Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2T8_LEIMU

TriTrypDb:

LmxM.31.1620

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2T8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.473
CLV_C14_Caspase3-7	152	156	PF00656	0.608
CLV_C14_Caspase3-7	511	515	PF00656	0.406
CLV_C14_Caspase3-7	730	734	PF00656	0.711
CLV_NRD_NRD_1	133	135	PF00675	0.532
CLV_NRD_NRD_1	233	235	PF00675	0.418
CLV_NRD_NRD_1	316	318	PF00675	0.508
CLV_NRD_NRD_1	717	719	PF00675	0.580
CLV_NRD_NRD_1	724	726	PF00675	0.604
CLV_PCSK_KEX2_1	133	135	PF00082	0.532
CLV_PCSK_KEX2_1	233	235	PF00082	0.418
CLV_PCSK_KEX2_1	237	239	PF00082	0.414
CLV_PCSK_KEX2_1	316	318	PF00082	0.516
CLV_PCSK_KEX2_1	480	482	PF00082	0.487
CLV_PCSK_KEX2_1	639	641	PF00082	0.478
CLV_PCSK_KEX2_1	717	719	PF00082	0.554
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.414
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.519
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.468
CLV_PCSK_PC7_1	233	239	PF00082	0.412
CLV_PCSK_SKI1_1	234	238	PF00082	0.415
CLV_PCSK_SKI1_1	455	459	PF00082	0.434
CLV_PCSK_SKI1_1	486	490	PF00082	0.375
CLV_PCSK_SKI1_1	506	510	PF00082	0.472
CLV_PCSK_SKI1_1	533	537	PF00082	0.542
CLV_PCSK_SKI1_1	542	546	PF00082	0.487
CLV_Separin_Metazoa	249	253	PF03568	0.503
DEG_APCC_DBOX_1	505	513	PF00400	0.501
DOC_CYCLIN_RxL_1	503	511	PF00134	0.493
DOC_CYCLIN_RxL_1	530	540	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	682	688	PF00134	0.545
DOC_MAPK_DCC_7	237	247	PF00069	0.446
DOC_MAPK_DCC_7	333	343	PF00069	0.453
DOC_MAPK_gen_1	233	242	PF00069	0.520
DOC_MAPK_gen_1	263	270	PF00069	0.541
DOC_MAPK_MEF2A_6	238	247	PF00069	0.442
DOC_PP1_RVXF_1	131	138	PF00149	0.486
DOC_PP1_RVXF_1	453	460	PF00149	0.240
DOC_PP1_RVXF_1	631	638	PF00149	0.464
DOC_PP2B_LxvP_1	240	243	PF13499	0.508
DOC_PP2B_LxvP_1	594	597	PF13499	0.514
DOC_PP2B_LxvP_1	682	685	PF13499	0.744
DOC_USP7_MATH_1	306	310	PF00917	0.501
DOC_USP7_MATH_1	353	357	PF00917	0.610
DOC_USP7_MATH_1	42	46	PF00917	0.522
DOC_USP7_MATH_1	470	474	PF00917	0.317
DOC_USP7_MATH_1	491	495	PF00917	0.551
DOC_USP7_MATH_1	555	559	PF00917	0.652
DOC_USP7_MATH_1	618	622	PF00917	0.627
DOC_USP7_MATH_1	626	630	PF00917	0.500
DOC_USP7_MATH_2	106	112	PF00917	0.562
DOC_USP7_UBL2_3	722	726	PF12436	0.543
DOC_WW_Pin1_4	11	16	PF00397	0.508
DOC_WW_Pin1_4	111	116	PF00397	0.677
