CRAL-TRIO domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B2Q1_LEIMU

TriTrypDb:

LmxM.31.1260

Length:

478

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.402
CLV_C14_Caspase3-7	433	437	PF00656	0.537
CLV_NRD_NRD_1	149	151	PF00675	0.396
CLV_NRD_NRD_1	168	170	PF00675	0.234
CLV_NRD_NRD_1	221	223	PF00675	0.267
CLV_PCSK_KEX2_1	149	151	PF00082	0.396
CLV_PCSK_KEX2_1	221	223	PF00082	0.275
CLV_PCSK_KEX2_1	417	419	PF00082	0.591
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.625
CLV_PCSK_SKI1_1	169	173	PF00082	0.344
CLV_PCSK_SKI1_1	241	245	PF00082	0.330
CLV_PCSK_SKI1_1	279	283	PF00082	0.390
CLV_PCSK_SKI1_1	414	418	PF00082	0.691
CLV_PCSK_SKI1_1	77	81	PF00082	0.431
CLV_PCSK_SKI1_1	91	95	PF00082	0.374
DOC_CKS1_1	53	58	PF01111	0.431
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.332
DOC_MAPK_gen_1	169	177	PF00069	0.396
DOC_MAPK_gen_1	221	229	PF00069	0.272
DOC_MAPK_gen_1	404	412	PF00069	0.585
DOC_MAPK_MEF2A_6	169	177	PF00069	0.234
DOC_MAPK_MEF2A_6	35	42	PF00069	0.398
DOC_MAPK_MEF2A_6	404	412	PF00069	0.585
DOC_MAPK_NFAT4_5	35	43	PF00069	0.255
DOC_PP1_RVXF_1	290	296	PF00149	0.301
DOC_PP4_FxxP_1	295	298	PF00568	0.354
DOC_SPAK_OSR1_1	387	391	PF12202	0.463
DOC_USP7_MATH_1	304	308	PF00917	0.411
DOC_WW_Pin1_4	124	129	PF00397	0.557
DOC_WW_Pin1_4	134	139	PF00397	0.403
DOC_WW_Pin1_4	294	299	PF00397	0.429
DOC_WW_Pin1_4	472	477	PF00397	0.502
DOC_WW_Pin1_4	52	57	PF00397	0.480
LIG_14-3-3_CanoR_1	22	30	PF00244	0.478
LIG_14-3-3_CanoR_1	279	289	PF00244	0.341
LIG_14-3-3_CanoR_1	387	391	PF00244	0.403
LIG_14-3-3_CanoR_1	418	426	PF00244	0.533
LIG_14-3-3_CanoR_1	465	473	PF00244	0.494
LIG_14-3-3_CanoR_1	48	56	PF00244	0.312
LIG_14-3-3_CanoR_1	71	76	PF00244	0.404
LIG_BIR_II_1	1	5	PF00653	0.499
LIG_BRCT_BRCA1_1	388	392	PF00533	0.426
LIG_deltaCOP1_diTrp_1	372	378	PF00928	0.347
LIG_deltaCOP1_diTrp_1	97	104	PF00928	0.440
LIG_FHA_1	1	7	PF00498	0.527
LIG_FHA_1	135	141	PF00498	0.496
LIG_FHA_1	162	168	PF00498	0.243
LIG_FHA_1	22	28	PF00498	0.435
LIG_FHA_1	224	230	PF00498	0.316
LIG_FHA_1	338	344	PF00498	0.632
LIG_FHA_1	349	355	PF00498	0.456
LIG_FHA_1	48	54	PF00498	0.517
LIG_FHA_2	16	22	PF00498	0.341
LIG_FHA_2	177	183	PF00498	0.308
LIG_FHA_2	337	343	PF00498	0.692
LIG_FHA_2	348	354	PF00498	0.458
LIG_FHA_2	417	423	PF00498	0.613
LIG_FHA_2	92	98	PF00498	0.286
LIG_GBD_Chelix_1	154	162	PF00786	0.203
LIG_LIR_Apic_2	294	298	PF02991	0.369
LIG_LIR_Apic_2	436	441	PF02991	0.527
LIG_LIR_Apic_2	97	101	PF02991	0.512
LIG_LIR_Gen_1	182	193	PF02991	0.396
LIG_LIR_Gen_1	385	394	PF02991	0.466
LIG_LIR_Nem_3	182	188	PF02991	0.300
LIG_Pex14_2	184	188	PF04695	0.234
LIG_Pex14_2	388	392	PF04695	0.360
LIG_Pex14_2	42	46	PF04695	0.312
LIG_Pex14_2	88	92	PF04695	0.366
LIG_RPA_C_Fungi	66	78	PF08784	0.277
LIG_SH2_CRK	278	282	PF00017	0.354
LIG_SH2_CRK	65	69	PF00017	0.332
LIG_SH2_SRC	202	205	PF00017	0.267
LIG_SH2_STAP1	65	69	PF00017	0.424
LIG_SH2_STAT3	393	396	PF00017	0.471
LIG_SH3_1	170	176	PF00018	0.213
LIG_SH3_3	170	176	PF00018	0.435
LIG_SH3_3	265	271	PF00018	0.386
LIG_SUMO_SIM_par_1	225	230	PF11976	0.368
LIG_TRAF2_1	18	21	PF00917	0.339
LIG_TRAF2_1	180	183	PF00917	0.376
LIG_TRFH_1	4	8	PF08558	0.311
LIG_TYR_ITIM	154	159	PF00017	0.413
LIG_TYR_ITIM	234	239	PF00017	0.394
LIG_TYR_ITIM	63	68	PF00017	0.234
LIG_UBA3_1	167	172	PF00899	0.398
LIG_WRC_WIRS_1	1	6	PF05994	0.352
MOD_CDK_SPxxK_3	124	131	PF00069	0.337
MOD_CK1_1	102	108	PF00069	0.466
