LeishMANIAdb
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ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP-dependent DNA helicase
Gene product:
helicase-like protein
Species:
Leishmania mexicana
UniProt:
E9B2T5_LEIMU
TriTrypDb:
LmxM.31.1590
Length:
937

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

E9B2T5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2T5

Function

Biological processes
Term Name Level Count
GO:0000723 telomere maintenance 5 9
GO:0006139 nucleobase-containing compound metabolic process 3 9
GO:0006259 DNA metabolic process 4 9
GO:0006281 DNA repair 5 9
GO:0006310 DNA recombination 5 9
GO:0006725 cellular aromatic compound metabolic process 3 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0006950 response to stress 2 9
GO:0006974 DNA damage response 4 9
GO:0006996 organelle organization 4 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0016043 cellular component organization 3 9
GO:0032200 telomere organization 6 9
GO:0033554 cellular response to stress 3 9
GO:0034641 cellular nitrogen compound metabolic process 3 9
GO:0043170 macromolecule metabolic process 3 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0044260 obsolete cellular macromolecule metabolic process 3 9
GO:0046483 heterocycle metabolic process 3 9
GO:0050896 response to stimulus 1 9
GO:0051276 chromosome organization 5 9
GO:0051716 cellular response to stimulus 2 9
GO:0071704 organic substance metabolic process 2 9
GO:0071840 cellular component organization or biogenesis 2 9
GO:0090304 nucleic acid metabolic process 4 9
GO:1901360 organic cyclic compound metabolic process 3 9
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003678 DNA helicase activity 3 9
GO:0003824 catalytic activity 1 9
GO:0004386 helicase activity 2 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0008094 ATP-dependent activity, acting on DNA 2 9
GO:0016462 pyrophosphatase activity 5 9
GO:0016787 hydrolase activity 2 9
GO:0016817 hydrolase activity, acting on acid anhydrides 3 9
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 9
GO:0016887 ATP hydrolysis activity 7 9
GO:0017076 purine nucleotide binding 4 9
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:0140097 catalytic activity, acting on DNA 3 9
GO:0140640 catalytic activity, acting on a nucleic acid 2 9
GO:0140657 ATP-dependent activity 1 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 522 526 PF00656 0.376
CLV_MEL_PAP_1 331 337 PF00089 0.412
CLV_NRD_NRD_1 263 265 PF00675 0.664
CLV_NRD_NRD_1 301 303 PF00675 0.454
CLV_NRD_NRD_1 339 341 PF00675 0.720
CLV_NRD_NRD_1 407 409 PF00675 0.781
CLV_NRD_NRD_1 423 425 PF00675 0.550
CLV_NRD_NRD_1 504 506 PF00675 0.488
