Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania mexicana

UniProt:

E9B2T3_LEIMU

TriTrypDb:

LmxM.31.1570

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2T3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	6
GO:0008047	enzyme activator activity	3	6
GO:0030234	enzyme regulator activity	2	6
GO:0030695	GTPase regulator activity	4	6
GO:0060589	nucleoside-triphosphatase regulator activity	3	6
GO:0098772	molecular function regulator activity	1	6
GO:0140677	molecular function activator activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.517
CLV_NRD_NRD_1	127	129	PF00675	0.412
CLV_NRD_NRD_1	315	317	PF00675	0.687
CLV_NRD_NRD_1	399	401	PF00675	0.838
CLV_NRD_NRD_1	450	452	PF00675	0.546
CLV_NRD_NRD_1	467	469	PF00675	0.662
CLV_NRD_NRD_1	616	618	PF00675	0.625
CLV_NRD_NRD_1	711	713	PF00675	0.623
CLV_NRD_NRD_1	725	727	PF00675	0.464
CLV_PCSK_FUR_1	313	317	PF00082	0.642
CLV_PCSK_FUR_1	399	403	PF00082	0.799
CLV_PCSK_FUR_1	723	727	PF00082	0.401
CLV_PCSK_FUR_1	91	95	PF00082	0.412
CLV_PCSK_KEX2_1	127	129	PF00082	0.412
CLV_PCSK_KEX2_1	313	315	PF00082	0.703
CLV_PCSK_KEX2_1	318	320	PF00082	0.646
CLV_PCSK_KEX2_1	399	401	PF00082	0.834
CLV_PCSK_KEX2_1	450	452	PF00082	0.525
CLV_PCSK_KEX2_1	616	618	PF00082	0.625
CLV_PCSK_KEX2_1	711	713	PF00082	0.617
CLV_PCSK_KEX2_1	725	727	PF00082	0.459
CLV_PCSK_KEX2_1	90	92	PF00082	0.384
CLV_PCSK_KEX2_1	93	95	PF00082	0.408
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.692
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.735
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.384
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.408
CLV_PCSK_PC7_1	314	320	PF00082	0.693
CLV_PCSK_SKI1_1	115	119	PF00082	0.345
CLV_PCSK_SKI1_1	131	135	PF00082	0.401
CLV_PCSK_SKI1_1	150	154	PF00082	0.581
CLV_PCSK_SKI1_1	20	24	PF00082	0.349
CLV_PCSK_SKI1_1	208	212	PF00082	0.661
CLV_PCSK_SKI1_1	229	233	PF00082	0.684
CLV_PCSK_SKI1_1	337	341	PF00082	0.585
CLV_PCSK_SKI1_1	443	447	PF00082	0.675
CLV_PCSK_SKI1_1	603	607	PF00082	0.618
CLV_PCSK_SKI1_1	616	620	PF00082	0.625
CLV_PCSK_SKI1_1	704	708	PF00082	0.395
CLV_PCSK_SKI1_1	718	722	PF00082	0.643
CLV_PCSK_SKI1_1	90	94	PF00082	0.267
DEG_APCC_DBOX_1	207	215	PF00400	0.514
DEG_APCC_DBOX_1	401	409	PF00400	0.680
DEG_MDM2_SWIB_1	561	568	PF02201	0.508
DEG_ODPH_VHL_1	436	447	PF01847	0.606
DEG_SPOP_SBC_1	520	524	PF00917	0.698
DOC_CDC14_PxL_1	507	515	PF14671	0.522
DOC_CKS1_1	573	578	PF01111	0.516
DOC_CKS1_1	685	690	PF01111	0.664
DOC_CYCLIN_RxL_1	15	27	PF00134	0.224
DOC_CYCLIN_yClb1_LxF_4	415	420	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	606	612	PF00134	0.546
DOC_MAPK_DCC_7	427	436	PF00069	0.634
DOC_MAPK_gen_1	67	75	PF00069	0.412
DOC_MAPK_gen_1	711	719	PF00069	0.607
