LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Clu domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Clu domain-containing protein
Gene product:
Translation initiation factor eIF3 subunit 135, putative
Species:
Leishmania mexicana
UniProt:
E9B2T2_LEIMU
TriTrypDb:
LmxM.31.1560
Length:
920

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9B2T2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2T2

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0071840 cellular component organization or biogenesis 2 11
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003743 translation initiation factor activity 4 2
GO:0005488 binding 1 2
GO:0008135 translation factor activity, RNA binding 3 2
GO:0045182 translation regulator activity 1 2
GO:0090079 translation regulator activity, nucleic acid binding 2 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 432 436 PF00656 0.557
CLV_C14_Caspase3-7 866 870 PF00656 0.506
CLV_NRD_NRD_1 327 329 PF00675 0.288
CLV_NRD_NRD_1 42 44 PF00675 0.645
CLV_NRD_NRD_1 456 458 PF00675 0.295
CLV_NRD_NRD_1 652 654 PF00675 0.412
CLV_NRD_NRD_1 77 79 PF00675 0.725
CLV_NRD_NRD_1 809 811 PF00675 0.665
CLV_NRD_NRD_1 882 884 PF00675 0.497
CLV_PCSK_FUR_1 454 458 PF00082 0.295
CLV_PCSK_FUR_1 75 79 PF00082 0.483
CLV_PCSK_KEX2_1 327 329 PF00082 0.333
CLV_PCSK_KEX2_1 41 43 PF00082 0.645
CLV_PCSK_KEX2_1 456 458 PF00082 0.252
CLV_PCSK_KEX2_1 77 79 PF00082 0.726
CLV_PCSK_KEX2_1 808 810 PF00082 0.662
CLV_PCSK_KEX2_1 881 883 PF00082 0.524
CLV_PCSK_PC1ET2_1 881 883 PF00082 0.524
CLV_PCSK_SKI1_1 118 122 PF00082 0.538
CLV_PCSK_SKI1_1 181 185 PF00082 0.631
CLV_PCSK_SKI1_1 246 250 PF00082 0.256
CLV_PCSK_SKI1_1 297 301 PF00082 0.284
CLV_PCSK_SKI1_1 363 367 PF00082 0.245
CLV_PCSK_SKI1_1 43 47 PF00082 0.602
CLV_PCSK_SKI1_1 622 626 PF00082 0.431
CLV_PCSK_SKI1_1 704 708 PF00082 0.295
CLV_PCSK_SKI1_1 715 719 PF00082 0.295
CLV_PCSK_SKI1_1 724 728 PF00082 0.219
CLV_PCSK_SKI1_1 886 890 PF00082 0.490
CLV_PCSK_SKI1_1 89 93 PF00082 0.463
DEG_APCC_DBOX_1 885 893 PF00400 0.562
DOC_AGCK_PIF_1 376 381 PF00069 0.488
DOC_ANK_TNKS_1 626 633 PF00023 0.373
DOC_CDC14_PxL_1 658 666 PF14671 0.408
DOC_CYCLIN_RxL_1 704 713 PF00134 0.488
DOC_CYCLIN_yClb1_LxF_4 598 604 PF00134 0.353
DOC_CYCLIN_yCln2_LP_2 366 372 PF00134 0.533
DOC_CYCLIN_yCln2_LP_2 466 469 PF00134 0.495
DOC_CYCLIN_yCln2_LP_2 734 740 PF00134 0.368
DOC_CYCLIN_yCln2_LP_2 848 854 PF00134 0.432
DOC_MAPK_DCC_7 465 473 PF00069 0.533
DOC_MAPK_DCC_7 576 586 PF00069 0.324
DOC_MAPK_gen_1 510 517 PF00069 0.643