CLV_NRD_NRD_1 632 634 PF00675 0.573
CLV_NRD_NRD_1 696 698 PF00675 0.535
CLV_NRD_NRD_1 710 712 PF00675 0.464
CLV_NRD_NRD_1 873 875 PF00675 0.478
CLV_PCSK_FUR_1 337 341 PF00082 0.753
CLV_PCSK_KEX2_1 263 265 PF00082 0.664
CLV_PCSK_KEX2_1 300 302 PF00082 0.459
CLV_PCSK_KEX2_1 337 339 PF00082 0.713
CLV_PCSK_KEX2_1 407 409 PF00082 0.787
CLV_PCSK_KEX2_1 422 424 PF00082 0.524
CLV_PCSK_KEX2_1 632 634 PF00082 0.542
CLV_PCSK_KEX2_1 696 698 PF00082 0.524
CLV_PCSK_KEX2_1 719 721 PF00082 0.463
CLV_PCSK_PC1ET2_1 407 409 PF00082 0.820
CLV_PCSK_PC1ET2_1 719 721 PF00082 0.401
CLV_PCSK_PC7_1 297 303 PF00082 0.203
CLV_PCSK_PC7_1 334 340 PF00082 0.448
CLV_PCSK_PC7_1 692 698 PF00082 0.621
CLV_PCSK_SKI1_1 13 17 PF00082 0.613
CLV_PCSK_SKI1_1 432 436 PF00082 0.467
CLV_PCSK_SKI1_1 505 509 PF00082 0.494
CLV_PCSK_SKI1_1 637 641 PF00082 0.537
CLV_PCSK_SKI1_1 64 68 PF00082 0.501
CLV_PCSK_SKI1_1 719 723 PF00082 0.442
CLV_PCSK_SKI1_1 726 730 PF00082 0.385
CLV_PCSK_SKI1_1 731 735 PF00082 0.459
CLV_PCSK_SKI1_1 755 759 PF00082 0.455
CLV_Separin_Metazoa 682 686 PF03568 0.608
DEG_APCC_DBOX_1 572 580 PF00400 0.577
DEG_Nend_UBRbox_1 1 4 PF02207 0.609
DEG_SCF_FBW7_1 323 330 PF00400 0.473
DEG_SCF_FBW7_2 15 20 PF00400 0.579
DEG_SPOP_SBC_1 28 32 PF00917 0.513
DEG_SPOP_SBC_1 57 61 PF00917 0.621
DOC_ANK_TNKS_1 796 803 PF00023 0.457
DOC_CKS1_1 205 210 PF01111 0.669
DOC_CKS1_1 324 329 PF01111 0.437
DOC_CKS1_1 831 836 PF01111 0.435
DOC_CYCLIN_RxL_1 258 270 PF00134 0.672
DOC_CYCLIN_yClb1_LxF_4 262 267 PF00134 0.601
DOC_CYCLIN_yCln2_LP_2 604 610 PF00134 0.636
DOC_MAPK_DCC_7 667 677 PF00069 0.368
DOC_MAPK_DCC_7 803 812 PF00069 0.376
DOC_MAPK_gen_1 719 729 PF00069 0.386
DOC_MAPK_gen_1 872 881 PF00069 0.479
DOC_MAPK_MEF2A_6 671 679 PF00069 0.558
DOC_MAPK_MEF2A_6 803 812 PF00069 0.372
DOC_PP1_RVXF_1 261 268 PF00149 0.659
DOC_PP2B_LxvP_1 925 928 PF13499 0.540
DOC_PP4_FxxP_1 201 204 PF00568 0.337
DOC_PP4_FxxP_1 259 262 PF00568 0.483
DOC_PP4_FxxP_1 559 562 PF00568 0.483
DOC_USP7_MATH_1 28 32 PF00917 0.756
DOC_USP7_MATH_1 327 331 PF00917 0.444
DOC_USP7_MATH_1 368 372 PF00917 0.778
DOC_USP7_MATH_1 382 386 PF00917 0.717
DOC_USP7_MATH_1 392 396 PF00917 0.742
DOC_USP7_MATH_1 403 407 PF00917 0.596
DOC_USP7_MATH_1 414 418 PF00917 0.728
DOC_USP7_MATH_1 562 566 PF00917 0.635
DOC_USP7_MATH_1 57 61 PF00917 0.627
DOC_USP7_MATH_1 595 599 PF00917 0.584
DOC_USP7_MATH_1 914 918 PF00917 0.535
DOC_USP7_UBL2_3 496 500 PF12436 0.562
DOC_WW_Pin1_4 129 134 PF00397 0.450
DOC_WW_Pin1_4 13 18 PF00397 0.670
DOC_WW_Pin1_4 204 209 PF00397 0.405
DOC_WW_Pin1_4 323 328 PF00397 0.437
DOC_WW_Pin1_4 359 364 PF00397 0.641
DOC_WW_Pin1_4 558 563 PF00397 0.668
DOC_WW_Pin1_4 603 608 PF00397 0.581
DOC_WW_Pin1_4 764 769 PF00397 0.652
