Bardet-Biedl syndrome 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 9 protein

Species:

Leishmania mexicana

UniProt:

E9B2P9_LEIMU

TriTrypDb:

LmxM.31.1240

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0030666	endocytic vesicle membrane	5	1
GO:0030669	clathrin-coated endocytic vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2P9

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0048870	cell motility	2	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0060271	cilium assembly	6	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.416
CLV_C14_Caspase3-7	790	794	PF00656	0.396
CLV_NRD_NRD_1	327	329	PF00675	0.347
CLV_NRD_NRD_1	601	603	PF00675	0.329
CLV_NRD_NRD_1	702	704	PF00675	0.268
CLV_NRD_NRD_1	705	707	PF00675	0.268
CLV_NRD_NRD_1	738	740	PF00675	0.291
CLV_PCSK_FUR_1	703	707	PF00082	0.147
CLV_PCSK_KEX2_1	327	329	PF00082	0.253
CLV_PCSK_KEX2_1	477	479	PF00082	0.784
CLV_PCSK_KEX2_1	601	603	PF00082	0.329
CLV_PCSK_KEX2_1	702	704	PF00082	0.269
CLV_PCSK_KEX2_1	705	707	PF00082	0.269
CLV_PCSK_KEX2_1	738	740	PF00082	0.280
CLV_PCSK_KEX2_1	760	762	PF00082	0.253
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.605
CLV_PCSK_PC1ET2_1	760	762	PF00082	0.253
CLV_PCSK_PC7_1	756	762	PF00082	0.287
CLV_PCSK_SKI1_1	210	214	PF00082	0.303
CLV_PCSK_SKI1_1	230	234	PF00082	0.436
CLV_PCSK_SKI1_1	297	301	PF00082	0.444
CLV_PCSK_SKI1_1	38	42	PF00082	0.347
CLV_PCSK_SKI1_1	571	575	PF00082	0.419
CLV_PCSK_SKI1_1	73	77	PF00082	0.428
CLV_PCSK_SKI1_1	760	764	PF00082	0.264
CLV_PCSK_SKI1_1	84	88	PF00082	0.369
DEG_COP1_1	717	727	PF00400	0.329
DEG_SCF_FBW7_1	563	568	PF00400	0.396
DEG_SPOP_SBC_1	124	128	PF00917	0.268
DOC_CKS1_1	562	567	PF01111	0.238
DOC_CYCLIN_RxL_1	858	867	PF00134	0.147
DOC_CYCLIN_RxL_1	98	109	PF00134	0.396
DOC_MAPK_gen_1	69	78	PF00069	0.331
DOC_MAPK_HePTP_8	66	78	PF00069	0.253
DOC_MAPK_MEF2A_6	101	108	PF00069	0.307
DOC_MAPK_MEF2A_6	69	78	PF00069	0.253
DOC_MAPK_NFAT4_5	101	109	PF00069	0.329
DOC_PP1_RVXF_1	99	106	PF00149	0.396
DOC_PP2B_LxvP_1	460	463	PF13499	0.644
DOC_PP2B_LxvP_1	583	586	PF13499	0.396
DOC_PP2B_LxvP_1	722	725	PF13499	0.367
DOC_PP4_FxxP_1	218	221	PF00568	0.258
DOC_PP4_FxxP_1	716	719	PF00568	0.226
DOC_USP7_MATH_1	110	114	PF00917	0.416
DOC_USP7_MATH_1	122	126	PF00917	0.262
DOC_USP7_MATH_1	139	143	PF00917	0.398
DOC_USP7_MATH_1	149	153	PF00917	0.341
DOC_USP7_MATH_1	30	34	PF00917	0.396
DOC_USP7_MATH_1	371	375	PF00917	0.348
DOC_USP7_MATH_1	397	401	PF00917	0.410
DOC_USP7_MATH_1	463	467	PF00917	0.704
