1	858	866	PF00069	0.667
MOD_Plk_1	351	357	PF00069	0.662
MOD_Plk_1	380	386	PF00069	0.650
MOD_Plk_1	428	434	PF00069	0.757
MOD_Plk_1	615	621	PF00069	0.279
MOD_Plk_1	772	778	PF00069	0.483
MOD_Plk_1	841	847	PF00069	0.504
MOD_Plk_2-3	104	110	PF00069	0.559
MOD_Plk_2-3	240	246	PF00069	0.820
MOD_Plk_2-3	772	778	PF00069	0.491
MOD_Plk_4	104	110	PF00069	0.590
MOD_Plk_4	386	392	PF00069	0.505
MOD_Plk_4	434	440	PF00069	0.672
MOD_Plk_4	528	534	PF00069	0.471
MOD_Plk_4	537	543	PF00069	0.520
MOD_Plk_4	615	621	PF00069	0.469
MOD_Plk_4	668	674	PF00069	0.478
MOD_Plk_4	724	730	PF00069	0.452
MOD_Plk_4	766	772	PF00069	0.485
MOD_Plk_4	787	793	PF00069	0.467
MOD_Plk_4	812	818	PF00069	0.628
MOD_ProDKin_1	12	18	PF00069	0.752
MOD_ProDKin_1	136	142	PF00069	0.730
MOD_ProDKin_1	261	267	PF00069	0.734
MOD_ProDKin_1	338	344	PF00069	0.680
MOD_ProDKin_1	475	481	PF00069	0.719
MOD_ProDKin_1	535	541	PF00069	0.549
MOD_ProDKin_1	560	566	PF00069	0.542
MOD_SUMO_rev_2	253	263	PF00179	0.705
TRG_DiLeu_BaEn_1	655	660	PF01217	0.525
TRG_DiLeu_BaEn_3	362	368	PF01217	0.480
TRG_ENDOCYTIC_2	207	210	PF00928	0.650
TRG_ENDOCYTIC_2	220	223	PF00928	0.656
TRG_ENDOCYTIC_2	419	422	PF00928	0.471
TRG_ENDOCYTIC_2	716	719	PF00928	0.490
TRG_ENDOCYTIC_2	739	742	PF00928	0.446
TRG_ER_diArg_1	432	434	PF00400	0.605
TRG_ER_diArg_1	497	500	PF00400	0.625
TRG_ER_diArg_1	503	505	PF00400	0.532
TRG_ER_diArg_1	533	536	PF00400	0.532
TRG_ER_diArg_1	557	559	PF00400	0.474
TRG_ER_diArg_1	858	861	PF00400	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN7	Leptomonas seymouri	69%	99%
A0A3S7X5H5	Leishmania donovani	92%	100%
A4HKF2	Leishmania braziliensis	81%	100%
A4I7Y0	Leishmania infantum	92%	100%
Q4Q5B5	Leishmania major	91%	100%