Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B2Q4_LEIMU

TriTrypDb:

LmxM.31.1290

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Q4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.658
CLV_C14_Caspase3-7	469	473	PF00656	0.586
CLV_C14_Caspase3-7	47	51	PF00656	0.681
CLV_NRD_NRD_1	239	241	PF00675	0.570
CLV_NRD_NRD_1	424	426	PF00675	0.408
CLV_NRD_NRD_1	548	550	PF00675	0.516
CLV_NRD_NRD_1	566	568	PF00675	0.433
CLV_PCSK_KEX2_1	239	241	PF00082	0.323
CLV_PCSK_KEX2_1	424	426	PF00082	0.408
CLV_PCSK_KEX2_1	508	510	PF00082	0.419
CLV_PCSK_KEX2_1	548	550	PF00082	0.555
CLV_PCSK_KEX2_1	566	568	PF00082	0.384
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.492
CLV_PCSK_SKI1_1	252	256	PF00082	0.370
CLV_Separin_Metazoa	531	535	PF03568	0.519
DEG_SCF_FBW7_1	411	418	PF00400	0.447
DEG_SPOP_SBC_1	140	144	PF00917	0.704
DEG_SPOP_SBC_1	308	312	PF00917	0.460
DEG_SPOP_SBC_1	329	333	PF00917	0.659
DEG_SPOP_SBC_1	338	342	PF00917	0.463
DOC_CKS1_1	254	259	PF01111	0.540
DOC_MAPK_MEF2A_6	261	269	PF00069	0.360
DOC_MAPK_MEF2A_6	493	500	PF00069	0.525
DOC_PP1_RVXF_1	482	489	PF00149	0.588
DOC_PP2B_LxvP_1	267	270	PF13499	0.376
DOC_PP2B_LxvP_1	283	286	PF13499	0.368
DOC_PP4_FxxP_1	254	257	PF00568	0.631
DOC_USP7_MATH_1	131	135	PF00917	0.559
DOC_USP7_MATH_1	141	145	PF00917	0.502
DOC_USP7_MATH_1	207	211	PF00917	0.657
DOC_USP7_MATH_1	329	333	PF00917	0.714
DOC_USP7_MATH_1	338	342	PF00917	0.526
DOC_USP7_MATH_1	351	355	PF00917	0.404
DOC_USP7_MATH_1	415	419	PF00917	0.426
DOC_USP7_UBL2_3	213	217	PF12436	0.564
DOC_WW_Pin1_4	136	141	PF00397	0.694
DOC_WW_Pin1_4	253	258	PF00397	0.609
DOC_WW_Pin1_4	302	307	PF00397	0.620
DOC_WW_Pin1_4	309	314	PF00397	0.647
DOC_WW_Pin1_4	411	416	PF00397	0.359
DOC_WW_Pin1_4	430	435	PF00397	0.335
LIG_14-3-3_CanoR_1	102	112	PF00244	0.578
LIG_14-3-3_CanoR_1	189	197	PF00244	0.476
LIG_14-3-3_CanoR_1	344	350	PF00244	0.489
LIG_14-3-3_CanoR_1	40	45	PF00244	0.566
LIG_14-3-3_CanoR_1	534	539	PF00244	0.482
LIG_BIR_II_1	1	5	PF00653	0.739
LIG_BRCT_BRCA1_1	2	6	PF00533	0.667
LIG_BRCT_BRCA1_1	250	254	PF00533	0.705
LIG_BRCT_BRCA1_1	339	343	PF00533	0.582
LIG_BRCT_BRCA1_1	40	44	PF00533	0.568
LIG_CaM_IQ_9	514	529	PF13499	0.246
LIG_CtBP_PxDLS_1	313	317	PF00389	0.464
LIG_deltaCOP1_diTrp_1	443	447	PF00928	0.447
LIG_eIF4E_1	262	268	PF01652	0.492
LIG_FHA_1	309	315	PF00498	0.678
LIG_FHA_1	461	467	PF00498	0.406
LIG_FHA_1	481	487	PF00498	0.576