MOD_CK1_1	455	461	PF00069	0.486
MOD_CK2_1	15	21	PF00069	0.363
MOD_CK2_1	176	182	PF00069	0.326
MOD_CK2_1	336	342	PF00069	0.520
MOD_CK2_1	416	422	PF00069	0.593
MOD_CK2_1	91	97	PF00069	0.310
MOD_Cter_Amidation	358	361	PF01082	0.470
MOD_GlcNHglycan	101	104	PF01048	0.464
MOD_GlcNHglycan	282	285	PF01048	0.364
MOD_GlcNHglycan	35	38	PF01048	0.333
MOD_GlcNHglycan	413	417	PF01048	0.434
MOD_GSK3_1	294	301	PF00069	0.341
MOD_GSK3_1	377	384	PF00069	0.434
MOD_GSK3_1	412	419	PF00069	0.572
MOD_GSK3_1	48	55	PF00069	0.546
MOD_N-GLC_1	334	339	PF02516	0.633
MOD_N-GLC_2	223	225	PF02516	0.396
MOD_NEK2_1	122	127	PF00069	0.483
MOD_NEK2_1	244	249	PF00069	0.354
MOD_NEK2_1	26	31	PF00069	0.359
MOD_NEK2_1	280	285	PF00069	0.307
MOD_NEK2_1	378	383	PF00069	0.377
MOD_PIKK_1	115	121	PF00454	0.270
MOD_PIKK_1	21	27	PF00454	0.447
MOD_PK_1	71	77	PF00069	0.221
MOD_PKA_1	417	423	PF00069	0.580
MOD_PKA_2	21	27	PF00069	0.480
MOD_PKA_2	386	392	PF00069	0.443
MOD_PKA_2	417	423	PF00069	0.545
MOD_PKA_2	47	53	PF00069	0.418
MOD_Plk_1	109	115	PF00069	0.247
MOD_Plk_1	334	340	PF00069	0.468
MOD_Plk_2-3	348	354	PF00069	0.409
MOD_Plk_4	163	169	PF00069	0.308
MOD_Plk_4	223	229	PF00069	0.375
MOD_Plk_4	304	310	PF00069	0.379
MOD_Plk_4	434	440	PF00069	0.437
MOD_Plk_4	452	458	PF00069	0.355
MOD_ProDKin_1	124	130	PF00069	0.552
MOD_ProDKin_1	134	140	PF00069	0.400
MOD_ProDKin_1	294	300	PF00069	0.429
MOD_ProDKin_1	472	478	PF00069	0.512
MOD_ProDKin_1	52	58	PF00069	0.472
MOD_SUMO_for_1	426	429	PF00179	0.440
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.213
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.515
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.329
TRG_ENDOCYTIC_2	130	133	PF00928	0.424
TRG_ENDOCYTIC_2	156	159	PF00928	0.388
TRG_ENDOCYTIC_2	236	239	PF00928	0.364
TRG_ENDOCYTIC_2	278	281	PF00928	0.354
TRG_ENDOCYTIC_2	65	68	PF00928	0.330
TRG_ER_diArg_1	220	222	PF00400	0.262
TRG_ER_diArg_1	408	411	PF00400	0.566
TRG_NLS_MonoExtC_3	168	173	PF00514	0.234
TRG_Pf-PMV_PEXEL_1	169	174	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	28%	91%
A0A0N0P991	Leptomonas seymouri	66%	100%
A0A0N0P9K9	Leptomonas seymouri	28%	100%
A0A0N1I2J8	Leptomonas seymouri	32%	100%
A0A0N1PCS4	Leptomonas seymouri	30%	100%
A0A0S4J7N0	Bodo saltans	25%	100%
A0A0S4KJL3	Bodo saltans	33%	100%
A0A1X0NUH5	Trypanosomatidae	25%	82%
A0A1X0NUJ5	Trypanosomatidae	31%	100%
A0A3Q8ICN0	Leishmania donovani	29%	96%
A0A3Q8IGQ2	Leishmania donovani	92%	100%
A0A3R7MUL5	Trypanosoma rangeli	24%	87%
A0A3S7X4P4	Leishmania donovani	28%	92%
A0A3S7X4R1	Leishmania donovani	33%	97%
A0A422P1E3	Trypanosoma rangeli	28%	100%
A4HJI7	Leishmania braziliensis	30%	100%
A4HJI8	Leishmania braziliensis	32%	100%
A4HJI9	Leishmania braziliensis	31%	99%
A4HKB3	Leishmania braziliensis	81%	100%
A4HKB4	Leishmania braziliensis	24%	99%
A4I6Y2	Leishmania infantum	28%	92%
A4I6Y3	Leishmania infantum	33%	97%
A4I6Y4	Leishmania infantum	30%	100%
A4I7U3	Leishmania infantum	92%	100%
A8Y5H7	Mus musculus	25%	67%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B205	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q0V9N0	Xenopus tropicalis	25%	68%
Q16KN5	Aedes aegypti	22%	74%
Q4Q5F6	Leishmania major	91%	100%
Q4Q655	Leishmania major	30%	100%
Q4Q656	Leishmania major	32%	100%
Q4Q657	Leishmania major	28%	100%
Q7PWB1	Anopheles gambiae	21%	70%
Q92503	Homo sapiens	25%	67%
V5BL84	Trypanosoma cruzi	27%	100%
V5BQT0	Trypanosoma cruzi	25%	86%