DOC_MAPK_gen_1 653 661 PF00069 0.441
DOC_MAPK_gen_1 881 890 PF00069 0.479
DOC_MAPK_HePTP_8 838 850 PF00069 0.343
DOC_MAPK_MEF2A_6 363 370 PF00069 0.495
DOC_MAPK_MEF2A_6 465 473 PF00069 0.533
DOC_MAPK_MEF2A_6 510 517 PF00069 0.564
DOC_MAPK_MEF2A_6 576 583 PF00069 0.340
DOC_MAPK_MEF2A_6 841 850 PF00069 0.491
DOC_PP1_RVXF_1 884 891 PF00149 0.464
DOC_PP2B_LxvP_1 265 268 PF13499 0.408
DOC_PP2B_LxvP_1 366 369 PF13499 0.479
DOC_PP2B_LxvP_1 466 469 PF13499 0.495
DOC_PP2B_LxvP_1 483 486 PF13499 0.644
DOC_PP2B_LxvP_1 659 662 PF13499 0.402
DOC_PP4_FxxP_1 253 256 PF00568 0.472
DOC_PP4_FxxP_1 575 578 PF00568 0.579
DOC_PP4_FxxP_1 850 853 PF00568 0.543
DOC_PP4_MxPP_1 301 304 PF00568 0.460
DOC_PP4_MxPP_1 855 858 PF00568 0.542
DOC_SPAK_OSR1_1 602 606 PF12202 0.314
DOC_USP7_MATH_1 12 16 PF00917 0.678
DOC_USP7_MATH_1 169 173 PF00917 0.624
DOC_USP7_MATH_1 183 187 PF00917 0.726
DOC_USP7_MATH_1 196 200 PF00917 0.617
DOC_USP7_MATH_1 259 263 PF00917 0.572
DOC_USP7_MATH_1 283 287 PF00917 0.488
DOC_USP7_MATH_1 424 428 PF00917 0.488
DOC_USP7_MATH_1 497 501 PF00917 0.573
DOC_USP7_MATH_1 537 541 PF00917 0.548
DOC_USP7_MATH_1 54 58 PF00917 0.663
DOC_USP7_MATH_1 544 548 PF00917 0.541
DOC_USP7_MATH_1 549 553 PF00917 0.489
DOC_USP7_MATH_1 62 66 PF00917 0.732
DOC_USP7_MATH_1 753 757 PF00917 0.442
DOC_USP7_MATH_1 76 80 PF00917 0.489
DOC_WW_Pin1_4 15 20 PF00397 0.714
DOC_WW_Pin1_4 164 169 PF00397 0.671
DOC_WW_Pin1_4 176 181 PF00397 0.680
DOC_WW_Pin1_4 205 210 PF00397 0.518
DOC_WW_Pin1_4 34 39 PF00397 0.809
DOC_WW_Pin1_4 412 417 PF00397 0.525
DOC_WW_Pin1_4 420 425 PF00397 0.495
DOC_WW_Pin1_4 481 486 PF00397 0.698
DOC_WW_Pin1_4 630 635 PF00397 0.375
DOC_WW_Pin1_4 716 721 PF00397 0.488
DOC_WW_Pin1_4 78 83 PF00397 0.657
DOC_WW_Pin1_4 821 826 PF00397 0.480
DOC_WW_Pin1_4 856 861 PF00397 0.751
DOC_WW_Pin1_4 892 897 PF00397 0.512
LIG_14-3-3_CanoR_1 457 467 PF00244 0.591
LIG_14-3-3_CanoR_1 498 503 PF00244 0.610
LIG_14-3-3_CanoR_1 684 693 PF00244 0.512
LIG_14-3-3_CanoR_1 715 720 PF00244 0.482
LIG_APCC_ABBAyCdc20_2 707 713 PF00400 0.368
LIG_BH_BH3_1 422 438 PF00452 0.460
LIG_BRCT_BRCA1_1 207 211 PF00533 0.276
LIG_BRCT_BRCA1_1 741 745 PF00533 0.506
LIG_BRCT_BRCA1_1 80 84 PF00533 0.551
LIG_Clathr_ClatBox_1 583 587 PF01394 0.456
LIG_deltaCOP1_diTrp_1 235 238 PF00928 0.470
LIG_DLG_GKlike_1 498 506 PF00625 0.508
LIG_eIF4E_1 389 395 PF01652 0.533
LIG_FHA_1 303 309 PF00498 0.368
LIG_FHA_1 389 395 PF00498 0.396
LIG_FHA_1 415 421 PF00498 0.538
LIG_FHA_1 461 467 PF00498 0.456
LIG_FHA_1 519 525 PF00498 0.589