DOC_MAPK_MEF2A_6	229	237	PF00069	0.605
DOC_MAPK_MEF2A_6	324	332	PF00069	0.739
DOC_MAPK_MEF2A_6	427	436	PF00069	0.697
DOC_PP1_RVXF_1	415	421	PF00149	0.510
DOC_PP2B_LxvP_1	214	217	PF13499	0.471
DOC_PP2B_LxvP_1	389	392	PF13499	0.548
DOC_PP2B_LxvP_1	620	623	PF13499	0.620
DOC_PP4_FxxP_1	581	584	PF00568	0.702
DOC_PP4_MxPP_1	326	329	PF00568	0.602
DOC_USP7_MATH_1	137	141	PF00917	0.686
DOC_USP7_MATH_1	194	198	PF00917	0.664
DOC_USP7_MATH_1	304	308	PF00917	0.739
DOC_USP7_MATH_1	449	453	PF00917	0.719
DOC_USP7_MATH_1	456	460	PF00917	0.643
DOC_USP7_MATH_1	589	593	PF00917	0.677
DOC_USP7_MATH_1	659	663	PF00917	0.691
DOC_USP7_MATH_1	82	86	PF00917	0.337
DOC_USP7_UBL2_3	86	90	PF12436	0.224
DOC_WW_Pin1_4	169	174	PF00397	0.712
DOC_WW_Pin1_4	203	208	PF00397	0.659
DOC_WW_Pin1_4	229	234	PF00397	0.585
DOC_WW_Pin1_4	271	276	PF00397	0.572
DOC_WW_Pin1_4	358	363	PF00397	0.785
DOC_WW_Pin1_4	400	405	PF00397	0.545
DOC_WW_Pin1_4	427	432	PF00397	0.763
DOC_WW_Pin1_4	436	441	PF00397	0.738
DOC_WW_Pin1_4	478	483	PF00397	0.698
DOC_WW_Pin1_4	569	574	PF00397	0.689
DOC_WW_Pin1_4	618	623	PF00397	0.608
DOC_WW_Pin1_4	657	662	PF00397	0.674
DOC_WW_Pin1_4	672	677	PF00397	0.572
DOC_WW_Pin1_4	684	689	PF00397	0.596
LIG_14-3-3_CanoR_1	316	326	PF00244	0.611
LIG_14-3-3_CanoR_1	450	460	PF00244	0.726
LIG_14-3-3_CanoR_1	504	514	PF00244	0.525
LIG_14-3-3_CanoR_1	637	641	PF00244	0.705
LIG_14-3-3_CanoR_1	725	730	PF00244	0.564
LIG_14-3-3_CanoR_1	91	97	PF00244	0.224
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_BIR_III_4	151	155	PF00653	0.536
LIG_BRCT_BRCA1_1	688	692	PF00533	0.736
LIG_CaM_IQ_9	1	16	PF13499	0.534
LIG_deltaCOP1_diTrp_1	74	83	PF00928	0.412
LIG_FHA_1	177	183	PF00498	0.634
LIG_FHA_1	230	236	PF00498	0.612
LIG_FHA_1	278	284	PF00498	0.587
LIG_FHA_1	338	344	PF00498	0.540
LIG_FHA_1	404	410	PF00498	0.789
LIG_FHA_1	442	448	PF00498	0.720
LIG_FHA_1	452	458	PF00498	0.599
LIG_FHA_1	485	491	PF00498	0.699
LIG_FHA_1	6	12	PF00498	0.538
LIG_FHA_1	698	704	PF00498	0.633
LIG_FHA_1	70	76	PF00498	0.412
LIG_FHA_2	157	163	PF00498	0.541
LIG_FHA_2	283	289	PF00498	0.655
LIG_FHA_2	504	510	PF00498	0.528
LIG_FHA_2	531	537	PF00498	0.678
LIG_LIR_Apic_2	103	107	PF02991	0.408
LIG_LIR_Gen_1	383	393	PF02991	0.546
LIG_LIR_Gen_1	40	49	PF02991	0.412
LIG_LIR_Gen_1	563	573	PF02991	0.507
LIG_LIR_Gen_1	664	674	PF02991	0.616
LIG_LIR_Nem_3	383	389	PF02991	0.616
LIG_LIR_Nem_3	40	44	PF02991	0.519
LIG_LIR_Nem_3	419	423	PF02991	0.657
LIG_LIR_Nem_3	563	568	PF02991	0.509
LIG_LIR_Nem_3	664	669	PF02991	0.612
LIG_NRBOX	18	24	PF00104	0.412
LIG_PCNA_yPIPBox_3	9	23	PF02747	0.492
LIG_Pex14_2	561	565	PF04695	0.507
LIG_SH2_CRK	129	133	PF00017	0.402
LIG_SH2_PTP2	104	107	PF00017	0.412
LIG_SH2_STAP1	643	647	PF00017	0.530
LIG_SH2_STAT3	630	633	PF00017	0.586
