Putative ATP-dependent zinc metallopeptidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Metalloprotease M41 FtsH, putative

Species:

Leishmania mexicana

UniProt:

E9B2S6_LEIMU

TriTrypDb:

LmxM.31.1500

Length:

719

Annotations

LeishMANIAdb annotations

Homologous to bacterial FtsH and Eukaryotic AFG3 proteins. Probably involved in mitochondrial protein processing.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	25
GO:0110165	cellular anatomical entity	1	26
GO:0005739	mitochondrion	5	1
GO:0005745	m-AAA complex	4	3
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	3
GO:0098798	mitochondrial protein-containing complex	2	3
GO:0098800	inner mitochondrial membrane protein complex	3	3
GO:1902494	catalytic complex	2	3
GO:1905368	peptidase complex	3	3

Expansion

Sequence features

E9B2S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2S6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	33
GO:0006807	nitrogen compound metabolic process	2	33
GO:0008152	metabolic process	1	33
GO:0019538	protein metabolic process	3	33
GO:0043170	macromolecule metabolic process	3	33
GO:0044238	primary metabolic process	2	33
GO:0071704	organic substance metabolic process	2	33
GO:1901564	organonitrogen compound metabolic process	3	33
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0016485	protein processing	5	3
GO:0022607	cellular component assembly	4	3
GO:0034982	mitochondrial protein processing	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0051604	protein maturation	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0071840	cellular component organization or biogenesis	2	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	33
GO:0003824	catalytic activity	1	33
GO:0004175	endopeptidase activity	4	33
GO:0004176	ATP-dependent peptidase activity	2	33
GO:0004222	metalloendopeptidase activity	5	33
GO:0005488	binding	1	33
GO:0005524	ATP binding	5	33
GO:0008233	peptidase activity	3	33
GO:0008237	metallopeptidase activity	4	33
GO:0016462	pyrophosphatase activity	5	33
GO:0016787	hydrolase activity	2	33
GO:0016817	hydrolase activity, acting on acid anhydrides	3	33
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	33
GO:0016887	ATP hydrolysis activity	7	33
GO:0017076	purine nucleotide binding	4	33
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	33
GO:0030554	adenyl nucleotide binding	5	33
GO:0032553	ribonucleotide binding	3	33
GO:0032555	purine ribonucleotide binding	4	33
GO:0032559	adenyl ribonucleotide binding	5	33
GO:0035639	purine ribonucleoside triphosphate binding	4	33
GO:0036094	small molecule binding	2	33
GO:0043167	ion binding	2	33
GO:0043168	anion binding	3	33
GO:0097159	organic cyclic compound binding	2	33
GO:0097367	carbohydrate derivative binding	2	33
GO:0140096	catalytic activity, acting on a protein	2	33
GO:0140657	ATP-dependent activity	1	33
GO:1901265	nucleoside phosphate binding	3	33
GO:1901363	heterocyclic compound binding	2	33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.424
CLV_C14_Caspase3-7	645	649	PF00656	0.485
CLV_NRD_NRD_1	157	159	PF00675	0.334
CLV_NRD_NRD_1	377	379	PF00675	0.233
CLV_PCSK_KEX2_1	157	159	PF00082	0.334