DOC_USP7_MATH_1	487	491	PF00917	0.781
DOC_USP7_MATH_1	498	502	PF00917	0.551
DOC_USP7_MATH_1	553	557	PF00917	0.437
DOC_USP7_MATH_1	565	569	PF00917	0.401
DOC_USP7_MATH_1	85	89	PF00917	0.375
DOC_USP7_UBL2_3	473	477	PF12436	0.648
DOC_USP7_UBL2_3	69	73	PF12436	0.208
DOC_WW_Pin1_4	18	23	PF00397	0.396
DOC_WW_Pin1_4	496	501	PF00397	0.724
DOC_WW_Pin1_4	546	551	PF00397	0.398
DOC_WW_Pin1_4	561	566	PF00397	0.342
DOC_WW_Pin1_4	767	772	PF00397	0.357
DOC_WW_Pin1_4	821	826	PF00397	0.459
LIG_14-3-3_CanoR_1	271	276	PF00244	0.386
LIG_14-3-3_CanoR_1	517	527	PF00244	0.346
LIG_14-3-3_CanoR_1	571	576	PF00244	0.382
LIG_14-3-3_CanoR_1	840	844	PF00244	0.396
LIG_APCC_ABBA_1	358	363	PF00400	0.253
LIG_APCC_ABBA_1	645	650	PF00400	0.287
LIG_APCC_ABBAyCdc20_2	101	107	PF00400	0.396
LIG_BRCT_BRCA1_1	243	247	PF00533	0.376
LIG_BRCT_BRCA1_1	32	36	PF00533	0.396
LIG_BRCT_BRCA1_1	523	527	PF00533	0.447
LIG_BRCT_BRCA1_1	835	839	PF00533	0.329
LIG_BRCT_BRCA1_2	32	38	PF00533	0.396
LIG_CaM_IQ_9	892	908	PF13499	0.380
LIG_Clathr_ClatBox_1	103	107	PF01394	0.396
LIG_deltaCOP1_diTrp_1	9	15	PF00928	0.347
LIG_eIF4E_1	245	251	PF01652	0.396
LIG_FHA_1	159	165	PF00498	0.351
LIG_FHA_1	278	284	PF00498	0.289
LIG_FHA_1	294	300	PF00498	0.277
LIG_FHA_1	309	315	PF00498	0.234
LIG_FHA_1	333	339	PF00498	0.319
LIG_FHA_1	407	413	PF00498	0.291
LIG_FHA_1	419	425	PF00498	0.301
LIG_FHA_1	526	532	PF00498	0.391
LIG_FHA_1	570	576	PF00498	0.336
LIG_FHA_1	656	662	PF00498	0.357
LIG_FHA_1	671	677	PF00498	0.198
LIG_FHA_1	699	705	PF00498	0.409
LIG_FHA_1	709	715	PF00498	0.409
LIG_FHA_1	853	859	PF00498	0.338
LIG_FHA_1	865	871	PF00498	0.279
LIG_FHA_1	872	878	PF00498	0.340
LIG_FHA_1	879	885	PF00498	0.352
LIG_FHA_2	198	204	PF00498	0.312
LIG_FHA_2	253	259	PF00498	0.362
LIG_FHA_2	298	304	PF00498	0.280
LIG_LIR_Apic_2	68	74	PF02991	0.253
LIG_LIR_Gen_1	102	110	PF02991	0.378
LIG_LIR_Gen_1	148	158	PF02991	0.353
LIG_LIR_Gen_1	244	252	PF02991	0.297
LIG_LIR_Gen_1	270	278	PF02991	0.369
LIG_LIR_Gen_1	33	44	PF02991	0.387
LIG_LIR_Gen_1	423	433	PF02991	0.265
LIG_LIR_Gen_1	512	522	PF02991	0.546
LIG_LIR_Gen_1	603	612	PF02991	0.329
LIG_LIR_Gen_1	646	654	PF02991	0.273
LIG_LIR_Gen_1	848	859	PF02991	0.266
LIG_LIR_Gen_1	9	20	PF02991	0.332
LIG_LIR_Nem_3	102	108	PF02991	0.378
LIG_LIR_Nem_3	148	153	PF02991	0.404
LIG_LIR_Nem_3	185	190	PF02991	0.383
LIG_LIR_Nem_3	203	207	PF02991	0.396
LIG_LIR_Nem_3	244	250	PF02991	0.297
LIG_LIR_Nem_3	270	275	PF02991	0.369
LIG_LIR_Nem_3	33	39	PF02991	0.341
LIG_LIR_Nem_3	353	357	PF02991	0.414
