LicD_family_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LicD family, putative

Species:

Leishmania mexicana

UniProt:

E9B2R0_LEIMU

TriTrypDb:

LmxM.31.1350

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2R0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.546
CLV_C14_Caspase3-7	224	228	PF00656	0.573
CLV_C14_Caspase3-7	326	330	PF00656	0.399
CLV_C14_Caspase3-7	70	74	PF00656	0.646
CLV_NRD_NRD_1	214	216	PF00675	0.570
CLV_NRD_NRD_1	241	243	PF00675	0.435
CLV_NRD_NRD_1	285	287	PF00675	0.516
CLV_NRD_NRD_1	421	423	PF00675	0.421
CLV_NRD_NRD_1	54	56	PF00675	0.479
CLV_NRD_NRD_1	89	91	PF00675	0.551
CLV_PCSK_KEX2_1	241	243	PF00082	0.427
CLV_PCSK_KEX2_1	285	287	PF00082	0.516
CLV_PCSK_KEX2_1	54	56	PF00082	0.479
CLV_PCSK_KEX2_1	89	91	PF00082	0.587
CLV_PCSK_SKI1_1	215	219	PF00082	0.582
CLV_PCSK_SKI1_1	273	277	PF00082	0.494
CLV_PCSK_SKI1_1	36	40	PF00082	0.560
CLV_PCSK_SKI1_1	452	456	PF00082	0.374
CLV_PCSK_SKI1_1	54	58	PF00082	0.478
CLV_PCSK_SKI1_1	90	94	PF00082	0.534
DEG_Nend_UBRbox_3	1	3	PF02207	0.613
DEG_SCF_FBW7_1	44	49	PF00400	0.466
DEG_SPOP_SBC_1	172	176	PF00917	0.564
DOC_CKS1_1	470	475	PF01111	0.386
DOC_CKS1_1	66	71	PF01111	0.545
DOC_CYCLIN_RxL_1	249	258	PF00134	0.370
DOC_CYCLIN_RxL_1	359	368	PF00134	0.238
DOC_CYCLIN_yCln2_LP_2	455	458	PF00134	0.413
DOC_MAPK_gen_1	190	197	PF00069	0.479
DOC_MAPK_MEF2A_6	316	323	PF00069	0.483
DOC_PP1_RVXF_1	150	157	PF00149	0.535
DOC_PP1_RVXF_1	250	257	PF00149	0.424
DOC_PP1_RVXF_1	269	275	PF00149	0.354
DOC_PP2B_LxvP_1	201	204	PF13499	0.649
DOC_PP2B_LxvP_1	455	458	PF13499	0.413
DOC_PP4_FxxP_1	454	457	PF00568	0.338
DOC_USP7_MATH_1	179	183	PF00917	0.743
DOC_USP7_MATH_1	344	348	PF00917	0.396
DOC_USP7_MATH_1	60	64	PF00917	0.707
DOC_USP7_UBL2_3	487	491	PF12436	0.479
DOC_WW_Pin1_4	29	34	PF00397	0.548
DOC_WW_Pin1_4	42	47	PF00397	0.552
DOC_WW_Pin1_4	469	474	PF00397	0.411
DOC_WW_Pin1_4	65	70	PF00397	0.692
LIG_14-3-3_CanoR_1	205	211	PF00244	0.622
LIG_14-3-3_CanoR_1	215	222	PF00244	0.604
LIG_14-3-3_CanoR_1	54	60	PF00244	0.565
LIG_14-3-3_CanoR_1	99	107	PF00244	0.724
LIG_APCC_ABBA_1	290	295	PF00400	0.270
LIG_APCC_ABBAyCdc20_2	17	23	PF00400	0.565
LIG_BRCT_BRCA1_1	82	86	PF00533	0.610
LIG_deltaCOP1_diTrp_1	95	100	PF00928	0.552
LIG_FHA_1	149	155	PF00498	0.588
LIG_FHA_1	173	179	PF00498	0.682
LIG_FHA_1	216	222	PF00498	0.689
LIG_FHA_1	224	230	PF00498	0.580
LIG_FHA_1	249	255	PF00498	0.403
LIG_FHA_1	366	372	PF00498	0.256
LIG_FHA_1	445	451	PF00498	0.621
LIG_FHA_2	142	148	PF00498	0.617
LIG_FHA_2	209	215	PF00498	0.561
LIG_FHA_2	309	315	PF00498	0.508
LIG_FHA_2	324	330	PF00498	0.505
LIG_FHA_2	434	440	PF00498	0.363
LIG_FHA_2	68	74	PF00498	0.783
LIG_LIR_Apic_2	468	473	PF02991	0.432
LIG_LIR_Gen_1	147	157	PF02991	0.688
LIG_LIR_Gen_1	332	341	PF02991	0.479
LIG_LIR_Gen_1	348	359	PF02991	0.306
LIG_LIR_Nem_3	131	137	PF02991	0.522
LIG_LIR_Nem_3	147	153	PF02991	0.562
LIG_LIR_Nem_3	234	238	PF02991	0.394
LIG_LIR_Nem_3	348	354	PF02991	0.375
LIG_LIR_Nem_3	484	489	PF02991	0.362
LIG_LYPXL_yS_3	383	386	PF13949	0.380
LIG_MYND_1	384	388	PF01753	0.275
LIG_PCNA_yPIPBox_3	335	349	PF02747	0.397
LIG_Pex14_1	411	415	PF04695	0.414
