Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2R7_LEIMU

TriTrypDb:

LmxM.31.1420

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2R7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	518	522	PF00656	0.508
CLV_NRD_NRD_1	148	150	PF00675	0.547
CLV_NRD_NRD_1	318	320	PF00675	0.558
CLV_NRD_NRD_1	385	387	PF00675	0.518
CLV_NRD_NRD_1	48	50	PF00675	0.615
CLV_NRD_NRD_1	548	550	PF00675	0.442
CLV_PCSK_KEX2_1	147	149	PF00082	0.560
CLV_PCSK_KEX2_1	23	25	PF00082	0.491
CLV_PCSK_KEX2_1	318	320	PF00082	0.510
CLV_PCSK_KEX2_1	420	422	PF00082	0.466
CLV_PCSK_KEX2_1	48	50	PF00082	0.617
CLV_PCSK_KEX2_1	497	499	PF00082	0.520
CLV_PCSK_KEX2_1	548	550	PF00082	0.541
CLV_PCSK_KEX2_1	642	644	PF00082	0.280
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.646
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.514
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.466
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.520
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.280
CLV_PCSK_SKI1_1	218	222	PF00082	0.435
CLV_PCSK_SKI1_1	314	318	PF00082	0.589
CLV_PCSK_SKI1_1	37	41	PF00082	0.659
CLV_PCSK_SKI1_1	527	531	PF00082	0.439
CLV_PCSK_SKI1_1	643	647	PF00082	0.416
CLV_PCSK_SKI1_1	85	89	PF00082	0.699
DOC_CKS1_1	274	279	PF01111	0.485
DOC_CYCLIN_RxL_1	215	224	PF00134	0.433
DOC_CYCLIN_RxL_1	378	389	PF00134	0.356
DOC_CYCLIN_RxL_1	613	625	PF00134	0.489
DOC_MAPK_gen_1	670	679	PF00069	0.582
DOC_MAPK_MEF2A_6	255	264	PF00069	0.527
DOC_PP1_RVXF_1	379	386	PF00149	0.482
DOC_PP2B_LxvP_1	512	515	PF13499	0.499
DOC_USP7_MATH_1	110	114	PF00917	0.701
DOC_USP7_MATH_1	150	154	PF00917	0.605
DOC_USP7_MATH_1	156	160	PF00917	0.544
DOC_USP7_MATH_1	270	274	PF00917	0.432
DOC_USP7_MATH_1	403	407	PF00917	0.619
DOC_USP7_MATH_1	515	519	PF00917	0.603
DOC_USP7_MATH_1	56	60	PF00917	0.502
DOC_USP7_MATH_1	560	564	PF00917	0.520
DOC_USP7_MATH_1	571	575	PF00917	0.479
DOC_USP7_MATH_1	620	624	PF00917	0.558
DOC_USP7_MATH_1	653	657	PF00917	0.496
DOC_USP7_MATH_1	93	97	PF00917	0.676
DOC_WW_Pin1_4	126	131	PF00397	0.692
DOC_WW_Pin1_4	273	278	PF00397	0.438
DOC_WW_Pin1_4	482	487	PF00397	0.770
DOC_WW_Pin1_4	57	62	PF00397	0.649
LIG_14-3-3_CanoR_1	107	117	PF00244	0.596
LIG_14-3-3_CanoR_1	166	171	PF00244	0.528
LIG_14-3-3_CanoR_1	527	536	PF00244	0.482
LIG_14-3-3_CanoR_1	583	593	PF00244	0.495
LIG_14-3-3_CanoR_1	643	649	PF00244	0.398
LIG_14-3-3_CanoR_1	85	95	PF00244	0.610
LIG_Actin_WH2_2	313	330	PF00022	0.461
LIG_Actin_WH2_2	428	445	PF00022	0.528
LIG_BRCT_BRCA1_1	605	609	PF00533	0.413