DOC_WW_Pin1_4	307	312	PF00397	0.568
LIG_14-3-3_CanoR_1	189	197	PF00244	0.495
LIG_14-3-3_CanoR_1	209	217	PF00244	0.215
LIG_14-3-3_CanoR_1	233	237	PF00244	0.418
LIG_14-3-3_CanoR_1	390	394	PF00244	0.605
LIG_14-3-3_CanoR_1	557	565	PF00244	0.589
LIG_14-3-3_CanoR_1	608	614	PF00244	0.525
LIG_14-3-3_CanoR_1	717	721	PF00244	0.550
LIG_Actin_WH2_2	440	457	PF00022	0.500
LIG_Actin_WH2_2	471	488	PF00022	0.548
LIG_APCC_ABBA_1	433	438	PF00400	0.330
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BIR_III_4	574	578	PF00653	0.466
LIG_CtBP_PxDLS_1	80	84	PF00389	0.476
LIG_deltaCOP1_diTrp_1	404	408	PF00928	0.374
LIG_EH1_1	261	269	PF00400	0.598
LIG_FHA_1	12	18	PF00498	0.580
LIG_FHA_1	167	173	PF00498	0.484
LIG_FHA_1	26	32	PF00498	0.491
LIG_FHA_1	288	294	PF00498	0.570
LIG_FHA_1	416	422	PF00498	0.392
LIG_FHA_1	557	563	PF00498	0.587
LIG_FHA_1	658	664	PF00498	0.431
LIG_FHA_2	447	453	PF00498	0.323
LIG_FHA_2	474	480	PF00498	0.598
LIG_FHA_2	585	591	PF00498	0.687
LIG_FHA_2	728	734	PF00498	0.686
LIG_FHA_2	82	88	PF00498	0.484
LIG_LIR_Gen_1	35	43	PF02991	0.533
LIG_LIR_Gen_1	370	381	PF02991	0.481
LIG_LIR_Gen_1	404	414	PF02991	0.347
LIG_LIR_Gen_1	418	427	PF02991	0.434
LIG_LIR_Gen_1	472	482	PF02991	0.446
LIG_LIR_Gen_1	657	667	PF02991	0.337
LIG_LIR_Nem_3	126	132	PF02991	0.501
LIG_LIR_Nem_3	200	204	PF02991	0.444
LIG_LIR_Nem_3	35	40	PF02991	0.531
LIG_LIR_Nem_3	359	365	PF02991	0.605
LIG_LIR_Nem_3	370	376	PF02991	0.453
LIG_LIR_Nem_3	404	409	PF02991	0.356
LIG_LIR_Nem_3	418	422	PF02991	0.365
LIG_LIR_Nem_3	657	662	PF02991	0.422
LIG_LYPXL_yS_3	201	204	PF13949	0.449
LIG_NRBOX	508	514	PF00104	0.354
LIG_Pex14_1	380	384	PF04695	0.372
LIG_SH2_CRK	132	136	PF00017	0.505
LIG_SH2_CRK	68	72	PF00017	0.416
LIG_SH2_CRK	690	694	PF00017	0.710
LIG_SH2_GRB2like	443	446	PF00017	0.437
LIG_SH2_NCK_1	690	694	PF00017	0.710
LIG_SH2_SRC	254	257	PF00017	0.566
LIG_SH2_SRC	443	446	PF00017	0.554
LIG_SH2_STAP1	526	530	PF00017	0.504
LIG_SH2_STAP1	546	550	PF00017	0.210
LIG_SH2_STAP1	72	76	PF00017	0.395
LIG_SH2_STAT5	23	26	PF00017	0.600
LIG_SH2_STAT5	373	376	PF00017	0.408
LIG_SH2_STAT5	384	387	PF00017	0.351
LIG_SH2_STAT5	443	446	PF00017	0.561
LIG_SH2_STAT5	631	634	PF00017	0.311
LIG_SH3_3	220	226	PF00018	0.583
LIG_SH3_3	242	248	PF00018	0.552
LIG_SH3_3	660	666	PF00018	0.519
LIG_SUMO_SIM_par_1	28	35	PF11976	0.497
LIG_SUMO_SIM_par_1	79	84	PF11976	0.470