CLV_PCSK_KEX2_1	291	293	PF00082	0.229
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.228
CLV_PCSK_SKI1_1	258	262	PF00082	0.224
CLV_PCSK_SKI1_1	294	298	PF00082	0.229
CLV_PCSK_SKI1_1	368	372	PF00082	0.227
CLV_PCSK_SKI1_1	378	382	PF00082	0.234
CLV_PCSK_SKI1_1	400	404	PF00082	0.279
CLV_PCSK_SKI1_1	442	446	PF00082	0.373
CLV_PCSK_SKI1_1	626	630	PF00082	0.278
CLV_PCSK_SKI1_1	680	684	PF00082	0.255
CLV_PCSK_SKI1_1	714	718	PF00082	0.337
DEG_Nend_UBRbox_3	1	3	PF02207	0.475
DEG_SPOP_SBC_1	436	440	PF00917	0.538
DOC_CYCLIN_RxL_1	291	299	PF00134	0.439
DOC_CYCLIN_RxL_1	677	687	PF00134	0.495
DOC_MAPK_gen_1	301	309	PF00069	0.474
DOC_MAPK_gen_1	372	382	PF00069	0.425
DOC_MAPK_gen_1	688	697	PF00069	0.415
DOC_MAPK_MEF2A_6	301	309	PF00069	0.423
DOC_MAPK_MEF2A_6	375	384	PF00069	0.424
DOC_MAPK_MEF2A_6	503	510	PF00069	0.592
DOC_MAPK_MEF2A_6	554	561	PF00069	0.381
DOC_MAPK_NFAT4_5	554	562	PF00069	0.518
DOC_PP2B_LxvP_1	38	41	PF13499	0.401
DOC_PP4_FxxP_1	149	152	PF00568	0.227
DOC_USP7_MATH_1	163	167	PF00917	0.639
DOC_USP7_MATH_1	180	184	PF00917	0.617
DOC_USP7_MATH_1	315	319	PF00917	0.437
DOC_USP7_MATH_1	423	427	PF00917	0.699
DOC_USP7_MATH_1	429	433	PF00917	0.698
DOC_USP7_MATH_1	436	440	PF00917	0.688
DOC_USP7_MATH_1	464	468	PF00917	0.521
DOC_USP7_MATH_1	8	12	PF00917	0.391
DOC_USP7_UBL2_3	221	225	PF12436	0.492
DOC_USP7_UBL2_3	232	236	PF12436	0.456
DOC_USP7_UBL2_3	554	558	PF12436	0.395
DOC_USP7_UBL2_3	642	646	PF12436	0.466
DOC_USP7_UBL2_3	700	704	PF12436	0.416
DOC_WW_Pin1_4	268	273	PF00397	0.461
DOC_WW_Pin1_4	4	9	PF00397	0.537
DOC_WW_Pin1_4	476	481	PF00397	0.494
LIG_14-3-3_CanoR_1	650	656	PF00244	0.462
LIG_BIR_III_2	454	458	PF00653	0.683
LIG_BIR_III_2	5	9	PF00653	0.361
LIG_BIR_III_4	314	318	PF00653	0.424
LIG_BRCT_BRCA1_1	269	273	PF00533	0.447
LIG_CaM_IQ_9	613	628	PF13499	0.418
LIG_FHA_1	445	451	PF00498	0.729
LIG_FHA_1	477	483	PF00498	0.489
LIG_FHA_1	547	553	PF00498	0.479
LIG_FHA_1	569	575	PF00498	0.400
LIG_FHA_1	706	712	PF00498	0.436
LIG_FHA_2	108	114	PF00498	0.309
LIG_FHA_2	208	214	PF00498	0.485
LIG_FHA_2	347	353	PF00498	0.453
LIG_FHA_2	415	421	PF00498	0.603
LIG_FHA_2	436	442	PF00498	0.690
LIG_FHA_2	652	658	PF00498	0.488
LIG_IBAR_NPY_1	58	60	PF08397	0.373
LIG_LIR_Apic_2	137	141	PF02991	0.295
LIG_LIR_Gen_1	11	19	PF02991	0.422
LIG_LIR_Gen_1	235	245	PF02991	0.485
LIG_LIR_Gen_1	280	285	PF02991	0.425
LIG_LIR_Gen_1	470	475	PF02991	0.619
LIG_LIR_Gen_1	536	546	PF02991	0.434
LIG_LIR_Gen_1	585	595	PF02991	0.457
LIG_LIR_Nem_3	114	120	PF02991	0.420
LIG_LIR_Nem_3	209	214	PF02991	0.504
LIG_LIR_Nem_3	235	240	PF02991	0.529
LIG_LIR_Nem_3	280	284	PF02991	0.425
LIG_LIR_Nem_3	392	397	PF02991	0.473
LIG_LIR_Nem_3	470	474	PF02991	0.623
LIG_LIR_Nem_3	536	541	PF02991	0.434
LIG_LIR_Nem_3	585	591	PF02991	0.451
LIG_LIR_Nem_3	72	77	PF02991	0.390
LIG_NRBOX	691	697	PF00104	0.421
LIG_PCNA_yPIPBox_3	512	525	PF02747	0.504
LIG_PDZ_Class_2	714	719	PF00595	0.630
LIG_Pex14_2	281	285	PF04695	0.418
LIG_PTB_Apo_2	142	149	PF02174	0.398
LIG_PTB_Apo_2	465	472	PF02174	0.501
LIG_PTB_Phospho_1	465	471	PF10480	0.505
LIG_SH2_CRK	471	475	PF00017	0.441
LIG_SH2_CRK	60	64	PF00017	0.547
LIG_SH2_GRB2like	397	400	PF00017	0.492
LIG_SH2_NCK_1	60	64	PF00017	0.343