LIG_FHA_1	553	559	PF00498	0.476
LIG_FHA_2	104	110	PF00498	0.422
LIG_FHA_2	254	260	PF00498	0.544
LIG_FHA_2	384	390	PF00498	0.355
LIG_FHA_2	454	460	PF00498	0.335
LIG_FHA_2	555	561	PF00498	0.530
LIG_LIR_Apic_2	251	257	PF02991	0.664
LIG_LIR_Gen_1	121	130	PF02991	0.753
LIG_LIR_Gen_1	259	270	PF02991	0.473
LIG_LIR_Gen_1	407	415	PF02991	0.335
LIG_LIR_Nem_3	121	125	PF02991	0.751
LIG_LIR_Nem_3	151	157	PF02991	0.624
LIG_LIR_Nem_3	259	265	PF02991	0.487
LIG_LIR_Nem_3	346	352	PF02991	0.452
LIG_LIR_Nem_3	407	411	PF02991	0.335
LIG_LIR_Nem_3	541	547	PF02991	0.432
LIG_LYPXL_S_1	26	30	PF13949	0.536
LIG_LYPXL_yS_3	27	30	PF13949	0.533
LIG_MYND_1	253	257	PF01753	0.643
LIG_PCNA_yPIPBox_3	102	112	PF02747	0.423
LIG_SH2_CRK	262	266	PF00017	0.497
LIG_SH2_NCK_1	70	74	PF00017	0.565
LIG_SH2_PTP2	25	28	PF00017	0.459
LIG_SH2_SRC	25	28	PF00017	0.556
LIG_SH2_STAT5	25	28	PF00017	0.723
LIG_SH2_STAT5	295	298	PF00017	0.517
LIG_SH2_STAT5	385	388	PF00017	0.451
LIG_SH2_STAT5	70	73	PF00017	0.569
LIG_SH3_3	179	185	PF00018	0.510
LIG_SH3_3	23	29	PF00018	0.677
LIG_SUMO_SIM_anti_2	497	502	PF11976	0.469
LIG_SUMO_SIM_par_1	310	317	PF11976	0.666
LIG_SUMO_SIM_par_1	450	456	PF11976	0.338
LIG_TRAF2_1	256	259	PF00917	0.560
LIG_UBA3_1	516	522	PF00899	0.370
MOD_CDK_SPxK_1	413	419	PF00069	0.480
MOD_CK1_1	132	138	PF00069	0.733
MOD_CK1_1	139	145	PF00069	0.703
MOD_CK1_1	150	156	PF00069	0.604
MOD_CK1_1	229	235	PF00069	0.483
MOD_CK1_1	244	250	PF00069	0.559
MOD_CK1_1	304	310	PF00069	0.443
MOD_CK1_1	413	419	PF00069	0.449
MOD_CK1_1	43	49	PF00069	0.724
MOD_CK1_1	430	436	PF00069	0.447
MOD_CK1_1	453	459	PF00069	0.341
MOD_CK1_1	552	558	PF00069	0.445
MOD_CK1_1	96	102	PF00069	0.750
MOD_CK2_1	103	109	PF00069	0.450
MOD_CK2_1	120	126	PF00069	0.771
MOD_CK2_1	221	227	PF00069	0.450
MOD_CK2_1	253	259	PF00069	0.578
MOD_CK2_1	288	294	PF00069	0.477
MOD_CK2_1	534	540	PF00069	0.475
MOD_CK2_1	554	560	PF00069	0.197
MOD_Cter_Amidation	506	509	PF01082	0.456
MOD_GlcNHglycan	114	117	PF01048	0.702
MOD_GlcNHglycan	121	125	PF01048	0.680
MOD_GlcNHglycan	143	146	PF01048	0.656
MOD_GlcNHglycan	2	5	PF01048	0.736
MOD_GlcNHglycan	306	309	PF01048	0.538
MOD_GlcNHglycan	358	361	PF01048	0.493
MOD_GlcNHglycan	50	53	PF01048	0.713
MOD_GSK3_1	120	127	PF00069	0.683
MOD_GSK3_1	131	138	PF00069	0.710
MOD_GSK3_1	140	147	PF00069	0.627
MOD_GSK3_1	185	192	PF00069	0.542
MOD_GSK3_1	226	233	PF00069	0.500
MOD_GSK3_1	241	248	PF00069	0.601
