Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2R4_LEIMU

TriTrypDb:

LmxM.31.1390

Length:

752

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2R4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.375
CLV_C14_Caspase3-7	738	742	PF00656	0.754
CLV_NRD_NRD_1	160	162	PF00675	0.550
CLV_NRD_NRD_1	382	384	PF00675	0.444
CLV_NRD_NRD_1	52	54	PF00675	0.721
CLV_NRD_NRD_1	676	678	PF00675	0.824
CLV_PCSK_KEX2_1	160	162	PF00082	0.553
CLV_PCSK_KEX2_1	314	316	PF00082	0.453
CLV_PCSK_KEX2_1	52	54	PF00082	0.723
CLV_PCSK_KEX2_1	676	678	PF00082	0.824
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.453
CLV_PCSK_SKI1_1	198	202	PF00082	0.530
CLV_PCSK_SKI1_1	210	214	PF00082	0.432
CLV_PCSK_SKI1_1	272	276	PF00082	0.530
CLV_PCSK_SKI1_1	310	314	PF00082	0.478
CLV_PCSK_SKI1_1	351	355	PF00082	0.620
CLV_PCSK_SKI1_1	400	404	PF00082	0.518
CLV_PCSK_SKI1_1	508	512	PF00082	0.414
CLV_PCSK_SKI1_1	74	78	PF00082	0.472
DEG_APCC_DBOX_1	159	167	PF00400	0.594
DEG_APCC_DBOX_1	73	81	PF00400	0.459
DEG_MDM2_SWIB_1	276	283	PF02201	0.483
DEG_Nend_Nbox_1	1	3	PF02207	0.696
DEG_SPOP_SBC_1	742	746	PF00917	0.549
DOC_CKS1_1	354	359	PF01111	0.627
DOC_CKS1_1	401	406	PF01111	0.473
DOC_CKS1_1	613	618	PF01111	0.463
DOC_CYCLIN_RxL_1	204	217	PF00134	0.446
DOC_CYCLIN_RxL_1	381	391	PF00134	0.521
DOC_MAPK_gen_1	666	675	PF00069	0.784
DOC_PP1_RVXF_1	280	286	PF00149	0.542
DOC_PP2B_LxvP_1	386	389	PF13499	0.538
DOC_PP2B_LxvP_1	418	421	PF13499	0.585
DOC_PP4_FxxP_1	646	649	PF00568	0.795
DOC_USP7_MATH_1	101	105	PF00917	0.727
DOC_USP7_MATH_1	108	112	PF00917	0.639
DOC_USP7_MATH_1	11	15	PF00917	0.601
DOC_USP7_MATH_1	122	126	PF00917	0.744
DOC_USP7_MATH_1	146	150	PF00917	0.511
DOC_USP7_MATH_1	215	219	PF00917	0.350
DOC_USP7_MATH_1	244	248	PF00917	0.459
DOC_USP7_MATH_1	332	336	PF00917	0.430
DOC_USP7_MATH_1	549	553	PF00917	0.530
DOC_USP7_MATH_1	564	568	PF00917	0.412
DOC_USP7_MATH_1	712	716	PF00917	0.768
DOC_USP7_MATH_1	742	746	PF00917	0.797
DOC_USP7_UBL2_3	268	272	PF12436	0.578
DOC_USP7_UBL2_3	310	314	PF12436	0.424
DOC_WW_Pin1_4	114	119	PF00397	0.784
DOC_WW_Pin1_4	18	23	PF00397	0.660
DOC_WW_Pin1_4	353	358	PF00397	0.585
DOC_WW_Pin1_4	400	405	PF00397	0.503
DOC_WW_Pin1_4	612	617	PF00397	0.429
DOC_WW_Pin1_4	707	712	PF00397	0.688