LIG_SH2_SRC	471	474	PF00017	0.429
LIG_SH2_STAP1	471	475	PF00017	0.493
LIG_SH2_STAP1	570	574	PF00017	0.438
LIG_SH2_STAP1	89	93	PF00017	0.392
LIG_SH2_STAT3	17	20	PF00017	0.418
LIG_SH2_STAT3	32	35	PF00017	0.487
LIG_SH2_STAT3	570	573	PF00017	0.418
LIG_SH2_STAT3	77	80	PF00017	0.461
LIG_SH2_STAT3	91	94	PF00017	0.546
LIG_SH2_STAT5	155	158	PF00017	0.339
LIG_SH2_STAT5	227	230	PF00017	0.476
LIG_SH2_STAT5	397	400	PF00017	0.475
LIG_SH2_STAT5	570	573	PF00017	0.432
LIG_SH2_STAT5	60	63	PF00017	0.492
LIG_SH2_STAT5	675	678	PF00017	0.448
LIG_SH2_STAT5	91	94	PF00017	0.463
LIG_SH3_3	103	109	PF00018	0.478
LIG_SH3_3	121	127	PF00018	0.349
LIG_SH3_3	193	199	PF00018	0.614
LIG_SH3_3	377	383	PF00018	0.420
LIG_SH3_3	38	44	PF00018	0.486
LIG_SH3_3	80	86	PF00018	0.379
LIG_SH3_4	409	416	PF00018	0.568
LIG_SH3_4	642	649	PF00018	0.518
LIG_Sin3_3	667	674	PF02671	0.377
LIG_SUMO_SIM_anti_2	352	358	PF11976	0.432
LIG_SxIP_EBH_1	558	568	PF03271	0.411
LIG_TRAF2_1	220	223	PF00917	0.456
LIG_TRAF2_1	331	334	PF00917	0.436
LIG_TYR_ITSM	534	541	PF00017	0.275
LIG_UBA3_1	190	198	PF00899	0.479
LIG_WW_1	104	107	PF00397	0.583
MOD_CK1_1	134	140	PF00069	0.398
MOD_CK1_1	476	482	PF00069	0.430
MOD_CK1_1	529	535	PF00069	0.284
MOD_CK2_1	328	334	PF00069	0.284
MOD_CK2_1	346	352	PF00069	0.237
MOD_CK2_1	414	420	PF00069	0.513
MOD_CK2_1	435	441	PF00069	0.629
MOD_CK2_1	464	470	PF00069	0.454
MOD_CK2_1	651	657	PF00069	0.347
MOD_CMANNOS	652	655	PF00535	0.398
MOD_Cter_Amidation	520	523	PF01082	0.402
MOD_Cter_Amidation	697	700	PF01082	0.422
MOD_GlcNHglycan	127	130	PF01048	0.475
MOD_GlcNHglycan	133	136	PF01048	0.446
MOD_GlcNHglycan	165	168	PF01048	0.573
MOD_GlcNHglycan	173	176	PF01048	0.667
MOD_GlcNHglycan	187	190	PF01048	0.560
MOD_GlcNHglycan	276	279	PF01048	0.253
MOD_GlcNHglycan	287	290	PF01048	0.292
MOD_GlcNHglycan	425	428	PF01048	0.722
MOD_GlcNHglycan	433	436	PF01048	0.731
MOD_GlcNHglycan	48	51	PF01048	0.493
MOD_GlcNHglycan	672	675	PF01048	0.324
MOD_GSK3_1	163	170	PF00069	0.574
MOD_GSK3_1	181	188	PF00069	0.589
MOD_GSK3_1	268	275	PF00069	0.262
MOD_GSK3_1	4	11	PF00069	0.500
MOD_GSK3_1	431	438	PF00069	0.553
MOD_GSK3_1	476	483	PF00069	0.352
MOD_GSK3_1	529	536	PF00069	0.282
MOD_N-GLC_1	334	339	PF02516	0.272
MOD_N-GLC_1	529	534	PF02516	0.186
MOD_NEK2_1	274	279	PF00069	0.193
MOD_NEK2_1	285	290	PF00069	0.208
MOD_NEK2_1	533	538	PF00069	0.250
MOD_NEK2_1	546	551	PF00069	0.262
MOD_NEK2_1	586	591	PF00069	0.255
MOD_NEK2_1	632	637	PF00069	0.292
MOD_NEK2_1	670	675	PF00069	0.249
MOD_NEK2_2	8	13	PF00069	0.599
MOD_PIKK_1	568	574	PF00454	0.268
MOD_PIKK_1	586	592	PF00454	0.268
MOD_PK_1	456	462	PF00069	0.388
MOD_PK_1	606	612	PF00069	0.398
MOD_PKA_1	378	384	PF00069	0.191
MOD_PKA_2	125	131	PF00069	0.491
MOD_PKA_2	526	532	PF00069	0.291
MOD_PKA_2	617	623	PF00069	0.272
MOD_Plk_1	334	340	PF00069	0.268
MOD_Plk_1	529	535	PF00069	0.276
MOD_Plk_1	606	612	PF00069	0.284
MOD_Plk_1	678	684	PF00069	0.352
MOD_Plk_1	705	711	PF00069	0.188
MOD_Plk_2-3	580	586	PF00069	0.398
MOD_Plk_4	134	140	PF00069	0.287
MOD_Plk_4	256	262	PF00069	0.279
MOD_Plk_4	486	492	PF00069	0.339
MOD_Plk_4	557	563	PF00069	0.311
MOD_Plk_4	678	684	PF00069	0.313
MOD_Plk_4	706	712	PF00069	0.312
MOD_Plk_4	8	14	PF00069	0.555
