Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2S3_LEIMU

TriTrypDb:

LmxM.31.1480

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2S3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.513
CLV_C14_Caspase3-7	70	74	PF00656	0.618
CLV_MEL_PAP_1	597	603	PF00089	0.656
CLV_NRD_NRD_1	148	150	PF00675	0.545
CLV_NRD_NRD_1	15	17	PF00675	0.630
CLV_NRD_NRD_1	236	238	PF00675	0.570
CLV_NRD_NRD_1	373	375	PF00675	0.375
CLV_NRD_NRD_1	397	399	PF00675	0.460
CLV_NRD_NRD_1	458	460	PF00675	0.411
CLV_NRD_NRD_1	595	597	PF00675	0.579
CLV_NRD_NRD_1	614	616	PF00675	0.536
CLV_PCSK_KEX2_1	15	17	PF00082	0.677
CLV_PCSK_KEX2_1	150	152	PF00082	0.520
CLV_PCSK_KEX2_1	236	238	PF00082	0.570
CLV_PCSK_KEX2_1	375	377	PF00082	0.492
CLV_PCSK_KEX2_1	458	460	PF00082	0.411
CLV_PCSK_KEX2_1	595	597	PF00082	0.579
CLV_PCSK_KEX2_1	614	616	PF00082	0.536
CLV_PCSK_KEX2_1	87	89	PF00082	0.555
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.529
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.492
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.555
CLV_PCSK_SKI1_1	151	155	PF00082	0.557
CLV_PCSK_SKI1_1	194	198	PF00082	0.688
CLV_PCSK_SKI1_1	268	272	PF00082	0.556
CLV_PCSK_SKI1_1	280	284	PF00082	0.518
CLV_PCSK_SKI1_1	369	373	PF00082	0.430
CLV_PCSK_SKI1_1	458	462	PF00082	0.427
CLV_PCSK_SKI1_1	476	480	PF00082	0.472
CLV_PCSK_SKI1_1	595	599	PF00082	0.486
CLV_PCSK_SKI1_1	614	618	PF00082	0.555
CLV_PCSK_SKI1_1	620	624	PF00082	0.506
CLV_PCSK_SKI1_1	77	81	PF00082	0.518
DEG_APCC_DBOX_1	599	607	PF00400	0.637
DEG_APCC_KENBOX_2	539	543	PF00400	0.587
DEG_Nend_UBRbox_1	1	4	PF02207	0.550
DEG_SPOP_SBC_1	173	177	PF00917	0.524
DEG_SPOP_SBC_1	631	635	PF00917	0.677
DOC_CKS1_1	54	59	PF01111	0.557
DOC_CYCLIN_yCln2_LP_2	575	581	PF00134	0.562
DOC_MAPK_gen_1	149	157	PF00069	0.542
DOC_MAPK_gen_1	15	25	PF00069	0.500
DOC_MAPK_gen_1	374	385	PF00069	0.431
DOC_MAPK_gen_1	479	488	PF00069	0.522
DOC_MAPK_MEF2A_6	378	387	PF00069	0.423
DOC_PP1_RVXF_1	229	236	PF00149	0.613
DOC_PP1_RVXF_1	266	272	PF00149	0.554
DOC_PP1_RVXF_1	278	285	PF00149	0.524
DOC_PP1_RVXF_1	321	328	PF00149	0.431
DOC_PP1_RVXF_1	355	362	PF00149	0.385
DOC_PP1_RVXF_1	367	374	PF00149	0.370
DOC_PP2B_LxvP_1	575	578	PF13499	0.553
DOC_PP2B_LxvP_1	607	610	PF13499	0.543
DOC_PP4_FxxP_1	387	390	PF00568	0.452
DOC_PP4_FxxP_1	433	436	PF00568	0.532
DOC_PP4_FxxP_1	468	471	PF00568	0.478
DOC_USP7_MATH_1	134	138	PF00917	0.562
DOC_USP7_MATH_1	156	160	PF00917	0.600
DOC_USP7_MATH_1	173	177	PF00917	0.602
DOC_USP7_MATH_1	179	183	PF00917	0.521
DOC_USP7_MATH_1	60	64	PF00917	0.704
DOC_USP7_MATH_1	632	636	PF00917	0.726
