Putative ATP-dependent zinc metallopeptidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Metalloprotease M41 FtsH, putative

Species:

Leishmania mexicana

UniProt:

E9B2S6_LEIMU

TriTrypDb:

LmxM.31.1500

Length:

719

Annotations

LeishMANIAdb annotations

Homologous to bacterial FtsH and Eukaryotic AFG3 proteins. Probably involved in mitochondrial protein processing.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005745	m-AAA complex	4	3
GO:0016020	membrane	2	25
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	3
GO:0098798	mitochondrial protein-containing complex	2	3

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Expansion

Sequence features

E9B2S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2S6

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	33
GO:0006807	nitrogen compound metabolic process	2	33
GO:0008152	metabolic process	1	33
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0016485	protein processing	5	3
GO:0019538	protein metabolic process	3	33
GO:0022607	cellular component assembly	4	3
GO:0034982	mitochondrial protein processing	6	3
GO:0043170	macromolecule metabolic process	3	33

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	33
GO:0003824	catalytic activity	1	33
GO:0004175	endopeptidase activity	4	33
GO:0004176	ATP-dependent peptidase activity	2	33
GO:0004222	metalloendopeptidase activity	5	33
GO:0005488	binding	1	33
GO:0005524	ATP binding	5	33
GO:0008233	peptidase activity	3	33
GO:0008237	metallopeptidase activity	4	33
GO:0016462	pyrophosphatase activity	5	33

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.424
CLV_C14_Caspase3-7	645	649	PF00656	0.485
CLV_NRD_NRD_1	157	159	PF00675	0.334
CLV_NRD_NRD_1	377	379	PF00675	0.233
CLV_PCSK_KEX2_1	157	159	PF00082	0.334
CLV_PCSK_KEX2_1	291	293	PF00082	0.229
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.228
CLV_PCSK_SKI1_1	258	262	PF00082	0.224
CLV_PCSK_SKI1_1	294	298	PF00082	0.229
CLV_PCSK_SKI1_1	368	372	PF00082	0.227

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A5	Leptomonas seymouri	47%	100%
A0A0N1I6C1	Leptomonas seymouri	35%	92%
A0A0N1IMN9	Leptomonas seymouri	78%	100%
A0A0N1PBB9	Leptomonas seymouri	48%	100%
A0A0N1PGD9	Leptomonas seymouri	32%	72%
A0A0S4J3N2	Bodo saltans	71%	100%
A0A0S4JAH0	Bodo saltans	50%	100%
A0A0S4JGG9	Bodo saltans	50%	100%
A0A0S4JTL4	Bodo saltans	33%	85%
A0A1X0NKD8	Trypanosomatidae	32%	100%

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