PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania mexicana

UniProt:

E9B2T1_LEIMU

TriTrypDb:

LmxM.31.1550

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2T1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.513
CLV_NRD_NRD_1	198	200	PF00675	0.595
CLV_NRD_NRD_1	221	223	PF00675	0.425
CLV_NRD_NRD_1	378	380	PF00675	0.548
CLV_NRD_NRD_1	385	387	PF00675	0.699
CLV_NRD_NRD_1	88	90	PF00675	0.433
CLV_PCSK_FUR_1	219	223	PF00082	0.428
CLV_PCSK_KEX2_1	131	133	PF00082	0.774
CLV_PCSK_KEX2_1	198	200	PF00082	0.681
CLV_PCSK_KEX2_1	216	218	PF00082	0.319
CLV_PCSK_KEX2_1	221	223	PF00082	0.425
CLV_PCSK_KEX2_1	385	387	PF00082	0.703
CLV_PCSK_KEX2_1	88	90	PF00082	0.433
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.774
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.444
CLV_PCSK_PC7_1	217	223	PF00082	0.436
CLV_PCSK_SKI1_1	160	164	PF00082	0.716
CLV_PCSK_SKI1_1	221	225	PF00082	0.417
CLV_PCSK_SKI1_1	287	291	PF00082	0.511
CLV_PCSK_SKI1_1	306	310	PF00082	0.196
CLV_PCSK_SKI1_1	354	358	PF00082	0.453
CLV_PCSK_SKI1_1	74	78	PF00082	0.608
DEG_APCC_DBOX_1	220	228	PF00400	0.552
DEG_APCC_DBOX_1	73	81	PF00400	0.548
DOC_MAPK_DCC_7	219	229	PF00069	0.548
DOC_MAPK_gen_1	318	325	PF00069	0.230
DOC_MAPK_gen_1	385	394	PF00069	0.576
DOC_MAPK_GRA24_9	213	229	PF00069	0.543
DOC_MAPK_MEF2A_6	385	394	PF00069	0.472
DOC_PP1_RVXF_1	334	340	PF00149	0.335
DOC_PP1_RVXF_1	389	395	PF00149	0.633
DOC_PP4_FxxP_1	223	226	PF00568	0.535
DOC_USP7_MATH_1	12	16	PF00917	0.360
DOC_USP7_MATH_1	146	150	PF00917	0.595
DOC_USP7_MATH_1	47	51	PF00917	0.753
DOC_USP7_MATH_1	64	68	PF00917	0.488
DOC_USP7_MATH_2	3	9	PF00917	0.606
DOC_WW_Pin1_4	122	127	PF00397	0.680
DOC_WW_Pin1_4	136	141	PF00397	0.735
DOC_WW_Pin1_4	154	159	PF00397	0.682
DOC_WW_Pin1_4	175	180	PF00397	0.631
DOC_WW_Pin1_4	222	227	PF00397	0.544
DOC_WW_Pin1_4	28	33	PF00397	0.524
DOC_WW_Pin1_4	38	43	PF00397	0.616
LIG_14-3-3_CanoR_1	11	17	PF00244	0.489
LIG_14-3-3_CanoR_1	147	151	PF00244	0.763
LIG_14-3-3_CanoR_1	177	187	PF00244	0.684
LIG_14-3-3_CanoR_1	287	294	PF00244	0.335
LIG_14-3-3_CanoR_1	306	315	PF00244	0.335
LIG_14-3-3_CanoR_1	318	324	PF00244	0.291
LIG_14-3-3_CterR_2	395	398	PF00244	0.470
LIG_APCC_ABBA_1	24	29	PF00400	0.374
LIG_BRCT_BRCA1_1	337	341	PF00533	0.335
LIG_FHA_1	231	237	PF00498	0.345
LIG_FHA_1	85	91	PF00498	0.538
LIG_FHA_2	209	215	PF00498	0.507
LIG_FHA_2	288	294	PF00498	0.387
LIG_FHA_2	309	315	PF00498	0.313
LIG_FHA_2	80	86	PF00498	0.562
LIG_GBD_Chelix_1	315	323	PF00786	0.313
LIG_LIR_Gen_1	15	24	PF02991	0.352
LIG_LIR_Gen_1	205	215	PF02991	0.463
LIG_LIR_Gen_1	233	238	PF02991	0.333
LIG_LIR_LC3C_4	244	249	PF02991	0.487
LIG_LIR_Nem_3	15	19	PF02991	0.366
LIG_LIR_Nem_3	233	237	PF02991	0.335
LIG_LIR_Nem_3	348	352	PF02991	0.340
LIG_LIR_Nem_3	355	360	PF02991	0.362
LIG_MLH1_MIPbox_1	337	341	PF16413	0.335