DOC_WW_Pin1_4 830 835 PF00397 0.431
DOC_WW_Pin1_4 882 887 PF00397 0.419
DOC_WW_Pin1_4 915 920 PF00397 0.533
DOC_WW_Pin1_4 932 937 PF00397 0.522
LIG_14-3-3_CanoR_1 114 123 PF00244 0.480
LIG_14-3-3_CanoR_1 178 187 PF00244 0.393
LIG_14-3-3_CanoR_1 26 36 PF00244 0.638
LIG_14-3-3_CanoR_1 632 637 PF00244 0.487
LIG_14-3-3_CanoR_1 731 736 PF00244 0.562
LIG_14-3-3_CanoR_1 749 758 PF00244 0.586
LIG_14-3-3_CanoR_1 887 892 PF00244 0.468
LIG_Actin_WH2_2 691 709 PF00022 0.626
LIG_BIR_III_4 799 803 PF00653 0.507
LIG_BRCT_BRCA1_1 307 311 PF00533 0.420
LIG_BRCT_BRCA1_1 318 322 PF00533 0.293
LIG_BRCT_BRCA1_1 331 335 PF00533 0.552
LIG_BRCT_BRCA1_1 436 440 PF00533 0.380
LIG_BRCT_BRCA1_1 59 63 PF00533 0.512
LIG_BRCT_BRCA1_1 894 898 PF00533 0.503
LIG_CaM_NSCaTE_8 821 828 PF13499 0.521
LIG_deltaCOP1_diTrp_1 426 435 PF00928 0.598
LIG_deltaCOP1_diTrp_1 436 440 PF00928 0.456
LIG_deltaCOP1_diTrp_1 820 823 PF00928 0.585
LIG_FHA_1 14 20 PF00498 0.679
LIG_FHA_1 198 204 PF00498 0.362
LIG_FHA_1 222 228 PF00498 0.635
LIG_FHA_1 268 274 PF00498 0.552
LIG_FHA_1 31 37 PF00498 0.756
LIG_FHA_1 386 392 PF00498 0.682
LIG_FHA_1 439 445 PF00498 0.418
LIG_FHA_1 550 556 PF00498 0.488
LIG_FHA_1 57 63 PF00498 0.656
LIG_FHA_1 623 629 PF00498 0.580
LIG_FHA_1 809 815 PF00498 0.540
LIG_FHA_1 897 903 PF00498 0.485
LIG_FHA_2 113 119 PF00498 0.731
LIG_FHA_2 138 144 PF00498 0.496
LIG_FHA_2 205 211 PF00498 0.620
LIG_FHA_2 520 526 PF00498 0.639
LIG_FHA_2 532 538 PF00498 0.565
LIG_FHA_2 585 591 PF00498 0.316
LIG_FHA_2 815 821 PF00498 0.534
LIG_Integrin_RGD_1 424 426 PF01839 0.465
LIG_LIR_Apic_2 199 204 PF02991 0.338
LIG_LIR_Apic_2 257 262 PF02991 0.628
LIG_LIR_Gen_1 319 329 PF02991 0.339
LIG_LIR_Nem_3 308 314 PF02991 0.405
LIG_LIR_Nem_3 319 325 PF02991 0.271
LIG_LIR_Nem_3 326 331 PF02991 0.200
LIG_LIR_Nem_3 437 443 PF02991 0.558
LIG_MAD2 355 363 PF02301 0.353
LIG_MYND_1 42 46 PF01753 0.585
LIG_PCNA_yPIPBox_3 739 749 PF02747 0.461
LIG_Pex14_2 197 201 PF04695 0.337
LIG_SH2_CRK 430 434 PF00017 0.532
LIG_SH2_CRK 602 606 PF00017 0.535
LIG_SH2_GRB2like 737 740 PF00017 0.425
LIG_SH2_SRC 737 740 PF00017 0.425
LIG_SH2_SRC 926 929 PF00017 0.515
LIG_SH2_STAP1 610 614 PF00017 0.607
LIG_SH2_STAP1 665 669 PF00017 0.442
LIG_SH2_STAP1 836 840 PF00017 0.382
LIG_SH2_STAT5 443 446 PF00017 0.503
LIG_SH2_STAT5 627 630 PF00017 0.429
LIG_SH2_STAT5 737 740 PF00017 0.425
LIG_SH2_STAT5 867 870 PF00017 0.362
LIG_SH2_STAT5 926 929 PF00017 0.621
LIG_SH3_2 42 47 PF14604 0.673
LIG_SH3_3 117 123 PF00018 0.739
LIG_SH3_3 200 206 PF00018 0.381
LIG_SH3_3 212 218 PF00018 0.644
LIG_SH3_3 39 45 PF00018 0.673
LIG_SH3_3 48 54 PF00018 0.782
LIG_SH3_3 59 65 PF00018 0.454
LIG_SH3_3 674 680 PF00018 0.361