LIG_FHA_1 605 611 PF00498 0.505
LIG_FHA_1 619 625 PF00498 0.263
LIG_FHA_2 145 151 PF00498 0.481
LIG_FHA_2 450 456 PF00498 0.512
LIG_FHA_2 487 493 PF00498 0.657
LIG_FHA_2 529 535 PF00498 0.600
LIG_FHA_2 631 637 PF00498 0.501
LIG_FHA_2 661 667 PF00498 0.344
LIG_FHA_2 717 723 PF00498 0.495
LIG_FHA_2 784 790 PF00498 0.569
LIG_FHA_2 809 815 PF00498 0.625
LIG_GBD_Chelix_1 425 433 PF00786 0.288
LIG_GBD_Chelix_1 569 577 PF00786 0.388
LIG_Integrin_isoDGR_2 73 75 PF01839 0.502
LIG_LIR_Apic_2 252 256 PF02991 0.467
LIG_LIR_Apic_2 847 853 PF02991 0.478
LIG_LIR_Gen_1 500 511 PF02991 0.618
LIG_LIR_Gen_1 657 664 PF02991 0.360
LIG_LIR_Gen_1 694 703 PF02991 0.496
LIG_LIR_Nem_3 115 120 PF02991 0.463
LIG_LIR_Nem_3 134 140 PF02991 0.260
LIG_LIR_Nem_3 217 222 PF02991 0.360
LIG_LIR_Nem_3 331 337 PF02991 0.526
LIG_LIR_Nem_3 375 379 PF02991 0.470
LIG_LIR_Nem_3 447 451 PF02991 0.514
LIG_LIR_Nem_3 500 506 PF02991 0.616
LIG_LIR_Nem_3 657 661 PF02991 0.353
LIG_LIR_Nem_3 694 699 PF02991 0.496
LIG_LIR_Nem_3 742 748 PF02991 0.420
LIG_NRBOX 276 282 PF00104 0.417
LIG_NRBOX 730 736 PF00104 0.439
LIG_PCNA_yPIPBox_3 274 285 PF02747 0.368
LIG_PCNA_yPIPBox_3 352 360 PF02747 0.536
LIG_Pex14_1 158 162 PF04695 0.421
LIG_Pex14_1 236 240 PF04695 0.333
LIG_Pex14_2 121 125 PF04695 0.392
LIG_PTAP_UEV_1 255 260 PF05743 0.390
LIG_PTAP_UEV_1 67 72 PF05743 0.612
LIG_REV1ctd_RIR_1 251 255 PF16727 0.391
LIG_SH2_CRK 334 338 PF00017 0.478
LIG_SH2_CRK 503 507 PF00017 0.641
LIG_SH2_CRK 620 624 PF00017 0.464
LIG_SH2_CRK 94 98 PF00017 0.416
LIG_SH2_STAP1 162 166 PF00017 0.527
LIG_SH2_STAP1 219 223 PF00017 0.399
LIG_SH2_STAP1 503 507 PF00017 0.529
LIG_SH2_STAP1 620 624 PF00017 0.350
LIG_SH2_STAT3 351 354 PF00017 0.488
LIG_SH2_STAT3 459 462 PF00017 0.488
LIG_SH2_STAT5 319 322 PF00017 0.488
LIG_SH2_STAT5 373 376 PF00017 0.449
LIG_SH2_STAT5 451 454 PF00017 0.444
LIG_SH2_STAT5 459 462 PF00017 0.436
LIG_SH2_STAT5 620 623 PF00017 0.377
LIG_SH2_STAT5 677 680 PF00017 0.479
LIG_SH2_STAT5 907 910 PF00017 0.518
LIG_SH3_3 17 23 PF00018 0.683
LIG_SH3_3 172 178 PF00018 0.734
LIG_SH3_3 253 259 PF00018 0.560
LIG_SH3_3 309 315 PF00018 0.472
LIG_SH3_3 356 362 PF00018 0.522
LIG_SH3_3 415 421 PF00018 0.523
LIG_SH3_3 466 472 PF00018 0.474
LIG_SH3_3 479 485 PF00018 0.627
LIG_SH3_3 491 497 PF00018 0.682
LIG_SH3_3 576 582 PF00018 0.461
LIG_SH3_3 65 71 PF00018 0.717
LIG_SH3_3 854 860 PF00018 0.731
LIG_SH3_3 913 919 PF00018 0.617
LIG_SUMO_SIM_anti_2 355 361 PF11976 0.488
LIG_SUMO_SIM_anti_2 476 484 PF11976 0.567
LIG_SUMO_SIM_anti_2 633 639 PF11976 0.329