LIG_TRAF2_1	174	177	PF00917	0.599
LIG_TRAF2_1	751	754	PF00917	0.799
LIG_TYR_ITIM	441	446	PF00017	0.496
LIG_UBA3_1	324	330	PF00899	0.454
LIG_WRC_WIRS_1	501	506	PF05994	0.379
MOD_CK1_1	110	116	PF00069	0.662
MOD_CK1_1	156	162	PF00069	0.616
MOD_CK1_1	191	197	PF00069	0.519
MOD_CK1_1	309	315	PF00069	0.648
MOD_CK1_1	32	38	PF00069	0.492
MOD_CK1_1	356	362	PF00069	0.608
MOD_CK1_1	473	479	PF00069	0.497
MOD_CK1_1	584	590	PF00069	0.677
MOD_CK1_1	621	627	PF00069	0.434
MOD_CK1_1	661	667	PF00069	0.482
MOD_CK1_1	675	681	PF00069	0.548
MOD_CK1_1	701	707	PF00069	0.670
MOD_CK2_1	473	479	PF00069	0.603
MOD_CK2_1	576	582	PF00069	0.658
MOD_CK2_1	584	590	PF00069	0.685
MOD_CK2_1	6	12	PF00069	0.507
MOD_CK2_1	671	677	PF00069	0.731
MOD_CK2_1	734	740	PF00069	0.712
MOD_CK2_1	748	754	PF00069	0.777
MOD_CK2_1	81	87	PF00069	0.494
MOD_CMANNOS	656	659	PF00535	0.530
MOD_CMANNOS	86	89	PF00535	0.406
MOD_GlcNHglycan	139	142	PF01048	0.549
MOD_GlcNHglycan	155	158	PF01048	0.421
MOD_GlcNHglycan	190	193	PF01048	0.474
MOD_GlcNHglycan	283	286	PF01048	0.489
MOD_GlcNHglycan	311	314	PF01048	0.662
MOD_GlcNHglycan	354	358	PF01048	0.676
MOD_GlcNHglycan	472	475	PF01048	0.607
MOD_GlcNHglycan	582	586	PF01048	0.704
MOD_GlcNHglycan	609	612	PF01048	0.487
MOD_GlcNHglycan	620	623	PF01048	0.541
MOD_GlcNHglycan	674	677	PF01048	0.649
MOD_GlcNHglycan	706	709	PF01048	0.600
MOD_GlcNHglycan	73	77	PF01048	0.469
MOD_GlcNHglycan	736	739	PF01048	0.685
MOD_GlcNHglycan	750	753	PF01048	0.773
MOD_GlcNHglycan	8	11	PF01048	0.546
MOD_GSK3_1	107	114	PF00069	0.667
MOD_GSK3_1	156	163	PF00069	0.575
MOD_GSK3_1	164	171	PF00069	0.448
MOD_GSK3_1	25	32	PF00069	0.494
MOD_GSK3_1	271	278	PF00069	0.530
MOD_GSK3_1	287	294	PF00069	0.485
MOD_GSK3_1	380	387	PF00069	0.537
MOD_GSK3_1	469	476	PF00069	0.521
MOD_GSK3_1	576	583	PF00069	0.490
MOD_GSK3_1	657	664	PF00069	0.514
MOD_GSK3_1	671	678	PF00069	0.704
MOD_GSK3_1	741	748	PF00069	0.735
MOD_N-GLC_1	25	30	PF02516	0.507
MOD_N-GLC_1	365	370	PF02516	0.473
MOD_NEK2_1	109	114	PF00069	0.675
MOD_NEK2_1	124	129	PF00069	0.433
MOD_NEK2_1	212	217	PF00069	0.502
MOD_NEK2_1	275	280	PF00069	0.475
MOD_NEK2_1	293	298	PF00069	0.393
MOD_NEK2_1	365	370	PF00069	0.452
MOD_NEK2_1	513	518	PF00069	0.544
MOD_NEK2_1	545	550	PF00069	0.487
MOD_NEK2_1	761	766	PF00069	0.735
MOD_NEK2_1	81	86	PF00069	0.488
MOD_NEK2_2	626	631	PF00069	0.406