LIG_CaM_IQ_9	77	92	PF13499	0.671
LIG_Clathr_ClatBox_1	608	612	PF01394	0.396
LIG_CtBP_PxDLS_1	388	394	PF00389	0.254
LIG_EH1_1	3	11	PF00400	0.632
LIG_eIF4E_1	363	369	PF01652	0.587
LIG_FHA_1	127	133	PF00498	0.672
LIG_FHA_1	14	20	PF00498	0.608
LIG_FHA_1	274	280	PF00498	0.418
LIG_FHA_1	328	334	PF00498	0.516
LIG_FHA_1	33	39	PF00498	0.603
LIG_FHA_1	455	461	PF00498	0.585
LIG_FHA_1	506	512	PF00498	0.518
LIG_FHA_1	524	530	PF00498	0.240
LIG_FHA_1	538	544	PF00498	0.412
LIG_FHA_1	58	64	PF00498	0.635
LIG_FHA_1	614	620	PF00498	0.421
LIG_FHA_1	623	629	PF00498	0.457
LIG_FHA_1	639	645	PF00498	0.519
LIG_FHA_1	82	88	PF00498	0.673
LIG_FHA_2	155	161	PF00498	0.570
LIG_FHA_2	474	480	PF00498	0.597
LIG_FHA_2	526	532	PF00498	0.482
LIG_FHA_2	585	591	PF00498	0.486
LIG_FHA_2	645	651	PF00498	0.466
LIG_LIR_Gen_1	30	39	PF02991	0.590
LIG_LIR_Gen_1	540	547	PF02991	0.486
LIG_LIR_Gen_1	623	632	PF02991	0.466
LIG_LIR_Nem_3	30	36	PF02991	0.522
LIG_LIR_Nem_3	390	396	PF02991	0.561
LIG_LIR_Nem_3	540	545	PF02991	0.489
LIG_LIR_Nem_3	623	629	PF02991	0.468
LIG_NRBOX	506	512	PF00104	0.518
LIG_Pex14_2	271	275	PF04695	0.428
LIG_SH2_CRK	33	37	PF00017	0.546
LIG_SH2_CRK	345	349	PF00017	0.357
LIG_SH2_CRK	626	630	PF00017	0.492
LIG_SH2_GRB2like	207	210	PF00017	0.526
LIG_SH2_NCK_1	170	174	PF00017	0.445
LIG_SH2_SRC	343	346	PF00017	0.551
LIG_SH2_STAP1	280	284	PF00017	0.375
LIG_SH2_STAP1	292	296	PF00017	0.444
LIG_SH2_STAT3	207	210	PF00017	0.526
LIG_SH2_STAT5	207	210	PF00017	0.454
LIG_SH2_STAT5	233	236	PF00017	0.428
LIG_SH2_STAT5	33	36	PF00017	0.648
LIG_SH2_STAT5	343	346	PF00017	0.551
LIG_SH2_STAT5	395	398	PF00017	0.534
LIG_SH2_STAT5	578	581	PF00017	0.509
LIG_SH3_2	136	141	PF14604	0.645
LIG_SH3_3	133	139	PF00018	0.646
LIG_SH3_3	330	336	PF00018	0.611
LIG_SH3_3	344	350	PF00018	0.490
LIG_SUMO_SIM_anti_2	227	232	PF11976	0.433
LIG_TRFH_1	440	444	PF08558	0.529
LIG_UBA3_1	379	387	PF00899	0.558
MOD_CDK_SPK_2	482	487	PF00069	0.692
MOD_CK1_1	108	114	PF00069	0.765
MOD_CK1_1	121	127	PF00069	0.565
MOD_CK1_1	154	160	PF00069	0.568
MOD_CK1_1	273	279	PF00069	0.421
MOD_CK1_1	359	365	PF00069	0.494
MOD_CK1_1	401	407	PF00069	0.597
MOD_CK1_1	485	491	PF00069	0.509
MOD_CK1_1	59	65	PF00069	0.710
MOD_CK2_1	154	160	PF00069	0.480
MOD_CK2_1	168	174	PF00069	0.461
MOD_CK2_1	473	479	PF00069	0.792
MOD_CK2_1	525	531	PF00069	0.516
MOD_CK2_1	584	590	PF00069	0.503
MOD_GlcNHglycan	105	110	PF01048	0.733
MOD_GlcNHglycan	112	115	PF01048	0.459
MOD_GlcNHglycan	29	32	PF01048	0.580
MOD_GlcNHglycan	323	326	PF01048	0.611
MOD_GlcNHglycan	358	361	PF01048	0.509
