Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B2Q7_LEIMU

TriTrypDb:

LmxM.31.1320

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.572
CLV_C14_Caspase3-7	96	100	PF00656	0.525
CLV_NRD_NRD_1	135	137	PF00675	0.740
CLV_NRD_NRD_1	203	205	PF00675	0.814
CLV_NRD_NRD_1	338	340	PF00675	0.647
CLV_NRD_NRD_1	513	515	PF00675	0.610
CLV_PCSK_FUR_1	336	340	PF00082	0.651
CLV_PCSK_KEX2_1	203	205	PF00082	0.783
CLV_PCSK_KEX2_1	222	224	PF00082	0.759
CLV_PCSK_KEX2_1	338	340	PF00082	0.647
CLV_PCSK_KEX2_1	495	497	PF00082	0.604
CLV_PCSK_KEX2_1	513	515	PF00082	0.367
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.724
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.604
CLV_PCSK_SKI1_1	222	226	PF00082	0.661
CLV_PCSK_SKI1_1	408	412	PF00082	0.563
CLV_PCSK_SKI1_1	41	45	PF00082	0.713
CLV_PCSK_SKI1_1	434	438	PF00082	0.484
CLV_PCSK_SKI1_1	456	460	PF00082	0.616
CLV_PCSK_SKI1_1	484	488	PF00082	0.608
CLV_PCSK_SKI1_1	496	500	PF00082	0.437
CLV_PCSK_SKI1_1	71	75	PF00082	0.620
CLV_Separin_Metazoa	242	246	PF03568	0.618
DEG_APCC_DBOX_1	337	345	PF00400	0.571
DEG_Nend_UBRbox_3	1	3	PF02207	0.671
DEG_SCF_FBW7_1	173	180	PF00400	0.567
DEG_SPOP_SBC_1	315	319	PF00917	0.726
DOC_CDC14_PxL_1	369	377	PF14671	0.538
DOC_CYCLIN_RxL_1	233	246	PF00134	0.628
DOC_CYCLIN_RxL_1	66	78	PF00134	0.611
DOC_MAPK_gen_1	334	343	PF00069	0.409
DOC_MAPK_MEF2A_6	7	14	PF00069	0.436
DOC_PP2B_LxvP_1	186	189	PF13499	0.735
DOC_PP2B_LxvP_1	241	244	PF13499	0.679
DOC_USP7_MATH_1	147	151	PF00917	0.711
DOC_USP7_MATH_1	307	311	PF00917	0.726
DOC_USP7_MATH_1	315	319	PF00917	0.644
DOC_WW_Pin1_4	143	148	PF00397	0.554
DOC_WW_Pin1_4	166	171	PF00397	0.792
DOC_WW_Pin1_4	173	178	PF00397	0.762
DOC_WW_Pin1_4	316	321	PF00397	0.720
LIG_14-3-3_CanoR_1	309	314	PF00244	0.748
LIG_14-3-3_CanoR_1	416	424	PF00244	0.361
LIG_14-3-3_CanoR_1	456	464	PF00244	0.558
LIG_14-3-3_CanoR_1	58	62	PF00244	0.701
LIG_14-3-3_CanoR_1	93	98	PF00244	0.521
LIG_BIR_III_2	99	103	PF00653	0.591
LIG_BRCT_BRCA1_1	525	529	PF00533	0.586
LIG_CaM_IQ_9	225	241	PF13499	0.625
LIG_EVH1_1	186	190	PF00568	0.734
LIG_FHA_1	223	229	PF00498	0.750
LIG_FHA_1	244	250	PF00498	0.670
LIG_FHA_1	325	331	PF00498	0.640
LIG_FHA_1	442	448	PF00498	0.666
LIG_FHA_1	452	458	PF00498	0.490
LIG_FHA_1	497	503	PF00498	0.367
LIG_FHA_2	114	120	PF00498	0.696
LIG_FHA_2	162	168	PF00498	0.744
LIG_FHA_2	178	184	PF00498	0.582
LIG_FHA_2	45	51	PF00498	0.711
LIG_FHA_2	488	494	PF00498	0.530
LIG_FHA_2	517	523	PF00498	0.556
LIG_FHA_2	58	64	PF00498	0.518
LIG_FHA_2	94	100	PF00498	0.519
LIG_KLC1_Yacidic_2	489	493	PF13176	0.434
LIG_LIR_Gen_1	40	49	PF02991	0.469
LIG_LIR_Gen_1	8	17	PF02991	0.625
LIG_LIR_Nem_3	231	235	PF02991	0.775
LIG_LIR_Nem_3	27	32	PF02991	0.635
LIG_LIR_Nem_3	40	45	PF02991	0.580
LIG_LIR_Nem_3	459	464	PF02991	0.559
LIG_LIR_Nem_3	69	73	PF02991	0.618
LIG_LIR_Nem_3	8	14	PF02991	0.635
LIG_PDZ_Class_2	538	543	PF00595	0.730
LIG_Pex14_1	420	424	PF04695	0.606
LIG_PTAP_UEV_1	303	308	PF05743	0.712
LIG_SH2_CRK	235	239	PF00017	0.702
LIG_SH2_CRK	29	33	PF00017	0.599
LIG_SH2_CRK	42	46	PF00017	0.535
LIG_SH2_GRB2like	11	14	PF00017	0.610
LIG_SH2_STAP1	285	289	PF00017	0.569
LIG_SH2_STAT3	505	508	PF00017	0.545
LIG_SH2_STAT5	11	14	PF00017	0.610
LIG_SH2_STAT5	260	263	PF00017	0.716
LIG_SH2_STAT5	38	41	PF00017	0.679
LIG_SH2_STAT5	491	494	PF00017	0.517