MOD_PIKK_1	25	31	PF00454	0.545
MOD_PIKK_1	365	371	PF00454	0.493
MOD_PIKK_1	556	562	PF00454	0.320
MOD_PKA_1	480	486	PF00069	0.533
MOD_PKA_2	188	194	PF00069	0.528
MOD_PKA_2	232	238	PF00069	0.403
MOD_PKA_2	389	395	PF00069	0.581
MOD_PKA_2	480	486	PF00069	0.480
MOD_PKA_2	556	562	PF00069	0.623
MOD_PKA_2	580	586	PF00069	0.522
MOD_PKA_2	607	613	PF00069	0.539
MOD_PKA_2	698	704	PF00069	0.690
MOD_PKA_2	716	722	PF00069	0.374
MOD_PKA_2	740	746	PF00069	0.774
MOD_Plk_1	657	663	PF00069	0.258
MOD_Plk_2-3	651	657	PF00069	0.494
MOD_Plk_4	124	130	PF00069	0.545
MOD_Plk_4	160	166	PF00069	0.659
MOD_Plk_4	168	174	PF00069	0.517
MOD_Plk_4	212	218	PF00069	0.440
MOD_Plk_4	275	281	PF00069	0.529
MOD_Plk_4	32	38	PF00069	0.537
MOD_Plk_4	323	329	PF00069	0.509
MOD_Plk_4	380	386	PF00069	0.452
MOD_Plk_4	42	48	PF00069	0.434
MOD_Plk_4	491	497	PF00069	0.452
MOD_Plk_4	545	551	PF00069	0.515
MOD_Plk_4	626	632	PF00069	0.474
MOD_Plk_4	651	657	PF00069	0.555
MOD_Plk_4	658	664	PF00069	0.430
MOD_Plk_4	701	707	PF00069	0.533
MOD_ProDKin_1	11	17	PF00069	0.505
MOD_ProDKin_1	111	117	PF00069	0.663
MOD_ProDKin_1	307	313	PF00069	0.561
MOD_SUMO_rev_2	255	264	PF00179	0.509
MOD_SUMO_rev_2	538	544	PF00179	0.493
TRG_DiLeu_BaEn_1	658	663	PF01217	0.506
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.457
TRG_DiLeu_LyEn_5	12	17	PF01217	0.498
TRG_ENDOCYTIC_2	128	131	PF00928	0.497
TRG_ENDOCYTIC_2	132	135	PF00928	0.495
TRG_ENDOCYTIC_2	201	204	PF00928	0.425
TRG_ENDOCYTIC_2	37	40	PF00928	0.538
TRG_ENDOCYTIC_2	373	376	PF00928	0.472
TRG_ENDOCYTIC_2	443	446	PF00928	0.491
TRG_ENDOCYTIC_2	546	549	PF00928	0.501
TRG_ENDOCYTIC_2	68	71	PF00928	0.375
TRG_ER_diArg_1	132	134	PF00400	0.531
TRG_ER_diArg_1	232	234	PF00400	0.426
TRG_NES_CRM1_1	540	553	PF08389	0.513
TRG_NES_CRM1_1	560	574	PF08389	0.241
TRG_NLS_MonoExtN_4	759	766	PF00514	0.738
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	506	511	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	533	538	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P980	Leptomonas seymouri	41%	100%
A0A1X0NUC5	Trypanosomatidae	25%	100%
A0A3Q8IG63	Leishmania donovani	89%	100%
A0A422NL86	Trypanosoma rangeli	28%	100%
A4HKE9	Leishmania braziliensis	70%	100%
A4I7X7	Leishmania infantum	89%	100%
D0AA42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q5B9	Leishmania major	88%	100%
V5AZI4	Trypanosoma cruzi	27%	100%