LIG_14-3-3_CanoR_1	315	324	PF00244	0.444
LIG_14-3-3_CanoR_1	340	349	PF00244	0.389
LIG_14-3-3_CanoR_1	383	387	PF00244	0.533
LIG_14-3-3_CanoR_1	414	421	PF00244	0.503
LIG_14-3-3_CanoR_1	441	448	PF00244	0.636
LIG_14-3-3_CanoR_1	516	520	PF00244	0.513
LIG_14-3-3_CanoR_1	676	684	PF00244	0.817
LIG_BRCT_BRCA1_1	482	486	PF00533	0.475
LIG_BRCT_BRCA1_1	663	667	PF00533	0.638
LIG_BRCT_BRCA1_2	663	669	PF00533	0.601
LIG_CtBP_PxDLS_1	364	368	PF00389	0.534
LIG_EH1_1	205	213	PF00400	0.486
LIG_eIF4E_1	307	313	PF01652	0.463
LIG_FHA_1	10	16	PF00498	0.604
LIG_FHA_1	124	130	PF00498	0.745
LIG_FHA_1	143	149	PF00498	0.512
LIG_FHA_1	165	171	PF00498	0.420
LIG_FHA_1	203	209	PF00498	0.529
LIG_FHA_1	222	228	PF00498	0.286
LIG_FHA_1	34	40	PF00498	0.401
LIG_FHA_1	397	403	PF00498	0.587
LIG_FHA_1	414	420	PF00498	0.381
LIG_FHA_1	449	455	PF00498	0.357
LIG_FHA_1	540	546	PF00498	0.501
LIG_FHA_1	636	642	PF00498	0.710
LIG_FHA_2	420	426	PF00498	0.560
LIG_FHA_2	733	739	PF00498	0.737
LIG_LIR_Apic_2	399	404	PF02991	0.485
LIG_LIR_Apic_2	644	649	PF02991	0.793
LIG_LIR_Gen_1	109	119	PF02991	0.513
LIG_LIR_Gen_1	277	286	PF02991	0.477
LIG_LIR_Gen_1	463	473	PF02991	0.406
LIG_LIR_Gen_1	671	679	PF02991	0.728
LIG_LIR_Gen_1	718	727	PF02991	0.660
LIG_LIR_Gen_1	85	95	PF02991	0.508
LIG_LIR_Nem_3	109	115	PF02991	0.714
LIG_LIR_Nem_3	277	283	PF02991	0.464
LIG_LIR_Nem_3	463	468	PF02991	0.400
LIG_LIR_Nem_3	483	489	PF02991	0.204
LIG_LIR_Nem_3	531	537	PF02991	0.462
LIG_LIR_Nem_3	671	675	PF02991	0.740
LIG_LIR_Nem_3	715	719	PF02991	0.688
LIG_LIR_Nem_3	85	91	PF02991	0.520
LIG_MLH1_MIPbox_1	482	486	PF16413	0.472
LIG_NRBOX	165	171	PF00104	0.473
LIG_NRBOX	86	92	PF00104	0.517
LIG_PCNA_APIM_2	533	539	PF02747	0.464
LIG_Pex14_2	216	220	PF04695	0.529
LIG_Pex14_2	276	280	PF04695	0.430
LIG_Pex14_2	663	667	PF04695	0.600
LIG_PTB_Apo_2	718	725	PF02174	0.653
LIG_Rb_LxCxE_1	339	358	PF01857	0.556
LIG_REV1ctd_RIR_1	306	314	PF16727	0.416
LIG_SH2_NCK_1	395	399	PF00017	0.586
LIG_SH2_PTP2	401	404	PF00017	0.501
LIG_SH2_PTP2	672	675	PF00017	0.724
LIG_SH2_SRC	292	295	PF00017	0.461
LIG_SH2_SRC	38	41	PF00017	0.555
LIG_SH2_SRC	432	435	PF00017	0.413
LIG_SH2_STAP1	317	321	PF00017	0.510
LIG_SH2_STAT5	292	295	PF00017	0.377
LIG_SH2_STAT5	305	308	PF00017	0.401
LIG_SH2_STAT5	337	340	PF00017	0.474
