PPPDE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PPPDE putative peptidase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B2Q8_LEIMU

TriTrypDb:

LmxM.31.1330

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B2Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Q8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0016787	hydrolase activity	2	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.257
CLV_C14_Caspase3-7	395	399	PF00656	0.379
CLV_NRD_NRD_1	117	119	PF00675	0.633
CLV_NRD_NRD_1	43	45	PF00675	0.757
CLV_NRD_NRD_1	537	539	PF00675	0.373
CLV_NRD_NRD_1	9	11	PF00675	0.590
CLV_PCSK_KEX2_1	174	176	PF00082	0.457
CLV_PCSK_KEX2_1	359	361	PF00082	0.530
CLV_PCSK_KEX2_1	374	376	PF00082	0.628
CLV_PCSK_KEX2_1	537	539	PF00082	0.408
CLV_PCSK_KEX2_1	57	59	PF00082	0.680
CLV_PCSK_KEX2_1	9	11	PF00082	0.604
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.457
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.578
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.536
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.637
CLV_PCSK_SKI1_1	111	115	PF00082	0.559
CLV_PCSK_SKI1_1	268	272	PF00082	0.544
CLV_PCSK_SKI1_1	360	364	PF00082	0.488
CLV_PCSK_SKI1_1	403	407	PF00082	0.534
CLV_PCSK_SKI1_1	538	542	PF00082	0.396
CLV_PCSK_SKI1_1	551	555	PF00082	0.293
CLV_PCSK_SKI1_1	588	592	PF00082	0.263
CLV_PCSK_SKI1_1	9	13	PF00082	0.670
CLV_Separin_Metazoa	471	475	PF03568	0.171
DEG_APCC_DBOX_1	468	476	PF00400	0.319
DEG_ODPH_VHL_1	400	411	PF01847	0.247
DOC_ANK_TNKS_1	462	469	PF00023	0.386
DOC_CYCLIN_RxL_1	115	123	PF00134	0.351
DOC_CYCLIN_RxL_1	265	273	PF00134	0.252
DOC_CYCLIN_RxL_1	356	366	PF00134	0.358
DOC_CYCLIN_RxL_1	400	410	PF00134	0.249
DOC_CYCLIN_yClb5_NLxxxL_5	68	74	PF00134	0.386
DOC_MAPK_gen_1	174	185	PF00069	0.221
DOC_MAPK_gen_1	359	365	PF00069	0.338
DOC_MAPK_gen_1	493	501	PF00069	0.334
DOC_MAPK_JIP1_4	379	385	PF00069	0.382
DOC_MAPK_MEF2A_6	178	185	PF00069	0.162
DOC_MAPK_MEF2A_6	68	76	PF00069	0.385
DOC_MAPK_RevD_3	524	538	PF00069	0.371
DOC_PP1_RVXF_1	401	407	PF00149	0.254
DOC_PP2B_LxvP_1	128	131	PF13499	0.543
DOC_PP2B_LxvP_1	183	186	PF13499	0.257
DOC_USP7_MATH_1	28	32	PF00917	0.535
DOC_USP7_MATH_1	293	297	PF00917	0.366
DOC_USP7_MATH_1	497	501	PF00917	0.298
DOC_USP7_MATH_1	569	573	PF00917	0.576
DOC_USP7_MATH_1	90	94	PF00917	0.555
DOC_USP7_UBL2_3	174	178	PF12436	0.234
DOC_USP7_UBL2_3	370	374	PF12436	0.305
DOC_WW_Pin1_4	363	368	PF00397	0.341
DOC_WW_Pin1_4	416	421	PF00397	0.319
LIG_14-3-3_CanoR_1	317	322	PF00244	0.354
LIG_14-3-3_CanoR_1	44	51	PF00244	0.541
LIG_14-3-3_CanoR_1	551	556	PF00244	0.584
LIG_14-3-3_CanoR_1	561	569	PF00244	0.563