MOD_GlcNHglycan	373	376	PF01048	0.287
MOD_GlcNHglycan	400	403	PF01048	0.607
MOD_GlcNHglycan	426	429	PF01048	0.694
MOD_GlcNHglycan	444	447	PF01048	0.435
MOD_GlcNHglycan	487	490	PF01048	0.761
MOD_GlcNHglycan	500	503	PF01048	0.545
MOD_GlcNHglycan	605	608	PF01048	0.406
MOD_GlcNHglycan	94	98	PF01048	0.714
MOD_GSK3_1	105	112	PF00069	0.547
MOD_GSK3_1	150	157	PF00069	0.511
MOD_GSK3_1	216	223	PF00069	0.434
MOD_GSK3_1	27	34	PF00069	0.453
MOD_GSK3_1	397	404	PF00069	0.515
MOD_GSK3_1	469	476	PF00069	0.679
MOD_GSK3_1	523	530	PF00069	0.421
MOD_GSK3_1	537	544	PF00069	0.414
MOD_GSK3_1	567	574	PF00069	0.509
MOD_N-GLC_1	221	226	PF02516	0.569
MOD_N-GLC_1	81	86	PF02516	0.574
MOD_NEK2_1	12	17	PF00069	0.585
MOD_NEK2_1	220	225	PF00069	0.480
MOD_NEK2_1	321	326	PF00069	0.568
MOD_NEK2_1	327	332	PF00069	0.673
MOD_NEK2_1	492	497	PF00069	0.635
MOD_NEK2_1	520	525	PF00069	0.473
MOD_NEK2_1	621	626	PF00069	0.482
MOD_NEK2_1	630	635	PF00069	0.395
MOD_NEK2_1	638	643	PF00069	0.336
MOD_NEK2_1	663	668	PF00069	0.439
MOD_NEK2_1	80	85	PF00069	0.579
MOD_PIKK_1	121	127	PF00454	0.679
MOD_PIKK_1	270	276	PF00454	0.501
MOD_PIKK_1	302	308	PF00454	0.596
MOD_PIKK_1	473	479	PF00454	0.690
MOD_PIKK_1	537	543	PF00454	0.466
MOD_PIKK_1	86	92	PF00454	0.464
MOD_PKA_2	327	333	PF00069	0.533
MOD_PKA_2	442	448	PF00069	0.521
MOD_Plk_1	520	526	PF00069	0.458
MOD_Plk_1	93	99	PF00069	0.767
MOD_Plk_2-3	258	264	PF00069	0.439
MOD_Plk_4	275	281	PF00069	0.414
MOD_Plk_4	359	365	PF00069	0.582
MOD_Plk_4	448	454	PF00069	0.402
MOD_Plk_4	520	526	PF00069	0.421
MOD_Plk_4	541	547	PF00069	0.401
MOD_Plk_4	59	65	PF00069	0.687
MOD_ProDKin_1	126	132	PF00069	0.694
MOD_ProDKin_1	273	279	PF00069	0.431
MOD_ProDKin_1	482	488	PF00069	0.768
MOD_ProDKin_1	57	63	PF00069	0.655
TRG_DiLeu_BaEn_1	73	78	PF01217	0.634
TRG_DiLeu_BaEn_1	94	99	PF01217	0.691
TRG_DiLeu_BaEn_4	73	79	PF01217	0.657
TRG_ENDOCYTIC_2	233	236	PF00928	0.501
TRG_ENDOCYTIC_2	33	36	PF00928	0.563
TRG_ENDOCYTIC_2	345	348	PF00928	0.391
TRG_ENDOCYTIC_2	626	629	PF00928	0.452
TRG_ER_diArg_1	148	150	PF00400	0.549
TRG_ER_diArg_1	317	319	PF00400	0.572
TRG_ER_diArg_1	440	443	PF00400	0.565
TRG_ER_diArg_1	547	549	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE35	Leptomonas seymouri	60%	100%
A0A1X0NVV3	Trypanosomatidae	34%	100%
A0A3Q8IT90	Leishmania donovani	88%	100%
A4I7V9	Leishmania infantum	87%	100%
D0AA22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AIV0	Leishmania braziliensis	76%	100%
Q4Q5E0	Leishmania major	87%	100%
V5BJJ3	Trypanosoma cruzi	35%	100%