LIG_SH2_STAT5	38	41	PF00017	0.531
LIG_SH2_STAT5	401	404	PF00017	0.501
LIG_SH2_STAT5	536	539	PF00017	0.472
LIG_SH2_STAT5	672	675	PF00017	0.671
LIG_SH2_STAT5	79	82	PF00017	0.506
LIG_SH3_3	112	118	PF00018	0.515
LIG_SH3_3	681	687	PF00018	0.824
LIG_SH3_4	268	275	PF00018	0.462
LIG_SUMO_SIM_anti_2	370	377	PF11976	0.392
LIG_SUMO_SIM_anti_2	403	409	PF11976	0.503
LIG_SUMO_SIM_par_1	293	299	PF11976	0.465
LIG_SUMO_SIM_par_1	690	696	PF11976	0.698
LIG_TRAF2_1	422	425	PF00917	0.567
LIG_TRAF2_1	605	608	PF00917	0.601
LIG_TRFH_1	452	456	PF08558	0.613
LIG_UBA3_1	378	384	PF00899	0.472
LIG_UBA3_1	87	94	PF00899	0.526
LIG_WRC_WIRS_1	169	174	PF05994	0.428
LIG_WRC_WIRS_1	716	721	PF05994	0.659
LIG_WRC_WIRS_1	726	731	PF05994	0.684
LIG_WW_3	683	687	PF00397	0.535
MOD_CK1_1	111	117	PF00069	0.781
MOD_CK1_1	202	208	PF00069	0.451
MOD_CK1_1	21	27	PF00069	0.640
MOD_CK1_1	259	265	PF00069	0.534
MOD_CK1_1	41	47	PF00069	0.348
MOD_CK1_1	567	573	PF00069	0.424
MOD_CK1_1	65	71	PF00069	0.630
MOD_CK1_1	655	661	PF00069	0.703
MOD_CK1_1	665	671	PF00069	0.684
MOD_CK1_1	715	721	PF00069	0.661
MOD_CK2_1	11	17	PF00069	0.605
MOD_CK2_1	215	221	PF00069	0.352
MOD_CK2_1	340	346	PF00069	0.447
MOD_CK2_1	419	425	PF00069	0.547
MOD_CK2_1	742	748	PF00069	0.778
MOD_GlcNHglycan	194	197	PF01048	0.480
MOD_GlcNHglycan	258	261	PF01048	0.497
MOD_GlcNHglycan	319	322	PF01048	0.408
MOD_GlcNHglycan	350	354	PF01048	0.585
MOD_GlcNHglycan	434	437	PF01048	0.668
MOD_GlcNHglycan	443	446	PF01048	0.572
MOD_GlcNHglycan	482	485	PF01048	0.509
MOD_GlcNHglycan	524	527	PF01048	0.566
MOD_GlcNHglycan	586	589	PF01048	0.519
MOD_GlcNHglycan	660	663	PF01048	0.713
MOD_GlcNHglycan	677	680	PF01048	0.643
MOD_GlcNHglycan	70	73	PF01048	0.583
MOD_GlcNHglycan	729	732	PF01048	0.776
MOD_GSK3_1	142	149	PF00069	0.559
MOD_GSK3_1	164	171	PF00069	0.482
MOD_GSK3_1	174	181	PF00069	0.476
MOD_GSK3_1	227	234	PF00069	0.578
MOD_GSK3_1	270	277	PF00069	0.476
MOD_GSK3_1	29	36	PF00069	0.401
MOD_GSK3_1	349	356	PF00069	0.641
MOD_GSK3_1	396	403	PF00069	0.521
MOD_GSK3_1	437	444	PF00069	0.629
MOD_GSK3_1	472	479	PF00069	0.475
MOD_GSK3_1	563	570	PF00069	0.477
MOD_GSK3_1	574	581	PF00069	0.465
MOD_GSK3_1	658	665	PF00069	0.717
MOD_N-GLC_1	164	169	PF02516	0.433
MOD_N-GLC_1	564	569	PF02516	0.497
MOD_N-GLC_1	577	582	PF02516	0.318