LIG_14-3-3_CanoR_1	75	82	PF00244	0.560
LIG_Actin_WH2_2	458	476	PF00022	0.320
LIG_Actin_WH2_2	536	553	PF00022	0.469
LIG_APCC_ABBA_1	198	203	PF00400	0.339
LIG_BRCT_BRCA1_1	232	236	PF00533	0.257
LIG_BRCT_BRCA1_1	595	599	PF00533	0.619
LIG_Clathr_ClatBox_1	180	184	PF01394	0.339
LIG_eIF4E_1	356	362	PF01652	0.201
LIG_FHA_1	2	8	PF00498	0.484
LIG_FHA_1	220	226	PF00498	0.281
LIG_FHA_1	343	349	PF00498	0.361
LIG_FHA_1	395	401	PF00498	0.388
LIG_FHA_1	411	417	PF00498	0.318
LIG_FHA_1	529	535	PF00498	0.390
LIG_FHA_1	552	558	PF00498	0.481
LIG_FHA_1	76	82	PF00498	0.558
LIG_FHA_2	153	159	PF00498	0.354
LIG_FHA_2	587	593	PF00498	0.436
LIG_FHA_2	622	628	PF00498	0.569
LIG_FHA_2	75	81	PF00498	0.593
LIG_GBD_Chelix_1	357	365	PF00786	0.521
LIG_GBD_Chelix_1	552	560	PF00786	0.323
LIG_LIR_Gen_1	496	506	PF02991	0.290
LIG_LIR_Gen_1	570	581	PF02991	0.561
LIG_LIR_Nem_3	222	227	PF02991	0.289
LIG_LIR_Nem_3	233	239	PF02991	0.338
LIG_LIR_Nem_3	251	255	PF02991	0.347
LIG_LIR_Nem_3	423	427	PF02991	0.314
LIG_LIR_Nem_3	460	464	PF02991	0.349
LIG_LIR_Nem_3	496	501	PF02991	0.309
LIG_LIR_Nem_3	570	576	PF02991	0.609
LIG_MLH1_MIPbox_1	232	236	PF16413	0.257
LIG_MYND_1	462	466	PF01753	0.369
LIG_NRBOX	551	557	PF00104	0.510
LIG_NRBOX	617	623	PF00104	0.519
LIG_PCNA_yPIPBox_3	567	581	PF02747	0.483
LIG_Pex14_1	424	428	PF04695	0.356
LIG_PTB_Apo_2	276	283	PF02174	0.162
LIG_PTB_Apo_2	440	447	PF02174	0.310
LIG_REV1ctd_RIR_1	233	241	PF16727	0.291
LIG_SH2_CRK	252	256	PF00017	0.304
LIG_SH2_STAP1	548	552	PF00017	0.565
LIG_SH2_STAP1	603	607	PF00017	0.537
LIG_SH2_STAT5	172	175	PF00017	0.323
LIG_SH2_STAT5	201	204	PF00017	0.331
LIG_SH2_STAT5	224	227	PF00017	0.283
LIG_SH2_STAT5	280	283	PF00017	0.286
LIG_SH2_STAT5	356	359	PF00017	0.336
LIG_SH2_STAT5	368	371	PF00017	0.302
LIG_SH2_STAT5	408	411	PF00017	0.300
LIG_SH2_STAT5	515	518	PF00017	0.289
LIG_SH2_STAT5	593	596	PF00017	0.563
LIG_SH3_3	22	28	PF00018	0.544
LIG_SH3_3	349	355	PF00018	0.231
LIG_SH3_3	592	598	PF00018	0.504
LIG_SH3_3	84	90	PF00018	0.579
LIG_Sin3_3	382	389	PF02671	0.252
LIG_SUMO_SIM_anti_2	452	457	PF11976	0.272
LIG_SUMO_SIM_par_1	361	366	PF11976	0.368
LIG_TRAF2_1	59	62	PF00917	0.501
LIG_TYR_ITSM	220	227	PF00017	0.205
LIG_UBA3_1	575	582	PF00899	0.376
MOD_CDK_SPxxK_3	363	370	PF00069	0.360
MOD_CK1_1	332	338	PF00069	0.372
MOD_CK1_1	46	52	PF00069	0.541
MOD_CK1_1	509	515	PF00069	0.205
MOD_CK1_1	586	592	PF00069	0.556
MOD_CK1_1	612	618	PF00069	0.591
MOD_CK2_1	293	299	PF00069	0.335
MOD_CK2_1	586	592	PF00069	0.490
MOD_CK2_1	74	80	PF00069	0.594
MOD_GlcNHglycan	190	193	PF01048	0.454
MOD_GlcNHglycan	331	334	PF01048	0.540