MOD_GSK3_1	297	304	PF00069	0.492
MOD_GSK3_1	308	315	PF00069	0.680
MOD_GSK3_1	339	346	PF00069	0.517
MOD_GSK3_1	379	386	PF00069	0.447
MOD_GSK3_1	411	418	PF00069	0.388
MOD_GSK3_1	426	433	PF00069	0.442
MOD_N-GLC_1	132	137	PF02516	0.767
MOD_N-GLC_1	288	293	PF02516	0.489
MOD_N-GLC_1	48	53	PF02516	0.581
MOD_NEK2_1	112	117	PF00069	0.643
MOD_NEK2_1	120	125	PF00069	0.583
MOD_NEK2_1	230	235	PF00069	0.494
MOD_NEK2_1	316	321	PF00069	0.733
MOD_NEK2_1	343	348	PF00069	0.500
MOD_NEK2_1	410	415	PF00069	0.406
MOD_NEK2_1	450	455	PF00069	0.466
MOD_NEK2_2	288	293	PF00069	0.484
MOD_NEK2_2	554	559	PF00069	0.469
MOD_PIKK_1	189	195	PF00454	0.480
MOD_PIKK_1	241	247	PF00454	0.375
MOD_PKA_2	174	180	PF00069	0.422
MOD_PKA_2	343	349	PF00069	0.534
MOD_PKA_2	480	486	PF00069	0.613
MOD_PKA_2	56	62	PF00069	0.663
MOD_PKA_2	93	99	PF00069	0.729
MOD_Plk_1	120	126	PF00069	0.620
MOD_Plk_1	132	138	PF00069	0.658
MOD_Plk_1	226	232	PF00069	0.483
MOD_Plk_1	288	294	PF00069	0.410
MOD_Plk_1	549	555	PF00069	0.459
MOD_Plk_2-3	93	99	PF00069	0.575
MOD_Plk_4	174	180	PF00069	0.422
MOD_Plk_4	226	232	PF00069	0.502
MOD_Plk_4	450	456	PF00069	0.327
MOD_Plk_4	534	540	PF00069	0.519
MOD_ProDKin_1	136	142	PF00069	0.693
MOD_ProDKin_1	253	259	PF00069	0.596
MOD_ProDKin_1	302	308	PF00069	0.625
MOD_ProDKin_1	309	315	PF00069	0.646
MOD_ProDKin_1	411	417	PF00069	0.359
MOD_ProDKin_1	430	436	PF00069	0.335
MOD_SUMO_rev_2	205	215	PF00179	0.584
TRG_DiLeu_BaEn_1	279	284	PF01217	0.529
TRG_DiLeu_BaEn_1	512	517	PF01217	0.496
TRG_DiLeu_BaEn_2	366	372	PF01217	0.480
TRG_DiLeu_BaEn_2	539	545	PF01217	0.531
TRG_DiLeu_BaEn_4	540	546	PF01217	0.499
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.561
TRG_ENDOCYTIC_2	122	125	PF00928	0.689
TRG_ENDOCYTIC_2	262	265	PF00928	0.405
TRG_ENDOCYTIC_2	27	30	PF00928	0.691
TRG_ENDOCYTIC_2	349	352	PF00928	0.457
TRG_ER_diArg_1	423	425	PF00400	0.410
TRG_ER_diArg_1	547	549	PF00400	0.538
TRG_ER_diArg_1	566	568	PF00400	0.319
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.778

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH1	Leptomonas seymouri	65%	100%
A0A1X0NUL0	Trypanosomatidae	39%	100%
A0A3S7X5E9	Leishmania donovani	88%	100%
A0A422P1A6	Trypanosoma rangeli	39%	100%
A4HKB7	Leishmania braziliensis	70%	99%
A4I7U6	Leishmania infantum	87%	100%
D0AA04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q5F3	Leishmania major	88%	99%
V5BGP5	Trypanosoma cruzi	39%	100%