Putative ADP-ribosylation factor GTPase activating protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor GTPase activating protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9B2P8_LEIMU

TriTrypDb:

LmxM.31.1230

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B2P8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B2P8

Function

Biological processes
Term	Name	Level	Count
GO:0006901	vesicle coating	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048200	Golgi transport vesicle coating	7	1
GO:0048205	COPI coating of Golgi vesicle	8	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	11
GO:0008047	enzyme activator activity	3	11
GO:0030234	enzyme regulator activity	2	11
GO:0030695	GTPase regulator activity	4	11
GO:0060589	nucleoside-triphosphatase regulator activity	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.625
CLV_C14_Caspase3-7	276	280	PF00656	0.734
CLV_C14_Caspase3-7	294	298	PF00656	0.555
CLV_C14_Caspase3-7	68	72	PF00656	0.321
CLV_NRD_NRD_1	286	288	PF00675	0.487
CLV_NRD_NRD_1	90	92	PF00675	0.311
CLV_PCSK_KEX2_1	286	288	PF00082	0.487
CLV_PCSK_KEX2_1	90	92	PF00082	0.321
DEG_SPOP_SBC_1	65	69	PF00917	0.321
DOC_CDC14_PxL_1	110	118	PF14671	0.477
DOC_CKS1_1	102	107	PF01111	0.356
DOC_MAPK_gen_1	77	86	PF00069	0.302
DOC_MAPK_gen_1	90	96	PF00069	0.302
DOC_MAPK_MEF2A_6	56	64	PF00069	0.321
DOC_PP1_RVXF_1	322	328	PF00149	0.570
DOC_PP1_RVXF_1	91	97	PF00149	0.380
DOC_USP7_MATH_1	14	18	PF00917	0.309
DOC_USP7_MATH_1	147	151	PF00917	0.580
DOC_USP7_MATH_1	156	160	PF00917	0.642
DOC_USP7_MATH_1	215	219	PF00917	0.713
DOC_USP7_MATH_1	23	27	PF00917	0.323
DOC_USP7_MATH_1	233	237	PF00917	0.619
DOC_USP7_MATH_1	251	255	PF00917	0.740
DOC_USP7_MATH_1	330	334	PF00917	0.765
DOC_USP7_MATH_1	335	339	PF00917	0.745
DOC_USP7_MATH_1	341	345	PF00917	0.729
DOC_USP7_MATH_1	353	357	PF00917	0.678
DOC_USP7_MATH_1	364	368	PF00917	0.720
DOC_USP7_UBL2_3	103	107	PF12436	0.325
DOC_WW_Pin1_4	101	106	PF00397	0.411
DOC_WW_Pin1_4	152	157	PF00397	0.748
DOC_WW_Pin1_4	32	37	PF00397	0.433
DOC_WW_Pin1_4	331	336	PF00397	0.767
DOC_WW_Pin1_4	346	351	PF00397	0.662
DOC_WW_Pin1_4	382	387	PF00397	0.693
DOC_WW_Pin1_4	5	10	PF00397	0.583
LIG_14-3-3_CanoR_1	225	229	PF00244	0.713
LIG_14-3-3_CanoR_1	66	71	PF00244	0.321
LIG_APCC_ABBAyCdc20_2	91	97	PF00400	0.380
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BRCT_BRCA1_1	25	29	PF00533	0.356
LIG_CaM_NSCaTE_8	141	148	PF13499	0.540
LIG_deltaCOP1_diTrp_1	133	141	PF00928	0.414
LIG_deltaCOP1_diTrp_1	395	399	PF00928	0.625
LIG_deltaCOP1_diTrp_1	71	76	PF00928	0.302
LIG_FHA_1	203	209	PF00498	0.573
LIG_FHA_1	211	217	PF00498	0.618
LIG_FHA_1	338	344	PF00498	0.802
LIG_FHA_2	390	396	PF00498	0.667
LIG_LIR_Apic_2	133	139	PF02991	0.414
LIG_LIR_Apic_2	344	350	PF02991	0.724
LIG_LIR_Gen_1	12	23	PF02991	0.359
LIG_LIR_Gen_1	188	195	PF02991	0.552
LIG_LIR_Gen_1	196	206	PF02991	0.518
LIG_LIR_Gen_1	35	46	PF02991	0.420
LIG_LIR_Nem_3	12	18	PF02991	0.471
LIG_LIR_Nem_3	166	171	PF02991	0.622
LIG_LIR_Nem_3	188	194	PF02991	0.544
LIG_LIR_Nem_3	196	201	PF02991	0.517
LIG_LIR_Nem_3	35	41	PF02991	0.464
LIG_LIR_Nem_3	45	49	PF02991	0.389
LIG_PDZ_Class_3	399	404	PF00595	0.713
LIG_Pex14_2	15	19	PF04695	0.259
LIG_SH2_CRK	142	146	PF00017	0.499
LIG_SH2_CRK	191	195	PF00017	0.567
LIG_SH2_PTP2	6	9	PF00017	0.575
LIG_SH2_STAP1	118	122	PF00017	0.382
LIG_SH2_STAP1	191	195	PF00017	0.640
LIG_SH2_STAP1	242	246	PF00017	0.528
LIG_SH2_STAT5	142	145	PF00017	0.526
LIG_SH2_STAT5	6	9	PF00017	0.575
LIG_SH2_STAT5	95	98	PF00017	0.321
LIG_SH3_2	102	107	PF14604	0.380
LIG_SH3_3	366	372	PF00018	0.723
LIG_SH3_3	99	105	PF00018	0.302
MOD_CDC14_SPxK_1	349	352	PF00782	0.719
MOD_CDK_SPxK_1	101	107	PF00069	0.411
MOD_CDK_SPxK_1	346	352	PF00069	0.723
MOD_CK1_1	152	158	PF00069	0.753
MOD_CK1_1	196	202	PF00069	0.433
MOD_CK1_1	314	320	PF00069	0.777
MOD_CK1_1	331	337	PF00069	0.714
MOD_CK1_1	342	348	PF00069	0.696
MOD_CK1_1	354	360	PF00069	0.616
MOD_CK1_1	389	395	PF00069	0.640
MOD_CK2_1	331	337	PF00069	0.714
MOD_CMANNOS	73	76	PF00535	0.302
MOD_GlcNHglycan	151	154	PF01048	0.588
MOD_GlcNHglycan	182	185	PF01048	0.642
MOD_GlcNHglycan	191	194	PF01048	0.495
MOD_GlcNHglycan	195	198	PF01048	0.470
MOD_GlcNHglycan	217	220	PF01048	0.602
MOD_GlcNHglycan	235	238	PF01048	0.563
MOD_GlcNHglycan	253	256	PF01048	0.523
MOD_GlcNHglycan	275	278	PF01048	0.553
MOD_GlcNHglycan	279	283	PF01048	0.576
MOD_GlcNHglycan	294	297	PF01048	0.578
MOD_GlcNHglycan	328	331	PF01048	0.711
MOD_GlcNHglycan	337	340	PF01048	0.725
MOD_GlcNHglycan	344	347	PF01048	0.756
MOD_GlcNHglycan	51	54	PF01048	0.324
MOD_GSK3_1	152	159	PF00069	0.695
MOD_GSK3_1	185	192	PF00069	0.598
MOD_GSK3_1	233	240	PF00069	0.555
MOD_GSK3_1	273	280	PF00069	0.482
MOD_GSK3_1	311	318	PF00069	0.692
MOD_GSK3_1	326	333	PF00069	0.600
MOD_GSK3_1	335	342	PF00069	0.740
MOD_GSK3_1	382	389	PF00069	0.527
MOD_GSK3_1	60	67	PF00069	0.302
MOD_N-GLC_1	49	54	PF02516	0.427
MOD_NEK2_1	224	229	PF00069	0.638
MOD_NEK2_1	315	320	PF00069	0.720
MOD_NEK2_1	326	331	PF00069	0.724
MOD_NEK2_1	42	47	PF00069	0.330
MOD_NEK2_1	49	54	PF00069	0.272
MOD_NEK2_1	64	69	PF00069	0.302
MOD_NEK2_2	14	19	PF00069	0.370
MOD_PIKK_1	199	205	PF00454	0.564
MOD_PIKK_1	386	392	PF00454	0.676
MOD_PKA_2	224	230	PF00069	0.718
MOD_PKA_2	273	279	PF00069	0.591
MOD_PKA_2	65	71	PF00069	0.321
MOD_Plk_1	132	138	PF00069	0.418
MOD_Plk_1	315	321	PF00069	0.695
MOD_Plk_4	14	20	PF00069	0.300
MOD_Plk_4	316	322	PF00069	0.679
MOD_Plk_4	42	48	PF00069	0.406
MOD_Plk_4	60	66	PF00069	0.180
MOD_ProDKin_1	101	107	PF00069	0.411
MOD_ProDKin_1	152	158	PF00069	0.750
MOD_ProDKin_1	32	38	PF00069	0.433
MOD_ProDKin_1	331	337	PF00069	0.769
MOD_ProDKin_1	346	352	PF00069	0.664
MOD_ProDKin_1	382	388	PF00069	0.694
MOD_ProDKin_1	5	11	PF00069	0.573
TRG_ENDOCYTIC_2	110	113	PF00928	0.372
TRG_ENDOCYTIC_2	118	121	PF00928	0.356
TRG_ENDOCYTIC_2	142	145	PF00928	0.436
TRG_ENDOCYTIC_2	191	194	PF00928	0.565
TRG_ENDOCYTIC_2	288	291	PF00928	0.739
TRG_ER_diArg_1	286	288	PF00400	0.487
TRG_ER_diArg_1	90	93	PF00400	0.317
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMX1	Leptomonas seymouri	59%	100%
A0A0S4KJM8	Bodo saltans	41%	72%
A0A1X0NUZ4	Trypanosomatidae	49%	100%
A0A3Q8IGX3	Leishmania donovani	89%	100%
A0A422P1B3	Trypanosoma rangeli	49%	100%
A4HKB0	Leishmania braziliensis	69%	99%
A4I7U0	Leishmania infantum	89%	100%
Q4Q5F9	Leishmania major	84%	100%
V5BGP1	Trypanosoma cruzi	48%	100%