MOD_ProDKin_1	268	274	PF00069	0.319
MOD_ProDKin_1	4	10	PF00069	0.705
MOD_ProDKin_1	476	482	PF00069	0.361
MOD_SUMO_for_1	220	223	PF00179	0.429
MOD_SUMO_for_1	455	458	PF00179	0.611
MOD_SUMO_for_1	661	664	PF00179	0.295
MOD_SUMO_rev_2	295	303	PF00179	0.352
MOD_SUMO_rev_2	373	381	PF00179	0.268
MOD_SUMO_rev_2	440	450	PF00179	0.714
MOD_SUMO_rev_2	453	457	PF00179	0.435
TRG_DiLeu_BaEn_1	446	451	PF01217	0.687
TRG_DiLeu_BaEn_1	666	671	PF01217	0.277
TRG_ENDOCYTIC_2	117	120	PF00928	0.524
TRG_ENDOCYTIC_2	227	230	PF00928	0.340
TRG_ENDOCYTIC_2	471	474	PF00928	0.536
TRG_ENDOCYTIC_2	538	541	PF00928	0.275
TRG_ER_diArg_1	156	158	PF00400	0.423
TRG_ER_diArg_1	525	528	PF00400	0.433
TRG_ER_diArg_1	563	566	PF00400	0.259
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	668	672	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A5	Leptomonas seymouri	47%	100%
A0A0N1I6C1	Leptomonas seymouri	35%	92%
A0A0N1IMN9	Leptomonas seymouri	78%	100%
A0A0N1PBB9	Leptomonas seymouri	48%	100%
A0A0N1PGD9	Leptomonas seymouri	32%	72%
A0A0S4J3N2	Bodo saltans	71%	100%
A0A0S4JAH0	Bodo saltans	50%	100%
A0A0S4JGG9	Bodo saltans	50%	100%
A0A0S4JTL4	Bodo saltans	33%	85%
A0A1X0NKD8	Trypanosomatidae	32%	100%
A0A1X0NW32	Trypanosomatidae	77%	100%
A0A1X0P749	Trypanosomatidae	51%	100%
A0A1X0P7E6	Trypanosomatidae	51%	100%
A0A1X0P9F5	Trypanosomatidae	35%	100%
A0A3Q8IFG3	Leishmania donovani	96%	100%
A0A3Q8IHD0	Leishmania donovani	35%	100%
A0A3Q8IJP7	Leishmania donovani	48%	100%
A0A3R7KKD0	Trypanosoma rangeli	47%	100%
A0A3R7L0P7	Trypanosoma rangeli	75%	100%
A0A3S5H775	Leishmania donovani	48%	100%
A0A3S5H828	Leishmania donovani	32%	100%
A0A422N673	Trypanosoma rangeli	36%	100%
A0A422NJ44	Trypanosoma rangeli	51%	100%
A0L4S0	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	35%	100%
A0LN68	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	35%	100%
A0LR74	Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B)	34%	100%
A0PXM8	Clostridium novyi (strain NT)	39%	100%
A1URA3	Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)	35%	94%
A2ZVG7	Oryza sativa subsp. japonica	35%	92%
A4H9H1	Leishmania braziliensis	49%	97%
A4HAA8	Leishmania braziliensis	46%	99%
A4HAL9	Leishmania braziliensis	35%	91%
A4HKD8	Leishmania braziliensis	86%	98%
A4HPD5	Leishmania braziliensis	33%	100%
A4HXT7	Leishmania infantum	48%	100%
A4HYI8	Leishmania infantum	48%	100%
A4I809	Leishmania infantum	96%	100%
A4I9Q6	Leishmania infantum	35%	100%
A4ICH8	Leishmania infantum	32%	100%
A5W382	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	36%	100%
A6LD25	Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)	32%	100%
A6QBN8	Sulfurovum sp. (strain NBC37-1)	34%	100%
A6TWP7	Alkaliphilus metalliredigens (strain QYMF)	37%	100%
A8ZNZ4	Acaryochloris marina (strain MBIC 11017)	35%	100%
A9BFL9	Petrotoga mobilis (strain DSM 10674 / SJ95)	33%	100%
A9BHD3	Petrotoga mobilis (strain DSM 10674 / SJ95)	33%	100%
A9EXK6	Sorangium cellulosum (strain So ce56)	34%	100%
A9NE17	Acholeplasma laidlawii (strain PG-8A)	36%	100%
B0B970	Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)	36%	79%
B0K5A3	Thermoanaerobacter sp. (strain X514)	36%	100%
B0K657	Thermoanaerobacter sp. (strain X514)	34%	100%