LIG_SH2_STAT5	104	107	PF00017	0.412
LIG_SH2_STAT5	124	127	PF00017	0.199
LIG_SH2_STAT5	215	218	PF00017	0.593
LIG_SH2_STAT5	610	613	PF00017	0.567
LIG_SH2_STAT5	630	633	PF00017	0.589
LIG_SH3_1	129	135	PF00018	0.500
LIG_SH3_1	270	276	PF00018	0.510
LIG_SH3_2	499	504	PF14604	0.531
LIG_SH3_2	573	578	PF14604	0.516
LIG_SH3_3	129	135	PF00018	0.620
LIG_SH3_3	244	250	PF00018	0.767
LIG_SH3_3	270	276	PF00018	0.589
LIG_SH3_3	325	331	PF00018	0.697
LIG_SH3_3	344	350	PF00018	0.667
LIG_SH3_3	361	367	PF00018	0.631
LIG_SH3_3	389	395	PF00018	0.551
LIG_SH3_3	410	416	PF00018	0.641
LIG_SH3_3	429	435	PF00018	0.609
LIG_SH3_3	476	482	PF00018	0.724
LIG_SH3_3	496	502	PF00018	0.519
LIG_SH3_3	570	576	PF00018	0.599
LIG_SH3_3	619	625	PF00018	0.588
LIG_SH3_3	685	691	PF00018	0.569
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.669
LIG_SUMO_SIM_par_1	261	266	PF11976	0.646
LIG_SUMO_SIM_par_1	277	285	PF11976	0.560
LIG_SUMO_SIM_par_1	443	448	PF11976	0.670
LIG_TRAF2_1	286	289	PF00917	0.539
LIG_TRAF2_1	385	388	PF00917	0.625
LIG_WW_3	490	494	PF00397	0.698
MOD_CDK_SPK_2	203	208	PF00069	0.649
MOD_CDK_SPxK_1	572	578	PF00069	0.578
MOD_CDK_SPxxK_3	358	365	PF00069	0.556
MOD_CDK_SPxxK_3	436	443	PF00069	0.661
MOD_CK1_1	261	267	PF00069	0.675
MOD_CK1_1	274	280	PF00069	0.601
MOD_CK1_1	317	323	PF00069	0.555
MOD_CK1_1	426	432	PF00069	0.704
MOD_CK1_1	503	509	PF00069	0.554
MOD_CK1_1	512	518	PF00069	0.594
MOD_CK1_1	524	530	PF00069	0.645
MOD_CK1_1	560	566	PF00069	0.670
MOD_CK1_1	639	645	PF00069	0.765
MOD_CK1_1	662	668	PF00069	0.663
MOD_CK1_1	672	678	PF00069	0.607
MOD_CK2_1	137	143	PF00069	0.535
MOD_CK2_1	156	162	PF00069	0.579
MOD_CK2_1	282	288	PF00069	0.583
MOD_CK2_1	427	433	PF00069	0.580
MOD_CK2_1	503	509	PF00069	0.532
MOD_CK2_1	530	536	PF00069	0.683
MOD_CK2_1	639	645	PF00069	0.678
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.440
MOD_GlcNHglycan	111	115	PF01048	0.362
MOD_GlcNHglycan	135	138	PF01048	0.599
MOD_GlcNHglycan	229	232	PF01048	0.486
MOD_GlcNHglycan	243	246	PF01048	0.698
MOD_GlcNHglycan	305	309	PF01048	0.722
MOD_GlcNHglycan	423	426	PF01048	0.643
MOD_GlcNHglycan	493	496	PF01048	0.641
MOD_GlcNHglycan	524	527	PF01048	0.680
MOD_GlcNHglycan	54	57	PF01048	0.412
MOD_GlcNHglycan	591	594	PF01048	0.522
MOD_GlcNHglycan	679	684	PF01048	0.623
MOD_GlcNHglycan	695	698	PF01048	0.544
MOD_GSK3_1	133	140	PF00069	0.612
MOD_GSK3_1	271	278	PF00069	0.628
MOD_GSK3_1	314	321	PF00069	0.658
MOD_GSK3_1	423	430	PF00069	0.691
MOD_GSK3_1	505	512	PF00069	0.632
MOD_GSK3_1	520	527	PF00069	0.650
MOD_GSK3_1	553	560	PF00069	0.643
MOD_GSK3_1	63	70	PF00069	0.424
MOD_GSK3_1	635	642	PF00069	0.705
MOD_GSK3_1	651	658	PF00069	0.540
MOD_GSK3_1	693	700	PF00069	0.718
MOD_GSK3_1	92	99	PF00069	0.375
MOD_N-GLC_1	241	246	PF02516	0.647