LIG_LIR_Nem_3	423	429	PF02991	0.395
LIG_LIR_Nem_3	512	518	PF02991	0.485
LIG_LIR_Nem_3	726	730	PF02991	0.272
LIG_LIR_Nem_3	783	788	PF02991	0.271
LIG_LIR_Nem_3	848	854	PF02991	0.266
LIG_LIR_Nem_3	9	15	PF02991	0.233
LIG_MYND_1	825	829	PF01753	0.280
LIG_MYND_2	641	645	PF01753	0.378
LIG_Pex14_1	11	15	PF04695	0.268
LIG_PTB_Apo_2	181	188	PF02174	0.280
LIG_PTB_Apo_2	624	631	PF02174	0.248
LIG_PTB_Phospho_1	181	187	PF10480	0.280
LIG_Rb_pABgroove_1	30	38	PF01858	0.396
LIG_SH2_CRK	187	191	PF00017	0.396
LIG_SH2_CRK	204	208	PF00017	0.396
LIG_SH2_CRK	346	350	PF00017	0.448
LIG_SH2_CRK	71	75	PF00017	0.256
LIG_SH2_CRK	785	789	PF00017	0.268
LIG_SH2_GRB2like	346	349	PF00017	0.329
LIG_SH2_GRB2like	666	669	PF00017	0.268
LIG_SH2_SRC	666	669	PF00017	0.287
LIG_SH2_STAP1	160	164	PF00017	0.332
LIG_SH2_STAP1	346	350	PF00017	0.359
LIG_SH2_STAP1	426	430	PF00017	0.394
LIG_SH2_STAP1	436	440	PF00017	0.378
LIG_SH2_STAT3	597	600	PF00017	0.280
LIG_SH2_STAT5	12	15	PF00017	0.310
LIG_SH2_STAT5	160	163	PF00017	0.410
LIG_SH2_STAT5	204	207	PF00017	0.147
LIG_SH2_STAT5	315	318	PF00017	0.371
LIG_SH2_STAT5	406	409	PF00017	0.253
LIG_SH2_STAT5	426	429	PF00017	0.378
LIG_SH2_STAT5	666	669	PF00017	0.253
LIG_SH3_2	621	626	PF14604	0.268
LIG_SH3_2	82	87	PF14604	0.409
LIG_SH3_3	56	62	PF00018	0.323
LIG_SH3_3	615	621	PF00018	0.304
LIG_SH3_3	79	85	PF00018	0.267
LIG_SH3_3	94	100	PF00018	0.216
LIG_SH3_4	73	80	PF00018	0.208
LIG_SUMO_SIM_anti_2	305	312	PF11976	0.257
LIG_SUMO_SIM_anti_2	539	545	PF11976	0.332
LIG_SUMO_SIM_anti_2	587	593	PF11976	0.396
LIG_SUMO_SIM_anti_2	890	897	PF11976	0.239
LIG_SUMO_SIM_par_1	160	167	PF11976	0.373
LIG_SUMO_SIM_par_1	196	203	PF11976	0.367
LIG_SUMO_SIM_par_1	305	312	PF11976	0.347
LIG_SUMO_SIM_par_1	526	533	PF11976	0.491
LIG_SUMO_SIM_par_1	671	677	PF11976	0.301
LIG_SUMO_SIM_par_1	872	881	PF11976	0.443
LIG_TRAF2_1	16	19	PF00917	0.347
LIG_TRAF2_1	300	303	PF00917	0.329
LIG_TRAF2_1	483	486	PF00917	0.631
LIG_TYR_ITIM	202	207	PF00017	0.329
LIG_TYR_ITIM	344	349	PF00017	0.329
LIG_TYR_ITIM	424	429	PF00017	0.378
LIG_UBA3_1	429	434	PF00899	0.226
LIG_WRC_WIRS_1	209	214	PF05994	0.396
LIG_WRC_WIRS_1	278	283	PF05994	0.378
LIG_WRC_WIRS_1	351	356	PF05994	0.396
LIG_WRPW_2	83	86	PF00400	0.396
MOD_CDK_SPxK_1	561	567	PF00069	0.147
MOD_CK1_1	125	131	PF00069	0.217
MOD_CK1_1	246	252	PF00069	0.261
MOD_CK1_1	270	276	PF00069	0.356
MOD_CK1_1	398	404	PF00069	0.320
MOD_CK1_1	418	424	PF00069	0.300
MOD_CK1_1	466	472	PF00069	0.705
MOD_CK1_1	510	516	PF00069	0.534
MOD_CK1_1	549	555	PF00069	0.338