LIG_PCNA_PIPBox_1	10	19	PF02747	0.432
LIG_PCNA_yPIPBox_3	350	360	PF02747	0.313
LIG_SH2_PTP2	234	237	PF00017	0.502
LIG_SH2_SRC	234	237	PF00017	0.502
LIG_SH2_STAT3	78	81	PF00017	0.630
LIG_SH2_STAT5	16	19	PF00017	0.524
LIG_SH2_STAT5	234	237	PF00017	0.502
LIG_SH2_STAT5	25	28	PF00017	0.458
LIG_SH2_STAT5	78	81	PF00017	0.580
LIG_SH3_3	232	238	PF00018	0.516
LIG_SH3_3	270	276	PF00018	0.645
LIG_SH3_3	53	59	PF00018	0.670
LIG_SUMO_SIM_anti_2	159	166	PF11976	0.500
LIG_TRAF2_1	290	293	PF00917	0.389
MOD_CDC14_SPxK_1	157	160	PF00782	0.734
MOD_CDK_SPK_2	136	141	PF00069	0.536
MOD_CDK_SPxK_1	154	160	PF00069	0.741
MOD_CK1_1	109	115	PF00069	0.635
MOD_CK1_1	181	187	PF00069	0.513
MOD_CK1_1	225	231	PF00069	0.555
MOD_CK1_1	33	39	PF00069	0.642
MOD_CK2_1	118	124	PF00069	0.747
MOD_CK2_1	208	214	PF00069	0.514
MOD_CK2_1	278	284	PF00069	0.459
MOD_CK2_1	287	293	PF00069	0.367
MOD_CK2_1	79	85	PF00069	0.486
MOD_GlcNHglycan	108	111	PF01048	0.703
MOD_GlcNHglycan	112	115	PF01048	0.704
MOD_GlcNHglycan	180	183	PF01048	0.683
MOD_GlcNHglycan	32	35	PF01048	0.651
MOD_GlcNHglycan	342	345	PF01048	0.412
MOD_GlcNHglycan	45	48	PF01048	0.572
MOD_GlcNHglycan	49	52	PF01048	0.563
MOD_GSK3_1	105	112	PF00069	0.603
MOD_GSK3_1	114	121	PF00069	0.712
MOD_GSK3_1	163	170	PF00069	0.710
MOD_GSK3_1	178	185	PF00069	0.528
MOD_GSK3_1	36	43	PF00069	0.626
MOD_NEK2_1	27	32	PF00069	0.569
MOD_NEK2_1	307	312	PF00069	0.453
MOD_NEK2_1	366	371	PF00069	0.558
MOD_NEK2_1	79	84	PF00069	0.552
MOD_NEK2_2	308	313	PF00069	0.313
MOD_PIKK_1	182	188	PF00454	0.684
MOD_PIKK_1	202	208	PF00454	0.522
MOD_PIKK_1	91	97	PF00454	0.602
MOD_PKA_2	103	109	PF00069	0.548
MOD_PKA_2	146	152	PF00069	0.708
MOD_PKA_2	187	193	PF00069	0.558
MOD_PKA_2	319	325	PF00069	0.214
MOD_Plk_2-3	300	306	PF00069	0.313
MOD_Plk_4	12	18	PF00069	0.352
MOD_Plk_4	146	152	PF00069	0.708
MOD_Plk_4	230	236	PF00069	0.359
MOD_Plk_4	278	284	PF00069	0.475
MOD_Plk_4	79	85	PF00069	0.614
MOD_ProDKin_1	122	128	PF00069	0.682
MOD_ProDKin_1	136	142	PF00069	0.735
MOD_ProDKin_1	154	160	PF00069	0.683
MOD_ProDKin_1	175	181	PF00069	0.630
MOD_ProDKin_1	222	228	PF00069	0.547
MOD_ProDKin_1	28	34	PF00069	0.530
MOD_ProDKin_1	38	44	PF00069	0.617
TRG_DiLeu_BaEn_4	292	298	PF01217	0.389
TRG_ENDOCYTIC_2	16	19	PF00928	0.524
TRG_ENDOCYTIC_2	234	237	PF00928	0.384
TRG_ER_diArg_1	217	220	PF00400	0.535
TRG_ER_diArg_1	221	223	PF00400	0.425
TRG_ER_diArg_1	318	321	PF00400	0.214
TRG_ER_diArg_1	389	392	PF00400	0.651
TRG_ER_diArg_1	88	90	PF00400	0.424
TRG_NES_CRM1_1	314	329	PF08389	0.389
TRG_NES_CRM1_1	9	22	PF08389	0.495
TRG_NLS_Bipartite_1	198	220	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P982	Leptomonas seymouri	46%	92%
A0A3S7X5G4	Leishmania donovani	87%	99%
A4HKE2	Leishmania braziliensis	69%	100%
A4I7X0	Leishmania infantum	86%	99%
Q4Q5C6	Leishmania major	87%	100%