NYN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2T7_LEIMU

TriTrypDb:

LmxM.31.1610

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2T7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.526
CLV_C14_Caspase3-7	56	60	PF00656	0.643
CLV_NRD_NRD_1	231	233	PF00675	0.470
CLV_NRD_NRD_1	239	241	PF00675	0.553
CLV_PCSK_FUR_1	229	233	PF00082	0.552
CLV_PCSK_KEX2_1	173	175	PF00082	0.420
CLV_PCSK_KEX2_1	231	233	PF00082	0.436
CLV_PCSK_KEX2_1	239	241	PF00082	0.523
CLV_PCSK_KEX2_1	260	262	PF00082	0.376
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.488
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.382
CLV_PCSK_SKI1_1	231	235	PF00082	0.511
DEG_APCC_DBOX_1	273	281	PF00400	0.417
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DOC_CKS1_1	187	192	PF01111	0.486
DOC_CYCLIN_RxL_1	228	238	PF00134	0.473
DOC_MAPK_DCC_7	95	105	PF00069	0.468
DOC_MAPK_gen_1	173	181	PF00069	0.435
DOC_MAPK_gen_1	32	40	PF00069	0.525
DOC_PP1_RVXF_1	1	8	PF00149	0.589
DOC_PP2B_PxIxI_1	101	107	PF00149	0.206
DOC_PP4_FxxP_1	187	190	PF00568	0.476
DOC_PP4_FxxP_1	40	43	PF00568	0.522
DOC_USP7_MATH_1	10	14	PF00917	0.555
DOC_USP7_MATH_1	148	152	PF00917	0.543
DOC_USP7_MATH_1	282	286	PF00917	0.449
DOC_USP7_MATH_1	71	75	PF00917	0.580
DOC_WW_Pin1_4	186	191	PF00397	0.350
LIG_14-3-3_CanoR_1	162	167	PF00244	0.568
LIG_14-3-3_CanoR_1	90	98	PF00244	0.419
LIG_Actin_WH2_2	262	280	PF00022	0.321
LIG_EH1_1	100	108	PF00400	0.320
LIG_eIF4E_1	123	129	PF01652	0.398
LIG_eIF4E_1	228	234	PF01652	0.503
LIG_FHA_1	216	222	PF00498	0.477
LIG_FHA_1	82	88	PF00498	0.395
LIG_FHA_2	120	126	PF00498	0.274
LIG_FHA_2	152	158	PF00498	0.543
LIG_FHA_2	274	280	PF00498	0.475
LIG_LIR_Gen_1	122	129	PF02991	0.360
LIG_LIR_Gen_1	175	181	PF02991	0.369
LIG_LIR_Gen_1	45	54	PF02991	0.475
LIG_LIR_Gen_1	89	98	PF02991	0.502
LIG_LIR_Nem_3	122	126	PF02991	0.376
LIG_LIR_Nem_3	175	180	PF02991	0.326
LIG_LIR_Nem_3	259	265	PF02991	0.503
LIG_LIR_Nem_3	45	51	PF02991	0.462
LIG_Pex14_2	138	142	PF04695	0.384
LIG_Pex14_2	262	266	PF04695	0.358
LIG_PTB_Apo_2	108	115	PF02174	0.344
LIG_PTB_Apo_2	222	229	PF02174	0.386
LIG_PTB_Phospho_1	222	228	PF10480	0.379
LIG_SH2_NCK_1	123	127	PF00017	0.345
LIG_SH2_SRC	123	126	PF00017	0.389
LIG_SUMO_SIM_anti_2	125	130	PF11976	0.464
LIG_SUMO_SIM_anti_2	220	226	PF11976	0.254
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.445
LIG_SUMO_SIM_par_1	102	108	PF11976	0.303
LIG_TRAF2_1	43	46	PF00917	0.668
LIG_UBA3_1	233	237	PF00899	0.550
LIG_WRC_WIRS_1	134	139	PF05994	0.423
MOD_CK1_1	119	125	PF00069	0.290
MOD_CK1_1	13	19	PF00069	0.643
MOD_CK1_1	140	146	PF00069	0.451
MOD_CK1_1	151	157	PF00069	0.426
MOD_CK1_1	268	274	PF00069	0.378
MOD_CK1_1	89	95	PF00069	0.479
MOD_CK2_1	151	157	PF00069	0.450
MOD_CK2_1	172	178	PF00069	0.458
MOD_GlcNHglycan	67	70	PF01048	0.578
MOD_GSK3_1	13	20	PF00069	0.619
MOD_GSK3_1	133	140	PF00069	0.445
MOD_GSK3_1	168	175	PF00069	0.605
MOD_GSK3_1	244	251	PF00069	0.530
MOD_NEK2_1	133	138	PF00069	0.312
MOD_NEK2_1	273	278	PF00069	0.493
MOD_PIKK_1	192	198	PF00454	0.389
MOD_PK_1	162	168	PF00069	0.611
MOD_PKA_2	273	279	PF00069	0.502
MOD_PKA_2	89	95	PF00069	0.385
MOD_Plk_1	151	157	PF00069	0.427
MOD_Plk_1	17	23	PF00069	0.444
MOD_Plk_1	3	9	PF00069	0.598
MOD_Plk_4	248	254	PF00069	0.536
MOD_ProDKin_1	186	192	PF00069	0.357
TRG_DiLeu_BaEn_3	45	51	PF01217	0.524
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.508
TRG_ENDOCYTIC_2	123	126	PF00928	0.464
TRG_ENDOCYTIC_2	91	94	PF00928	0.520
TRG_ER_diArg_1	228	231	PF00400	0.449
TRG_NES_CRM1_1	207	220	PF08389	0.420
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW3	Leptomonas seymouri	65%	98%
A0A1X0NUU9	Trypanosomatidae	45%	94%
A0A3S7X5I4	Leishmania donovani	91%	100%
A0A422NL68	Trypanosoma rangeli	40%	100%
A4HKE8	Leishmania braziliensis	78%	100%
A4I7X6	Leishmania infantum	91%	100%
D0AA41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	93%
Q4Q5C0	Leishmania major	89%	100%
V5BF01	Trypanosoma cruzi	39%	100%