MOD_CK1_1	878	884	PF00069	0.379
MOD_CK2_1	149	155	PF00069	0.423
MOD_CK2_1	251	257	PF00069	0.455
MOD_CK2_1	297	303	PF00069	0.461
MOD_CK2_1	359	365	PF00069	0.351
MOD_CK2_1	446	452	PF00069	0.283
MOD_CK2_1	466	472	PF00069	0.529
MOD_CK2_1	478	484	PF00069	0.610
MOD_CK2_1	51	57	PF00069	0.266
MOD_CK2_1	685	691	PF00069	0.253
MOD_GlcNHglycan	119	123	PF01048	0.365
MOD_GlcNHglycan	141	144	PF01048	0.244
MOD_GlcNHglycan	22	25	PF01048	0.286
MOD_GlcNHglycan	319	322	PF01048	0.387
MOD_GlcNHglycan	368	371	PF01048	0.275
MOD_GlcNHglycan	373	376	PF01048	0.286
MOD_GlcNHglycan	448	451	PF01048	0.673
MOD_GlcNHglycan	522	526	PF01048	0.415
MOD_GlcNHglycan	53	56	PF01048	0.312
MOD_GlcNHglycan	551	554	PF01048	0.259
MOD_GlcNHglycan	744	747	PF01048	0.402
MOD_GlcNHglycan	805	808	PF01048	0.369
MOD_GlcNHglycan	835	838	PF01048	0.301
MOD_GlcNHglycan	87	90	PF01048	0.382
MOD_GlcNHglycan	896	899	PF01048	0.450
MOD_GlcNHglycan	902	905	PF01048	0.532
MOD_GSK3_1	106	113	PF00069	0.252
MOD_GSK3_1	118	125	PF00069	0.437
MOD_GSK3_1	232	239	PF00069	0.332
MOD_GSK3_1	241	248	PF00069	0.271
MOD_GSK3_1	267	274	PF00069	0.342
MOD_GSK3_1	293	300	PF00069	0.289
MOD_GSK3_1	420	427	PF00069	0.453
MOD_GSK3_1	442	449	PF00069	0.177
MOD_GSK3_1	463	470	PF00069	0.706
MOD_GSK3_1	487	494	PF00069	0.638
MOD_GSK3_1	505	512	PF00069	0.630
MOD_GSK3_1	513	520	PF00069	0.511
MOD_GSK3_1	521	528	PF00069	0.320
MOD_GSK3_1	549	556	PF00069	0.430
MOD_GSK3_1	561	568	PF00069	0.349
MOD_GSK3_1	670	677	PF00069	0.277
MOD_GSK3_1	793	800	PF00069	0.379
MOD_GSK3_1	821	828	PF00069	0.249
MOD_GSK3_1	871	878	PF00069	0.358
MOD_GSK3_1	890	897	PF00069	0.412
MOD_N-GLC_1	236	241	PF02516	0.271
MOD_N-GLC_1	252	257	PF02516	0.282
MOD_N-GLC_1	518	523	PF02516	0.375
MOD_N-GLC_1	708	713	PF02516	0.147
MOD_N-GLC_2	810	812	PF02516	0.329
MOD_NEK2_1	10	15	PF00069	0.369
MOD_NEK2_1	106	111	PF00069	0.317
MOD_NEK2_1	170	175	PF00069	0.317
MOD_NEK2_1	208	213	PF00069	0.365
MOD_NEK2_1	224	229	PF00069	0.226
MOD_NEK2_1	241	246	PF00069	0.186
MOD_NEK2_1	309	314	PF00069	0.310
MOD_NEK2_1	317	322	PF00069	0.251
MOD_NEK2_1	350	355	PF00069	0.287
MOD_NEK2_1	366	371	PF00069	0.233
MOD_NEK2_1	379	384	PF00069	0.282
MOD_NEK2_1	465	470	PF00069	0.593
MOD_NEK2_1	527	532	PF00069	0.329
MOD_NEK2_1	685	690	PF00069	0.290
MOD_NEK2_1	839	844	PF00069	0.337
MOD_NEK2_1	875	880	PF00069	0.402
MOD_NEK2_2	149	154	PF00069	0.341
MOD_NEK2_2	236	241	PF00069	0.347
MOD_PIKK_1	553	559	PF00454	0.369
MOD_PIKK_1	902	908	PF00454	0.499
MOD_PKA_2	270	276	PF00069	0.331
MOD_PKA_2	293	299	PF00069	0.268