LIG_SH2_STAT5	59	62	PF00017	0.702
LIG_SH3_1	137	143	PF00018	0.783
LIG_SH3_1	248	254	PF00018	0.545
LIG_SH3_2	304	309	PF14604	0.722
LIG_SH3_3	135	141	PF00018	0.834
LIG_SH3_3	184	190	PF00018	0.738
LIG_SH3_3	248	254	PF00018	0.605
LIG_SH3_3	301	307	PF00018	0.702
LIG_SUMO_SIM_anti_2	340	345	PF11976	0.389
LIG_SUMO_SIM_anti_2	49	58	PF11976	0.698
LIG_TRAF2_1	124	127	PF00917	0.694
LIG_UBA3_1	264	273	PF00899	0.587
LIG_UBA3_1	36	41	PF00899	0.649
LIG_WW_3	139	143	PF00397	0.549
MOD_CK1_1	206	212	PF00069	0.740
MOD_CK1_1	283	289	PF00069	0.645
MOD_CK1_1	302	308	PF00069	0.514
MOD_CK1_1	318	324	PF00069	0.620
MOD_CK2_1	117	123	PF00069	0.757
MOD_CK2_1	361	367	PF00069	0.643
MOD_CK2_1	415	421	PF00069	0.535
MOD_CK2_1	44	50	PF00069	0.714
MOD_CK2_1	487	493	PF00069	0.530
MOD_CK2_1	527	533	PF00069	0.490
MOD_CK2_1	57	63	PF00069	0.513
MOD_GlcNHglycan	205	208	PF01048	0.750
MOD_GlcNHglycan	301	304	PF01048	0.703
MOD_GlcNHglycan	480	483	PF01048	0.601
MOD_GlcNHglycan	529	532	PF01048	0.618
MOD_GSK3_1	113	120	PF00069	0.753
MOD_GSK3_1	143	150	PF00069	0.555
MOD_GSK3_1	173	180	PF00069	0.647
MOD_GSK3_1	189	196	PF00069	0.800
MOD_GSK3_1	199	206	PF00069	0.698
MOD_GSK3_1	298	305	PF00069	0.694
MOD_GSK3_1	314	321	PF00069	0.609
MOD_GSK3_1	44	51	PF00069	0.713
MOD_GSK3_1	469	476	PF00069	0.476
MOD_GSK3_1	523	530	PF00069	0.581
MOD_GSK3_1	62	69	PF00069	0.413
MOD_LATS_1	485	491	PF00433	0.530
MOD_NEK2_1	264	269	PF00069	0.600
MOD_NEK2_1	329	334	PF00069	0.502
MOD_NEK2_1	37	42	PF00069	0.433
MOD_NEK2_1	478	483	PF00069	0.609
MOD_NEK2_1	516	521	PF00069	0.541
MOD_NEK2_1	523	528	PF00069	0.498
MOD_PIKK_1	189	195	PF00454	0.811
MOD_PIKK_1	222	228	PF00454	0.779
MOD_PIKK_1	451	457	PF00454	0.565
MOD_PKA_1	203	209	PF00069	0.779
MOD_PKA_1	222	228	PF00069	0.715
MOD_PKA_1	280	286	PF00069	0.396
MOD_PKA_1	527	533	PF00069	0.617
MOD_PKA_2	104	110	PF00069	0.641
MOD_PKA_2	203	209	PF00069	0.779
MOD_PKA_2	222	228	PF00069	0.779
MOD_PKA_2	283	289	PF00069	0.645
MOD_PKA_2	299	305	PF00069	0.540
MOD_PKA_2	308	314	PF00069	0.703
MOD_PKA_2	415	421	PF00069	0.535
MOD_PKA_2	516	522	PF00069	0.542
MOD_PKA_2	57	63	PF00069	0.689
MOD_PKB_1	439	447	PF00069	0.599
MOD_PKB_1	64	72	PF00069	0.641
MOD_Plk_2-3	119	125	PF00069	0.770
MOD_Plk_4	168	174	PF00069	0.568
MOD_Plk_4	473	479	PF00069	0.497
MOD_Plk_4	487	493	PF00069	0.440
MOD_ProDKin_1	143	149	PF00069	0.555
MOD_ProDKin_1	166	172	PF00069	0.793
MOD_ProDKin_1	173	179	PF00069	0.763
MOD_ProDKin_1	316	322	PF00069	0.716
MOD_SUMO_for_1	400	403	PF00179	0.468
MOD_SUMO_rev_2	218	224	PF00179	0.551
MOD_SUMO_rev_2	266	275	PF00179	0.571
MOD_SUMO_rev_2	360	369	PF00179	0.606
MOD_SUMO_rev_2	421	430	PF00179	0.601
MOD_SUMO_rev_2	489	497	PF00179	0.609
TRG_DiLeu_BaEn_1	52	57	PF01217	0.696
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.646
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.621
TRG_ENDOCYTIC_2	11	14	PF00928	0.610
TRG_ENDOCYTIC_2	235	238	PF00928	0.765
TRG_ENDOCYTIC_2	29	32	PF00928	0.606
TRG_ENDOCYTIC_2	42	45	PF00928	0.536
TRG_ER_diArg_1	293	296	PF00400	0.608
TRG_ER_diArg_1	335	338	PF00400	0.654
TRG_NES_CRM1_1	34	49	PF08389	0.440
TRG_NES_CRM1_1	340	351	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKZ7	Leishmania donovani	89%	100%
A4HKC0	Leishmania braziliensis	68%	100%
A4I7U9	Leishmania infantum	89%	100%
Q4Q5F0	Leishmania major	87%	100%