LIG_TRAF2_1 531 534 PF00917 0.518
LIG_WRC_WIRS_1 373 378 PF05994 0.408
LIG_WW_3 24 28 PF00397 0.662
MOD_CDC14_SPxK_1 18 21 PF00782 0.566
MOD_CDK_SPK_2 176 181 PF00069 0.585
MOD_CDK_SPxK_1 15 21 PF00069 0.573
MOD_CDK_SPxxK_3 34 41 PF00069 0.655
MOD_CDK_SPxxK_3 481 488 PF00069 0.593
MOD_CK1_1 15 21 PF00069 0.778
MOD_CK1_1 266 272 PF00069 0.581
MOD_CK1_1 412 418 PF00069 0.532
MOD_CK1_1 484 490 PF00069 0.730
MOD_CK1_1 532 538 PF00069 0.630
MOD_CK1_1 716 722 PF00069 0.522
MOD_CK1_1 790 796 PF00069 0.401
MOD_CK1_1 799 805 PF00069 0.554
MOD_CK2_1 144 150 PF00069 0.629
MOD_CK2_1 283 289 PF00069 0.583
MOD_CK2_1 486 492 PF00069 0.659
MOD_CK2_1 528 534 PF00069 0.602
MOD_CK2_1 625 631 PF00069 0.407
MOD_CK2_1 660 666 PF00069 0.344
MOD_CK2_1 716 722 PF00069 0.470
MOD_CK2_1 783 789 PF00069 0.493
MOD_CK2_1 808 814 PF00069 0.658
MOD_Cter_Amidation 879 882 PF01082 0.356
MOD_DYRK1A_RPxSP_1 78 82 PF00069 0.513
MOD_GlcNHglycan 15 18 PF01048 0.816
MOD_GlcNHglycan 265 268 PF01048 0.581
MOD_GlcNHglycan 321 324 PF01048 0.234
MOD_GlcNHglycan 411 414 PF01048 0.384
MOD_GlcNHglycan 534 537 PF01048 0.532
MOD_GlcNHglycan 546 549 PF01048 0.378
MOD_GlcNHglycan 56 59 PF01048 0.662
MOD_GlcNHglycan 592 595 PF01048 0.348
MOD_GlcNHglycan 628 631 PF01048 0.649
MOD_GlcNHglycan 643 646 PF01048 0.255
MOD_GlcNHglycan 68 71 PF01048 0.681
MOD_GlcNHglycan 715 718 PF01048 0.297
MOD_GlcNHglycan 798 801 PF01048 0.536
MOD_GlcNHglycan 8 12 PF01048 0.776
MOD_GlcNHglycan 825 828 PF01048 0.510
MOD_GlcNHglycan 878 881 PF01048 0.488
MOD_GSK3_1 140 147 PF00069 0.597
MOD_GSK3_1 201 208 PF00069 0.570
MOD_GSK3_1 254 261 PF00069 0.551
MOD_GSK3_1 377 384 PF00069 0.481
MOD_GSK3_1 420 427 PF00069 0.480
MOD_GSK3_1 498 505 PF00069 0.605
MOD_GSK3_1 528 535 PF00069 0.549
MOD_GSK3_1 54 61 PF00069 0.645
MOD_GSK3_1 556 563 PF00069 0.528
MOD_GSK3_1 62 69 PF00069 0.706
MOD_GSK3_1 626 633 PF00069 0.429
MOD_GSK3_1 783 790 PF00069 0.425
MOD_GSK3_1 794 801 PF00069 0.394
MOD_GSK3_1 808 815 PF00069 0.600
MOD_GSK3_1 858 865 PF00069 0.811
MOD_GSK3_1 908 915 PF00069 0.481
MOD_N-GLC_1 12 17 PF02516 0.689
MOD_N-GLC_2 526 528 PF02516 0.625
MOD_N-GLC_2 590 592 PF02516 0.481
MOD_NEK2_1 112 117 PF00069 0.495
MOD_NEK2_1 381 386 PF00069 0.502
MOD_NEK2_1 429 434 PF00069 0.470
MOD_NEK2_1 458 463 PF00069 0.467
MOD_NEK2_1 502 507 PF00069 0.591
MOD_NEK2_1 625 630 PF00069 0.573
MOD_NEK2_1 765 770 PF00069 0.351
MOD_NEK2_1 787 792 PF00069 0.538
MOD_NEK2_1 798 803 PF00069 0.446
MOD_NEK2_1 908 913 PF00069 0.572
MOD_NEK2_2 222 227 PF00069 0.488