LIG_SH3_3 788 794 PF00018 0.530
LIG_SH3_3 802 808 PF00018 0.356
LIG_SH3_3 828 834 PF00018 0.383
LIG_SH3_3 888 894 PF00018 0.498
LIG_SUMO_SIM_anti_2 275 280 PF11976 0.343
LIG_SUMO_SIM_par_1 221 229 PF11976 0.542
LIG_SUMO_SIM_par_1 277 283 PF11976 0.339
LIG_SUMO_SIM_par_1 506 511 PF11976 0.566
LIG_SUMO_SIM_par_1 811 817 PF11976 0.508
LIG_TRAF2_1 587 590 PF00917 0.311
LIG_UBA3_1 164 171 PF00899 0.413
LIG_UBA3_1 211 217 PF00899 0.641
LIG_WRC_WIRS_1 292 297 PF05994 0.473
LIG_WRC_WIRS_1 748 753 PF05994 0.472
LIG_WW_2 42 45 PF00397 0.585
LIG_WW_3 44 48 PF00397 0.685
MOD_CDC14_SPxK_1 561 564 PF00782 0.424
MOD_CDK_SPK_2 882 887 PF00069 0.471
MOD_CDK_SPK_2 915 920 PF00069 0.378
MOD_CDK_SPK_2 932 937 PF00069 0.458
MOD_CDK_SPxK_1 558 564 PF00069 0.405
MOD_CDK_SPxxK_3 129 136 PF00069 0.429
MOD_CK1_1 132 138 PF00069 0.376
MOD_CK1_1 362 368 PF00069 0.675
MOD_CK1_1 385 391 PF00069 0.716
MOD_CK1_1 412 418 PF00069 0.729
MOD_CK1_1 531 537 PF00069 0.641
MOD_CK1_1 58 64 PF00069 0.802
MOD_CK1_1 606 612 PF00069 0.616
MOD_CK1_1 622 628 PF00069 0.594
MOD_CK1_1 741 747 PF00069 0.299
MOD_CK2_1 368 374 PF00069 0.773
MOD_CK2_1 392 398 PF00069 0.722
MOD_CK2_1 531 537 PF00069 0.750
MOD_CK2_1 584 590 PF00069 0.429
MOD_Cter_Amidation 335 338 PF01082 0.713
MOD_GlcNHglycan 318 321 PF01048 0.362
MOD_GlcNHglycan 331 334 PF01048 0.556
MOD_GlcNHglycan 370 373 PF01048 0.674
MOD_GlcNHglycan 411 414 PF01048 0.628
MOD_GlcNHglycan 416 420 PF01048 0.685
MOD_GlcNHglycan 47 50 PF01048 0.678
MOD_GlcNHglycan 478 481 PF01048 0.441
MOD_GlcNHglycan 564 567 PF01048 0.640
MOD_GlcNHglycan 614 617 PF01048 0.557
MOD_GlcNHglycan 621 624 PF01048 0.609
MOD_GlcNHglycan 643 646 PF01048 0.634
MOD_GlcNHglycan 751 754 PF01048 0.568
MOD_GlcNHglycan 781 784 PF01048 0.556
MOD_GlcNHglycan 788 791 PF01048 0.557
MOD_GlcNHglycan 920 923 PF01048 0.651
MOD_GSK3_1 108 115 PF00069 0.705
MOD_GSK3_1 193 200 PF00069 0.369
MOD_GSK3_1 28 35 PF00069 0.768
MOD_GSK3_1 323 330 PF00069 0.407
MOD_GSK3_1 392 399 PF00069 0.723
MOD_GSK3_1 414 421 PF00069 0.756
MOD_GSK3_1 434 441 PF00069 0.477
MOD_GSK3_1 52 59 PF00069 0.749
MOD_GSK3_1 558 565 PF00069 0.668
MOD_GSK3_1 606 613 PF00069 0.557
MOD_GSK3_1 64 71 PF00069 0.700
MOD_GSK3_1 75 82 PF00069 0.761
MOD_GSK3_1 808 815 PF00069 0.586
MOD_GSK3_1 892 899 PF00069 0.468
MOD_GSK3_1 914 921 PF00069 0.566
MOD_N-GLC_1 731 736 PF02516 0.472
MOD_N-GLC_1 738 743 PF02516 0.400
MOD_N-GLC_1 882 887 PF02516 0.427
MOD_NEK2_1 102 107 PF00069 0.596
MOD_NEK2_1 197 202 PF00069 0.362
MOD_NEK2_1 267 272 PF00069 0.583
MOD_NEK2_1 434 439 PF00069 0.462
MOD_NEK2_1 476 481 PF00069 0.434
MOD_NEK2_1 579 584 PF00069 0.563
MOD_NEK2_1 608 613 PF00069 0.567
MOD_NEK2_1 779 784 PF00069 0.503
MOD_NEK2_1 896 901 PF00069 0.450
MOD_NEK2_2 193 198 PF00069 0.362
MOD_NEK2_2 382 387 PF00069 0.661
MOD_NEK2_2 821 826 PF00069 0.534
MOD_NEK2_2 836 841 PF00069 0.343
MOD_PIKK_1 516 522 PF00454 0.538
MOD_PIKK_1 79 85 PF00454 0.729
MOD_PIKK_1 896 902 PF00454 0.514
MOD_PK_1 2 8 PF00069 0.559
MOD_PK_1 528 534 PF00069 0.477
MOD_PK_1 887 893 PF00069 0.506
MOD_PK_1 901 907 PF00069 0.518
MOD_PKA_1 409 415 PF00069 0.801
MOD_PKA_1 632 638 PF00069 0.492
MOD_PKA_1 711 717 PF00069 0.574
MOD_PKA_2 267 273 PF00069 0.586
MOD_PKA_2 409 415 PF00069 0.801
MOD_PKA_2 474 480 PF00069 0.449
MOD_PKA_2 595 601 PF00069 0.493
MOD_PKA_2 619 625 PF00069 0.563
MOD_PKA_2 632 638 PF00069 0.564
MOD_PKB_1 558 566 PF00069 0.408
MOD_Plk_1 221 227 PF00069 0.698
MOD_Plk_1 282 288 PF00069 0.337
MOD_Plk_1 373 379 PF00069 0.630
MOD_Plk_1 397 403 PF00069 0.558
MOD_Plk_1 579 585 PF00069 0.453
MOD_Plk_1 731 737 PF00069 0.482
MOD_Plk_2-3 112 118 PF00069 0.439
MOD_Plk_2-3 137 143 PF00069 0.473
MOD_Plk_2-3 97 103 PF00069 0.519
MOD_Plk_4 147 153 PF00069 0.308
MOD_Plk_4 282 288 PF00069 0.318
MOD_Plk_4 549 555 PF00069 0.504
MOD_Plk_4 58 64 PF00069 0.514
MOD_Plk_4 711 717 PF00069 0.569
MOD_Plk_4 741 747 PF00069 0.301
MOD_Plk_4 892 898 PF00069 0.482
MOD_ProDKin_1 129 135 PF00069 0.434
MOD_ProDKin_1 13 19 PF00069 0.671
MOD_ProDKin_1 204 210 PF00069 0.405
MOD_ProDKin_1 323 329 PF00069 0.437
MOD_ProDKin_1 359 365 PF00069 0.652
MOD_ProDKin_1 558 564 PF00069 0.675
MOD_ProDKin_1 603 609 PF00069 0.581
MOD_ProDKin_1 764 770 PF00069 0.648
MOD_ProDKin_1 830 836 PF00069 0.433
MOD_ProDKin_1 882 888 PF00069 0.417
MOD_ProDKin_1 915 921 PF00069 0.524
MOD_SUMO_rev_2 756 764 PF00179 0.635
MOD_SUMO_rev_2 799 805 PF00179 0.382
TRG_DiLeu_BaLyEn_6 488 493 PF01217 0.528
TRG_ENDOCYTIC_2 341 344 PF00928 0.687
TRG_ER_diArg_1 1 4 PF00400 0.727
TRG_ER_diArg_1 262 264 PF00400 0.694
TRG_ER_diArg_1 300 302 PF00400 0.459
TRG_ER_diArg_1 337 340 PF00400 0.720
TRG_ER_diArg_1 408 411 PF00400 0.741
TRG_ER_diArg_1 422 424 PF00400 0.554
TRG_ER_diArg_1 573 576 PF00400 0.598
TRG_ER_diArg_1 631 633 PF00400 0.444
TRG_ER_diArg_1 695 697 PF00400 0.542
TRG_NLS_MonoCore_2 406 411 PF00514 0.609
TRG_NLS_MonoExtN_4 404 411 PF00514 0.817
TRG_Pf-PMV_PEXEL_1 166 170 PF00026 0.393
TRG_Pf-PMV_PEXEL_1 586 590 PF00026 0.605
TRG_Pf-PMV_PEXEL_1 731 736 PF00026 0.471

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAU3 Leptomonas seymouri 49% 100%
A0A1X0NW19 Trypanosomatidae 32% 100%
A0A3R7LZC1 Trypanosoma rangeli 38% 100%
A0A3S7X5K3 Leishmania donovani 84% 100%
A4HKE6 Leishmania braziliensis 66% 100%
A4I7X4 Leishmania infantum 85% 86%
D0AA39 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
Q381V6 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS