Putative ubiquitin hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin hydrolase, putative

Species:

Leishmania mexicana

UniProt:

E9B2Q0_LEIMU

TriTrypDb:

LmxM.31.1250

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B2Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2Q0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	10
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	10
GO:0009057	macromolecule catabolic process	4	10
GO:0009987	cellular process	1	10
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	10
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044265	obsolete cellular macromolecule catabolic process	4	10
GO:0051603	proteolysis involved in protein catabolic process	5	10
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.225
CLV_NRD_NRD_1	281	283	PF00675	0.334
CLV_PCSK_FUR_1	299	303	PF00082	0.286
CLV_PCSK_KEX2_1	281	283	PF00082	0.330
CLV_PCSK_KEX2_1	301	303	PF00082	0.367
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.411
CLV_PCSK_SKI1_1	302	306	PF00082	0.425
DEG_Nend_UBRbox_3	1	3	PF02207	0.328
DEG_SPOP_SBC_1	163	167	PF00917	0.266
DOC_CYCLIN_RxL_1	299	309	PF00134	0.340
DOC_MAPK_DCC_7	268	277	PF00069	0.321
DOC_MAPK_gen_1	177	184	PF00069	0.340
DOC_MAPK_gen_1	212	221	PF00069	0.328
DOC_MAPK_gen_1	299	306	PF00069	0.414
DOC_MAPK_MEF2A_6	214	223	PF00069	0.426
DOC_MAPK_MEF2A_6	225	233	PF00069	0.390
DOC_MAPK_MEF2A_6	268	277	PF00069	0.321
DOC_MAPK_RevD_3	267	282	PF00069	0.390
DOC_PP2B_LxvP_1	304	307	PF13499	0.305
DOC_PP4_FxxP_1	18	21	PF00568	0.181
DOC_USP7_MATH_1	128	132	PF00917	0.347
DOC_USP7_MATH_1	134	138	PF00917	0.331
DOC_USP7_MATH_1	147	151	PF00917	0.376
DOC_USP7_MATH_1	163	167	PF00917	0.391
DOC_USP7_MATH_1	75	79	PF00917	0.368
DOC_USP7_UBL2_3	177	181	PF12436	0.362
DOC_USP7_UBL2_3	393	397	PF12436	0.426
DOC_WW_Pin1_4	348	353	PF00397	0.392
DOC_WW_Pin1_4	369	374	PF00397	0.431
LIG_14-3-3_CanoR_1	216	222	PF00244	0.374
LIG_14-3-3_CanoR_1	247	255	PF00244	0.377
LIG_14-3-3_CanoR_1	299	305	PF00244	0.419
LIG_14-3-3_CanoR_1	324	329	PF00244	0.418
LIG_BIR_III_4	189	193	PF00653	0.357
LIG_BRCT_BRCA1_1	273	277	PF00533	0.450
LIG_Clathr_ClatBox_1	118	122	PF01394	0.426
LIG_Clathr_ClatBox_1	291	295	PF01394	0.340
LIG_FHA_1	249	255	PF00498	0.365
LIG_FHA_1	264	270	PF00498	0.314
LIG_FHA_1	301	307	PF00498	0.281
LIG_FHA_1	320	326	PF00498	0.237
LIG_FHA_1	341	347	PF00498	0.342
LIG_FHA_1	349	355	PF00498	0.329
LIG_FHA_1	365	371	PF00498	0.405
LIG_FHA_1	374	380	PF00498	0.403
LIG_FHA_2	133	139	PF00498	0.389
LIG_Integrin_RGD_1	332	334	PF01839	0.426
LIG_LIR_Apic_2	224	230	PF02991	0.426
LIG_LIR_Apic_2	49	55	PF02991	0.354
LIG_LIR_Gen_1	112	121	PF02991	0.417
LIG_LIR_Gen_1	274	285	PF02991	0.405
LIG_LIR_Gen_1	4	13	PF02991	0.267
LIG_LIR_Nem_3	112	118	PF02991	0.284
LIG_LIR_Nem_3	224	229	PF02991	0.312
LIG_LIR_Nem_3	274	280	PF02991	0.405
LIG_LIR_Nem_3	320	326	PF02991	0.313
LIG_LIR_Nem_3	398	404	PF02991	0.299
LIG_MYND_1	65	69	PF01753	0.451