MOD_GlcNHglycan	481	484	PF01048	0.431
MOD_GlcNHglycan	563	566	PF01048	0.393
MOD_GSK3_1	1	8	PF00069	0.530
MOD_GSK3_1	211	218	PF00069	0.263
MOD_GSK3_1	338	345	PF00069	0.374
MOD_GSK3_1	412	419	PF00069	0.362
MOD_GSK3_1	445	452	PF00069	0.375
MOD_GSK3_1	509	516	PF00069	0.205
MOD_GSK3_1	582	589	PF00069	0.510
MOD_GSK3_1	70	77	PF00069	0.495
MOD_GSK3_1	90	97	PF00069	0.513
MOD_LATS_1	447	453	PF00433	0.349
MOD_N-GLC_1	273	278	PF02516	0.418
MOD_N-GLC_1	561	566	PF02516	0.227
MOD_N-GLC_1	586	591	PF02516	0.395
MOD_N-GLC_1	612	617	PF02516	0.309
MOD_N-GLC_2	608	610	PF02516	0.223
MOD_NEK2_1	120	125	PF00069	0.583
MOD_NEK2_1	225	230	PF00069	0.249
MOD_NEK2_1	301	306	PF00069	0.420
MOD_NEK2_1	308	313	PF00069	0.440
MOD_NEK2_1	329	334	PF00069	0.379
MOD_NEK2_1	479	484	PF00069	0.202
MOD_NEK2_1	506	511	PF00069	0.354
MOD_NEK2_1	583	588	PF00069	0.452
MOD_NEK2_1	70	75	PF00069	0.611
MOD_PIKK_1	538	544	PF00454	0.557
MOD_PIKK_1	57	63	PF00454	0.479
MOD_PK_1	323	329	PF00069	0.408
MOD_PK_1	449	455	PF00069	0.307
MOD_PK_1	94	100	PF00069	0.467
MOD_PKA_1	57	63	PF00069	0.383
MOD_PKA_2	43	49	PF00069	0.572
MOD_PKA_2	57	63	PF00069	0.539
MOD_PKA_2	74	80	PF00069	0.413
MOD_PKB_1	213	221	PF00069	0.214
MOD_Plk_1	132	138	PF00069	0.432
MOD_Plk_1	273	279	PF00069	0.218
MOD_Plk_1	538	544	PF00069	0.608
MOD_Plk_1	586	592	PF00069	0.607
MOD_Plk_4	143	149	PF00069	0.343
MOD_Plk_4	28	34	PF00069	0.573
MOD_Plk_4	412	418	PF00069	0.294
MOD_Plk_4	449	455	PF00069	0.333
MOD_Plk_4	497	503	PF00069	0.283
MOD_Plk_4	509	515	PF00069	0.254
MOD_Plk_4	551	557	PF00069	0.475
MOD_ProDKin_1	363	369	PF00069	0.338
MOD_ProDKin_1	416	422	PF00069	0.322
MOD_SUMO_for_1	289	292	PF00179	0.291
MOD_SUMO_rev_2	60	70	PF00179	0.428
TRG_DiLeu_BaEn_1	614	619	PF01217	0.502
TRG_DiLeu_BaEn_2	264	270	PF01217	0.291
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.375
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.366
TRG_ENDOCYTIC_2	224	227	PF00928	0.223
TRG_ENDOCYTIC_2	252	255	PF00928	0.280
TRG_ENDOCYTIC_2	408	411	PF00928	0.278
TRG_ENDOCYTIC_2	603	606	PF00928	0.507
TRG_ER_diArg_1	213	216	PF00400	0.280
TRG_ER_diArg_1	316	319	PF00400	0.432
TRG_ER_diArg_1	536	538	PF00400	0.569
TRG_ER_diArg_1	560	563	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICK7	Leptomonas seymouri	63%	100%
A0A0S4J986	Bodo saltans	30%	100%
A0A1X0NUY4	Trypanosomatidae	40%	100%
A0A3Q8IFV8	Leishmania donovani	85%	100%
A0A3R7KQA7	Trypanosoma rangeli	33%	100%
A4HKC1	Leishmania braziliensis	74%	100%
A4I7V0	Leishmania infantum	85%	100%
D0AA08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q5E9	Leishmania major	86%	100%
V5BQT4	Trypanosoma cruzi	37%	100%