MOD_NEK2_1	172	177	PF00069	0.490
MOD_NEK2_1	199	204	PF00069	0.506
MOD_NEK2_1	220	225	PF00069	0.514
MOD_NEK2_1	231	236	PF00069	0.509
MOD_NEK2_1	256	261	PF00069	0.527
MOD_NEK2_1	275	280	PF00069	0.267
MOD_NEK2_1	394	399	PF00069	0.484
MOD_NEK2_1	480	485	PF00069	0.473
MOD_NEK2_1	502	507	PF00069	0.309
MOD_NEK2_1	584	589	PF00069	0.553
MOD_NEK2_2	509	514	PF00069	0.525
MOD_PIKK_1	132	138	PF00454	0.548
MOD_PIKK_1	174	180	PF00454	0.528
MOD_PIKK_1	199	205	PF00454	0.490
MOD_PIKK_1	221	227	PF00454	0.508
MOD_PIKK_1	275	281	PF00454	0.513
MOD_PKA_2	382	388	PF00069	0.473
MOD_PKA_2	413	419	PF00069	0.495
MOD_PKA_2	515	521	PF00069	0.509
MOD_PKA_2	624	630	PF00069	0.688
MOD_PKA_2	635	641	PF00069	0.588
MOD_PKA_2	655	661	PF00069	0.725
MOD_PKA_2	675	681	PF00069	0.487
MOD_PKB_1	623	631	PF00069	0.463
MOD_Plk_1	349	355	PF00069	0.512
MOD_Plk_1	476	482	PF00069	0.479
MOD_Plk_1	564	570	PF00069	0.577
MOD_Plk_1	577	583	PF00069	0.351
MOD_Plk_2-3	732	738	PF00069	0.734
MOD_Plk_4	108	114	PF00069	0.725
MOD_Plk_4	146	152	PF00069	0.655
MOD_Plk_4	244	250	PF00069	0.407
MOD_Plk_4	374	380	PF00069	0.401
MOD_Plk_4	382	388	PF00069	0.473
MOD_Plk_4	476	482	PF00069	0.501
MOD_Plk_4	509	515	PF00069	0.416
MOD_Plk_4	539	545	PF00069	0.576
MOD_Plk_4	549	555	PF00069	0.384
MOD_Plk_4	668	674	PF00069	0.706
MOD_Plk_4	83	89	PF00069	0.525
MOD_ProDKin_1	114	120	PF00069	0.783
MOD_ProDKin_1	18	24	PF00069	0.653
MOD_ProDKin_1	353	359	PF00069	0.584
MOD_ProDKin_1	400	406	PF00069	0.502
MOD_ProDKin_1	612	618	PF00069	0.431
MOD_ProDKin_1	707	713	PF00069	0.691
MOD_SUMO_for_1	698	701	PF00179	0.665
TRG_DiLeu_BaEn_1	350	355	PF01217	0.403
TRG_DiLeu_BaEn_4	700	706	PF01217	0.665
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.421
TRG_ENDOCYTIC_2	292	295	PF00928	0.447
TRG_ENDOCYTIC_2	303	306	PF00928	0.402
TRG_ENDOCYTIC_2	672	675	PF00928	0.724
TRG_ENDOCYTIC_2	716	719	PF00928	0.632
TRG_ER_diArg_1	675	677	PF00400	0.820
TRG_NES_CRM1_1	463	477	PF08389	0.425
TRG_NES_CRM1_1	574	586	PF08389	0.558
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J2	Leptomonas seymouri	58%	99%
A0A1X0NUI7	Trypanosomatidae	30%	100%
A0A3S7X5F7	Leishmania donovani	90%	100%
A4HKC7	Leishmania braziliensis	74%	100%
A4I7V6	Leishmania infantum	91%	100%
Q4Q5E3	Leishmania major	88%	100%