DOC_USP7_UBL2_3	395	399	PF12436	0.536
DOC_WW_Pin1_4	175	180	PF00397	0.610
DOC_WW_Pin1_4	275	280	PF00397	0.544
DOC_WW_Pin1_4	45	50	PF00397	0.567
DOC_WW_Pin1_4	504	509	PF00397	0.453
DOC_WW_Pin1_4	53	58	PF00397	0.539
DOC_WW_Pin1_4	641	646	PF00397	0.740
LIG_14-3-3_CanoR_1	151	156	PF00244	0.516
LIG_14-3-3_CanoR_1	19	25	PF00244	0.583
LIG_14-3-3_CanoR_1	2	10	PF00244	0.550
LIG_14-3-3_CanoR_1	37	45	PF00244	0.527
LIG_14-3-3_CanoR_1	376	385	PF00244	0.445
LIG_14-3-3_CanoR_1	600	604	PF00244	0.642
LIG_14-3-3_CanoR_1	77	84	PF00244	0.614
LIG_14-3-3_CanoR_1	88	93	PF00244	0.572
LIG_Actin_WH2_2	234	252	PF00022	0.494
LIG_APCC_ABBA_1	256	261	PF00400	0.550
LIG_BRCT_BRCA1_1	335	339	PF00533	0.445
LIG_BRCT_BRCA1_1	572	576	PF00533	0.564
LIG_deltaCOP1_diTrp_1	261	271	PF00928	0.542
LIG_deltaCOP1_diTrp_1	514	523	PF00928	0.433
LIG_EH1_1	522	530	PF00400	0.356
LIG_eIF4E_1	469	475	PF01652	0.518
LIG_FHA_1	109	115	PF00498	0.622
LIG_FHA_1	152	158	PF00498	0.590
LIG_FHA_1	191	197	PF00498	0.521
LIG_FHA_1	20	26	PF00498	0.654
LIG_FHA_1	320	326	PF00498	0.449
LIG_FHA_1	338	344	PF00498	0.368
LIG_FHA_1	366	372	PF00498	0.371
LIG_FHA_1	378	384	PF00498	0.447
LIG_FHA_1	437	443	PF00498	0.444
LIG_FHA_1	475	481	PF00498	0.521
LIG_FHA_1	572	578	PF00498	0.674
LIG_FHA_1	611	617	PF00498	0.532
LIG_FHA_1	637	643	PF00498	0.654
LIG_FHA_2	119	125	PF00498	0.573
LIG_FHA_2	160	166	PF00498	0.622
LIG_FHA_2	281	287	PF00498	0.567
LIG_FHA_2	480	486	PF00498	0.585
LIG_FHA_2	505	511	PF00498	0.438
LIG_FHA_2	621	627	PF00498	0.545
LIG_LIR_Apic_2	430	436	PF02991	0.557
LIG_LIR_Apic_2	467	471	PF02991	0.478
LIG_LIR_Gen_1	306	315	PF02991	0.437
LIG_LIR_Gen_1	336	346	PF02991	0.433
LIG_LIR_Gen_1	381	390	PF02991	0.457
LIG_LIR_Gen_1	391	400	PF02991	0.509
LIG_LIR_Gen_1	425	436	PF02991	0.563
LIG_LIR_Gen_1	450	457	PF02991	0.376
LIG_LIR_Gen_1	547	555	PF02991	0.525
LIG_LIR_Nem_3	210	214	PF02991	0.588
LIG_LIR_Nem_3	232	238	PF02991	0.562
LIG_LIR_Nem_3	306	312	PF02991	0.431
LIG_LIR_Nem_3	336	342	PF02991	0.425
LIG_LIR_Nem_3	381	387	PF02991	0.406
LIG_LIR_Nem_3	391	396	PF02991	0.422
LIG_LIR_Nem_3	40	45	PF02991	0.644
LIG_LIR_Nem_3	416	422	PF02991	0.573
LIG_LIR_Nem_3	425	431	PF02991	0.574
LIG_LIR_Nem_3	450	454	PF02991	0.374
LIG_LIR_Nem_3	500	506	PF02991	0.468
LIG_LIR_Nem_3	547	551	PF02991	0.530
LIG_LIR_Nem_3	573	579	PF02991	0.558
LIG_LIR_Nem_3	618	622	PF02991	0.541
LIG_PCNA_yPIPBox_3	582	596	PF02747	0.643
LIG_Pex14_2	271	275	PF04695	0.554
LIG_Pex14_2	309	313	PF04695	0.347
LIG_PTB_Apo_2	539	546	PF02174	0.506
LIG_SH2_CRK	152	156	PF00017	0.565
LIG_SH2_CRK	211	215	PF00017	0.573