LIG_Pex14_1	96	100	PF04695	0.611
LIG_SH2_CRK	339	343	PF00017	0.433
LIG_SH2_NCK_1	303	307	PF00017	0.332
LIG_SH2_NCK_1	416	420	PF00017	0.368
LIG_SH2_SRC	40	43	PF00017	0.470
LIG_SH2_SRC	478	481	PF00017	0.316
LIG_SH2_STAP1	303	307	PF00017	0.394
LIG_SH2_STAT5	137	140	PF00017	0.538
LIG_SH2_STAT5	238	241	PF00017	0.372
LIG_SH2_STAT5	303	306	PF00017	0.305
LIG_SH2_STAT5	333	336	PF00017	0.305
LIG_SH2_STAT5	40	43	PF00017	0.636
LIG_SH2_STAT5	461	464	PF00017	0.331
LIG_SH3_1	382	388	PF00018	0.256
LIG_SH3_3	104	110	PF00018	0.513
LIG_SH3_3	192	198	PF00018	0.587
LIG_SH3_3	382	388	PF00018	0.292
LIG_SUMO_SIM_par_1	258	265	PF11976	0.392
LIG_TRAF2_1	144	147	PF00917	0.541
LIG_TRAF2_1	255	258	PF00917	0.345
LIG_TRAF2_1	262	265	PF00917	0.364
LIG_TYR_ITIM	301	306	PF00017	0.255
LIG_TYR_ITIM	381	386	PF00017	0.332
MOD_CDK_SPK_2	469	474	PF00069	0.379
MOD_CDK_SPxK_1	65	71	PF00069	0.548
MOD_CDK_SPxxK_3	29	36	PF00069	0.446
MOD_CK1_1	168	174	PF00069	0.645
MOD_CK1_1	322	328	PF00069	0.632
MOD_CK1_1	58	64	PF00069	0.699
MOD_CK2_1	112	118	PF00069	0.774
MOD_CK2_1	141	147	PF00069	0.694
MOD_CK2_1	208	214	PF00069	0.615
MOD_CK2_1	411	417	PF00069	0.334
MOD_CK2_1	433	439	PF00069	0.513
MOD_CK2_1	474	480	PF00069	0.405
MOD_CK2_1	81	87	PF00069	0.542
MOD_CK2_1	98	104	PF00069	0.618
MOD_Cter_Amidation	239	242	PF01082	0.267
MOD_Cter_Amidation	52	55	PF01082	0.472
MOD_GlcNHglycan	167	170	PF01048	0.757
MOD_GlcNHglycan	175	178	PF01048	0.612
MOD_GlcNHglycan	181	184	PF01048	0.618
MOD_GlcNHglycan	373	376	PF01048	0.370
MOD_GlcNHglycan	60	63	PF01048	0.624
MOD_GSK3_1	168	175	PF00069	0.690
MOD_GSK3_1	319	326	PF00069	0.475
MOD_GSK3_1	40	47	PF00069	0.704
MOD_GSK3_1	54	61	PF00069	0.727
MOD_NEK2_1	124	129	PF00069	0.618
MOD_NEK2_1	345	350	PF00069	0.444
MOD_NEK2_1	371	376	PF00069	0.435
MOD_NEK2_2	411	416	PF00069	0.419
MOD_PIKK_1	266	272	PF00454	0.282
MOD_PIKK_1	60	66	PF00454	0.786
MOD_PK_1	446	452	PF00069	0.481
MOD_PKA_1	215	221	PF00069	0.577
MOD_PKA_1	54	60	PF00069	0.475
MOD_PKA_2	2	8	PF00069	0.598
MOD_PKA_2	54	60	PF00069	0.475
MOD_PKA_2	98	104	PF00069	0.638
MOD_Plk_1	124	130	PF00069	0.668
MOD_Plk_1	319	325	PF00069	0.563
MOD_Plk_1	72	78	PF00069	0.681
MOD_Plk_4	234	240	PF00069	0.512
MOD_Plk_4	329	335	PF00069	0.443
MOD_Plk_4	411	417	PF00069	0.414
MOD_Plk_4	46	52	PF00069	0.550
MOD_Plk_4	81	87	PF00069	0.665
MOD_ProDKin_1	29	35	PF00069	0.552
MOD_ProDKin_1	42	48	PF00069	0.552
MOD_ProDKin_1	469	475	PF00069	0.417
MOD_ProDKin_1	65	71	PF00069	0.608
MOD_SUMO_rev_2	212	218	PF00179	0.713
MOD_SUMO_rev_2	480	489	PF00179	0.367
TRG_DiLeu_BaEn_2	404	410	PF01217	0.436
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.406
TRG_ENDOCYTIC_2	303	306	PF00928	0.316
TRG_ENDOCYTIC_2	333	336	PF00928	0.469
TRG_ENDOCYTIC_2	339	342	PF00928	0.383
TRG_ENDOCYTIC_2	383	386	PF00928	0.355
TRG_ER_diArg_1	241	243	PF00400	0.450
TRG_ER_diArg_1	54	56	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW8	Leptomonas seymouri	45%	100%
A0A1X0NUG9	Trypanosomatidae	32%	100%
A0A3S7X5H6	Leishmania donovani	86%	100%
A0A422P1A8	Trypanosoma rangeli	35%	100%
A4HKC3	Leishmania braziliensis	70%	99%
A4I7V4	Leishmania infantum	86%	100%
Q4Q5E7	Leishmania major	86%	100%