B1AI94	Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)	32%	100%
B1ZMG6	Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)	33%	100%
B2JVU2	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	36%	100%
B2UE66	Ralstonia pickettii (strain 12J)	36%	100%
B2UMY1	Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)	34%	89%
B3DY14	Methylacidiphilum infernorum (isolate V4)	36%	100%
B3PNH3	Metamycoplasma arthritidis (strain 158L3-1)	34%	97%
B3QZS3	Phytoplasma mali (strain AT)	32%	100%
B3R057	Phytoplasma mali (strain AT)	34%	100%
B3R0R7	Phytoplasma mali (strain AT)	34%	100%
B4SCV5	Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)	35%	100%
B4U7U4	Hydrogenobaculum sp. (strain Y04AAS1)	33%	100%
B7J0N5	Borreliella burgdorferi (strain ZS7)	34%	100%
B7T1V0	Vaucheria litorea	33%	100%
B8D065	Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)	35%	100%
B8G4Q6	Chloroflexus aggregans (strain MD-66 / DSM 9485)	33%	100%
B8H444	Caulobacter vibrioides (strain NA1000 / CB15N)	35%	100%
B8I4B9	Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)	34%	100%
B8J992	Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)	35%	100%
B9L3S8	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)	37%	100%
B9MPK5	Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)	38%	100%
C0ZPK5	Rhodococcus erythropolis (strain PR4 / NBRC 100887)	35%	84%
C1F8X6	Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)	37%	100%
C5CES8	Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)	35%	100%
C5J6A7	Mesomycoplasma conjunctivae (strain ATCC 25834 / NCTC 10147 / HRC/581)	33%	95%
C6V4R9	Neorickettsia risticii (strain Illinois)	33%	100%
C6VKW6	Lactiplantibacillus plantarum (strain JDM1)	38%	97%
C7M0M0	Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)	35%	100%
C7N1I1	Slackia heliotrinireducens (strain ATCC 29202 / DSM 20476 / NCTC 11029 / RHS 1)	34%	92%
C7N914	Leptotrichia buccalis (strain ATCC 14201 / DSM 1135 / JCM 12969 / NCTC 10249 / C-1013-b)	36%	94%
C8W731	Lancefieldella parvula (strain ATCC 33793 / DSM 20469 / CCUG 32760 / JCM 10300 / KCTC 3663 / VPI 0546 / 1246)	33%	100%
C8WEG0	Zymomonas mobilis subsp. mobilis (strain NCIMB 11163 / B70)	36%	100%
C9ZMX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZN81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	82%
C9ZZX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D0A0W3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A3J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0AA32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
D0LWB8	Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)	36%	100%
D0MGU8	Rhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10)	35%	100%
D1AXT4	Streptobacillus moniliformis (strain ATCC 14647 / DSM 12112 / NCTC 10651 / 9901)	37%	100%
D1BLD0	Veillonella parvula (strain ATCC 10790 / DSM 2008 / CCUG 5123 / JCM 12972 / NCTC 11810 / Te3)	35%	100%
D1C2C6	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	36%	100%
D1C8C0	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	34%	100%
D1CDT8	Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)	37%	100%
D2NQQ7	Rothia mucilaginosa (strain DY-18)	36%	95%