LIG_NRBOX	106	112	PF00104	0.362
LIG_Pex14_1	48	52	PF04695	0.321
LIG_Pex14_1	53	57	PF04695	0.321
LIG_Pex14_2	18	22	PF04695	0.340
LIG_SH2_CRK	227	231	PF00017	0.451
LIG_SH2_CRK	323	327	PF00017	0.340
LIG_SH2_NCK_1	187	191	PF00017	0.163
LIG_SH2_SRC	187	190	PF00017	0.163
LIG_SH2_STAP1	115	119	PF00017	0.163
LIG_SH2_STAT5	227	230	PF00017	0.427
LIG_SH2_STAT5	341	344	PF00017	0.305
LIG_SH2_STAT5	401	404	PF00017	0.305
LIG_SH3_3	66	72	PF00018	0.451
LIG_SUMO_SIM_par_1	116	123	PF11976	0.225
LIG_TRAF2_1	120	123	PF00917	0.197
LIG_TRAF2_1	98	101	PF00917	0.340
LIG_TYR_ITSM	397	404	PF00017	0.426
LIG_UBA3_1	67	76	PF00899	0.163
MOD_CK1_1	149	155	PF00069	0.412
MOD_CK1_1	77	83	PF00069	0.324
MOD_CK2_1	117	123	PF00069	0.303
MOD_CK2_1	254	260	PF00069	0.383
MOD_CK2_1	95	101	PF00069	0.325
MOD_GlcNHglycan	149	152	PF01048	0.419
MOD_GlcNHglycan	79	82	PF01048	0.407
MOD_GlcNHglycan	84	87	PF01048	0.413
MOD_GSK3_1	128	135	PF00069	0.330
MOD_GSK3_1	23	30	PF00069	0.418
MOD_GSK3_1	312	319	PF00069	0.350
MOD_GSK3_1	369	376	PF00069	0.225
MOD_N-GLC_1	1	6	PF02516	0.274
MOD_N-GLC_1	385	390	PF02516	0.430
MOD_N-GLC_2	5	7	PF02516	0.321
MOD_NEK2_1	1	6	PF00069	0.355
MOD_NEK2_1	196	201	PF00069	0.387
MOD_NEK2_1	245	250	PF00069	0.306
MOD_NEK2_1	25	30	PF00069	0.122
MOD_NEK2_1	263	268	PF00069	0.321
MOD_NEK2_1	8	13	PF00069	0.320
MOD_NEK2_1	95	100	PF00069	0.332
MOD_PIKK_1	88	94	PF00454	0.378
MOD_PK_1	324	330	PF00069	0.451
MOD_PKA_2	217	223	PF00069	0.451
MOD_Plk_1	237	243	PF00069	0.320
MOD_Plk_1	245	251	PF00069	0.195
MOD_Plk_1	312	318	PF00069	0.299
MOD_Plk_1	319	325	PF00069	0.302
MOD_Plk_1	385	391	PF00069	0.426
MOD_Plk_2-3	117	123	PF00069	0.337
MOD_Plk_2-3	132	138	PF00069	0.440
MOD_Plk_4	196	202	PF00069	0.398
MOD_Plk_4	217	223	PF00069	0.308
MOD_Plk_4	271	277	PF00069	0.365
MOD_Plk_4	324	330	PF00069	0.363
MOD_Plk_4	340	346	PF00069	0.336
MOD_Plk_4	375	381	PF00069	0.390
MOD_Plk_4	396	402	PF00069	0.426
MOD_Plk_4	8	14	PF00069	0.418
MOD_ProDKin_1	348	354	PF00069	0.392
MOD_ProDKin_1	369	375	PF00069	0.431
TRG_DiLeu_BaEn_2	397	403	PF01217	0.390
TRG_DiLeu_BaEn_4	116	122	PF01217	0.451
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.426
TRG_ENDOCYTIC_2	115	118	PF00928	0.163
TRG_ENDOCYTIC_2	226	229	PF00928	0.426
TRG_ENDOCYTIC_2	323	326	PF00928	0.305
TRG_ENDOCYTIC_2	401	404	PF00928	0.305
TRG_ER_diArg_1	216	219	PF00400	0.266
TRG_ER_diArg_1	280	282	PF00400	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP3	Leptomonas seymouri	66%	80%
A0A0S4IXL6	Bodo saltans	33%	75%
A0A1X0NUI1	Trypanosomatidae	45%	92%
A0A3S7X5G6	Leishmania donovani	87%	97%
A0A422P1B8	Trypanosoma rangeli	43%	93%
A4HKB2	Leishmania braziliensis	78%	100%
A4I7U2	Leishmania infantum	88%	76%
D0AA02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	93%
O94269	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	80%
Q4Q5F7	Leishmania major	89%	100%
Q9FPS3	Arabidopsis thaliana	23%	74%
V5DHM6	Trypanosoma cruzi	41%	100%