LIG_SH2_NCK_1	152	156	PF00017	0.584
LIG_SH2_NCK_1	506	510	PF00017	0.486
LIG_SH2_STAP1	115	119	PF00017	0.530
LIG_SH2_STAP1	379	383	PF00017	0.440
LIG_SH2_STAP1	405	409	PF00017	0.513
LIG_SH2_STAP1	440	444	PF00017	0.420
LIG_SH2_STAT5	115	118	PF00017	0.642
LIG_SH2_STAT5	314	317	PF00017	0.462
LIG_SH2_STAT5	379	382	PF00017	0.454
LIG_SH2_STAT5	384	387	PF00017	0.383
LIG_SH2_STAT5	506	509	PF00017	0.486
LIG_SH2_STAT5	537	540	PF00017	0.514
LIG_SH3_1	51	57	PF00018	0.527
LIG_SH3_3	203	209	PF00018	0.619
LIG_SH3_3	46	52	PF00018	0.564
LIG_SH3_3	54	60	PF00018	0.530
LIG_SH3_3	639	645	PF00018	0.554
LIG_SUMO_SIM_par_1	21	27	PF11976	0.513
LIG_SUMO_SIM_par_1	295	302	PF11976	0.461
LIG_TRAF2_1	221	224	PF00917	0.574
LIG_TRAF2_1	260	263	PF00917	0.551
LIG_UBA3_1	245	250	PF00899	0.486
LIG_WW_3	48	52	PF00397	0.525
MOD_CDK_SPK_2	275	280	PF00069	0.544
MOD_CDK_SPxK_1	45	51	PF00069	0.529
MOD_CK1_1	137	143	PF00069	0.612
MOD_CK1_1	159	165	PF00069	0.719
MOD_CK1_1	174	180	PF00069	0.636
MOD_CK1_1	18	24	PF00069	0.564
MOD_CK1_1	229	235	PF00069	0.622
MOD_CK1_1	31	37	PF00069	0.506
MOD_CK1_1	377	383	PF00069	0.448
MOD_CK1_1	40	46	PF00069	0.565
MOD_CK1_1	547	553	PF00069	0.527
MOD_CK1_1	599	605	PF00069	0.564
MOD_CK1_1	62	68	PF00069	0.586
MOD_CK1_1	91	97	PF00069	0.621
MOD_CK2_1	159	165	PF00069	0.567
MOD_CK2_1	179	185	PF00069	0.675
MOD_CK2_1	218	224	PF00069	0.606
MOD_CK2_1	280	286	PF00069	0.518
MOD_CK2_1	331	337	PF00069	0.447
MOD_CK2_1	479	485	PF00069	0.591
MOD_CK2_1	504	510	PF00069	0.452
MOD_GlcNHglycan	100	103	PF01048	0.593
MOD_GlcNHglycan	132	135	PF01048	0.785
MOD_GlcNHglycan	159	162	PF01048	0.614
MOD_GlcNHglycan	3	6	PF01048	0.551
MOD_GlcNHglycan	327	330	PF01048	0.441
MOD_GlcNHglycan	444	447	PF01048	0.446
MOD_GlcNHglycan	65	68	PF01048	0.666
MOD_GlcNHglycan	94	97	PF01048	0.587
MOD_GSK3_1	125	132	PF00069	0.531
MOD_GSK3_1	134	141	PF00069	0.575
MOD_GSK3_1	15	22	PF00069	0.651
MOD_GSK3_1	167	174	PF00069	0.667
MOD_GSK3_1	175	182	PF00069	0.576
MOD_GSK3_1	214	221	PF00069	0.616
MOD_GSK3_1	24	31	PF00069	0.589
MOD_GSK3_1	313	320	PF00069	0.474
MOD_GSK3_1	333	340	PF00069	0.292
MOD_GSK3_1	365	372	PF00069	0.401
MOD_GSK3_1	374	381	PF00069	0.419
MOD_GSK3_1	40	47	PF00069	0.535
MOD_GSK3_1	577	584	PF00069	0.676
MOD_GSK3_1	59	66	PF00069	0.629
MOD_GSK3_1	626	633	PF00069	0.638
MOD_GSK3_1	83	90	PF00069	0.601
MOD_GSK3_1	94	101	PF00069	0.657
MOD_N-GLC_1	167	172	PF02516	0.569
MOD_N-GLC_1	19	24	PF02516	0.560
MOD_N-GLC_1	581	586	PF02516	0.640
MOD_NEK2_1	1	6	PF00069	0.518
MOD_NEK2_1	157	162	PF00069	0.530
MOD_NEK2_1	214	219	PF00069	0.624
MOD_NEK2_1	226	231	PF00069	0.592