D2QZ34	Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128)	35%	100%
D3EZK2	Conexibacter woesei (strain DSM 14684 / CIP 108061 / JCM 11494 / NBRC 100937 / ID131577)	37%	96%
D3FFN2	Mycoplasma gallisepticum (strain R(high / passage 156))	33%	94%
D4HA34	Cutibacterium acnes (strain SK137)	36%	100%
D5D8E3	Sulcia muelleri (strain DMIN)	35%	100%
D5H7Z5	Salinibacter ruber (strain M8)	35%	100%
D5HA94	Salinibacter ruber (strain M8)	33%	100%
E9ARJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	97%
E9ASB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AT49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1M1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	81%
E9B4S8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
O19922	Cyanidium caldarium	35%	100%
O32617	Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)	34%	100%
O59824	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
O69076	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	37%	100%
O78516	Guillardia theta	34%	100%
O80860	Arabidopsis thaliana	34%	100%
O80983	Arabidopsis thaliana	36%	100%
O82150	Nicotiana tabacum	37%	100%
O88967	Mus musculus	35%	100%
P0AAI3	Escherichia coli (strain K12)	33%	100%
P0AAI4	Shigella flexneri	33%	100%
P32795	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	96%
P37476	Bacillus subtilis (strain 168)	35%	100%
P39925	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	94%
P40341	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	87%
P46469	Lactococcus lactis subsp. lactis (strain IL1403)	34%	100%
P47695	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	34%	100%
P49825	Trieres chinensis	33%	100%
P51327	Porphyra purpurea	33%	100%
P54813	Caenorhabditis elegans	35%	99%
P57462	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	32%	100%
P59652	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	37%	100%
P63343	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	100%
P63344	Salmonella typhi	33%	100%
P71377	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	33%	100%
P71408	Helicobacter pylori (strain ATCC 700392 / 26695)	33%	100%
P72991	Synechocystis sp. (strain PCC 6803 / Kazusa)	35%	100%
P73179	Synechocystis sp. (strain PCC 6803 / Kazusa)	35%	100%
P73437	Synechocystis sp. (strain PCC 6803 / Kazusa)	33%	100%
P75120	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	34%	100%
P94304	Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4)	35%	100%
P9WQN2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	35%	95%
Q04Q03	Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)	32%	100%
Q0DHL4	Oryza sativa subsp. japonica	38%	87%
Q0TTK8	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	33%	100%
Q10ZF7	Trichodesmium erythraeum (strain IMS101)	36%	100%
Q1AV13	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1)	37%	100%
Q1D491	Myxococcus xanthus (strain DK1622)	36%	100%
Q1LLA9	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	34%	100%
Q1PDW5	Arabidopsis thaliana	36%	100%
Q1RGP0	Rickettsia bellii (strain RML369-C)	31%	100%
Q1XDF9	Neopyropia yezoensis	35%	100%
Q2JNP0	Synechococcus sp. (strain JA-2-3B'a(2-13))	37%	100%
Q2KJI7	Bos taurus	35%	89%