MOD_NEK2_2 62 67 PF00069 0.502
MOD_NMyristoyl 1 7 PF02799 0.574
MOD_PIKK_1 184 190 PF00454 0.541
MOD_PIKK_1 458 464 PF00454 0.488
MOD_PIKK_1 529 535 PF00454 0.520
MOD_PIKK_1 549 555 PF00454 0.396
MOD_PKA_1 808 814 PF00069 0.655
MOD_PKA_2 254 260 PF00069 0.381
MOD_PKA_2 26 32 PF00069 0.711
MOD_PKA_2 497 503 PF00069 0.615
MOD_PKA_2 537 543 PF00069 0.574
MOD_PKA_2 626 632 PF00069 0.390
MOD_PKA_2 76 82 PF00069 0.593
MOD_PKA_2 808 814 PF00069 0.655
MOD_PKB_1 808 816 PF00069 0.625
MOD_Plk_1 112 118 PF00069 0.479
MOD_Plk_1 297 303 PF00069 0.543
MOD_Plk_1 340 346 PF00069 0.499
MOD_Plk_1 407 413 PF00069 0.460
MOD_Plk_1 476 482 PF00069 0.708
MOD_Plk_1 908 914 PF00069 0.490
MOD_Plk_4 259 265 PF00069 0.701
MOD_Plk_4 498 504 PF00069 0.555
MOD_Plk_4 556 562 PF00069 0.494
MOD_Plk_4 654 660 PF00069 0.371
MOD_Plk_4 730 736 PF00069 0.544
MOD_Plk_4 844 850 PF00069 0.355
MOD_Plk_4 908 914 PF00069 0.585
MOD_ProDKin_1 15 21 PF00069 0.716
MOD_ProDKin_1 164 170 PF00069 0.676
MOD_ProDKin_1 176 182 PF00069 0.679
MOD_ProDKin_1 205 211 PF00069 0.506
MOD_ProDKin_1 34 40 PF00069 0.806
MOD_ProDKin_1 412 418 PF00069 0.525
MOD_ProDKin_1 420 426 PF00069 0.495
MOD_ProDKin_1 481 487 PF00069 0.696
MOD_ProDKin_1 630 636 PF00069 0.372
MOD_ProDKin_1 716 722 PF00069 0.488
MOD_ProDKin_1 78 84 PF00069 0.644
MOD_ProDKin_1 821 827 PF00069 0.478
MOD_ProDKin_1 856 862 PF00069 0.753
MOD_ProDKin_1 892 898 PF00069 0.514
MOD_SUMO_for_1 561 564 PF00179 0.365
TRG_DiLeu_BaEn_1 276 281 PF01217 0.417
TRG_DiLeu_BaLyEn_6 462 467 PF01217 0.495
TRG_DiLeu_BaLyEn_6 883 888 PF01217 0.463
TRG_ENDOCYTIC_2 117 120 PF00928 0.454
TRG_ENDOCYTIC_2 334 337 PF00928 0.436
TRG_ENDOCYTIC_2 373 376 PF00928 0.492
TRG_ENDOCYTIC_2 503 506 PF00928 0.587
TRG_ENDOCYTIC_2 620 623 PF00928 0.467
TRG_ER_diArg_1 228 231 PF00400 0.382
TRG_ER_diArg_1 326 328 PF00400 0.488
TRG_ER_diArg_1 40 43 PF00400 0.657
TRG_ER_diArg_1 456 458 PF00400 0.495
TRG_ER_diArg_1 509 512 PF00400 0.516
TRG_ER_diArg_1 746 749 PF00400 0.514
TRG_ER_diArg_1 75 78 PF00400 0.708
TRG_ER_diArg_1 807 810 PF00400 0.633
TRG_Pf-PMV_PEXEL_1 522 527 PF00026 0.478

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9B5 Leptomonas seymouri 45% 100%
A0A0S4IN68 Bodo saltans 27% 100%
A0A1X0NUD8 Trypanosomatidae 28% 100%
A0A3S7X5I2 Leishmania donovani 86% 100%
A0A422NLC9 Trypanosoma rangeli 28% 100%
A4HKE3 Leishmania braziliensis 68% 100%
A4I7X1 Leishmania infantum 86% 100%
Q4Q5C5 Leishmania major 86% 100%
V5BP08 Trypanosoma cruzi 29% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS