Nudix hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase, putative

Species:

Leishmania mexicana

UniProt:

E9B2T0_LEIMU

TriTrypDb:

LmxM.31.1540

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2T0

Function

Biological processes
Term	Name	Level	Count
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0110154	RNA decapping	6	1
GO:0110156	methylguanosine-cap decapping	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	14
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0050072	obsolete m7G(5')pppN diphosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	38	40	PF00675	0.307
CLV_PCSK_KEX2_1	38	40	PF00082	0.307
CLV_PCSK_SKI1_1	97	101	PF00082	0.414
DEG_APCC_DBOX_1	232	240	PF00400	0.374
DEG_Nend_Nbox_1	1	3	PF02207	0.605
DOC_CKS1_1	122	127	PF01111	0.681
DOC_MAPK_gen_1	210	216	PF00069	0.497
DOC_MAPK_gen_1	38	45	PF00069	0.314
DOC_MAPK_MEF2A_6	38	45	PF00069	0.328
DOC_PP1_RVXF_1	190	197	PF00149	0.524
DOC_PP4_FxxP_1	168	171	PF00568	0.438
DOC_USP7_MATH_1	108	112	PF00917	0.454
DOC_USP7_MATH_1	19	23	PF00917	0.644
DOC_USP7_MATH_1	31	35	PF00917	0.323
DOC_WW_Pin1_4	121	126	PF00397	0.684
DOC_WW_Pin1_4	75	80	PF00397	0.373
LIG_14-3-3_CanoR_1	181	185	PF00244	0.522
LIG_14-3-3_CanoR_1	38	42	PF00244	0.289
LIG_14-3-3_CanoR_1	66	70	PF00244	0.431
LIG_CtBP_PxDLS_1	92	97	PF00389	0.316
LIG_FHA_1	223	229	PF00498	0.505
LIG_FHA_1	98	104	PF00498	0.316
LIG_FHA_2	122	128	PF00498	0.683
LIG_LIR_Apic_2	140	145	PF02991	0.321
LIG_LIR_Apic_2	230	235	PF02991	0.252
LIG_LIR_Gen_1	86	96	PF02991	0.323
LIG_LIR_Nem_3	162	167	PF02991	0.324
LIG_LIR_Nem_3	190	194	PF02991	0.358
LIG_LIR_Nem_3	86	91	PF02991	0.323
LIG_LYPXL_S_1	163	167	PF13949	0.323
LIG_LYPXL_yS_3	164	167	PF13949	0.322
LIG_RPA_C_Fungi	111	123	PF08784	0.396
LIG_SH2_CRK	142	146	PF00017	0.302
LIG_SH3_3	102	108	PF00018	0.497
LIG_SH3_3	213	219	PF00018	0.361
LIG_TRAF2_1	87	90	PF00917	0.436
MOD_CDK_SPK_2	121	126	PF00069	0.396
MOD_CK1_1	115	121	PF00069	0.636
MOD_CK2_1	131	137	PF00069	0.646
MOD_GlcNHglycan	117	120	PF01048	0.620
MOD_GlcNHglycan	134	137	PF01048	0.510
MOD_GSK3_1	108	115	PF00069	0.563
MOD_GSK3_1	75	82	PF00069	0.321
MOD_N-GLC_1	132	137	PF02516	0.473
MOD_N-GLC_1	58	63	PF02516	0.203
MOD_NEK2_1	7	12	PF00069	0.646
MOD_PKA_2	115	121	PF00069	0.497
MOD_PKA_2	180	186	PF00069	0.267
MOD_PKA_2	37	43	PF00069	0.303
MOD_PKA_2	65	71	PF00069	0.389
MOD_Plk_1	97	103	PF00069	0.458
MOD_Plk_4	212	218	PF00069	0.543
MOD_Plk_4	97	103	PF00069	0.452
MOD_ProDKin_1	121	127	PF00069	0.682
MOD_ProDKin_1	75	81	PF00069	0.373
TRG_DiLeu_BaEn_2	47	53	PF01217	0.399
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.232
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.403
TRG_ENDOCYTIC_2	164	167	PF00928	0.334
TRG_ER_diArg_1	37	39	PF00400	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9K0	Leptomonas seymouri	57%	100%
A0A1X0P292	Trypanosomatidae	35%	80%
A0A3Q8IFW7	Leishmania donovani	89%	100%
A0A3Q8IL17	Leishmania donovani	46%	93%
A0A422P4Y4	Trypanosoma rangeli	36%	100%
A4HKE1	Leishmania braziliensis	48%	100%
A4I7W9	Leishmania infantum	88%	100%
C9ZQT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	81%
Q4Q5C7	Leishmania major	89%	100%
Q4Q5C8	Leishmania major	49%	99%
V5BU70	Trypanosoma cruzi	38%	95%
V5DQQ5	Trypanosoma cruzi	38%	95%