MOD_N-GLC_1	557	562	PF02516	0.634
MOD_N-GLC_1	662	667	PF02516	0.631
MOD_NEK2_1	241	246	PF00069	0.687
MOD_NEK2_1	263	268	PF00069	0.607
MOD_NEK2_1	423	428	PF00069	0.683
MOD_NEK2_1	521	526	PF00069	0.557
MOD_NEK2_1	557	562	PF00069	0.649
MOD_NEK2_1	611	616	PF00069	0.654
MOD_NEK2_1	655	660	PF00069	0.640
MOD_NEK2_1	669	674	PF00069	0.667
MOD_NEK2_1	96	101	PF00069	0.274
MOD_PIKK_1	372	378	PF00454	0.553
MOD_PIKK_1	484	490	PF00454	0.849
MOD_PIKK_1	681	687	PF00454	0.619
MOD_PKA_1	314	320	PF00069	0.686
MOD_PKA_1	450	456	PF00069	0.518
MOD_PKA_1	725	731	PF00069	0.440
MOD_PKA_2	109	115	PF00069	0.299
MOD_PKA_2	176	182	PF00069	0.663
MOD_PKA_2	314	320	PF00069	0.697
MOD_PKA_2	426	432	PF00069	0.660
MOD_PKA_2	449	455	PF00069	0.724
MOD_PKA_2	461	467	PF00069	0.670
MOD_PKA_2	5	11	PF00069	0.601
MOD_PKA_2	503	509	PF00069	0.562
MOD_PKA_2	52	58	PF00069	0.412
MOD_PKA_2	582	588	PF00069	0.661
MOD_PKA_2	636	642	PF00069	0.655
MOD_PKA_2	669	675	PF00069	0.630
MOD_PKA_2	725	731	PF00069	0.440
MOD_PKB_1	35	43	PF00069	0.224
MOD_PKB_1	723	731	PF00069	0.567
MOD_Plk_1	343	349	PF00069	0.589
MOD_Plk_1	546	552	PF00069	0.582
MOD_Plk_1	557	563	PF00069	0.512
MOD_Plk_1	662	668	PF00069	0.641
MOD_Plk_1	96	102	PF00069	0.412
MOD_Plk_4	100	106	PF00069	0.412
MOD_Plk_4	258	264	PF00069	0.592
MOD_Plk_4	277	283	PF00069	0.571
MOD_Plk_4	343	349	PF00069	0.543
MOD_Plk_4	509	515	PF00069	0.521
MOD_Plk_4	669	675	PF00069	0.754
MOD_ProDKin_1	169	175	PF00069	0.707
MOD_ProDKin_1	203	209	PF00069	0.658
MOD_ProDKin_1	229	235	PF00069	0.592
MOD_ProDKin_1	271	277	PF00069	0.575
MOD_ProDKin_1	358	364	PF00069	0.779
MOD_ProDKin_1	400	406	PF00069	0.543
MOD_ProDKin_1	427	433	PF00069	0.769
MOD_ProDKin_1	436	442	PF00069	0.739
MOD_ProDKin_1	478	484	PF00069	0.700
MOD_ProDKin_1	569	575	PF00069	0.690
MOD_ProDKin_1	618	624	PF00069	0.611
MOD_ProDKin_1	657	663	PF00069	0.673
MOD_ProDKin_1	672	678	PF00069	0.572
MOD_ProDKin_1	684	690	PF00069	0.598
MOD_SUMO_rev_2	146	155	PF00179	0.627
MOD_SUMO_rev_2	366	374	PF00179	0.678
TRG_DiLeu_BaEn_1	509	514	PF01217	0.521
TRG_DiLeu_BaEn_2	78	84	PF01217	0.412
TRG_DiLeu_LyEn_5	178	183	PF01217	0.525
TRG_ENDOCYTIC_2	386	389	PF00928	0.549
TRG_ER_diArg_1	127	129	PF00400	0.412
TRG_ER_diArg_1	164	167	PF00400	0.546
TRG_ER_diArg_1	313	316	PF00400	0.691
TRG_ER_diArg_1	399	402	PF00400	0.813
TRG_ER_diArg_1	449	451	PF00400	0.561
TRG_ER_diArg_1	711	713	PF00400	0.548
TRG_ER_diArg_1	724	726	PF00400	0.459
TRG_NES_CRM1_1	708	722	PF08389	0.504
TRG_NLS_MonoExtC_3	399	404	PF00514	0.681
TRG_NLS_MonoExtC_3	89	94	PF00514	0.224
TRG_NLS_MonoExtN_4	399	404	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5J1	Leishmania donovani	75%	100%
A4HKE4	Leishmania braziliensis	47%	100%
A4I7X2	Leishmania infantum	75%	100%
Q4Q5C4	Leishmania major	72%	100%