Q2NIN5	Aster yellows witches'-broom phytoplasma (strain AYWB)	35%	100%
Q2SF13	Hahella chejuensis (strain KCTC 2396)	31%	100%
Q39102	Arabidopsis thaliana	36%	100%
Q39444	Capsicum annuum	36%	100%
Q3B6R3	Chlorobium luteolum (strain DSM 273 / BCRC 81028 / 2530)	36%	100%
Q3JEE4	Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)	36%	100%
Q3ULF4	Mus musculus	37%	92%
Q4A5F0	Mycoplasmopsis synoviae (strain 53)	33%	100%
Q4Q1E9	Leishmania major	32%	100%
Q4Q399	Leishmania major	35%	100%
Q4Q5D1	Leishmania major	96%	100%
Q4Q6J3	Leishmania major	31%	100%
Q4QD50	Leishmania major	47%	99%
Q4QDY0	Leishmania major	48%	97%
Q4UN68	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	33%	100%
Q55700	Synechocystis sp. (strain PCC 6803 / Kazusa)	34%	100%
Q5Z974	Oryza sativa subsp. japonica	36%	100%
Q60AK1	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	34%	100%
Q655S1	Oryza sativa subsp. japonica	35%	100%
Q67JH0	Symbiobacterium thermophilum (strain T / IAM 14863)	39%	100%
Q67LC0	Symbiobacterium thermophilum (strain T / IAM 14863)	35%	100%
Q67WJ2	Oryza sativa subsp. japonica	35%	100%
Q68XR9	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	33%	100%
Q6KHA4	Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)	33%	100%
Q6LUJ8	Photobacterium profundum (strain SS9)	35%	100%
Q6MDI5	Protochlamydia amoebophila (strain UWE25)	36%	78%
Q6MLS7	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	34%	100%
Q7TT47	Rattus norvegicus	37%	92%
Q7URM7	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	33%	99%
Q7UUZ7	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	36%	100%
Q83FV7	Tropheryma whipplei (strain Twist)	35%	100%
Q83XX3	Oenococcus oeni	34%	100%
Q84WU8	Arabidopsis thaliana	38%	89%
Q88Z31	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	38%	97%
Q89AF2	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	32%	100%
Q8EUA6	Malacoplasma penetrans (strain HF-2)	35%	87%
Q8JZQ2	Mus musculus	35%	90%
Q8K9G8	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	32%	100%
Q8LQJ8	Oryza sativa subsp. japonica	37%	100%
Q8LQJ9	Oryza sativa subsp. japonica	37%	100%
Q8S2A7	Oryza sativa subsp. japonica	36%	90%
Q8VZI8	Arabidopsis thaliana	37%	88%
Q8W585	Arabidopsis thaliana	35%	100%
Q8X9L0	Escherichia coli O157:H7	33%	100%
Q8YMZ8	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	35%	100%
Q920A7	Mus musculus	37%	91%
Q925S8	Rattus norvegicus	36%	100%
Q92JJ9	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	32%	100%
Q96TA2	Homo sapiens	36%	93%
Q98PE4	Mycoplasmopsis pulmonis (strain UAB CTIP)	33%	99%
Q9BAE0	Medicago sativa	36%	100%
Q9FH02	Arabidopsis thaliana	37%	100%
Q9HGM3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	93%
Q9N3T5	Caenorhabditis elegans	36%	92%
Q9TJ83	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	34%	100%
Q9UQ90	Homo sapiens	36%	90%
Q9WZ49	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	36%	100%
Q9Y4W6	Homo sapiens	35%	90%
Q9ZEA2	Rickettsia prowazekii (strain Madrid E)	33%	100%
Q9ZM66	Helicobacter pylori (strain J99 / ATCC 700824)	33%	100%
V5B092	Trypanosoma cruzi	32%	100%
V5B4C8	Trypanosoma cruzi	48%	100%
V5BEV9	Trypanosoma cruzi	36%	100%
V5BP04	Trypanosoma cruzi	76%	100%