MOD_NEK2_1	30	35	PF00069	0.551
MOD_NEK2_1	325	330	PF00069	0.532
MOD_NEK2_1	474	479	PF00069	0.521
MOD_NEK2_1	83	88	PF00069	0.510
MOD_NEK2_1	92	97	PF00069	0.518
MOD_NEK2_2	571	576	PF00069	0.621
MOD_NEK2_2	6	11	PF00069	0.524
MOD_PIKK_1	469	475	PF00454	0.458
MOD_PIKK_1	633	639	PF00454	0.598
MOD_PIKK_1	94	100	PF00454	0.522
MOD_PKA_1	15	21	PF00069	0.532
MOD_PKA_1	318	324	PF00069	0.347
MOD_PKA_1	374	380	PF00069	0.448
MOD_PKA_1	87	93	PF00069	0.557
MOD_PKA_2	1	7	PF00069	0.518
MOD_PKA_2	15	21	PF00069	0.565
MOD_PKA_2	157	163	PF00069	0.539
MOD_PKA_2	214	220	PF00069	0.587
MOD_PKA_2	31	37	PF00069	0.602
MOD_PKA_2	377	383	PF00069	0.448
MOD_PKA_2	469	475	PF00069	0.458
MOD_PKA_2	599	605	PF00069	0.641
MOD_PKA_2	87	93	PF00069	0.626
MOD_PKA_2	98	104	PF00069	0.768
MOD_PKB_1	149	157	PF00069	0.603
MOD_PKB_1	376	384	PF00069	0.509
MOD_Plk_1	19	25	PF00069	0.562
MOD_Plk_1	331	337	PF00069	0.447
MOD_Plk_1	369	375	PF00069	0.433
MOD_Plk_1	405	411	PF00069	0.501
MOD_Plk_1	581	587	PF00069	0.626
MOD_Plk_1	648	654	PF00069	0.649
MOD_Plk_4	115	121	PF00069	0.577
MOD_Plk_4	544	550	PF00069	0.583
MOD_Plk_4	571	577	PF00069	0.622
MOD_Plk_4	6	12	PF00069	0.595
MOD_ProDKin_1	175	181	PF00069	0.610
MOD_ProDKin_1	275	281	PF00069	0.540
MOD_ProDKin_1	45	51	PF00069	0.568
MOD_ProDKin_1	504	510	PF00069	0.452
MOD_ProDKin_1	53	59	PF00069	0.532
MOD_ProDKin_1	641	647	PF00069	0.723
MOD_SUMO_for_1	480	483	PF00179	0.490
MOD_SUMO_for_1	538	541	PF00179	0.579
MOD_SUMO_rev_2	223	232	PF00179	0.594
MOD_SUMO_rev_2	242	252	PF00179	0.614
MOD_SUMO_rev_2	427	436	PF00179	0.564
MOD_SUMO_rev_2	612	622	PF00179	0.595
TRG_DiLeu_BaEn_3	306	312	PF01217	0.325
TRG_DiLeu_BaLyEn_6	456	461	PF01217	0.443
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.553
TRG_ENDOCYTIC_2	152	155	PF00928	0.569
TRG_ENDOCYTIC_2	211	214	PF00928	0.579
TRG_ENDOCYTIC_2	384	387	PF00928	0.442
TRG_ENDOCYTIC_2	393	396	PF00928	0.498
TRG_ENDOCYTIC_2	419	422	PF00928	0.409
TRG_ENDOCYTIC_2	506	509	PF00928	0.444
TRG_ER_diArg_1	149	152	PF00400	0.551
TRG_ER_diArg_1	15	17	PF00400	0.620
TRG_ER_diArg_1	235	237	PF00400	0.572
TRG_ER_diArg_1	373	376	PF00400	0.459
TRG_ER_diArg_1	457	459	PF00400	0.411
TRG_ER_diArg_1	595	597	PF00400	0.579
TRG_ER_diArg_1	614	616	PF00400	0.536
TRG_NLS_MonoExtC_3	373	378	PF00514	0.423
TRG_NLS_MonoExtN_4	374	379	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICK2	Leptomonas seymouri	70%	99%
A0A0S4J6R5	Bodo saltans	59%	100%
A0A3S7X5I1	Leishmania donovani	95%	100%
A4HKD5	Leishmania braziliensis	89%	100%
A4I7W5	Leishmania infantum	95%	100%
Q4Q5D4	Leishmania major	93%	100%