Peptide deformylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peptide deformylase

Gene product:

polypeptide deformylase-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9B2Q5_LEIMU

TriTrypDb:

LmxM.31.1300

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Q5

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0019538	protein metabolic process	3	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0043043	peptide biosynthetic process	5	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0043686	co-translational protein modification	5	1
GO:0006508	proteolysis	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0005488	binding	1	14
GO:0016787	hydrolase activity	2	14
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	14
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	14
GO:0042586	peptide deformylase activity	5	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.177
CLV_NRD_NRD_1	2	4	PF00675	0.620
CLV_NRD_NRD_1	51	53	PF00675	0.482
CLV_NRD_NRD_1	8	10	PF00675	0.624
CLV_PCSK_KEX2_1	2	4	PF00082	0.621
CLV_PCSK_KEX2_1	51	53	PF00082	0.482
CLV_PCSK_KEX2_1	8	10	PF00082	0.620
CLV_PCSK_SKI1_1	197	201	PF00082	0.373
CLV_PCSK_SKI1_1	59	63	PF00082	0.330
DEG_Nend_UBRbox_1	1	4	PF02207	0.713
DOC_CKS1_1	232	237	PF01111	0.514
DOC_MAPK_MEF2A_6	63	70	PF00069	0.197
DOC_PP4_FxxP_1	97	100	PF00568	0.358
DOC_USP7_MATH_1	57	61	PF00917	0.354
DOC_WW_Pin1_4	231	236	PF00397	0.503
DOC_WW_Pin1_4	29	34	PF00397	0.603
DOC_WW_Pin1_4	72	77	PF00397	0.376
LIG_14-3-3_CanoR_1	162	168	PF00244	0.403
LIG_Actin_WH2_2	36	53	PF00022	0.511
LIG_BRCT_BRCA1_1	31	35	PF00533	0.661
LIG_BRCT_BRCA1_1	74	78	PF00533	0.402
LIG_FHA_1	13	19	PF00498	0.677
LIG_FHA_1	152	158	PF00498	0.399
LIG_FHA_1	22	28	PF00498	0.587
LIG_FHA_1	60	66	PF00498	0.390
LIG_LIR_Apic_2	121	126	PF02991	0.308
LIG_LIR_Apic_2	96	100	PF02991	0.358
LIG_Pex14_1	221	225	PF04695	0.431
LIG_SH2_SRC	168	171	PF00017	0.463
LIG_SH2_STAP1	120	124	PF00017	0.468
LIG_SH2_STAP1	256	260	PF00017	0.543
LIG_SH2_STAT5	231	234	PF00017	0.419
LIG_SH2_STAT5	241	244	PF00017	0.410
LIG_SH3_3	123	129	PF00018	0.358
LIG_SH3_3	154	160	PF00018	0.343
LIG_SH3_3	229	235	PF00018	0.507
LIG_SH3_3	244	250	PF00018	0.402
LIG_SH3_3	61	67	PF00018	0.374
LIG_TRAF2_1	260	263	PF00917	0.394
LIG_TRAF2_2	235	240	PF00917	0.455
MOD_CDK_SPxxK_3	29	36	PF00069	0.593
MOD_CK1_1	149	155	PF00069	0.468
MOD_CK1_1	29	35	PF00069	0.633
MOD_CK2_1	31	37	PF00069	0.571
MOD_GlcNHglycan	165	168	PF01048	0.342
MOD_GlcNHglycan	226	229	PF01048	0.529
MOD_GlcNHglycan	29	32	PF01048	0.448
MOD_GlcNHglycan	97	100	PF01048	0.340
MOD_GSK3_1	27	34	PF00069	0.628
MOD_GSK3_1	68	75	PF00069	0.421
MOD_N-GLC_1	243	248	PF02516	0.547
MOD_NEK2_1	195	200	PF00069	0.383
MOD_NEK2_1	208	213	PF00069	0.340
MOD_NEK2_1	78	83	PF00069	0.349
MOD_NEK2_1	95	100	PF00069	0.265
MOD_PIKK_1	68	74	PF00454	0.446
MOD_PKA_2	161	167	PF00069	0.451
MOD_Plk_1	243	249	PF00069	0.547
MOD_Plk_4	195	201	PF00069	0.343
MOD_Plk_4	243	249	PF00069	0.528
MOD_Plk_4	78	84	PF00069	0.431
MOD_ProDKin_1	231	237	PF00069	0.500
MOD_ProDKin_1	29	35	PF00069	0.599
MOD_ProDKin_1	72	78	PF00069	0.376
MOD_SUMO_rev_2	34	43	PF00179	0.609
TRG_DiLeu_BaEn_1	190	195	PF01217	0.445
TRG_ER_diArg_1	1	3	PF00400	0.668
TRG_ER_diArg_1	182	185	PF00400	0.330
TRG_ER_diArg_1	50	52	PF00400	0.463
TRG_ER_diArg_1	7	9	PF00400	0.654
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A0	Leptomonas seymouri	73%	99%
A0A0S4JJP7	Bodo saltans	23%	72%
A0A0S4KJX6	Bodo saltans	54%	98%
A0A1X0NUS7	Trypanosomatidae	66%	100%
A0A3R7P233	Trypanosoma rangeli	65%	100%
A0A3S7X5G9	Leishmania donovani	94%	100%
A4HKB8	Leishmania braziliensis	85%	100%
A4I7U7	Leishmania infantum	94%	100%
D0AA05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
Q4Q5F2	Leishmania major	93%	100%
V5B173	Trypanosoma cruzi	63%	100%
V5BDN2	Trypanosoma cruzi	24%	78%