MOD_PKA_2	839	845	PF00069	0.329
MOD_PKB_1	801	809	PF00069	0.396
MOD_Plk_1	236	242	PF00069	0.271
MOD_Plk_1	331	337	PF00069	0.359
MOD_Plk_1	398	404	PF00069	0.387
MOD_Plk_1	513	519	PF00069	0.398
MOD_Plk_1	525	531	PF00069	0.433
MOD_Plk_1	670	676	PF00069	0.268
MOD_Plk_1	772	778	PF00069	0.323
MOD_Plk_4	197	203	PF00069	0.292
MOD_Plk_4	236	242	PF00069	0.387
MOD_Plk_4	246	252	PF00069	0.335
MOD_Plk_4	309	315	PF00069	0.279
MOD_Plk_4	487	493	PF00069	0.511
MOD_Plk_4	539	545	PF00069	0.278
MOD_Plk_4	640	646	PF00069	0.287
MOD_Plk_4	670	676	PF00069	0.268
MOD_Plk_4	887	893	PF00069	0.317
MOD_ProDKin_1	18	24	PF00069	0.396
MOD_ProDKin_1	496	502	PF00069	0.726
MOD_ProDKin_1	546	552	PF00069	0.398
MOD_ProDKin_1	561	567	PF00069	0.342
MOD_ProDKin_1	767	773	PF00069	0.357
MOD_ProDKin_1	821	827	PF00069	0.459
MOD_SUMO_for_1	714	717	PF00179	0.329
MOD_SUMO_rev_2	185	190	PF00179	0.280
MOD_SUMO_rev_2	417	424	PF00179	0.373
TRG_DiLeu_BaEn_1	539	544	PF01217	0.455
TRG_DiLeu_BaEn_1	691	696	PF01217	0.312
TRG_DiLeu_BaEn_1	783	788	PF01217	0.396
TRG_DiLeu_BaLyEn_6	758	763	PF01217	0.253
TRG_DiLeu_LyEn_5	783	788	PF01217	0.226
TRG_ENDOCYTIC_2	12	15	PF00928	0.367
TRG_ENDOCYTIC_2	187	190	PF00928	0.396
TRG_ENDOCYTIC_2	204	207	PF00928	0.396
TRG_ENDOCYTIC_2	209	212	PF00928	0.377
TRG_ENDOCYTIC_2	346	349	PF00928	0.453
TRG_ENDOCYTIC_2	426	429	PF00928	0.268
TRG_ENDOCYTIC_2	436	439	PF00928	0.268
TRG_ENDOCYTIC_2	44	47	PF00928	0.329
TRG_ENDOCYTIC_2	604	607	PF00928	0.396
TRG_ENDOCYTIC_2	785	788	PF00928	0.253
TRG_ER_diArg_1	134	137	PF00400	0.373
TRG_ER_diArg_1	326	328	PF00400	0.349
TRG_ER_diArg_1	702	705	PF00400	0.271
TRG_ER_diArg_1	737	739	PF00400	0.280
TRG_NES_CRM1_1	155	167	PF08389	0.349
TRG_NLS_MonoCore_2	474	479	PF00514	0.524
TRG_NLS_MonoExtN_4	473	480	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	297	302	PF00026	0.268
TRG_Pf-PMV_PEXEL_1	327	332	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	786	790	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFT7	Leptomonas seymouri	60%	99%
A0A0S4KJV3	Bodo saltans	35%	100%
A0A1X0NUH9	Trypanosomatidae	36%	100%
A0A3S7X5H2	Leishmania donovani	88%	98%
A0A422P1E8	Trypanosoma rangeli	40%	100%
A4HKB1	Leishmania braziliensis	78%	100%
A4I7U1	Leishmania infantum	88%	98%
D0AA01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
O01514	Caenorhabditis elegans	21%	100%
Q3SYG4	Homo sapiens	27%	100%
Q4Q5F8	Leishmania major	88%	100%
Q6AX60	Xenopus laevis	27%	100%
Q811G0	Mus musculus	27%	100%
V5B167	Trypanosoma cruzi	37%	100%